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Journal Articles

Zinc-Dependent Homomultimerization of Mutant Calreticulin Is Required for MPN Pathogenesis

Jeanne F Rivera, BSc, April Joy Baral, MSc, Rachael Smyth, MSc, Fatima Nadat, PhD, Emma Burman, BSc, Ghadah Alameer, MSc, Sally A Boxall, PhD, Brian R Jackson, PhD, Ann Mullally, MD, Edwin Chen, PhD

Blood (2019) 134 (Supplement_1): 312.

https://doi.org/10.1182/blood-2019-124005

Published: 2019

Journal Articles

STAG2 Mutations Alter Cohesin Ring Function and Provide Therapeutic Vulnerabilities in Acute Myeloid Leukemia

Blood (2018) 132 (Supplement 1): 940.

https://doi.org/10.1182/blood-2018-99-117480

Published: 2018

Journal Articles

Defining the requirements for the pathogenic interaction between mutant calreticulin and MPL in MPN

Shannon Elf, Nouran S. Abdelfattah, April J. Baral, Danielle Beeson, Jeanne F. Rivera, Amy Ko, Natalie Florescu, Gabriel Birrane, Edwin Chen, Ann Mullally

Blood (2018) 131 (7): 782–786.

https://doi.org/10.1182/blood-2017-08-800896

Published: 2018

Includes: Supplemental data

Journal Articles

Functional and Molecular Basis of Thrombopoietin Receptor Activation By Mutant Calreticulin

Shannon Elf, PhD, Nouran Abdelfattah, MPhil, April Joy Baral, MSc, BSc, Danielle Beeson, Amy Ko, Natalie Florescu, Edwin Chen, PhD, Ann Mullally, MD

Blood (2017) 130 (Supplement 1): 382.

https://doi.org/10.1182/blood.V130.Suppl_1.382.382

Published: 2017

Journal Articles

Physical Interaction Between Mutant Calreticulin and the Thrombopoietin Receptor Is Required for Hematopoietic Transformation

Shannon Elf, PhD, Nouran Abdelfattah, MPhil, Edwin Chen, PhD, Javier Perales-Patón, Emily Rosen, BS, Amy Ko, Fabian Peisker, Natalie Florescu, Silvia Giannini, PhD, Ofir Wolach, MD, Elizabeth A. Morgan, MD, Julie-Aurore Losman, MD, PhD, Rebekka K. Schneider, MD, Fatima Al-Shahrour, PhD, Ann Mullally, MD

Blood (2015) 126 (23): LBA-4.

https://doi.org/10.1182/blood.V126.23.LBA-4.LBA-4

Published: 2015

Journal Articles

Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms

Edwin Chen, Rebekka K. Schneider, Lawrence J. Breyfogle, Emily A. Rosen, Luke Poveromo, Shannon Elf, Amy Ko, Kristina Brumme, Ross Levine, Benjamin L. Ebert, Ann Mullally

Blood (2015) 125 (2): 327–335.

https://doi.org/10.1182/blood-2014-04-567024

Published: 2015

Includes: Supplemental data

Journal Articles

The Recql5 Helicase Is a Novel Downstream Target of Jak2V617F and Maintains Genome Stability in Response to Replication Stress

Edwin Chen, PhD, Jong-Sook Ahn, PhD, Lawrence J Breyfogle, Anthony R Green, PhDFRCP FRCPath, Benjamin L. Ebert, MDPhD, Ann Mullally, MD

Blood (2014) 124 (21): 822.

https://doi.org/10.1182/blood.V124.21.822.822

Published: 2014

Journal Articles

JAK2V617F homozygosity drives a phenotypic switch in myeloproliferative neoplasms, but is insufficient to sustain disease

Juan Li, David G. Kent, Anna L. Godfrey, Harriet Manning, Jyoti Nangalia, Athar Aziz, Edwin Chen, Kourosh Saeb-Parsy, Juergen Fink, Rachel Sneade, Tina L. Hamilton, Dean C. Pask, Yvonne Silber, Xiaodong Zhao, Cedric Ghevaert, Pentao Liu, Anthony R. Green

Blood (2014) 123 (20): 3139–3151.

https://doi.org/10.1182/blood-2013-06-510222

Published: 2014

Includes: Supplemental data

Journal Articles

Tet2 Loss Accelerates The Myeloproliferative Neoplasm (MPN) Phenotype Of Jak2V617F Knockin Mice But Is Insufficient To Cause Leukemic Transformation

Edwin Chen, Lawrence J Breyfogle, Rebekka K. Schneider, MD, Luke Poveromo, BS, Ross L. Levine, MD, Benjamin L. Ebert, MD, PhD, Ann Mullally, MD

Blood (2013) 122 (21): 4095.

https://doi.org/10.1182/blood.V122.21.4095.4095

Published: 2013

Journal Articles

JAK2V617F homozygosity arises commonly and recurrently in PV and ET, but PV is characterized by expansion of a dominant homozygous subclone

Anna L. Godfrey, Edwin Chen, Francesca Pagano, Christina A. Ortmann, Yvonne Silber, Beatriz Bellosillo, Paola Guglielmelli, Claire N. Harrison, John T. Reilly, Frank Stegelmann, Fontanet Bijou, Eric Lippert, Mary F. McMullin, Jean-Michel Boiron, Konstanze Döhner, Alessandro M. Vannucchi, Carlos Besses, Peter J. Campbell, Anthony R. Green

Blood (2012) 120 (13): 2704–2707.

https://doi.org/10.1182/blood-2012-05-431791

Published: 2012

Includes: Supplemental data

Journal Articles

JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F–positive essential thrombocythemia

Juan Li, Dominik Spensberger, Jong Sook Ahn, Shubha Anand, Philip A. Beer, Cedric Ghevaert, Edwin Chen, Ariel Forrai, Linda M. Scott, Rita Ferreira, Peter J. Campbell, Steve P. Watson, Pentao Liu, Wendy N. Erber, Brian J. P. Huntly, Katrin Ottersbach, Anthony R. Green

Blood (2010) 116 (9): 1528–1538.

https://doi.org/10.1182/blood-2009-12-259747

Published: 2010

Includes: Supplemental data

Journal Articles

Two routes to leukemic transformation after a JAK2 mutation–positive myeloproliferative neoplasm

Philip A. Beer, François Delhommeau, Jean-Pierre LeCouédic, Mark A. Dawson, Edwin Chen, David Bareford, Rajko Kušec, Mary Frances McMullin, Claire N. Harrison, Alessandro M. Vannucchi, William Vainchenker, Anthony R. Green

Blood (2010) 115 (14): 2891–2900.

https://doi.org/10.1182/blood-2009-08-236596

Published: 2010

Journal Articles

ID1 promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signaling

Andrew D. Wood, Edwin Chen, Ian J. Donaldson, Shilpa Hattangadi, Karly A. Burke, Mark A. Dawson, Diego Miranda-Saavedra, Harvey F. Lodish, Anthony R. Green, Berthold Göttgens

Blood (2009) 114 (9): 1820–1830.

https://doi.org/10.1182/blood-2009-02-206573

Published: 2009

Includes: Supplemental data

Journal Articles

Loss of Ubr1 Cooperatively Synergizes with HOX11 in B Cell Lymphomagenesis.

Edwin Chen, MS, Suzana Rosic-Kablar, MD, Lim S. Megan, MD, PhD, Hough R. Margaret, PhD

Blood (2004) 104 (11): 215.

https://doi.org/10.1182/blood.V104.11.215.215

Published: 2004

NARROW

Zinc-Dependent Homomultimerization of Mutant Calreticulin Is Required for MPN Pathogenesis

STAG2 Mutations Alter Cohesin Ring Function and Provide Therapeutic Vulnerabilities in Acute Myeloid Leukemia

Defining the requirements for the pathogenic interaction between mutant calreticulin and MPL in MPN

Functional and Molecular Basis of Thrombopoietin Receptor Activation By Mutant Calreticulin

Physical Interaction Between Mutant Calreticulin and the Thrombopoietin Receptor Is Required for Hematopoietic Transformation

Distinct effects of concomitant Jak2V617F expression and Tet2 loss in mice promote disease progression in myeloproliferative neoplasms

The Recql5 Helicase Is a Novel Downstream Target of Jak2V617F and Maintains Genome Stability in Response to Replication Stress

JAK2V617F homozygosity drives a phenotypic switch in myeloproliferative neoplasms, but is insufficient to sustain disease

Tet2 Loss Accelerates The Myeloproliferative Neoplasm (MPN) Phenotype Of Jak2V617F Knockin Mice But Is Insufficient To Cause Leukemic Transformation

JAK2V617F homozygosity arises commonly and recurrently in PV and ET, but PV is characterized by expansion of a dominant homozygous subclone

JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F–positive essential thrombocythemia

Two routes to leukemic transformation after a JAK2 mutation–positive myeloproliferative neoplasm

ID1 promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signaling

Loss of Ubr1 Cooperatively Synergizes with HOX11 in B Cell Lymphomagenesis.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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