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Volume 91, Issue 11

June 1 1998

In this Issue

REVIEW ARTICLES
RAPID COMMUNICATIONS
TRANSPLANTATION
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
RED CELLS
CORRESPONDENCE
ERRATA

REVIEW ARTICLES

Clinical Significance of Cytogenetic Abnormalities in Adult Acute Lymphoblastic Leukemia

Stefan Faderl,Hagop M. Kantarjian,Moshe Talpaz,Zeev Estrov

View Articletitled, Clinical Significance of Cytogenetic Abnormalities in Adult Acute Lymphoblastic Leukemia

RAPID COMMUNICATIONS

Cloning and Characterization of Two Toll/Interleukin-1 Receptor–Like Genes TIL3 and TIL4: Evidence for a Multi-Gene Receptor Family in Humans

Preet M. Chaudhary,Camari Ferguson,Vilaska Nguyen,Oanh Nguyen,Hillary F. Massa,Michael Eby,Alan Jasmin,Barbara J. Trask,Leroy Hood,Peter S. Nelson

View Articletitled, Cloning and Characterization of Two Toll/Interleukin-1 Receptor–Like Genes TIL3 and TIL4: Evidence for a Multi-Gene Receptor Family in Humans

The Partner Gene of AML1 in t(16;21) Myeloid Malignancies Is a Novel Member of the MTG8(ETO) Family

Toshie Gamou,Eiko Kitamura,Fumie Hosoda,Kimiko Shimizu,Kenji Shinohara,Yasuhide Hayashi,Takahiro Nagase,Yasunobu Yokoyama,Misao Ohki

View Articletitled, The Partner Gene of AML1 in t(16;21) Myeloid Malignancies Is a Novel Member of the MTG8(ETO) Family

TRANSPLANTATION

Prevention of Marrow Graft Rejection Without Induction of Graft-Versus-Host Disease by a Cytotoxic T-Cell Clone That Recognizes Recipient Alloantigens

Yoichiro Kusunoki,Wei Chen,Paul J. Martin

View Articletitled, Prevention of Marrow Graft Rejection Without Induction of Graft-Versus-Host Disease by a Cytotoxic T-Cell Clone That Recognizes Recipient Alloantigens

Non–Host-Reactive Donor CD8⁺ T Cells of Tc2 Phenotype Potently Inhibit Marrow Graft Rejection

Daniel H. Fowler,Bernard Whitfield,Michael Livingston,Paul Chrobak,Ronald E. Gress

View Articletitled, Non–Host-Reactive Donor CD8+ T Cells of Tc2 Phenotype Potently Inhibit Marrow Graft Rejection

Differential Effects of Anti-Fas Ligand and Anti-Tumor Necrosis Factor α Antibodies on Acute Graft-Versus-Host Disease Pathologies

Koichi Hattori,Takao Hirano,Hiroaki Miyajima,Norifumi Yamakawa,Masatoshi Tateno,Kazuo Oshimi,Nobuhiko Kayagaki,Hideo Yagita,Ko Okumura

View Articletitled, Differential Effects of Anti-Fas Ligand and Anti-Tumor Necrosis Factor α Antibodies on Acute Graft-Versus-Host Disease Pathologies

HEMATOPOIESIS

Quantitative Long-Term Culture-Initiating Cell Assays Require Accessory Cell Depletion That Can Be Achieved by CD34-Enrichment or 5-Fluorouracil Exposure

Manfred R. Koller,Ilana Manchel,Alan K. Smith

View Articletitled, Quantitative Long-Term Culture-Initiating Cell Assays Require Accessory Cell Depletion That Can Be Achieved by CD34-Enrichment or 5-Fluorouracil Exposure

Thrombopoietin Enhances the Production of Myeloid Cells, but not Megakaryocytes, in Juvenile Chronic Myelogenous Leukemia

Nobukuni Sawai,Kenichi Koike,Tsukasa Higuchi,Kinya Ogami,Megumi Oda

View Articletitled, Thrombopoietin Enhances the Production of Myeloid Cells, but not Megakaryocytes, in Juvenile Chronic Myelogenous Leukemia

Suppression of Hematopoietic Activity in Tenascin-C–Deficient Mice

Masatsugu Ohta,Takao Sakai,Yumiko Saga,Shin-ichi Aizawa,Masaki Saito

View Articletitled, Suppression of Hematopoietic Activity in Tenascin-C–Deficient Mice

The Notch Ligand, Jagged-1, Influences the Development of Primitive Hematopoietic Precursor Cells

Barbara Varnum-Finney,Louise E. Purton,Monica Yu,Carolyn Brashem-Stein,David Flowers,Steven Staats,Kateri A. Moore,Isabelle Le Roux,Robert Mann,Grace Gray,Spyros Artavanis-Tsakonas,Irwin D. Bernstein

View Articletitled, The Notch Ligand, Jagged-1, Influences the Development of Primitive Hematopoietic Precursor Cells

Multiple Inhibitory Cytokines Induce Deregulated Progenitor Growth and Apoptosis in Hematopoietic Cells From Fac^−/− Mice

Laura S. Haneline,Hal E. Broxmeyer,Scott Cooper,Giao Hangoc,Madeleine Carreau,Manuel Buchwald,D. Wade Clapp

View Articletitled, Multiple Inhibitory Cytokines Induce Deregulated Progenitor Growth and Apoptosis in Hematopoietic Cells From Fac−/− Mice

Anti–LFA-1 Blocking Antibodies Prevent Mobilization of Hematopoietic Progenitor Cells Induced by Interleukin-8

Johannes F.M. Pruijt,Yvette van Kooyk,Carl G. Figdor,Ivan J.D. Lindley,Roel Willemze,Willem E. Fibbe

View Articletitled, Anti–LFA-1 Blocking Antibodies Prevent Mobilization of Hematopoietic Progenitor Cells Induced by Interleukin-8

Rhodamine-123 Staining in Hematopoietic Stem Cells of Young Mice Indicates Mitochondrial Activation Rather Than Dye Efflux

MiJung Kim,Donna D. Cooper,Stanley F. Hayes,Gerald J. Spangrude

View Articletitled, Rhodamine-123 Staining in Hematopoietic Stem Cells of Young Mice Indicates Mitochondrial Activation Rather Than Dye Efflux

Thrombopoietin Requires Additional Megakaryocyte-Active Cytokines for Optimal Ex Vivo Expansion of Megakaryocyte Precursor Cells

J. Lynne Williams,George G. Pipia,Nabanita S. Datta,Michael W. Long

View Articletitled, Thrombopoietin Requires Additional Megakaryocyte-Active Cytokines for Optimal Ex Vivo Expansion of Megakaryocyte Precursor Cells

Growth Inhibition of Granulocyte-Macrophage Colony-Forming Cells by Human Cytidine Deaminase Requires the Catalytic Function of the Protein

Christine Gran,Arne Bøyum,Rune F. Johansen,Dagfinn Løvhaug,Erling C. Seeberg

View Articletitled, Growth Inhibition of Granulocyte-Macrophage Colony-Forming Cells by Human Cytidine Deaminase Requires the Catalytic Function of the Protein

NF-κB Transcription Factors Are Involved in Normal Erythropoiesis

Min-Ying Zhang,Shao-Cong Sun,Laurie Bell,Barbara A. Miller

View Articletitled, NF-κB Transcription Factors Are Involved in Normal Erythropoiesis

In Vitro Identification of Single CD34⁺CD38⁻ Cells With Both Lymphoid and Myeloid Potential

Qian-Lin Hao,Elzbieta M. Smogorzewska,Lora W. Barsky,Gay M. Crooks

View Articletitled, In Vitro Identification of Single CD34+CD38− Cells With Both Lymphoid and Myeloid Potential

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Antibodies to Protease-Activated Receptor 3 Inhibit Activation of Mouse Platelets by Thrombin

Hiroaki Ishihara,Dewan Zeng,Andrew J. Connolly,Carmen Tam,Shaun R. Coughlin

View Articletitled, Antibodies to Protease-Activated Receptor 3 Inhibit Activation of Mouse Platelets by Thrombin

Methylenetetrahydrofolate Reductase C₆₇₇T Mutation, Plasma Homocysteine, and Folate in Subjects From Northern Italy With or Without Angiographically Documented Severe Coronary Atherosclerotic Disease: Evidence for an Important Genetic-Environmental Interaction

Domenico Girelli,Simonetta Friso,Elisabetta Trabetti,Oliviero Olivieri,Carla Russo,Renzo Pessotto,Giovanni Faccini,Pier Franco Pignatti,Alessandro Mazzucco,Roberto Corrocher

View Articletitled, Methylenetetrahydrofolate Reductase C677T Mutation, Plasma Homocysteine, and Folate in Subjects From Northern Italy With or Without Angiographically Documented Severe Coronary Atherosclerotic Disease: Evidence for an Important Genetic-Environmental Interaction

Fluid Shear Stress Attenuates Tumor Necrosis Factor-α–Induced Tissue Factor Expression in Cultured Human Endothelial Cells

Yutaka Matsumoto,Yohko Kawai,Kiyoaki Watanabe,Kazuo Sakai,Mitsuru Murata,Makoto Handa,Shin Nakamura,Yasuo Ikeda

View Articletitled, Fluid Shear Stress Attenuates Tumor Necrosis Factor-α–Induced Tissue Factor Expression in Cultured Human Endothelial Cells

Plasmin Can Reduce the Function of Human β₂Glycoprotein I by Cleaving Domain V Into a Nicked Form

Naoki Ohkura,Yoshihisa Hagihara,Tetsuro Yoshimura,Yuji Goto,Hisao Kato

View Articletitled, Plasmin Can Reduce the Function of Human β2Glycoprotein I by Cleaving Domain V Into a Nicked Form

Analysis of Ferritins in Lymphoblastoid Cell Lines and in the Lens of Subjects With Hereditary Hyperferritinemia-Cataract Syndrome

Sonia Levi,Domenico Girelli,Federica Perrone,Marcella Pasti,Carole Beaumont,Roberto Corrocher,Alberto Albertini,Paolo Arosio

View Articletitled, Analysis of Ferritins in Lymphoblastoid Cell Lines and in the Lens of Subjects With Hereditary Hyperferritinemia-Cataract Syndrome

Inhibitory Anti–Factor V Antibodies Bind to the Factor V C2 Domain and Are Associated With Hemorrhagic Manifestations

Thomas L. Ortel,Karen D. Moore,Mary Ann Quinn-Allen,Takashi Okamura,Allen J. Sinclair,John Lazarchick,Ramaswamy Govindan,Françoise Carmagnol,William H. Kane

View Articletitled, Inhibitory Anti–Factor V Antibodies Bind to the Factor V C2 Domain and Are Associated With Hemorrhagic Manifestations

Biochemical and Pharmacological Properties of SANORG 34006, a Potent and Long-Acting Synthetic Pentasaccharide

J.M. Herbert,J.P. Hérault,A. Bernat,R.G.M. van Amsterdam,J.C. Lormeau,M. Petitou,C. van Boeckel,P. Hoffmann,D.G. Meuleman

View Articletitled, Biochemical and Pharmacological Properties of SANORG 34006, a Potent and Long-Acting Synthetic Pentasaccharide

RhoA and the Function of Platelet Integrin α_IIbβ₃

Lijun Leng,Hirokazu Kashiwagi,Xiang-Dong Ren,Sanford J. Shattil

View Articletitled, RhoA and the Function of Platelet Integrin αIIbβ3

Whole Blood Tissue Factor Procoagulant Activity Is Elevated in Patients With Sickle Cell Disease

Nigel S. Key,Arne Slungaard,Luke Dandelet,Stephen C. Nelson,Christopher Moertel,Lori A. Styles,Frans A. Kuypers,Ronald R. Bach

View Articletitled, Whole Blood Tissue Factor Procoagulant Activity Is Elevated in Patients With Sickle Cell Disease

IMMUNOBIOLOGY

Correction of Abnormal T-Cell Receptor Repertoire During Interferon-α Therapy in Patients With Hairy Cell Leukemia

Hanneke C. Kluin-Nelemans,Michel G.D. Kester,Lisette van deCorput,Patrick P.C. Boor,Jim E. Landegent,Jacques J.M. van Dongen,Roel Willemze,J.H. Frederik Falkenburg

View Articletitled, Correction of Abnormal T-Cell Receptor Repertoire During Interferon-α Therapy in Patients With Hairy Cell Leukemia

T-Cell Receptor Signaling Pathway Exerts a Negative Control on Thrombin-Mediated Increase in [Ca²⁺]_i and p38 MAPK Activation in Jurkat T Cells: Implication of the Tyrosine Kinase p56Lck

Laurence Maulon,Sandrine Guérin,Jean-Ehrland Ricci,Dariush FarahiFar,Jean-Philippe Breittmayer,Patrick Auberger

View Articletitled, T-Cell Receptor Signaling Pathway Exerts a Negative Control on Thrombin-Mediated Increase in [Ca2+]i and p38 MAPK Activation in Jurkat T Cells: Implication of the Tyrosine Kinase p56Lck

Characterization of a Novel CC Chemokine, HCC-4, Whose Expression Is Increased by Interleukin-10

Joseph A. Hedrick,Allison Helms,Alain Vicari,Albert Zlotnik

View Articletitled, Characterization of a Novel CC Chemokine, HCC-4, Whose Expression Is Increased by Interleukin-10

Viral Superantigen-Induced Negative Selection of TCR Transgenic CD4⁺ CD8⁺ Thymocytes Depends on Activation, but not Proliferation

Isabel Ferrero,Fabienne Anjuère,Iñigo Azcoitia,Toufic Renno,H. Robson MacDonald,Carlos Ardavı́n

View Articletitled, Viral Superantigen-Induced Negative Selection of TCR Transgenic CD4+ CD8+ Thymocytes Depends on Activation, but not Proliferation

Differential Regulation of Interleukin-10 (IL-10) and IL-12 by Glucocorticoids In Vitro

Jeroen Visser,Anette van Boxel-Dezaire,Dion Methorst,Tibor Brunt,E. Ronald de Kloet,Lex Nagelkerken

View Articletitled, Differential Regulation of Interleukin-10 (IL-10) and IL-12 by Glucocorticoids In Vitro

Interleukin-15 (IL-15) Can Replace the IL-2 Signal in IL-2–Dependent Adult T-Cell Leukemia (ATL) Cell Lines: Expression of IL-15 Receptor α on ATL Cells

Yasuaki Yamada,Kazuyuki Sugawara,Tomoko Hata,Kazuto Tsuruta,Ryozo Moriuchi,Takahiro Maeda,Sunao Atogami,Ken Murata,Kenshi Fujimoto,Tomoko Kohno,Kunihiro Tsukasaki,Masao Tomonaga,Yo-ichi Hirakata,Shimeru Kamihira

View Articletitled, Interleukin-15 (IL-15) Can Replace the IL-2 Signal in IL-2–Dependent Adult T-Cell Leukemia (ATL) Cell Lines: Expression of IL-15 Receptor α on ATL Cells

Differential Sensitivity of CD4⁺ and CD8⁺T Lymphocytes to the Killing Efficacy of Fas (Apo-1/CD95) Ligand⁺ Tumor Cells in B Chronic Lymphocytic Leukemia

Inge Tinhofer,Ingrid Marschitz,Marion Kos,Traudl Henn,Alexander Egle,Andreas Villunger,Richard Greil

View Articletitled, Differential Sensitivity of CD4+ and CD8+T Lymphocytes to the Killing Efficacy of Fas (Apo-1/CD95) Ligand+ Tumor Cells in B Chronic Lymphocytic Leukemia

NEOPLASIA

A Directly Spliced Exon 10–Containing CD44 Variant Promotes the Metastasis and Homotypic Aggregation of Aggressive Non-Hodgkin's Lymphoma

Yoshihiro Yakushijin,Joshua Steckel,Samir Kharbanda,Robert Hasserjian,Donna Neuberg,Wei-meng Jiang,Ian Anderson,Margaret A. Shipp

View Articletitled, A Directly Spliced Exon 10–Containing CD44 Variant Promotes the Metastasis and Homotypic Aggregation of Aggressive Non-Hodgkin's Lymphoma

Analysis of V_H Genes in Follicular and Diffuse Lymphoma Shows Ongoing Somatic Mutation and Multiple Isotype Transcripts in Early Disease With Changes During Disease Progression

Christian H. Ottensmeier,Andrew R. Thompsett,Delin Zhu,Bridget S. Wilkins,John W. Sweetenham,Freda K. Stevenson

View Articletitled, Analysis of VH Genes in Follicular and Diffuse Lymphoma Shows Ongoing Somatic Mutation and Multiple Isotype Transcripts in Early Disease With Changes During Disease Progression

Combined Arsenic and Retinoic Acid Treatment Enhances Differentiation and Apoptosis in Arsenic-Resistant NB4 Cells

Maurizio Giannı̀,Marcel H.M. Koken,Mounira K. Chelbi-Alix,Gérard Benoit,Michel Lanotte,Zhu Chen,Hugues de Thé

View Articletitled, Combined Arsenic and Retinoic Acid Treatment Enhances Differentiation and Apoptosis in Arsenic-Resistant NB4 Cells

Caspase Activation Is Required for Nitric Oxide–Mediated, CD95(APO-1/Fas)–Dependent and Independent Apoptosis in Human Neoplastic Lymphoid Cells

Katerina Chlichlia,Marcus E. Peter,Marian Rocha,Carsten Scaffidi,Mariana Bucur,Peter H. Krammer,Volker Schirrmacher,Victor Umansky

View Articletitled, Caspase Activation Is Required for Nitric Oxide–Mediated, CD95(APO-1/Fas)–Dependent and Independent Apoptosis in Human Neoplastic Lymphoid Cells

Characteristic Pattern of Chromosomal Gains and Losses in Primary Large B-Cell Lymphomas of the Gastrointestinal Tract

Thomas F.E. Barth,Hartmut Döhner,Claudius A. Werner,Stephan Stilgenbauer,Magdalena Schlotter,Michael Pawlita,Peter Lichter,Peter Möller,Martin Bentz

View Articletitled, Characteristic Pattern of Chromosomal Gains and Losses in Primary Large B-Cell Lymphomas of the Gastrointestinal Tract

Isolation of Tumor-Specific Cytotoxic CD4⁺ and CD4⁺CD8dim⁺ T-Cell Clones Infiltrating a Cutaneous T-Cell Lymphoma

Martine Bagot,Hamid Echchakir,Fathia Mami-Chouaib,Marie-Hélène Delfau-Larue,Dominique Charue,Alain Bernheim,Salem Chouaib,Laurence Boumsell,Armand Bensussan

View Articletitled, Isolation of Tumor-Specific Cytotoxic CD4+ and CD4+CD8dim+ T-Cell Clones Infiltrating a Cutaneous T-Cell Lymphoma

p53 Expression in B-Cell Chronic Lymphocytic Leukemia: A Marker of Disease Progression and Poor Prognosis

Iole Cordone,Serena Masi,Francesca Romana Mauro,Silvia Soddu,Ornella Morsilli,Tiziana Valentini,Maria Luce Vegna,Cesare Guglielmi,Francesca Mancini,Sonia Giuliacci,Ada Sacchi,Franco Mandelli,Robert Foa

View Articletitled, p53 Expression in B-Cell Chronic Lymphocytic Leukemia: A Marker of Disease Progression and Poor Prognosis

Increases in Neutral, Mg²⁺-Dependent and Acidic, Mg²⁺-Independent Sphingomyelinase Activities Precede Commitment to Apoptosis and Are Not a Consequence of Caspase 3–Like Activity in Molt-4 Cells in Response to Thymidylate Synthase Inhibition by GW1843

Ronald M. Laethem,Yusuf A. Hannun,Supriya Jayadev,Connie J. Sexton,Jay C. Strum,Rebecca Sundseth,Gary K. Smith

View Articletitled, Increases in Neutral, Mg2+-Dependent and Acidic, Mg2+-Independent Sphingomyelinase Activities Precede Commitment to Apoptosis and Are Not a Consequence of Caspase 3–Like Activity in Molt-4 Cells in Response to Thymidylate Synthase Inhibition by GW1843

RED CELLS

A Large Deletion Within the Protein 4.1 Gene Associated With a Stable Truncated mRNA and an Unaltered Tissue-Specific Alternative Splicing

N. Dalla Venezia,P. Maillet,L. Morlé,L. Roda,J. Delaunay,F. Baklouti

View Articletitled, A Large Deletion Within the Protein 4.1 Gene Associated With a Stable Truncated mRNA and an Unaltered Tissue-Specific Alternative Splicing

Biliary Iron Excretion in Rats Following Treatment With Analogs of Pyridoxal Isonicotinoyl Hydrazone

Karel Bláha,Miroslav Cikrt,Jana Nerudová,Helena Fornusková,Premysl Ponka

View Articletitled, Biliary Iron Excretion in Rats Following Treatment With Analogs of Pyridoxal Isonicotinoyl Hydrazone

The Efficacy of Reducing Agents or Antioxidants in Blocking the Formation of Dense Cells and Irreversibly Sickled Cells In Vitro

Xunda A. Gibson,Archil Shartava,Jonah McIntyre,Carlos A. Monteiro,Yalin Zhang,Arvind Shah,Naomi F. Campbell,Steven R. Goodman

View Articletitled, The Efficacy of Reducing Agents or Antioxidants in Blocking the Formation of Dense Cells and Irreversibly Sickled Cells In Vitro

Molecular Chaperone GRP94 Binds to the Fanconi Anemia Group C Protein and Regulates Its Intracellular Expression

Taizo Hoshino,Jianxiang Wang,Marcel P. Devetten,Nobuhisa Iwata,Sachiko Kajigaya,Robert J. Wise,Johnson M. Liu,Hagop Youssoufian

View Articletitled, Molecular Chaperone GRP94 Binds to the Fanconi Anemia Group C Protein and Regulates Its Intracellular Expression

CORRESPONDENCE

Erythropoietin Prevents the Development of Interleukin-12–Induced Anemia and Thrombocytopenia But Does Not Decrease Its Antitumor Activity in Mice

Jakub Golab,Radoslaw Zagozdzon,Tomasz Stoklosa,Witold Lasek,Marek Jakobisiak,Zygmunt Pojda,Eugeniusz Machaj

View Articletitled, Erythropoietin Prevents the Development of Interleukin-12–Induced Anemia and Thrombocytopenia But Does Not Decrease Its Antitumor Activity in Mice

Alterations of the MMAC1/PTEN Gene in Lymphoid Malignancies

Kirsten Grønbæk,Jesper Zeuthen,Per Guldberg,Elisabeth Ralfkiær,Klaus Hou-Jensen

View Articletitled, Alterations of the MMAC1/PTEN Gene in Lymphoid Malignancies

A Response to AC133 Hematopoietic Stem Cell Antigen: Human Homologue of Mouse Kidney Prominin or Distinct Member of a Novel Protein Family?

Sheri Miraglia,Wayne Godfrey,David Buck

View Articletitled, A Response to AC133 Hematopoietic Stem Cell Antigen: Human Homologue of Mouse Kidney Prominin or Distinct Member of a Novel Protein Family?

Multiple Myeloma and HHV8 Infection

Gieri Cathomas,Aline Stalder,Michael O. Kurrer,Nicolas Regamey,Peter Erb,Helen I. Joller-Jemelka

View Articletitled, Multiple Myeloma and HHV8 Infection

Detection of Human Herpesvirus-8 DNA in Bone Marrow Biopsies From Patients With Multiple Myeloma and Waldenström's Macroglobulinemia

Félix Agbalika,Xavier Mariette,Jean-Pierre Marolleau,Jean-Paul Fermand,Jean-Claude Brouet

View Articletitled, Detection of Human Herpesvirus-8 DNA in Bone Marrow Biopsies From Patients With Multiple Myeloma and Waldenström's Macroglobulinemia

Pancytopenia Secondary to Oxalosis in a 23-Year-Old Woman

Matthew J. Walter,Chi V. Dang

View Articletitled, Pancytopenia Secondary to Oxalosis in a 23-Year-Old Woman

ERRATA

ERRATUM

View Articletitled, ERRATUM

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Table of Contents

REVIEW ARTICLES

RAPID COMMUNICATIONS

TRANSPLANTATION

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

IMMUNOBIOLOGY

NEOPLASIA

RED CELLS

CORRESPONDENCE

ERRATA

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