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Journal Articles

Treg sensitivity to FasL and relative IL-2 deprivation drive idiopathic aplastic anemia immune dysfunction

Shok Ping Lim, Benedetta Costantini, Syed A. Mian, Pilar Perez Abellan, Shreyans Gandhi, Marc Martinez Llordella, Juan Jose Lozano, Rita Antunes dos Reis, Giovanni A. M. Povoleri, Thanos P. Mourikis, Ander Abarrategi, Linda Ariza-McNaughton, Susanne Heck, Jonathan M. Irish, Giovanna Lombardi, Judith C. W. Marsh, Dominique Bonnet, Shahram Kordasti, Ghulam J. Mufti

Blood (2020) 136 (7): 885–897.

https://doi.org/10.1182/blood.2019001347

Published: 2020

Includes: Supplemental data

Journal Articles

Functional Characteristics of FAS-L Resistant and IL-2 Deprived Regulatory T Cells (Treg A) in Idiopathic Aplastic Anaemia

Benedetta Costantini, MD, Syed A Mian, PhD, Shok Ping Lim, PhD, Frederic Toulza, PhD, Stephen Orr, PhD, Pilar Perez-Abellan, MSc, Ander Abarrategi, PhD, Farzin Farzaneh, PhD, Dominique Bonnet, PhD, Judith Marsh, MD, Shahram Kordasti, MD PhD, Ghulam Mufti, DM, FRCP, FRCPath

Blood (2017) 130 (Supplement 1): 2450.

https://doi.org/10.1182/blood.V130.Suppl_1.2450.2450

Published: 2017

Journal Articles

Donor Lymphocyte Infusions Correct Deficiency of Naive T Cells and Improve T-Cell Competence after Allogeneic Haematopoietic Stem Cell Transplantation with Lymphocyte Depletion

Monera Al Rukhayes, Victoria T Potter, Pilar Perez-Abellan, Jesus Feliu, Lajos Floro, Ruby Quartey-Papafio, Farzin Farzaneh, Pramila Krishnamurthy, Jennifer Clay, Carmel Rice, Antonio Pagliuca, MBBS MA FRCP FRCPath, Ghulam J Mufti, Linda D Barber

Blood (2016) 128 (22): 2233.

https://doi.org/10.1182/blood.V128.22.2233.2233

Published: 2016

Journal Articles

Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment

Blood (2016) 128 (9): 1193–1205.

https://doi.org/10.1182/blood-2016-03-703702

Published: 2016

Includes: Supplemental data

Journal Articles

Immunological Profile of Patients after HSCT Using the FCC Conditioning Regimen for Treatment of Severe Aplastic Anemia Shows Sustained Mixed T-Cell Chimerism Is Due to Persistence of Recipient CD8 T Cells and Indicates Potential Basis for Tolerance and Extremely Low Incidence of Graft Versus Host Disease

Francesco Grimaldi, MD, Pilar Perez-Abellan, Steven Best, PhD, Nicholas Lea, PhD, John Veluchamy, Muhammad Atif, MD, Rosemary Grain, Monica Sen, Austin G. Kulasekararaj, MBBS, MD MRCP, FRCPath, Antonio Pagliuca, MBBS, FRCP, FRCPath, MA, Victoria T Potter, MD FRCPA, FRACP, Ghulam J Mufti, FRCP, FRCPath, Judith C.W. Marsh, MD, Linda D Barber, PhD

Blood (2015) 126 (23): 3129.

https://doi.org/10.1182/blood.V126.23.3129.3129

Published: 2015

Journal Articles

King’s College Hospital FCC Conditioning for Severe Aplastic Anemia Induces Tolerance with Mixed T-Cell Chimerism and Extremely Low Incidence of Gvhd

Francesco Grimaldi, MD, Linda D Barber, PhD, Pilar Perez-Abellan, MSc, Rosemary Grain, Victoria T Potter, MD FRCPA, FRACP, Austin Kulasekararaj, Donal McLornan, MD PhD FRCPath, Kavita Raj, MD PhD FRCPath, Hugues de Lavallade, MD PhD, Antonio Pagliuca, MBBS, FRCP, FRCPath, MA, Ghulam J. Mufti, MD PhD, Judith C Marsh, MD

Blood (2014) 124 (21): 1594.

https://doi.org/10.1182/blood.V124.21.1594.1594

Published: 2014

Journal Articles

JAK Inhibition Reduces CD25 high CD27 + FOXp3 + T Regulatory Cells and Causes a Silencing Of T Effector Cells In Patients With Myeloproliferative Neoplasms Whilst Promoting a TH17 Phenotype

Clodagh Keohane, MD, Shahram Y Kordasti, MD, PhD, Thomas Seidl, Pilar Perez Abellan, Nicholas Shaun B. Thomas, PhD, Ghulam J Mufti, FRCP, FRCPath, Claire N Harrison, DM, FRCP, FRCPath, Donal McLornan, MD, PhD

Blood (2013) 122 (21): 4092.

https://doi.org/10.1182/blood.V122.21.4092.4092

Published: 2013

Journal Articles

Functional characterization of CD4 + T cells in aplastic anemia

Shahram Kordasti, Judith Marsh, Sufyan Al-Khan, Jie Jiang, Alexander Smith, Azim Mohamedali, Pilar Perez Abellan, Caroline Veen, Benedetta Costantini, Austin G. Kulasekararaj, Nana Benson-Quarm, Thomas Seidl, Syed A. Mian, Farzin Farzaneh, Ghulam J. Mufti

Blood (2012) 119 (9): 2033–2043.

https://doi.org/10.1182/blood-2011-08-368308

Published: 2012

Includes: Supplemental data

Journal Articles

Functional Characterization of CD4 + T-Cells in Aplastic Anemia (AA)

Shahram Y Kordasti, MD, PhD, Judith C. W. Marsh, Prof MD PhD, Sufyan Al-Khan, MD, Jie Jiang, PhD, Alexander E Smith, PhD, Azim M Mohamedali, PhD, Pilar Perez Abellan, Caroline Veen, Benedetta Costantini, MD, Nana Benson Quarm, Thomas Seidl, Syed A Mian, Farzin Farzaneh, DPhil, Ghulam J. Mufti, MD

Blood (2011) 118 (21): 1340.

https://doi.org/10.1182/blood.V118.21.1340.1340

Published: 2011

Journal Articles

5-Azacytidine Specifically Depletes Regulatory T Cells (Tregs) in Myelodysplastic Syndrome (MDS) Patients

Benedetta Costantini, MD, Shahram Y Kordasti, MD, PhD, Austin G Kulasekararaj, MBBS, MD, MRCP, FRCP, Jie Jiang, PhD, Thomas Seidl, Pilar Perez Abellan, Janet Hayden, Farzin Farzaneh, DPhil, Ghulam J. Mufti, MD

Blood (2011) 118 (21): 787.

https://doi.org/10.1182/blood.V118.21.787.787

Published: 2011

Journal Articles

Reduction of Tregs with Expansion of Th1 Cells and Lack of IFN-γ Secretion by GPI Negative T-Cells In PNH

Shahram Kordasti, MD, PhD, Modupe Elebute, MBBS, MD, MRCP, FRCPath, Pilar Perez Abellan, Austin G Kulasekararaj, Janet Hayden, Azim Mohamedali, PHD, Ghulam J. Mufti, DM, FRCP, FRCPath

Blood (2010) 116 (21): 2240.

https://doi.org/10.1182/blood.V116.21.2240.2240

Published: 2010

Journal Articles

Dysfunctional Tregs with Absence of Cytokine-Secreting CD4 + T-Cell Subsets and Marked Expansion of Th1 Cells Is a Hallmark of Idiopathic Aplastic Anaemia (AA)

Shahram Kordasti, MD, PhD, Judith C. W. Marsh, MD, Pilar Perez Abellan, Sufyan Alkhan, Janet Hayden, Caroline Veen, Jie Jiang, Farzin Farzaneh, DPhil, Ghulam J. Mufti, DM, FRCP, FRCPath

Blood (2010) 116 (21): 2233.

https://doi.org/10.1182/blood.V116.21.2233.2233

Published: 2010

Journal Articles

Contrasting Roles of Th1 and Th17 Cells in Aplastic Anaemia (AA) and Myelodysplastic Syndrome (MDS).

Shahram Y Kordasti, MD, Sufyan M AlKhan, Ziyi Lim, Pilar Perez Abellan, Judith C W Marsh, Ghulam J Mufti, MBBS, DM, FRCP, FRCPath

Blood (2009) 114 (22): 1090.

https://doi.org/10.1182/blood.V114.22.1090.1090

Published: 2009

NARROW

Treg sensitivity to FasL and relative IL-2 deprivation drive idiopathic aplastic anemia immune dysfunction

Functional Characteristics of FAS-L Resistant and IL-2 Deprived Regulatory T Cells (Treg A) in Idiopathic Aplastic Anaemia

Donor Lymphocyte Infusions Correct Deficiency of Naive T Cells and Improve T-Cell Competence after Allogeneic Haematopoietic Stem Cell Transplantation with Lymphocyte Depletion

Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment

King’s College Hospital FCC Conditioning for Severe Aplastic Anemia Induces Tolerance with Mixed T-Cell Chimerism and Extremely Low Incidence of Gvhd

JAK Inhibition Reduces CD25 high CD27 + FOXp3 + T Regulatory Cells and Causes a Silencing Of T Effector Cells In Patients With Myeloproliferative Neoplasms Whilst Promoting a TH17 Phenotype

Functional characterization of CD4 + T cells in aplastic anemia

Functional Characterization of CD4 + T-Cells in Aplastic Anemia (AA)

5-Azacytidine Specifically Depletes Regulatory T Cells (Tregs) in Myelodysplastic Syndrome (MDS) Patients

Reduction of Tregs with Expansion of Th1 Cells and Lack of IFN-γ Secretion by GPI Negative T-Cells In PNH

Dysfunctional Tregs with Absence of Cytokine-Secreting CD4 + T-Cell Subsets and Marked Expansion of Th1 Cells Is a Hallmark of Idiopathic Aplastic Anaemia (AA)

Contrasting Roles of Th1 and Th17 Cells in Aplastic Anaemia (AA) and Myelodysplastic Syndrome (MDS).

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American Society of Hematology

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ASH Publications

American Society of Hematology

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