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Journal Articles

Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment

Shahram Kordasti, Benedetta Costantini, Thomas Seidl, Pilar Perez Abellan, Marc Martinez Llordella, Donal McLornan, Kirsten E. Diggins, Austin Kulasekararaj, Cinzia Benfatto, Xingmin Feng, Alexander Smith, Syed A. Mian, Rossella Melchiotti, Emanuele de Rinaldis, Richard Ellis, Nedyalko Petrov, Giovanni A. M. Povoleri, Sun Sook Chung, N. Shaun B. Thomas, Farzin Farzaneh, Jonathan M. Irish, Susanne Heck, Neal S. Young, Judith C. W. Marsh, Ghulam J. Mufti
Journal: Blood
Blood (2016) 128 (9): 1193–1205.
https://doi.org/10.1182/blood-2016-03-703702
Published: 2016
Includes: Supplemental data
Journal Articles

High Resolution Mass Cytometry (CyTOF) in Aplastic Anaemia (AA) Can Identify an Aberrant Treg Subset with Pro-Inflammatory Properties, Predicting Poor Response to Immunosuppressive Therapy

Shahram Kordasti, MD PhD, Thomas Seidl, Richard J Ellis, PhD, Austin Kulasekararaj, Xingmin Feng, PhD, Danielle M. Townsley, MD MSc, Susanne Heck, PhD, Neal S. Young, MD, Judith C Marsh, MD, Ghulam J. Mufti, DM, FRCP, FRCPath
Journal: Blood
Blood (2014) 124 (21): 1600.
https://doi.org/10.1182/blood.V124.21.1600.1600
Published: 2014
Journal Articles

RPL27A Is a Target for Mir-595 and Contributes to Myelodysplastic Phenotype through Ribosomal Dysgenesis

Heba A Alkhatabi, MSc, Joop Gaken, PhD, Austin Kulasekararaj, Shengjiang Tan, PhD, Farooq Malik, BSc, PhD, Alan John Warren, PhD FRCP, FRCPath, FMedSci, Thomas Seidl, David C Darling, PhD, Ghulam Mufti, MD DM, FRCP, FRCPath
Journal: Blood
Blood (2014) 124 (21): 1895.
https://doi.org/10.1182/blood.V124.21.1895.1895
Published: 2014
Journal Articles

JAK Inhibition Reduces CD25 high CD27 + FOXp3 + T Regulatory Cells and Causes a Silencing Of T Effector Cells In Patients With Myeloproliferative Neoplasms Whilst Promoting a TH17 Phenotype

Clodagh Keohane, MD, Shahram Y Kordasti, MD, PhD, Thomas Seidl, Pilar Perez Abellan, Nicholas Shaun B. Thomas, PhD, Ghulam J Mufti, FRCP, FRCPath, Claire N Harrison, DM, FRCP, FRCPath, Donal McLornan, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 4092.
https://doi.org/10.1182/blood.V122.21.4092.4092
Published: 2013
Journal Articles

Myeloid Derived Suppressor Cell Expansion Correlates With Increased regulatory T Cells In Myelodysplastic Syndrome

Astrid Olsnes Kittang, MD, PhD, Shahram Kordasti, MD, PhD, Kristoffer Evebø Sand, MD, Pilar Perezabellan, Thomas Seidl, Kristin Paulsen Rye, Karen Marie Hagen, Geir Hallan, MD, PhD, Austin G Kulasekararaj, MD, PhD, Øystein Bruserud, MD, PhD, Ghulam J. Mufti, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 2766.
https://doi.org/10.1182/blood.V122.21.2766.2766
Published: 2013
Journal Articles

SF3B1 Mutant Clones From Patients With Refractory Anaemia With Ringed Sideroblasts (RARS) Originate From The Early Haematopoietic Stem Cells and Maintain Their Engraftment Potential

Syed A Mian, Kevin Rouault-Pierre, PhD, Alexander E Smith, PhD, Thomas Seidl, Austin G Kulasekararaj, MBBS, MD, MRCP, FRCP, Azim M Mohamedali, PhD, Sneha Shinde, Msc., Dominique Bonnet, PhD, Ghulam J. Mufti, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 262.
https://doi.org/10.1182/blood.V122.21.262.262
Published: 2013
Journal Articles

Expansion of CD141 int Dendritic Cells in Myelodysplastic Syndrome (MDS)

Nathalie Kerkhoff, Shahram Kordasti, Thomas Seidl, Arjan A. Van de Loosdrecht, MD, PhD, Ghulam J. Mufti, MD
Journal: Blood
Blood (2012) 120 (21): 3856.
https://doi.org/10.1182/blood.V120.21.3856.3856
Published: 2012
Journal Articles

Functional characterization of CD4 + T cells in aplastic anemia

Shahram Kordasti, Judith Marsh, Sufyan Al-Khan, Jie Jiang, Alexander Smith, Azim Mohamedali, Pilar Perez Abellan, Caroline Veen, Benedetta Costantini, Austin G. Kulasekararaj, Nana Benson-Quarm, Thomas Seidl, Syed A. Mian, Farzin Farzaneh, Ghulam J. Mufti
Journal: Blood
Blood (2012) 119 (9): 2033–2043.
https://doi.org/10.1182/blood-2011-08-368308
Published: 2012
Includes: Supplemental data
Journal Articles

Functional Characterization of CD4 + T-Cells in Aplastic Anemia (AA)

Shahram Y Kordasti, MD, PhD, Judith C. W. Marsh, Prof MD PhD, Sufyan Al-Khan, MD, Jie Jiang, PhD, Alexander E Smith, PhD, Azim M Mohamedali, PhD, Pilar Perez Abellan, Caroline Veen, Benedetta Costantini, MD, Nana Benson Quarm, Thomas Seidl, Syed A Mian, Farzin Farzaneh, DPhil, Ghulam J. Mufti, MD
Journal: Blood
Blood (2011) 118 (21): 1340.
https://doi.org/10.1182/blood.V118.21.1340.1340
Published: 2011
Journal Articles

5-Azacytidine Specifically Depletes Regulatory T Cells (Tregs) in Myelodysplastic Syndrome (MDS) Patients

Benedetta Costantini, MD, Shahram Y Kordasti, MD, PhD, Austin G Kulasekararaj, MBBS, MD, MRCP, FRCP, Jie Jiang, PhD, Thomas Seidl, Pilar Perez Abellan, Janet Hayden, Farzin Farzaneh, DPhil, Ghulam J. Mufti, MD
Journal: Blood
Blood (2011) 118 (21): 787.
https://doi.org/10.1182/blood.V118.21.787.787
Published: 2011
Journal Articles

Evidence for reduced B-cell progenitors in early (low-risk) myelodysplastic syndrome

Clinical Trials & Observations
Alexander Sternberg, Sally Killick, Tim Littlewood, Chris Hatton, Andy Peniket, Thomas Seidl, Shamit Soneji, Joanne Leach, David Bowen, Claire Chapman, Graham Standen, Edwin Massey, Lisa Robinson, Bipin Vadher, Richard Kaczmarski, Riaz Janmohammed, Kim Clipsham, Andrew Carr, Paresh Vyas
Journal: Blood
Blood (2005) 106 (9): 2982–2991.
https://doi.org/10.1182/blood-2005-04-1543
Published: 2005
Includes: Supplemental data