Ulf-Henrik Mellqvist,for the Nordic Myeloma Study Group,Peter Gimsing,for the Nordic Myeloma Study Group,Oyvind Hjertner,for the Nordic Myeloma Study Group,Stig Lenhoff,for the Nordic Myeloma Study Group,Edward Laane,for the Nordic Myeloma Study Group,Kari Remes,for the Nordic Myeloma Study Group,Hlif Steingrimsdottir,for the Nordic Myeloma Study Group,Niels Abildgaard,for the Nordic Myeloma Study Group,Lucia Ahlberg,for the Nordic Myeloma Study Group,Cecilie Blimark,for the Nordic Myeloma Study Group,Inger Marie Dahl,for the Nordic Myeloma Study Group,Karin Forsberg,for the Nordic Myeloma Study Group,Tobias Gedde-Dahl,for the Nordic Myeloma Study Group,Henrik Gregersen,for the Nordic Myeloma Study Group,Astrid Gruber,for the Nordic Myeloma Study Group,Nina Guldbrandsen,for the Nordic Myeloma Study Group,Einar Haukås,for the Nordic Myeloma Study Group,Kristina Carlson,for the Nordic Myeloma Study Group,Ann Kristin Kvam,for the Nordic Myeloma Study Group,Hareth Nahi,for the Nordic Myeloma Study Group,Roald Lindås,for the Nordic Myeloma Study Group,Niels Frost Andersen,for the Nordic Myeloma Study Group,Ingemar Turesson,for the Nordic Myeloma Study Group,Anders Waage,for the Nordic Myeloma Study Group,Jan Westin,for the Nordic Myeloma Study Group

View Articletitled, Bortezomib consolidation after autologous stem cell transplantation in multiple myeloma: a Nordic Myeloma Study Group randomized phase 3 trial

Phase 2 study of azacytidine plus sorafenib in patients with acute myeloid leukemia and FLT-3 internal tandem duplication mutation
Clinical Trials & Observations

Farhad Ravandi,Mona Lisa Alattar,Michael R. Grunwald,Michelle A. Rudek,Trivikram Rajkhowa,Mary Ann Richie,Sherry Pierce,Naval Daver,Guillermo Garcia-Manero,Stefan Faderl,Aziz Nazha,Marina Konopleva,Gautam Borthakur,Jan Burger,Tapan Kadia,Sara Dellasala,Michael Andreeff,Jorge Cortes,Hagop Kantarjian,Mark Levis

View Articletitled, Phase 2 study of azacytidine plus sorafenib in patients with acute myeloid leukemia and FLT-3 internal tandem duplication mutation

Supplemental data

IMMUNOBIOLOGY

MicroRNAs activate natural killer cells through Toll-like receptor signaling

Shun He,Jianhong Chu,Lai-Chu Wu,Hsiaoyin Mao,Yong Peng,Christopher A. Alvarez-Breckenridge,Tiffany Hughes,Min Wei,Jianying Zhang,Shunzong Yuan,Sumeet Sandhu,Sumithira Vasu,Don M. Benson, Jr,Craig C. Hofmeister,Xiaoming He,Kalpana Ghoshal,Steven M. Devine,Michael A. Caligiuri,Jianhua Yu

View Articletitled, MicroRNAs activate natural killer cells through Toll-like receptor signaling

Supplemental data

LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity

Konrad Krzewski,Aleksandra Gil-Krzewska,Victoria Nguyen,Giovanna Peruzzi,John E. Coligan

View Articletitled, LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity

Supplemental data

TCR triggering modulates the responsiveness and homeostatic proliferation of CD4⁺ thymic emigrants to IL-7 therapy

Olga Hennion-Tscheltzoff,Dominique Leboeuf,Simon-David Gauthier,Martine Dupuis,Brigitte Assouline,Anne Grégoire,Stéphanie Thiant,Martin Guimond

View Articletitled, TCR triggering modulates the responsiveness and homeostatic proliferation of CD4+ thymic emigrants to IL-7 therapy

Supplemental data

Rituximab causes a polarization of B cells that augments its therapeutic function in NK-cell–mediated antibody-dependent cellular cytotoxicity

Dominika Rudnicka,Anna Oszmiana,Donna K. Finch,Ian Strickland,Darren J. Schofield,David C. Lowe,Matthew A. Sleeman,Daniel M. Davis

View Articletitled, Rituximab causes a polarization of B cells that augments its therapeutic function in NK-cell–mediated antibody-dependent cellular cytotoxicity

Supplemental data

Influence of KIR gene copy number on natural killer cell education
Brief Report

Vivien Béziat,James A. Traherne,Lisa L. Liu,Jyothi Jayaraman,Monika Enqvist,Stella Larsson,John Trowsdale,Karl-Johan Malmberg

View Articletitled, Influence of KIR gene copy number on natural killer cell education

Supplemental data

LYMPHOID NEOPLASIA

Autoantigenic targets of B-cell receptors derived from chronic lymphocytic leukemias bind to and induce proliferation of leukemic cells

Carsten Zwick,Natalie Fadle,Evi Regitz,Maria Kemele,Stephan Stilgenbauer,Andreas Bühler,Michael Pfreundschuh,Klaus-Dieter Preuss

View Articletitled, Autoantigenic targets of B-cell receptors derived from chronic lymphocytic leukemias bind to and induce proliferation of leukemic cells

Supplemental data

Trimeric G protein-CARMA1 axis links smoothened, the hedgehog receptor transducer, to NF-κB activation in diffuse large B-cell lymphoma

Changju Qu,Yadong Liu,Kranthi Kunkalla,Rajesh R. Singh,Marzenna Blonska,Xin Lin,Nitin Kumar Agarwal,Francisco Vega

View Articletitled, Trimeric G protein-CARMA1 axis links smoothened, the hedgehog receptor transducer, to NF-κB activation in diffuse large B-cell lymphoma

Supplemental data

Nucleolin inhibits Fas ligand binding and suppresses Fas-mediated apoptosis in vivo via a surface nucleolin-Fas complex

Jillian F. Wise,Zuzana Berkova,Rohit Mathur,Haifeng Zhu,Frank K. Braun,Rong-Hua Tao,Anita L. Sabichi,Xue Ao,Hoyoung Maeng,Felipe Samaniego

View Articletitled, Nucleolin inhibits Fas ligand binding and suppresses Fas-mediated apoptosis in vivo via a surface nucleolin-Fas complex

Supplemental data

CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma

James L. Rubenstein,Valerie S. Wong,Cigall Kadoch,Hua-Xin Gao,Ramon Barajas,Lingjing Chen,S. Andrew Josephson,Brian Scott,Vanja Douglas,Mekhala Maiti,Lawrence D. Kaplan,Patrick A. Treseler,Soonmee Cha,Jimmy H. Hwang,Paola Cinque,Jason G. Cyster,Clifford Lowell

View Articletitled, CXCL13 plus interleukin 10 is highly specific for the diagnosis of CNS lymphoma

Supplemental data

Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations
Brief Report

Martin Neumann,Sandra Heesch,Cornelia Schlee,Stefan Schwartz,Nicola Gökbuget,Dieter Hoelzer,Nikola P. Konstandin,Bianka Ksienzyk,Sebastian Vosberg,Alexander Graf,Stefan Krebs,Helmut Blum,Thorsten Raff,Monika Brüggemann,Wolf-Karsten Hofmann,Jochen Hecht,Stefan K. Bohlander,Philipp A. Greif,Claudia D. Baldus

View Articletitled, Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations

Supplemental data

Risk factors for MDS and acute leukemia following total therapy 2 and 3 for multiple myeloma
Brief Report

Saad Z. Usmani,Jeffrey Sawyer,Adam Rosenthal,Michele Cottler-Fox,Joshua Epstein,Shmuel Yaccoby,Rachael Sexton,Antje Hoering,Zeba Singh,Christoph J. Heuck,Sarah Waheed,Nabeel Chauhan,Donald Johann,Al-Ola Abdallah,Jameel Muzaffar,Nathan Petty,Clyde Bailey,John Crowley,Frits van Rhee,Bart Barlogie

View Articletitled, Risk factors for MDS and acute leukemia following total therapy 2 and 3 for multiple myeloma

Supplemental data

MYELOID NEOPLASIA

A CALM-derived nuclear export signal is essential for CALM-AF10–mediated leukemogenesis

Amanda E. Conway,Paula B. Scotland,Catherine P. Lavau,Daniel S. Wechsler

View Articletitled, A CALM-derived nuclear export signal is essential for CALM-AF10–mediated leukemogenesis

Supplemental data

Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG)

Verena I. Gaidzik,Richard F. Schlenk,Peter Paschka,Anja Stölzle,Daniela Späth,Andrea Kuendgen,Marie von Lilienfeld-Toal,Wolfram Brugger,Hans Günter Derigs,Stephan Kremers,Richard Greil,Aruna Raghavachar,Mark Ringhoffer,Helmut R. Salih,Mohammed Wattad,Heinz G. Kirchen,Volker Runde,Gerhard Heil,Andreas L. Petzer,Michael Girschikofsky,Michael Heuser,Sabine Kayser,Gudrun Goehring,Maria-Veronica Teleanu,Brigitte Schlegelberger,Arnold Ganser,Jürgen Krauter,Lars Bullinger,Hartmut Döhner,Konstanze Döhner

View Articletitled, Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG)

Supplemental data

Revised response criteria for polycythemia vera and essential thrombocythemia: an ELN and IWG-MRT consensus project
Brief Report

Giovanni Barosi,Ruben Mesa,Guido Finazzi,Claire Harrison,Jean-Jacques Kiladjian,Eva Lengfelder,Mary F. McMullin,Francesco Passamonti,Alessandro M. Vannucchi,Carlos Besses,Heinz Gisslinger,Jan Samuelsson,Srdan Verstovsek,Ronald Hoffman,Animesh Pardanani,Francisco Cervantes,Ayalew Tefferi,Tiziano Barbui

View Articletitled, Revised response criteria for polycythemia vera and essential thrombocythemia: an ELN and IWG-MRT consensus project

PLATELETS AND THROMBOPOIESIS

Splenectomy and the incidence of venous thromboembolism and sepsis in patients with immune thrombocytopenia

Soames Boyle,Richard H. White,Ann Brunson,Ted Wun

View Articletitled, Splenectomy and the incidence of venous thromboembolism and sepsis in patients with immune thrombocytopenia

RED CELLS, IRON, AND ERYTHROPOIESIS

Congenital dyserythropoietic anemia type III (CDA III) is caused by a mutation in kinesin family member, KIF23

Maria Liljeholm,Andrew F. Irvine,Ann-Louise Vikberg,Anna Norberg,Stacy Month,Herbert Sandström,Anders Wahlin,Masanori Mishima,Irina Golovleva

View Articletitled, Congenital dyserythropoietic anemia type III (CDA III) is caused by a mutation in kinesin family member, KIF23

Supplemental data

TRANSPLANTATION

The impact of HLA unidirectional mismatches on the outcome of myeloablative hematopoietic stem cell transplantation with unrelated donors

Carolyn Katovich Hurley,Ann Woolfrey,Tao Wang,Michael Haagenson,John Umejiego,Mahmoud Aljurf,Medhat Askar,Minoo Battiwalla,Jason Dehn,John Horan,Machteld Oudshoorn,Joseph Pidala,Wael Saber,Victoria Turner,Stephanie J. Lee,Stephen R. Spellman

View Articletitled, The impact of HLA unidirectional mismatches on the outcome of myeloablative hematopoietic stem cell transplantation with unrelated donors

CORRESPONDENCE

Development of Hodgkin lymphoma in homozygotic triplets with constitutional deletion in MKL1

Magnus Björkholm,Jan Sjöberg,Ulla Axdorph Nygell,Anna Porwit,Erik Björck

View Articletitled, Development of Hodgkin lymphoma in homozygotic triplets with constitutional deletion in MKL1

Novel childhood ALL susceptibility locus BMI1-PIP4K2A is specifically associated with the hyperdiploid subtype

Kyle M. Walsh,Adam J. de Smith,Anand P. Chokkalingam,Catherine Metayer,Gary V. Dahl,Ling-i Hsu,Lisa F. Barcellos,Joseph L. Wiemels,Patricia A. Buffler

View Articletitled, Novel childhood ALL susceptibility locus BMI1-PIP4K2A is specifically associated with the hyperdiploid subtype

Gender influences the birth order effect in HLA-identical stem cell transplantation

Miranda P. Dierselhuis,Eric Spierings,Ronald Brand,Matthijs Hendriks,Angelica Canossi,Harry Dolstra,Jean-François Eliaou,Jürgen Enczmann,Thibaut Gervais,Brigitte Kircher,David Laurin,Pascale Loiseau,Ruhena Sergeant,Els Goulmy

View Articletitled, Gender influences the birth order effect in HLA-identical stem cell transplantation

Cover Image

Cover Image

The cover confocal microscopy image shows murine embryonic fibroblasts (MEFs) expressing mutated CALM-AF10 lacking the hydrophobic residues of the CALM-derived nuclear export signal (NES). Mutant CALM-AF10 is detected with an anti-Flag primary antibody and 568-conjugated anti-mouse secondary antibody (red), and nuclei are stained with DAPI (blue). Although CALM-AF10 normally localizes to the cytoplasm, point mutation of the NES prevents nuclear export and results in exclusive nuclear localization of CALM-AF10. The authors determine the CALM-derived NES is necessary and sufficient for CALM-AF10-mediated leukemogenesis, emphasizing a critical role for the nuclear export pathway in these leukemias. See the article by Conway et al on page 4758.
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Table of Contents

INSIDE BLOOD

BLOOD WORK

PLENARY PAPER

REVIEW ARTICLE

CLINICAL TRIALS AND OBSERVATIONS

The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trial Clinical Trials & Observations

Bortezomib consolidation after autologous stem cell transplantation in multiple myeloma: a Nordic Myeloma Study Group randomized phase 3 trial Clinical Trials & Observations

Phase 2 study of azacytidine plus sorafenib in patients with acute myeloid leukemia and FLT-3 internal tandem duplication mutation Clinical Trials & Observations

IMMUNOBIOLOGY

Influence of KIR gene copy number on natural killer cell education Brief Report

LYMPHOID NEOPLASIA

Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations Brief Report

Risk factors for MDS and acute leukemia following total therapy 2 and 3 for multiple myeloma Brief Report

MYELOID NEOPLASIA

Revised response criteria for polycythemia vera and essential thrombocythemia: an ELN and IWG-MRT consensus project Brief Report

PLATELETS AND THROMBOPOIESIS

RED CELLS, IRON, AND ERYTHROPOIESIS

TRANSPLANTATION

CORRESPONDENCE

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ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only

The immunologic effects of maraviroc intensification in treated HIV-infected individuals with incomplete CD4+ T-cell recovery: a randomized trial
Clinical Trials & Observations

Bortezomib consolidation after autologous stem cell transplantation in multiple myeloma: a Nordic Myeloma Study Group randomized phase 3 trial
Clinical Trials & Observations

Phase 2 study of azacytidine plus sorafenib in patients with acute myeloid leukemia and FLT-3 internal tandem duplication mutation
Clinical Trials & Observations

Influence of KIR gene copy number on natural killer cell education
Brief Report

Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations
Brief Report

Risk factors for MDS and acute leukemia following total therapy 2 and 3 for multiple myeloma
Brief Report

Revised response criteria for polycythemia vera and essential thrombocythemia: an ELN and IWG-MRT consensus project
Brief Report