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Journal Articles

Treg sensitivity to FasL and relative IL-2 deprivation drive idiopathic aplastic anemia immune dysfunction

Shok Ping Lim, Benedetta Costantini, Syed A. Mian, Pilar Perez Abellan, Shreyans Gandhi, Marc Martinez Llordella, Juan Jose Lozano, Rita Antunes dos Reis, Giovanni A. M. Povoleri, Thanos P. Mourikis, Ander Abarrategi, Linda Ariza-McNaughton, Susanne Heck, Jonathan M. Irish, Giovanna Lombardi, Judith C. W. Marsh, Dominique Bonnet, Shahram Kordasti, Ghulam J. Mufti

Blood (2020) 136 (7): 885–897.

https://doi.org/10.1182/blood.2019001347

Published: 2020

Includes: Supplemental data

Journal Articles

Functional Characteristics of FAS-L Resistant and IL-2 Deprived Regulatory T Cells (Treg A) in Idiopathic Aplastic Anaemia

Benedetta Costantini, MD, Syed A Mian, PhD, Shok Ping Lim, PhD, Frederic Toulza, PhD, Stephen Orr, PhD, Pilar Perez-Abellan, MSc, Ander Abarrategi, PhD, Farzin Farzaneh, PhD, Dominique Bonnet, PhD, Judith Marsh, MD, Shahram Kordasti, MD PhD, Ghulam Mufti, DM, FRCP, FRCPath

Blood (2017) 130 (Supplement 1): 2450.

https://doi.org/10.1182/blood.V130.Suppl_1.2450.2450

Published: 2017

Journal Articles

Bone Marrow Stem Cells from Patients with Myelodysplastic Syndrome (MDS) Engraft and Migrate in-between the Humanized Niches in Immuno-Compromised Mouse Models

Syed A Mian, PhD, Kevin Rouault-Pierre, PhD, Alexander E Smith, PhD, Ander Abarrategi, PhD, Thomas Coats, MD, Donal McLornan, Ghulam Mufti, DM, FRCP, FRCPath, Dominique Bonnet, PhD

Blood (2017) 130 (Supplement 1): 49.

https://doi.org/10.1182/blood.V130.Suppl_1.49.49

Published: 2017

Journal Articles

P53 Protein Expression Correlates with Adverse Outcome in Low-Risk Myelodysplastic Syndromes

Francesca Donatelli, Austin G. Kulasekararaj, MBBS, MD MRCP, FRCPath, Alexander e Smith, PhD, Jon Salisbury, Syed A Mian, BSc, M.Phil, Robin M. Ireland, FRCP, FRCPath, Abu Arqoub Hadil, Victoria T Potter, Ghulam J. Mufti, MD PhD

Blood (2016) 128 (22): 5505.

https://doi.org/10.1182/blood.V128.22.5505.5505

Published: 2016

Journal Articles

Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment

Blood (2016) 128 (9): 1193–1205.

https://doi.org/10.1182/blood-2016-03-703702

Published: 2016

Includes: Supplemental data

Journal Articles

Mutations in Cohesin Complex As Potential Targets for Therapeutic Intervention By PARP (Poly ADP Ribose Polymerase) Inhibitors in Myelodysplastic Syndrome

Nazia Matto, Terry J Gaymes, Austin G. Kulasekararaj, MBBS, MD MRCP, FRCPath, Syed A Mian, BSc, M.Phil, Ghulam J Mufti, FRCP, FRCPath

Blood (2015) 126 (23): 1221.

https://doi.org/10.1182/blood.V126.23.1221.1221

Published: 2015

Journal Articles

Telomere Length and Telomerase Assay Assist in Identifying Novel Telomere Gene Complex Mutations in a Cohort of Patients with Aplastic Anemia

Shreyans Gandhi, MBBS,MDDNB,MRCP,FRCPath, Jie Jiang, PhD, Nana Benson-Quarm, B.Sc, Dip (Nursing), Hanna Renshaw, MBBS, MA, Syed A Mian, BSc, M.Phil, Austin G. Kulasekararaj, MBBS, MD MRCP, FRCPath, Ghulam J Mufti, MBBS, DM, FRCP, FRCPath, Judith C. W. Marsh, MD FRCP, FRCPath

Blood (2015) 126 (23): 667.

https://doi.org/10.1182/blood.V126.23.667.667

Published: 2015

Journal Articles

NLRP3 Inflammosome Polymorphisms Are Enriched in Myelodysplastic Syndrome Patients with Autoimmune Disorders

Syed A Mian, BSc, M.Phil, Austin G. Kulasekararaj, MBBS, MD MRCP, FRCPath, Aytug Kizilors, PhD, Kathy L McGraw, PhD, Shahram Kordasti, MD PhD, Stephan Menzel, PhD, Alexander e Smith, PhD, Pilar Perezabellan, BSc, David Sallman, MD, Alan F. List, MD, Ghulam J Mufti, FRCP, FRCPath

Blood (2015) 126 (23): 1659.

https://doi.org/10.1182/blood.V126.23.1659.1659

Published: 2015

Journal Articles

Telomere Gene Complex Mutations Are Frequently Found with Shortened Telomeres in Bone Marrow Failure Syndromes and Idiopathic Pulmonary Fibrosis; Correlation with Haematological and Clinical Features

Shreyans A Gandhi, MD DNB, MRCP, FRCPath, Jie Jiang, PhD, Nana benson-Quarm, Syed A Mian, Steve Best, PhD, Austin Kulasekararaj, Judith C Marsh, MD, Ghulam Mufti, MD DM, FRCP, FRCPath

Blood (2014) 124 (21): 2935.

https://doi.org/10.1182/blood.V124.21.2935.2935

Published: 2014

Journal Articles

Comprehensive Mutational Screening Of 5-Azacitidne Treated Myelodysplastic Syndrome (MDS) Patients Fails To Identify a Specific Mutational Profile Predicting Response To Therapy

Austin G. Kulasekararaj, Azim M Mohamedali, PhD, Alexander E Smith, PhD, Syed A Mian, Nazia Matto, Terry J Gaymes, DPhil, Nicholas Lea, PhD, Joop Gaken, PhD, Ghulam J. Mufti, DM, FRCP, FRCPath

Blood (2013) 122 (21): 2792.

https://doi.org/10.1182/blood.V122.21.2792.2792

Published: 2013

Journal Articles

SF3B1 Mutant Clones From Patients With Refractory Anaemia With Ringed Sideroblasts (RARS) Originate From The Early Haematopoietic Stem Cells and Maintain Their Engraftment Potential

Syed A Mian, Kevin Rouault-Pierre, PhD, Alexander E Smith, PhD, Thomas Seidl, Austin G Kulasekararaj, MBBS, MD, MRCP, FRCP, Azim M Mohamedali, PhD, Sneha Shinde, Msc., Dominique Bonnet, PhD, Ghulam J. Mufti, MD, PhD

Blood (2013) 122 (21): 262.

https://doi.org/10.1182/blood.V122.21.262.262

Published: 2013

Journal Articles

Utility of Peripheral Blood for Cytogenetic and Mutation Analysis in Myelodysplastic Syndrome

Heba A Alkhatabi, MSc, Azim M Mohamedali, PhD, Austin G Kulasekararaj, Sneha Shinde, Msc., Joop Gaken, PhD, Syed A Mian, MSc, Alexander E Smith, PhD, Ghulam J. Mufti, MD

Blood (2012) 120 (21): 1707.

https://doi.org/10.1182/blood.V120.21.1707.1707

Published: 2012

Journal Articles

Functional characterization of CD4 + T cells in aplastic anemia

Shahram Kordasti, Judith Marsh, Sufyan Al-Khan, Jie Jiang, Alexander Smith, Azim Mohamedali, Pilar Perez Abellan, Caroline Veen, Benedetta Costantini, Austin G. Kulasekararaj, Nana Benson-Quarm, Thomas Seidl, Syed A. Mian, Farzin Farzaneh, Ghulam J. Mufti

Blood (2012) 119 (9): 2033–2043.

https://doi.org/10.1182/blood-2011-08-368308

Published: 2012

Includes: Supplemental data

Journal Articles

Kings Health Partners 17 Gene Amplicon Panel for Next Generation Sequencing One Stop Mutational Assessment In Myeloid Malignancies

Nicholas C Lea, PhD, Atiyeh Abdallah, PhD, Aytug Kizilors, PhD, Alexander E Smith, PhD, Syed A Mian, Azim M Mohamedali, PhD, Ghulam J Mufti, MBBS, DM, FRCP, FRCPath

Blood (2011) 118 (21): 748.

https://doi.org/10.1182/blood.V118.21.748.748

Published: 2011

Journal Articles

TP53 Mutations Are Restricted Predominantly to 5q- Syndrome and Myelodysplastic Syndrome Patients with Complex Cytogenetics, and Correlate with Adverse Prognosis

Austin G Kulasekararaj, Alexander E Smith, PhD, Syed A Mian, Pramila Krishnamurthy, Azim M Mohamedali, PhD, Nicholas C Lea, PhD, Janet Hayden, Joop Gaken, Modupe Elebute, Robin M. Ireland, FRCP, FRCPath, Sabine Pomplun, ZiYi Lim, MD, Judith C. W. Marsh, Prof MD PhD, Ghulam J. Mufti, MD

Blood (2011) 118 (21): 792.

https://doi.org/10.1182/blood.V118.21.792.792

Published: 2011

Journal Articles

Telomere Length In MDS Patients Bone Marrow Is Highly Correlated with Complex Cytogenetics, IPSS Risk Groups and Transfusion Dependency,

Jie Jiang, PhD, Austin G Kulasekararaj, Pramila Krishnamurthy, Alexander E Smith, PhD, Syed A Mian, Shreyans Gandhi, Janet Hayden, Joop Gaken, Modupe Elebute, Robin M. Ireland, FRCP, FRCPath, ZiYi Lim, MD, Judith C. W. Marsh, Prof MD PhD, Ghulam J. Mufti, MD

Blood (2011) 118 (21): 3826.

https://doi.org/10.1182/blood.V118.21.3826.3826

Published: 2011

Journal Articles

Functional Characterization of CD4 + T-Cells in Aplastic Anemia (AA)

Shahram Y Kordasti, MD, PhD, Judith C. W. Marsh, Prof MD PhD, Sufyan Al-Khan, MD, Jie Jiang, PhD, Alexander E Smith, PhD, Azim M Mohamedali, PhD, Pilar Perez Abellan, Caroline Veen, Benedetta Costantini, MD, Nana Benson Quarm, Thomas Seidl, Syed A Mian, Farzin Farzaneh, DPhil, Ghulam J. Mufti, MD

Blood (2011) 118 (21): 1340.

https://doi.org/10.1182/blood.V118.21.1340.1340

Published: 2011

Journal Articles

Whole Exome Sequencing Reveals Acquired SF3B1 Mutations Defining Patients with Acquired Idiopathic Sideroblastic Anaemia

Alexander E Smith, PhD, Syed A Mian, Austin G Kulasekararaj, Azim M Mohamedali, PhD, Ghulam J. Mufti, MD

Blood (2011) 118 (21): 2793.

https://doi.org/10.1182/blood.V118.21.2793.2793

Published: 2011

Journal Articles

Polycomb Complex Group Gene Mutations and Their Prognostic Relevance In 5-Azacitidine Treated Myelodysplastic Syndrome Patients

Blood (2010) 116 (21): 125.

https://doi.org/10.1182/blood.V116.21.125.125

Published: 2010

Journal Articles

Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value

Alexander E. Smith, Azim M. Mohamedali, Austin Kulasekararaj, ZiYi Lim, Joop Gäken, Nicholas C. Lea, Bartlomiej Przychodzen, Syed A. Mian, Erick E. Nasser, Claire Shooter, Nigel B. Westwood, Corinna Strupp, Norbert Gattermann, Jaroslaw P. Maciejewski, Ulrich Germing, Ghulam J. Mufti

Blood (2010) 116 (19): 3923–3932.

https://doi.org/10.1182/blood-2010-03-274704

Published: 2010

Includes: Supplemental data

NARROW

Treg sensitivity to FasL and relative IL-2 deprivation drive idiopathic aplastic anemia immune dysfunction

Functional Characteristics of FAS-L Resistant and IL-2 Deprived Regulatory T Cells (Treg A) in Idiopathic Aplastic Anaemia

Bone Marrow Stem Cells from Patients with Myelodysplastic Syndrome (MDS) Engraft and Migrate in-between the Humanized Niches in Immuno-Compromised Mouse Models

P53 Protein Expression Correlates with Adverse Outcome in Low-Risk Myelodysplastic Syndromes

Deep phenotyping of Tregs identifies an immune signature for idiopathic aplastic anemia and predicts response to treatment

Mutations in Cohesin Complex As Potential Targets for Therapeutic Intervention By PARP (Poly ADP Ribose Polymerase) Inhibitors in Myelodysplastic Syndrome

Telomere Length and Telomerase Assay Assist in Identifying Novel Telomere Gene Complex Mutations in a Cohort of Patients with Aplastic Anemia

NLRP3 Inflammosome Polymorphisms Are Enriched in Myelodysplastic Syndrome Patients with Autoimmune Disorders

Telomere Gene Complex Mutations Are Frequently Found with Shortened Telomeres in Bone Marrow Failure Syndromes and Idiopathic Pulmonary Fibrosis; Correlation with Haematological and Clinical Features

Comprehensive Mutational Screening Of 5-Azacitidne Treated Myelodysplastic Syndrome (MDS) Patients Fails To Identify a Specific Mutational Profile Predicting Response To Therapy

SF3B1 Mutant Clones From Patients With Refractory Anaemia With Ringed Sideroblasts (RARS) Originate From The Early Haematopoietic Stem Cells and Maintain Their Engraftment Potential

Utility of Peripheral Blood for Cytogenetic and Mutation Analysis in Myelodysplastic Syndrome

Functional characterization of CD4 + T cells in aplastic anemia

Kings Health Partners 17 Gene Amplicon Panel for Next Generation Sequencing One Stop Mutational Assessment In Myeloid Malignancies

TP53 Mutations Are Restricted Predominantly to 5q- Syndrome and Myelodysplastic Syndrome Patients with Complex Cytogenetics, and Correlate with Adverse Prognosis

Telomere Length In MDS Patients Bone Marrow Is Highly Correlated with Complex Cytogenetics, IPSS Risk Groups and Transfusion Dependency,

Functional Characterization of CD4 + T-Cells in Aplastic Anemia (AA)

Whole Exome Sequencing Reveals Acquired SF3B1 Mutations Defining Patients with Acquired Idiopathic Sideroblastic Anaemia

Polycomb Complex Group Gene Mutations and Their Prognostic Relevance In 5-Azacitidine Treated Myelodysplastic Syndrome Patients

Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value

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American Society of Hematology

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American Society of Hematology

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