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Superficial venous thrombosis: deeper than meets the eye?
Rap1-GTP–interacting adaptor molecule (RIAM) is dispensable for platelet integrin activation and function in mice
Ibritumomab consolidation after 3 cycles of CHOP plus radiotherapy in high-risk limited-stage aggressive B-cell lymphoma: SWOG S0313
A phase 1/1b study of rituximab, bendamustine, and ibrutinib in patients with untreated and relapsed/refractory non-Hodgkin lymphoma
Higher-than-expected prevalence of silent cerebral infarcts in children with hemoglobin SC disease
Issue Archive
January 8 2015
In this Issue
Table of Contents
INSIDE BLOOD COMMENTARIES
INSIDE BLOOD COMMENTARY
Superficial venous thrombosis: deeper than meets the eye?
Clinical Trials & Observations
PLENARY PAPER
PLATELETS AND THROMBOPOIESIS
Rap1-GTP–interacting adaptor molecule (RIAM) is dispensable for platelet integrin activation and function in mice
Brief Report
BLOOD SPOTLIGHT
CLINICAL TRIALS AND OBSERVATIONS
Ibritumomab consolidation after 3 cycles of CHOP plus radiotherapy in high-risk limited-stage aggressive B-cell lymphoma: SWOG S0313
Clinical Trials & Observations
Daniel O. Persky,Thomas P. Miller,Joseph M. Unger,Catherine M. Spier,Soham Puvvada,B. Dino Stea,Oliver W. Press,Louis S. Constine,Kevin P. Barton,Jonathan W. Friedberg,Michael LeBlanc,Richard I. Fisher
A phase 1/1b study of rituximab, bendamustine, and ibrutinib in patients with untreated and relapsed/refractory non-Hodgkin lymphoma
Clinical Trials & Observations
Kami Maddocks,Beth Christian,Samantha Jaglowski,Joseph Flynn,Jeffery A. Jones,Pierluigi Porcu,Lai Wei,Cynthia Jenkins,Gerard Lozanski,John C. Byrd,Kristie A. Blum
HEMATOPOIESIS AND STEM CELLS
Epigenetic and in vivo comparison of diverse MSC sources reveals an endochondral signature for human hematopoietic niche formation
Andreas Reinisch,Nathalie Etchart,Daniel Thomas,Nicole A. Hofmann,Margareta Fruehwirth,Subarna Sinha,Charles K. Chan,Kshemendra Senarath-Yapa,Eun-Young Seo,Taylor Wearda,Udo F. Hartwig,Christine Beham-Schmid,Slave Trajanoski,Qiong Lin,Wolfgang Wagner,Christian Dullin,Frauke Alves,Michael Andreeff,Irving L. Weissman,Michael T. Longaker,Katharina Schallmoser,Ravindra Majeti,Dirk Strunk
IMMUNOBIOLOGY
Boost and loss of immune responses against tumor-associated antigens in the course of pregnancy as a model for allogeneic immunotherapy
Mathias Lutz,Andrea Worschech,Miriam Alb,Sabine Gahn,Laura Bernhard,Michael Schwab,Stefanie Obermeier,Hermann Einsele,Ulrike Kämmerer,Peter Heuschmann,Erdwine Klinker,Christoph Otto,Stephan Mielke
LYMPHOID NEOPLASIA
OSU-T315: a novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells
Ta-Ming Liu,Yonghua Ling,Jennifer A. Woyach,Kyle Beckwith,Yuh-Ying Yeh,Erin Hertlein,Xiaoli Zhang,Amy Lehman,Farrukh Awan,Jeffrey A. Jones,Leslie A. Andritsos,Kami Maddocks,Jessica MacMurray,Santosh B. Salunke,Ching-Shih Chen,Mitch A. Phelps,John C. Byrd,Amy J. Johnson
MYELOID NEOPLASIA
IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition
Andrew Kernytsky,Fang Wang,Erica Hansen,Stefanie Schalm,Kimberly Straley,Camelia Gliser,Hua Yang,Jeremy Travins,Stuart Murray,Marion Dorsch,Sam Agresta,David P. Schenkein,Scott A. Biller,Shinsan M. Su,Wei Liu,Katharine E. Yen
Loss of TET2 has dual roles in murine myeloproliferative neoplasms: disease sustainer and disease accelerator
Takuro Kameda,Kotaro Shide,Takumi Yamaji,Ayako Kamiunten,Masaaki Sekine,Yasuhiro Taniguchi,Tomonori Hidaka,Yoko Kubuki,Haruko Shimoda,Kousuke Marutsuka,Goro Sashida,Kazumasa Aoyama,Makoto Yoshimitsu,Taku Harada,Hiroo Abe,Tadashi Miike,Hisayoshi Iwakiri,Yoshihiro Tahara,Mitsue Sueta,Shojiro Yamamoto,Satoru Hasuike,Kenji Nagata,Atsushi Iwama,Akira Kitanaka,Kazuya Shimoda
Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia
Bowen Xu,Doan M. On,Anqi Ma,Trevor Parton,Kyle D. Konze,Samantha G. Pattenden,David F. Allison,Ling Cai,Shira Rockowitz,Shichong Liu,Ying Liu,Fengling Li,Masoud Vedadi,Stephen V. Frye,Benjamin A. Garcia,Deyou Zheng,Jian Jin,Gang Greg Wang
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS
Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells
Haruka Sasaki,Daisuke Kurotaki,Naoki Osato,Hideaki Sato,Izumi Sasaki,Shin-ichi Koizumi,Hongsheng Wang,Chika Kaneda,Akira Nishiyama,Tsuneyasu Kaisho,Hiroyuki Aburatani,Herbert C. Morse, III,Keiko Ozato,Tomohiko Tamura
RED CELLS, IRON, AND ERYTHROPOIESIS
THROMBOSIS AND HEMOSTASIS
CORRESPONDENCE
Higher-than-expected prevalence of silent cerebral infarcts in children with hemoglobin SC disease
Clinical Trials & Observations
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Cover Image
Cover Image
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The lipid raft compartment at the plasma membrane plays an indispensable role for recruiting AKT and triggers downstream survival signaling in chronic lymphocytic leukemia. The raft marker, ganglioside GM1, is labeled with Alexa 488, while AKT is marked with Alexa 594. Administration of OSU-T315 can impede the recruitment of AKT to the raft portion. See the article by Liu et al on page 284.
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