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Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs
Safety and prolonged activity of recombinant factor VIII Fc fusion protein in hemophilia A patients
Imatinib mesylate directly impairs class switch recombination through down-regulation of AID: its potential efficacy as an AID suppressor
Characterization and discovery of novel miRNAs and moRNAs in JAK2V617F-mutated SET2 cells
Issue Archive
March 29 2012
In this Issue
Table of Contents
Inside Blood
Blood Work
Plenary Paper
Review Articles
IMWG consensus on maintenance therapy in multiple myeloma
Heinz Ludwig,on behalf of the International Myeloma Working Group,Brian G. M. Durie,on behalf of the International Myeloma Working Group,Philip McCarthy,on behalf of the International Myeloma Working Group,Antonio Palumbo,on behalf of the International Myeloma Working Group,Jésus San Miguel,on behalf of the International Myeloma Working Group,Bart Barlogie,on behalf of the International Myeloma Working Group,Gareth Morgan,on behalf of the International Myeloma Working Group,Pieter Sonneveld,on behalf of the International Myeloma Working Group,Andrew Spencer,on behalf of the International Myeloma Working Group,Kenneth C. Andersen,on behalf of the International Myeloma Working Group,Thierry Facon,on behalf of the International Myeloma Working Group,Keith A. Stewart,on behalf of the International Myeloma Working Group,Hermann Einsele,on behalf of the International Myeloma Working Group,Maria-Victoria Mateos,on behalf of the International Myeloma Working Group,Pierre Wijermans,on behalf of the International Myeloma Working Group,Anders Waage,on behalf of the International Myeloma Working Group,Meral Beksac,on behalf of the International Myeloma Working Group,Paul G. Richardson,on behalf of the International Myeloma Working Group,Cyrille Hulin,on behalf of the International Myeloma Working Group,Ruben Niesvizky,on behalf of the International Myeloma Working Group,Henk Lokhorst,on behalf of the International Myeloma Working Group,Ola Landgren,on behalf of the International Myeloma Working Group,P. Leif Bergsagel,on behalf of the International Myeloma Working Group,Robert Orlowski,on behalf of the International Myeloma Working Group,Axel Hinke,on behalf of the International Myeloma Working Group,Michele Cavo,on behalf of the International Myeloma Working Group,Michel Attal,on behalf of the International Myeloma Working Group
How I Treat
Clinical Trials and Observations
Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs
Clinical Trials & Observations
Jennifer A. Dumont,Tongyao Liu,Susan C. Low,Xin Zhang,George Kamphaus,Paul Sakorafas,Cara Fraley,Douglas Drager,Thomas Reidy,Justin McCue,Helen W. G. Franck,Elizabeth P. Merricks,Timothy C. Nichols,Alan J. Bitonti,Glenn F. Pierce,Haiyan Jiang
Safety and prolonged activity of recombinant factor VIII Fc fusion protein in hemophilia A patients
Clinical Trials & Observations
Jerry S. Powell,Neil C. Josephson,Doris Quon,Margaret V. Ragni,Gregory Cheng,Ella Li,Haiyan Jiang,Lian Li,Jennifer A. Dumont,Jaya Goyal,Xin Zhang,Jurg Sommer,Justin McCue,Margaret Barbetti,Alvin Luk,Glenn F. Pierce
Gene Therapy
Hematopoiesis and Stem Cells
Down-regulated expression of hsa-miR-181c in Fanconi anemia patients: implications in TNFα regulation and proliferation of hematopoietic progenitor cells
Paula Río,Xabier Agirre,Leire Garate,Rocío Baños,Lara Álvarez,Edurne San José-Enériz,Isabel Badell,José A. Casado,Marina Garín,Felipe Prósper,Juan A. Bueren
Immunobiology
Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9
Michelle K. Gleason,Todd R. Lenvik,Valarie McCullar,Martin Felices,M. Shea O'Brien,Sarah A. Cooley,Michael R. Verneris,Frank Cichocki,Carol J. Holman,Angela Panoskaltsis-Mortari,Toshiro Niki,Mitsuomi Hirashima,Bruce R. Blazar,Jeffrey S. Miller
Delineation of antigen-specific and antigen-nonspecific CD8+ memory T-cell responses after cytokine-based cancer immunotherapy
Julia K. Tietze,Danice E. C. Wilkins,Gail D. Sckisel,Myriam N. Bouchlaka,Kory L. Alderson,Jonathan M. Weiss,Erik Ames,Kevin W. Bruhn,Noah Craft,Robert H. Wiltrout,Dan L. Longo,Lewis L. Lanier,Bruce R. Blazar,Doug Redelman,William J. Murphy
Imatinib mesylate directly impairs class switch recombination through down-regulation of AID: its potential efficacy as an AID suppressor
Brief Report
Toyotaka Kawamata,Jun Lu,Tadayuki Sato,Masafumi Tanaka,Hitoshi Nagaoka,Yasutoshi Agata,Takae Toyoshima,Kazuaki Yokoyama,Naoki Oyaizu,Naoya Nakamura,Kiyoshi Ando,Arinobu Tojo,Ai Kotani
Lymphoid Neoplasia
Myeloid Neoplasia
Characterization and discovery of novel miRNAs and moRNAs in JAK2V617F-mutated SET2 cells
e-blood
Stefania Bortoluzzi,on behalf of the AGIMM (Associazione Italiana per la Ricerca sul Cancro–Gruppo Italiano Malattie Mieloproliferative) Investigators,Andrea Bisognin,on behalf of the AGIMM (Associazione Italiana per la Ricerca sul Cancro–Gruppo Italiano Malattie Mieloproliferative) Investigators,Marta Biasiolo,on behalf of the AGIMM (Associazione Italiana per la Ricerca sul Cancro–Gruppo Italiano Malattie Mieloproliferative) Investigators,Paola Guglielmelli,on behalf of the AGIMM (Associazione Italiana per la Ricerca sul Cancro–Gruppo Italiano Malattie Mieloproliferative) Investigators,Flavia Biamonte,on behalf of the AGIMM (Associazione Italiana per la Ricerca sul Cancro–Gruppo Italiano Malattie Mieloproliferative) Investigators,Ruggiero Norfo,on behalf of the AGIMM (Associazione Italiana per la Ricerca sul Cancro–Gruppo Italiano Malattie Mieloproliferative) Investigators,Rossella Manfredini,on behalf of the AGIMM (Associazione Italiana per la Ricerca sul Cancro–Gruppo Italiano Malattie Mieloproliferative) Investigators,Alessandro M. Vannucchi,on behalf of the AGIMM (Associazione Italiana per la Ricerca sul Cancro–Gruppo Italiano Malattie Mieloproliferative) Investigators
Phagocytes, Granulocytes, and Myelopoiesis
Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice
Ana M. Gil-Bernabé,Špela Ferjančič,Monika Tlalka,Lei Zhao,Philip D. Allen,Jae Hong Im,Karla Watson,Sally A. Hill,Ali Amirkhosravi,John L. Francis,Jeffrey W. Pollard,Wolfram Ruf,Ruth J. Muschel
Thrombosis and Hemostasis
Transplantation
Novel myeloma-associated antigens revealed in the context of syngeneic hematopoietic stem cell transplantation
Melinda A. Biernacki,Yu-tzu Tai,Guang Lan Zhang,Anselmo Alonso,Wandi Zhang,Rao Prabhala,Li Zhang,Nikhil Munshi,Donna Neuberg,Robert J. Soiffer,Jerome Ritz,Edwin P. Alyea,Vladimir Brusic,Kenneth C. Anderson,Catherine J. Wu
Correspondence
Long-term results of chemoimmunotherapy with low-dose fludarabine, cyclophosphamide and high-dose rituximab as initial treatment for patients with chronic lymphocytic leukemia
Kenneth A. Foon,Dhaval Mehta,Suzanne Lentzsch,Patricia Kropf,Stanley Marks,Diana Lenzner,Louis Pietragallo,Mathew Sulecki,Ahmad Tarhini,Michael Boyiadzis
Exome sequencing reveals a pallidin mutation in a Hermansky-Pudlak–like primary immunodeficiency syndrome
Raffaele Badolato,Alberto Prandini,Sonia Caracciolo,Francesca Colombo,Giovanna Tabellini,Mauro Giacomelli,Maria E. Cantarini,Andrea Pession,Callum J. Bell,Darrell L. Dinwiddie,Neil A. Miller,Shannon L. Hateley,Carol J. Saunders,Lu Zhang,Gary P. Schroth,Alessandro Plebani,Silvia Parolini,Stephen F. Kingsmore
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Cover Image
Cover Image
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The figure illustrates, in a schematic manner, the complexity of small RNAs that can be produced by canonical and noncanonical processing (“the scissors”) of hairpin precursors in a model of myeloproliferative disease. This complexity has been dissected by Illumina sequencing of the small RNA fraction from the JAK2V617F-mutated SET2 cell line. In addition to variably expressed known mature miRNAs (5′ and 3′ miRs, dark and light green rectangles), several “novel miRNAs” expressed from known hairpin precursors were identified. Furthermore, an unexpectedly high number of additional short RNAs were discovered: “isomiRs,” ie, sequence variants produced mainly by noncanonical processing of hairpin precursors; and “moRNAs” (5′ and 3′ moRs, dark and light blue), ie, micro-RNA offset RNAs, approximately 20-nt long RNAs that originate predominantly from the 5′ arm of pre-miRNAs with a biogenesis linked to that of miRNAs but not necessarily interdependent. A fraction of moRNAs have been reported to localize to the nucleus (purple area), unlike mature miRNAs that have a cytoplasmic distribution (black area). See the online article by Bortoluzzi et al on page e120.
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