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Nicholas C Lea
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Journal Articles

Correlation between the Integrated MDS Flow Cytometry Score and Genomic Abnormalities - a Single Centre Analysis from King's College Hospital

Henry Wood, Lauren Jamieson, Charles Manogaran, Katy Jones, Kar Lok Kong, Josephine Goodwin, Steve Best, Azim Mohamedali, Aytug Kizilors, Nicholas C Lea, Zoe Thorn, Frances Aldridge, Liron Barnea Slonim, Prudence Hardefeldt, Guy Hannah, Shireen Kassam, Deborah Yallop, Austin G. Kulasekararaj
Journal: Blood
Blood (2024) 144 (Supplement 1): 6751.
https://doi.org/10.1182/blood-2024-211268
Published: 2024
Journal Articles

Kings Health Partners 17 Gene Amplicon Panel for Next Generation Sequencing One Stop Mutational Assessment In Myeloid Malignancies

Nicholas C Lea, PhD, Atiyeh Abdallah, PhD, Aytug Kizilors, PhD, Alexander E Smith, PhD, Syed A Mian, Azim M Mohamedali, PhD, Ghulam J Mufti, MBBS, DM, FRCP, FRCPath
Journal: Blood
Blood (2011) 118 (21): 748.
https://doi.org/10.1182/blood.V118.21.748.748
Published: 2011
Journal Articles

TP53 Mutations Are Restricted Predominantly to 5q- Syndrome and Myelodysplastic Syndrome Patients with Complex Cytogenetics, and Correlate with Adverse Prognosis

Austin G Kulasekararaj, Alexander E Smith, PhD, Syed A Mian, Pramila Krishnamurthy, Azim M Mohamedali, PhD, Nicholas C Lea, PhD, Janet Hayden, Joop Gaken, Modupe Elebute, Robin M. Ireland, FRCP, FRCPath, Sabine Pomplun, ZiYi Lim, MD, Judith C. W. Marsh, Prof MD PhD, Ghulam J. Mufti, MD
Journal: Blood
Blood (2011) 118 (21): 792.
https://doi.org/10.1182/blood.V118.21.792.792
Published: 2011
Journal Articles

Polycomb Complex Group Gene Mutations and Their Prognostic Relevance In 5-Azacitidine Treated Myelodysplastic Syndrome Patients

Austin G Kulasekararaj, Azim M Mohamedali, Alexander E Smith, Nicholas C Lea, Aytug Kizilors, Atiyeh Abdallah, Erik E Nasser, Syed A Mian, Richard Yiu, Joop Gaken, Sabine Pomplun, Jie Jiang, Terry J Gaymes, DPhil, Patience Pasipanodya, Janet Hayden, Robin M. Ireland, FRCP, FRCPath, ZiYi Lim, MD, Aloysius Y Ho, Judith C. W. Marsh, MD, Ghulam J. Mufti, DM, FRCP, FRCPath
Journal: Blood
Blood (2010) 116 (21): 125.
https://doi.org/10.1182/blood.V116.21.125.125
Published: 2010
Journal Articles

Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value

Clinical Trials & Observations
Alexander E. Smith, Azim M. Mohamedali, Austin Kulasekararaj, ZiYi Lim, Joop Gäken, Nicholas C. Lea, Bartlomiej Przychodzen, Syed A. Mian, Erick E. Nasser, Claire Shooter, Nigel B. Westwood, Corinna Strupp, Norbert Gattermann, Jaroslaw P. Maciejewski, Ulrich Germing, Ghulam J. Mufti
Journal: Blood
Blood (2010) 116 (19): 3923–3932.
https://doi.org/10.1182/blood-2010-03-274704
Published: 2010
Includes: Supplemental data
Journal Articles

Deep Sequencing the Tet2 Gene in 360 Patients with Myeloid Neoplasms Provides a Comprehensive and Quantitative Mutation Map and Reveals Low Level Mutant Clones.

Alexander E Smith, Azim M Mohamedali, PhD, Syed a Mian, Technician, Nicholas C Lea, BSc, PhD, Nigel Westwood, PhD, CSci, FIBMS, Austin G Kulasekararaj, Joop Gaken, PhD, Corinna Strupp, Norbert Gattermann, MD, PhD, Ulrich Germing, Ghulam J Mufti, MBBS, DM, FRCP, FRCPath
Journal: Blood
Blood (2009) 114 (22): 733.
https://doi.org/10.1182/blood.V114.22.733.733
Published: 2009
Journal Articles

Prevalence of 46/1 JAK2 Haplotype in Patients with Budd-Chiari Syndrome with and without JAK2V617F and TET2 Mutations.

Nicholas C Lea, PhD, Lara N Roberts, Raj K Patel, Rachel Westbrook, Michael A Heneghan, Azim M Mohamedali, PhD, Alex E Smith, Atiyeh Abdallah, Nigel Westwood, PhD, CSci, FIBMS, Trisevgeni Kontou, Deborah Yallop, BSc, FRCPath, MB, BS, MRCP, Roopen Arya, Antonio Pagliuca, MBBS, FRCP, FRCPath, MA, Joop Gaken, PhD, Nigel D Heaton, Ghulam J Mufti, MBBS, DM, FRCP, FRCPath
Journal: Blood
Blood (2009) 114 (22): 434.
https://doi.org/10.1182/blood.V114.22.434.434
Published: 2009
Journal Articles

Systems Biology Analysis of Human Primary T Cells Identifies SAP145 as Rate Limiting for the G 1 →S Phase Transition.

Stephen J. Orr, MSc, Rong Wang, Ph.D., Nicholas C. Lea, Ph.D., Constantinos Chronis, M.Sc., Arun K. Ramani, Ph.D, Ghulam J. Mufti, MBBS, DM, FRCP, FRCPath, Edward M. Marcotte, Ph.D, N. Shaun B. Thomas, Ph.D
Journal: Blood
Blood (2007) 110 (11): 3350.
https://doi.org/10.1182/blood.V110.11.3350.3350
Published: 2007
Journal Articles

Prevalence and prognostic significance of allelic imbalance by single-nucleotide polymorphism analysis in low-risk myelodysplastic syndromes

Azim Mohamedali, Joop Gäken, Natalie A. Twine, Wendy Ingram, Nigel Westwood, Nicholas C. Lea, Janet Hayden, Nora Donaldson, Carlo Aul, Norbert Gattermann, Aristotle Giagounidis, Ulrich Germing, Alan F. List, Ghulam J. Mufti
Journal: Blood
Blood (2007) 110 (9): 3365–3373.
https://doi.org/10.1182/blood-2007-03-079673
Published: 2007
Includes: Supplemental data
Journal Articles

Kinesin Family Member 20A (KIF20A) Is Specifically down Regulated in 5q- CD34+ and CD61+ Cells and Uniparental Disomy Is Not a Feature of 5q- Syndrome.

Nicholas C. Lea, PhD, Azim Mohamedali, PhD, Natalie Twine, MSc, Joop Gaken, Phd, Nigel Westwood, Phd, Wendy Ingram, MBBS, Ghulam Mufti, MD
Journal: Blood
Blood (2006) 108 (11): 2611.
https://doi.org/10.1182/blood.V108.11.2611.2611
Published: 2006