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Journal Articles

Multicenter, Randomized Crossover Trial Comparing Recombinant Von Willebrand Factor and Tranexamic Acid for Heavy Menstrual Bleeding in Von Willebrand Disease

Blood (2022) 140 (Supplement 1): 1413–1415.

https://doi.org/10.1182/blood-2022-156921

Published: 2022

Journal Articles

Long-Term Real-World Safety and Efficacy of Liver-Directed AAV Gene Therapy for Severe Hemophilia with and without Inbibitors in Privately Owned Dogs

Bhavya S Doshi, Ben J Samelson-Jones, Timothy C Nichols, Elizabeth P Merricks, Valder R Arruda, Mary Beth Callan

Blood (2022) 140 (Supplement 1): 7780–7781.

https://doi.org/10.1182/blood-2022-164470

Published: 2022

Journal Articles

FVIII Protein Is Not Detectable in Human PBMCs or Livers from Dogs with an Intron-22 Inversion Mutation: Implications for FVIII Immunogenicity and Tolerance

Devi Gunasekera, MBBS, Pooja Vir, PhD, Ahmad Faisal Karim, PhD, Margaret V. Ragni, MD MPH, Elizabeth P. Merricks, PhD, Timothy C. Nichols, MD, Kathleen P. Pratt, PhD

Blood (2019) 134 (Supplement_1): 630.

https://doi.org/10.1182/blood-2019-124880

Published: 2019

Journal Articles

Long-Term AAV-Mediated Factor VIII Expression in Nine Hemophilia A Dogs: A 10 Year Follow-up Analysis on Durability, Safety and Vector Integration

Giang N. Nguyen, BS, John K. Everett, PhD, Hayley Raymond, BA, Samita Kafle, BS, Elizabeth P. Merricks, PhD, Haig H. Kazazian, MD, Timothy C. Nichols, MD, Frederic D. Bushman, PhD, Denise E. Sabatino, PhD

Blood (2019) 134 (Supplement_1): 611.

https://doi.org/10.1182/blood-2019-126007

Published: 2019

Journal Articles

Hemophilia A Dogs Tolerant to Human Factor VIII Provide a Unique Model to Determine Efficacy and Safety of AAV Delivery of Novel Factor VIII Variants

Giang N. Nguyen, BS, Lauren E. Wimsey, DVM, Elizabeth P. Merricks, PhD, Katherine P. Ponder, MD, Timothy C. Nichols, MD, Denise E. Sabatino, PhD

Blood (2019) 134 (Supplement_1): 3628.

https://doi.org/10.1182/blood-2019-126085

Published: 2019

Journal Articles

Unexpected Role of PACE/Furin Cleavage Site in FVIII Biology: Implications for Hemophilia a Therapy

Joshua I Siner, Julie M Crudele, Courtney T Connolly, Shangzhen Zhou, MD, Elizabeth P. Merricks, PhD, Timothy C. Nichols, MD, Rodney M. Camire, PhD, Valder R. Arruda, MD PhD

Blood (2014) 124 (21): 105.

https://doi.org/10.1182/blood.V124.21.105.105

Published: 2014

Journal Articles

The efficacy and the risk of immunogenicity of FIX Padua (R338L) in hemophilia B dogs treated by AAV muscle gene therapy

Jonathan D. Finn, Timothy C. Nichols, Nikolaos Svoronos, Elizabeth P. Merricks, Dwight A. Bellenger, Shangshen Zhou, Paolo Simioni, Katherine A. High, Valder R. Arruda

Blood (2012) 120 (23): 4521–4523.

https://doi.org/10.1182/blood-2012-06-440123

Published: 2012

Journal Articles

Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs

Jennifer A. Dumont, Tongyao Liu, Susan C. Low, Xin Zhang, George Kamphaus, Paul Sakorafas, Cara Fraley, Douglas Drager, Thomas Reidy, Justin McCue, Helen W. G. Franck, Elizabeth P. Merricks, Timothy C. Nichols, Alan J. Bitonti, Glenn F. Pierce, Haiyan Jiang

Blood (2012) 119 (13): 3024–3030.

https://doi.org/10.1182/blood-2011-08-367813

Published: 2012

Includes: Supplemental data

Journal Articles

Phase II Biologic Effects Trial of Recombinant Interleukin-11 (rhIL-11, Neumega) in Moderate or Mild Hemophilia A or Von Willebrand Disease Unable to Use DDAVP,

Margaret V. Ragni, MD, MPH, Enrico M. Novelli, MD, Anila Murshed, BS, Elizabeth P. Merricks, PhD, Mark T. Kloos, BS, Timothy C. Nichols, MD

Blood (2011) 118 (21): 3308.

https://doi.org/10.1182/blood.V118.21.3308.3308

Published: 2011

Journal Articles

Eradication of neutralizing antibodies to factor VIII in canine hemophilia A after liver gene therapy

Jonathan D. Finn, Margareth C. Ozelo, Denise E. Sabatino, Helen W. G. Franck, Elizabeth P. Merricks, Julie M. Crudele, Shangzhen Zhou, Haig H. Kazazian, David Lillicrap, Timothy C. Nichols, Valder R. Arruda

Blood (2010) 116 (26): 5842–5848.

https://doi.org/10.1182/blood-2010-06-288001

Published: 2010

Journal Articles

De Novo Synthesis & Storage of Human Factor VIII In Platelets Reduces Bleeding In Canine Hemophilia A

Lily M. Du, MD, Helen W.G. Franck, BS, Elizabeth P. Merricks, PhD, Paquita Nurden, MD, Eric S. Jensen, DVM, Sandra L. Haberichter, PhD, Troy B. Hawkins, PhD, Paula M. Jacobi, BS, Juan Fang, MD, Timothy C. Nichols, MD, Sevasti B. Koukouritaki, PhD, Qizhen Shi, MD, PhD, Robert R. Montgomery, MD, Kenneth Cornetta, MD, Alan T. Nurden, PhD, David A. Wilcox, PhD

Blood (2010) 116 (21): 2198.

https://doi.org/10.1182/blood.V116.21.2198.2198

Published: 2010

Journal Articles

Prolonged activity of factor IX as a monomeric Fc fusion protein

Robert T. Peters, Susan C. Low, George D. Kamphaus, Jennifer A. Dumont, John V. Amari, Qi Lu, Greg Zarbis-Papastoitsis, Thomas J. Reidy, Elizabeth P. Merricks, Timothy C. Nichols, Alan J. Bitonti

Blood (2010) 115 (10): 2057–2064.

https://doi.org/10.1182/blood-2009-08-239665

Published: 2010

Journal Articles

Factor VIII-Fc Fusion Protein Shows Extended Half-Life and Hemostatic Activity in Hemophilia A Dogs.

Jennifer A Dumont, PhD, George D Kamphaus, PhD, Cara Fraley, MS, Tamera Ashworth, BS, Helen Franck, BS, Elizabeth P. Merricks, BS, Timothy C. Nichols, MD, Alan J Bitonti, PhD

Blood (2009) 114 (22): 545.

https://doi.org/10.1182/blood.V114.22.545.545

Published: 2009

Journal Articles

Successful Long Term Therapeutic Expression of Factor VIII in Hemophilia A Dogs After Administration of AAV-cFVIII Using a Two-Chain or Single Chain Delivery Approach.

Denise E. Sabatino, Ph.D., Ekaterina Altynova, B.S., Amy M. Lange, B.S., Shangzhen Zhou, M.D., Elizabeth P. Merricks, B.S., Aaron M. Dillow, B.S., Timothy C. Nichols, M.D., Valder R. Arruda, M.D., Ph.D., Haig H. Kazazian, Jr., M.D.

Blood (2009) 114 (22): 546.

https://doi.org/10.1182/blood.V114.22.546.546

Published: 2009

Journal Articles

Recombinant canine B-domain–deleted FVIII exhibits high specific activity and is safe in the canine hemophilia A model

Denise E. Sabatino, Christian Furlan Freguia, Raffaella Toso, Andrey Santos, Elizabeth P. Merricks, Haig H. Kazazian, Jr, Timothy C. Nichols, Rodney M. Camire, Valder R. Arruda

Blood (2009) 114 (20): 4562–4565.

https://doi.org/10.1182/blood-2009-05-220327

Published: 2009

Includes: Supplemental data

Journal Articles

Recombinant Interleukin-11 (rhIL-11) in Women with Refractory Menorrhagia and Von Willebrand Disease.

Rachel C. Jankowitz, MD, Margaret V. Ragni, MD, MPH, Holly L. Chapman, RN, Elizabeth P. Merricks, BS, Mark T. Kloos, BS, Aaron M. Dillow, BS, Helen Franck, BS, Timothy C. Nichols, MD

Blood (2008) 112 (11): 1210.

https://doi.org/10.1182/blood.V112.11.1210.1210

Published: 2008

Journal Articles

Re-establishment of VWF-dependent Weibel-Palade bodies in VWD endothelial cells

Sandra L. Haberichter, Elizabeth P. Merricks, Scot A. Fahs, Pamela A. Christopherson, Timothy C. Nichols, Robert R. Montgomery

Blood (2005) 105 (1): 145–152.

https://doi.org/10.1182/blood-2004-02-0464

Published: 2005

Journal Articles

Reduced bleeding events with subcutaneous administration of recombinant human factor IX in immune-tolerant hemophilia B dogs

Karen E. Russell, Eva H. N. Olsen, Robin A. Raymer, Elizabeth P. Merricks, Dwight A. Bellinger, Marjorie S. Read, Bonita J. Rup, James C. Keith, Jr, Kyle P. McCarthy, Robert G. Schaub, Timothy C. Nichols

Blood (2003) 102 (13): 4393–4398.

https://doi.org/10.1182/blood-2003-05-1498

Published: 2003

Journal Articles

PECAM-1 negatively regulates GPIb/V/IX signaling in murine platelets

Vipul Rathore, Michelle A. Stapleton, Cheryl A. Hillery, Robert R. Montgomery, Timothy C. Nichols, Elizabeth P. Merricks, Debra K. Newman, Peter J. Newman

Blood (2003) 102 (10): 3658–3664.

https://doi.org/10.1182/blood-2003-06-1888

Published: 2003

Journal Articles

Comparative response of plasma VWF in dogs to up-regulation of VWF mRNA by interleukin-11 versus Weibel-Palade body release by desmopressin (DDAVP)

Eva H. N. Olsen, Arlene S. McCain, Elizabeth P. Merricks, Thomas H. Fischer, Ivy M. Dillon, Robin A. Raymer, Dwight A. Bellinger, Scot A. Fahs, Robert R. Montgomery, James C. Keith, Jr, Robert G. Schaub, Timothy C. Nichols

Blood (2003) 102 (2): 436–441.

https://doi.org/10.1182/blood-2003-01-0290

Published: 2003

NARROW

Multicenter, Randomized Crossover Trial Comparing Recombinant Von Willebrand Factor and Tranexamic Acid for Heavy Menstrual Bleeding in Von Willebrand Disease

Long-Term Real-World Safety and Efficacy of Liver-Directed AAV Gene Therapy for Severe Hemophilia with and without Inbibitors in Privately Owned Dogs

FVIII Protein Is Not Detectable in Human PBMCs or Livers from Dogs with an Intron-22 Inversion Mutation: Implications for FVIII Immunogenicity and Tolerance

Long-Term AAV-Mediated Factor VIII Expression in Nine Hemophilia A Dogs: A 10 Year Follow-up Analysis on Durability, Safety and Vector Integration

Hemophilia A Dogs Tolerant to Human Factor VIII Provide a Unique Model to Determine Efficacy and Safety of AAV Delivery of Novel Factor VIII Variants

Unexpected Role of PACE/Furin Cleavage Site in FVIII Biology: Implications for Hemophilia a Therapy

The efficacy and the risk of immunogenicity of FIX Padua (R338L) in hemophilia B dogs treated by AAV muscle gene therapy

Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs

Phase II Biologic Effects Trial of Recombinant Interleukin-11 (rhIL-11, Neumega) in Moderate or Mild Hemophilia A or Von Willebrand Disease Unable to Use DDAVP,

Eradication of neutralizing antibodies to factor VIII in canine hemophilia A after liver gene therapy

De Novo Synthesis & Storage of Human Factor VIII In Platelets Reduces Bleeding In Canine Hemophilia A

Prolonged activity of factor IX as a monomeric Fc fusion protein

Factor VIII-Fc Fusion Protein Shows Extended Half-Life and Hemostatic Activity in Hemophilia A Dogs.

Successful Long Term Therapeutic Expression of Factor VIII in Hemophilia A Dogs After Administration of AAV-cFVIII Using a Two-Chain or Single Chain Delivery Approach.

Recombinant canine B-domain–deleted FVIII exhibits high specific activity and is safe in the canine hemophilia A model

Recombinant Interleukin-11 (rhIL-11) in Women with Refractory Menorrhagia and Von Willebrand Disease.

Re-establishment of VWF-dependent Weibel-Palade bodies in VWD endothelial cells

Reduced bleeding events with subcutaneous administration of recombinant human factor IX in immune-tolerant hemophilia B dogs

PECAM-1 negatively regulates GPIb/V/IX signaling in murine platelets

Comparative response of plasma VWF in dogs to up-regulation of VWF mRNA by interleukin-11 versus Weibel-Palade body release by desmopressin (DDAVP)

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American Society of Hematology

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American Society of Hematology

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