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Carfilzomib significantly improves the progression-free survival of high-risk patients in multiple myeloma
Targeted sequencing of refractory myeloma reveals a high incidence of mutations in CRBN and Ras pathway genes
Integrated mate-pair and RNA sequencing identifies novel, targetable gene fusions in peripheral T-cell lymphoma
Stem cell transplantation for tetratricopeptide repeat domain 7A deficiency: long-term follow-up
Issue Archive
September 1 2016
In this Issue
Table of Contents
BLOOD FLASHBACK
INSIDE BLOOD COMMENTARIES
REVIEW ARTICLE
CLINICAL TRIALS AND OBSERVATIONS
Carfilzomib significantly improves the progression-free survival of high-risk patients in multiple myeloma
Clinical Trials & Observations
Hervé Avet-Loiseau,Rafael Fonseca,David Siegel,Meletios A. Dimopoulos,Ivan Špička,Tamás Masszi,Roman Hájek,Laura Rosiñol,Vesselina Goranova-Marinova,Georgi Mihaylov,Vladimír Maisnar,Maria-Victoria Mateos,Michael Wang,Ruben Niesvizky,Albert Oriol,Andrzej Jakubowiak,Jiri Minarik,Antonio Palumbo,William Bensinger,Vishal Kukreti,Dina Ben-Yehuda,A. Keith Stewart,Mihaela Obreja,Philippe Moreau
HEMATOPOIESIS AND STEM CELLS
Identification of factors promoting ex vivo maintenance of mouse hematopoietic stem cells by long-term single-cell quantification
Konstantinos D. Kokkaliaris,Erin Drew,Max Endele,Dirk Loeffler,Philipp S. Hoppe,Oliver Hilsenbeck,Bernhard Schauberger,Christoph Hinzen,Stavroula Skylaki,Marina Theodorou,Matthias Kieslinger,Ihor Lemischka,Kateri Moore,Timm Schroeder
IMMUNOBIOLOGY
Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment
Shahram Kordasti,Benedetta Costantini,Thomas Seidl,Pilar Perez Abellan,Marc Martinez Llordella,Donal McLornan,Kirsten E. Diggins,Austin Kulasekararaj,Cinzia Benfatto,Xingmin Feng,Alexander Smith,Syed A. Mian,Rossella Melchiotti,Emanuele de Rinaldis,Richard Ellis,Nedyalko Petrov,Giovanni A. M. Povoleri,Sun Sook Chung,N. Shaun B. Thomas,Farzin Farzaneh,Jonathan M. Irish,Susanne Heck,Neal S. Young,Judith C. W. Marsh,Ghulam J. Mufti
LYMPHOID NEOPLASIA
Comprehensive characterization of programmed death ligand structural rearrangements in B-cell non-Hodgkin lymphomas
Lauren C. Chong,David D. W. Twa,Anja Mottok,Susana Ben-Neriah,Bruce W. Woolcock,Yongjun Zhao,Kerry J. Savage,Marco A. Marra,David W. Scott,Randy D. Gascoyne,Ryan D. Morin,Andrew J. Mungall,Christian Steidl
Targeted sequencing of refractory myeloma reveals a high incidence of mutations in CRBN and Ras pathway genes
Clinical Trials & Observations
K. Martin Kortüm,Elias K. Mai,Nur H. Hanafiah,Chang-Xi Shi,Yuan-Xiao Zhu,Laura Bruins,Santiago Barrio,Patrick Jedlowski,Maximilian Merz,Jing Xu,Robert A. Stewart,Mindaugas Andrulis,Anna Jauch,Jens Hillengass,Hartmut Goldschmidt,P. Leif Bergsagel,Esteban Braggio,A. Keith Stewart,Marc S. Raab
Integrated mate-pair and RNA sequencing identifies novel, targetable gene fusions in peripheral T-cell lymphoma
Clinical Trials & Observations
Rebecca L. Boddicker,Gina L. Razidlo,Surendra Dasari,Yu Zeng,Guangzhen Hu,Ryan A. Knudson,Patricia T. Greipp,Jaime I. Davila,Sarah H. Johnson,Julie C. Porcher,James B. Smadbeck,Bruce W. Eckloff,Daniel D. Billadeau,Paul J. Kurtin,Mark A. McNiven,Brian K. Link,Stephen M. Ansell,James R. Cerhan,Yan W. Asmann,George Vasmatzis,Andrew L. Feldman
MYELOID NEOPLASIA
Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure
Maximilian Mossner,Johann-Christoph Jann,Janina Wittig,Florian Nolte,Stephanie Fey,Verena Nowak,Julia Obländer,Jovita Pressler,Iris Palme,Christina Xanthopoulos,Tobias Boch,Georgia Metzgeroth,Henning Röhl,Stephanie H. Witt,Helene Dukal,Corinna Klein,Steffen Schmitt,Patrick Gelß,Uwe Platzbecker,Ekaterina Balaian,Alice Fabarius,Helmut Blum,Torsten J. Schulze,Manja Meggendorfer,Claudia Haferlach,Andreas Trumpp,Wolf-Karsten Hofmann,Hind Medyouf,Daniel Nowak
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS
PLATELETS AND THROMBOPOIESIS
Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction
María Luisa Lozano,Aaron Cook,José María Bastida,David S. Paul,Gemma Iruin,Ana Rosa Cid,Rosa Adan-Pedroso,José Ramón González-Porras,Jesús María Hernández-Rivas,Sarah J. Fletcher,Ben Johnson,Neil Morgan,Francisca Ferrer-Marin,Vicente Vicente,John Sondek,Steve P. Watson,Wolfgang Bergmeier,José Rivera
RED CELLS, IRON, AND ERYTHROPOIESIS
Adenosine monophosphate deaminase 3 activation shortens erythrocyte half-life and provides malaria resistance in mice
Elinor Hortle,Brunda Nijagal,Denis C. Bauer,Lora M. Jensen,Seong Beom Ahn,Ian A. Cockburn,Shelley Lampkin,Dedreia Tull,Malcolm J. McConville,Brendan J. McMorran,Simon J. Foote,Gaetan Burgio
LETTERS TO BLOOD
Stem cell transplantation for tetratricopeptide repeat domain 7A deficiency: long-term follow-up
Clinical Trials & Observations
Jochen Kammermeier,Giovanna Lucchini,Sung-Yun Pai,Austen Worth,Dyanne Rampling,Persis Amrolia,Juliana Silva,Robert Chiesa,Kanchan Rao,Gabriele Noble-Jamieson,Marco Gasparetto,Drew Ellershaw,Holm Uhlig,Neil Sebire,Mamoun Elawad,Luigi Notarangelo,Neil Shah,Paul Veys
BLOOD WORK
ERRATA
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Cover Image
Cover Image
Visual stochastic neighbor embedding (viSNE) plots from mass cytometry reveal 2 subpopulations within regulatory T cells (Tregs), designated Treg A and B. Their frequencies correlated with response to immunosuppressive therapy (IST) in aplastic anemia (AA). The example shown is from a patient with AA at the time of diagnosis who responded to IST. See the article by Kordasti et al on page 1193.
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