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Journal Articles

IDH1 Mutant AML Is Susceptible to Targeting De Novo Lipid Synthesis Independent of 2-Hydroxyglutarate and Has a Distinct Metabolic Profile from IDH2 Mutant AML

Daniel Thomas, MD PhD, Yusuke Nakauchi, MD PhD, Manhong Wu, PhD, Ming Zheng, PhD, Subarna Sinha, PhD, David Dill, PhD, Gary Peltz, MD PhD, Ravindra Majeti, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 440.
https://doi.org/10.1182/blood-2018-99-115040
Published: 2018
Journal Articles

Isocitrate Dehydrogenase 1 Mutant Cancers Are Metabolically Vulnerable to Inhibition of Acetyl CoA Carboxylase Via a 2-Hydroxyglutarate Independent Mechanism

Daniel Thomas, MD PhD, Subarna Sinha, PhD, Steven M. Chan, MD PhD, Manhong Wu, Damoun Torabi, Gary Peltz, MD PhD, Yang Gao, David L Dill, PhD, Ravi Majeti, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1054.
https://doi.org/10.1182/blood.V128.22.1054.1054
Published: 2016
Journal Articles

Boolean Implication Mining for Synthetic Lethal Interactions in AML Identifies Acetyl-CoA Carboxylase As a Synthetic Lethal Partner of the IDH1 mutation

Subarna Sinha, PhD, Daniel Thomas, MD PhD, Steven M. Chan, MD PhD, Yang Gao, Rolf Jansen, PhD, Ravi Majeti, MD PhD, David L Dill, PhD
Journal: Blood
Blood (2015) 126 (23): 1404.
https://doi.org/10.1182/blood.V126.23.1404.1404
Published: 2015
Journal Articles

Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML and responds to EZH2 inhibition

Subarna Sinha, Daniel Thomas, Linda Yu, Andrew J. Gentles, Namyoung Jung, M. Ryan Corces-Zimmerman, Steven M. Chan, Andreas Reinisch, Andrew P. Feinberg, David L. Dill, Ravindra Majeti
Journal: Blood
Blood (2015) 125 (2): 316–326.
https://doi.org/10.1182/blood-2014-03-566018
Published: 2015
Includes: Supplemental data
Journal Articles

Epigenetic and in vivo comparison of diverse MSC sources reveals an endochondral signature for human hematopoietic niche formation

Andreas Reinisch, Nathalie Etchart, Daniel Thomas, Nicole A. Hofmann, Margareta Fruehwirth, Subarna Sinha, Charles K. Chan, Kshemendra Senarath-Yapa, Eun-Young Seo, Taylor Wearda, Udo F. Hartwig, Christine Beham-Schmid, Slave Trajanoski, Qiong Lin, Wolfgang Wagner, Christian Dullin, Frauke Alves, Michael Andreeff, Irving L. Weissman, Michael T. Longaker, Katharina Schallmoser, Ravindra Majeti, Dirk Strunk
Journal: Blood
Blood (2015) 125 (2): 249–260.
https://doi.org/10.1182/blood-2014-04-572255
Published: 2015
Includes: Multimedia, Supplemental data
Journal Articles

Mutation in Wilms' Tumor 1 Induces DNA Hypermethylation of PRC2 Targets, Blocks Myelomonocytic Differentiation, and Defines a Novel Subtype of AML Responsive to EZH2 Inhibition

Daniel Thomas, MD PhD, Subarna Sinha, PhD, Linda Yu, Namyoung Jung, BS, Bo Dai, PhD, Andrew J Gentles, PhD, Andrew P. Feinberg, MD, David Dill, PhD, Ravindra Majeti, MD PhD
Journal: Blood
Blood (2014) 124 (21): 780.
https://doi.org/10.1182/blood.V124.21.780.780
Published: 2014