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Patrick Jedlowski
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Journal Articles

Targeted sequencing of refractory myeloma reveals a high incidence of mutations in CRBN and Ras pathway genes

Clinical Trials & Observations
K. Martin Kortüm, Elias K. Mai, Nur H. Hanafiah, Chang-Xi Shi, Yuan-Xiao Zhu, Laura Bruins, Santiago Barrio, Patrick Jedlowski, Maximilian Merz, Jing Xu, Robert A. Stewart, Mindaugas Andrulis, Anna Jauch, Jens Hillengass, Hartmut Goldschmidt, P. Leif Bergsagel, Esteban Braggio, A. Keith Stewart, Marc S. Raab
Journal: Blood
Blood (2016) 128 (9): 1226–1233.
https://doi.org/10.1182/blood-2016-02-698092
Published: 2016
Includes: Supplemental data
Journal Articles

Crispr Sgrnas Genome-Wide Screen Identifies the Proteasome Regulatory Subunit PSMC6 As a Bortezomib Resistance Gene in Human Multiple Myeloma Cells

Chang-Xin Shi, PhD, Klaus M Kortum, MD, Yuan Xiao Zhu, PhD, Patrick Jedlowski, Esteban Braggio, PhD, Laura Ann Bruins, Patrick G. Votruba, M.S., Moulun Luo, PhD, Robert A. Stewart, Jonathan M. Ahmann, A. Keith Stewart
Journal: Blood
Blood (2015) 126 (23): 450.
https://doi.org/10.1182/blood.V126.23.450.450
Published: 2015
Journal Articles

Targeted Sequencing of Relapsed/Refractory Myeloma Patients Identifies an Enrichment of Mutations in Cereblon and MAPK Pathways

Elias Karl Mai, MD, K. Martin Kortuem, MD, Nur Hanafiah, Santiago Barrio, Laura Ann Bruins, Maximilian Merz, MD, Jing Xu, Koenuel Pashayeva, MD, Yuan-Xiao Zhu, Chang-Xin Shi, PhD, R. Alexander Stewart, Patrick Jedlowski, Mindaugas Andrulis, MD, Anna Jauch, Prof., Jens Hillengass, MD, Hartmut Goldschmidt, MD, P. Leif Bergsagel, MD PhD, Esteban Braggio, PhD, A. Keith Stewart, MD, Marc Steffen Raab, MD PhD
Journal: Blood
Blood (2015) 126 (23): 723.
https://doi.org/10.1182/blood.V126.23.723.723
Published: 2015
Journal Articles

Identification of FAM46C As a Multiple Myeloma Repressor

Yuan Xiao Zhu, PhD, Chang-Xin Shi, PhD, Patrick Jedlowski, Klaus Martin Kortum, Laura Ann Bruins, Jonathan Ahmann, Esteban Braggio, PhD, Xuewei Wang, A. Keith Stewart
Journal: Blood
Blood (2015) 126 (23): 836.
https://doi.org/10.1182/blood.V126.23.836.836
Published: 2015
Journal Articles

RNA interference screening identifies lenalidomide sensitizers in multiple myeloma, including RSK2

Yuan Xiao Zhu, Hongwei Yin, Laura A. Bruins, Chang-Xin Shi, Patrick Jedlowski, Meraj Aziz, Chris Sereduk, Klaus Martin Kortuem, Jessica E. Schmidt, Mia Champion, Esteban Braggio, A. Keith Stewart
Journal: Blood
Blood (2015) 125 (3): 483–491.
https://doi.org/10.1182/blood-2014-05-577130
Published: 2015
Includes: Supplemental data
Journal Articles

Ikaros Degradation Efficiency Correlates with Response of Multiple Myeloma (MM) Cells to IMiD Therapy and Is Blocked By Proteasome Inhibitors

Chang-Xin Shi, PhD, Yuan Xiao Zhu, PhD, Patrick Jedlowski, Laura Bruins, Martin Kortuem, MD, A. Keith Stewart, MD
Journal: Blood
Blood (2014) 124 (21): 2247.
https://doi.org/10.1182/blood.V124.21.2247.2247
Published: 2014
Journal Articles

Identification of cereblon-binding proteins and relationship with response and survival after IMiDs in multiple myeloma

Yuan Xiao Zhu, Esteban Braggio, Chang-Xin Shi, K. Martin Kortuem, Laura A. Bruins, Jessica E. Schmidt, Xiu-Bao Chang, Paul Langlais, Moulun Luo, Patrick Jedlowski, Betsy LaPlant, Kristina Laumann, Rafael Fonseca, P. Leif Bergsagel, Joseph Mikhael, Martha Lacy, Mia D. Champion, A. Keith Stewart
Journal: Blood
Blood (2014) 124 (4): 536–545.
https://doi.org/10.1182/blood-2014-02-557819
Published: 2014
Includes: Supplemental data