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Julie M. Crudele
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Journal Articles

The Role of Transgene Levels in Immune Tolerance Induction after AAV Gene Therapy in Hemophilia B Canine Models

Ben J. Samelson-Jones, MD PhD, Robert Andrew French, BS, Julie M. Crudele, PhD, Timothy C. Nichols, MD, Valder R Arruda, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2057.
https://doi.org/10.1182/blood.V130.Suppl_1.2057.2057
Published: 2017
Journal Articles

AAV liver expression of FIX-Padua prevents and eradicates FIX inhibitor without increasing thrombogenicity in hemophilia B dogs and mice

Julie M. Crudele, Jonathan D. Finn, Joshua I. Siner, Nicholas B. Martin, Glenn P. Niemeyer, Shangzhen Zhou, Federico Mingozzi, Clinton D. Lothrop, Jr, Valder R. Arruda
Journal: Blood
Blood (2015) 125 (10): 1553–1561.
https://doi.org/10.1182/blood-2014-07-588194
Published: 2015
Includes: Supplemental data
Journal Articles

Unexpected Role of PACE/Furin Cleavage Site in FVIII Biology: Implications for Hemophilia a Therapy

Joshua I Siner, Julie M Crudele, Courtney T Connolly, Shangzhen Zhou, MD, Elizabeth P. Merricks, PhD, Timothy C. Nichols, MD, Rodney M. Camire, PhD, Valder R. Arruda, MD PhD
Journal: Blood
Blood (2014) 124 (21): 105.
https://doi.org/10.1182/blood.V124.21.105.105
Published: 2014
Journal Articles

Tolerance Induction To FIX Padua With AAV Liver Gene Transfer In Inhibitor-Prone Hemophilia B Dogs

Julie M Crudele, Jonathan D Finn, PhD, Nicholas B Martin, Joshua I Siner, Yifeng Chen, MD, Shangzhen Zhou, MD, Glenn Niemeyer, PhD, Clinton D. Lothrop, PhD, DVM, Federico Mingozzi, PhD., Katherine A. High, MD, Valder R. Arruda, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 4203.
https://doi.org/10.1182/blood.V122.21.4203.4203
Published: 2013
Journal Articles

Insights Into the Mechanism of Zymogen Protein C Protection Against Cancer Progression

Julie M Crudele, BA, Geerte L. Van Sluis, MD, Paris Margaritis, DPhil, Joshua I Siner, Michael Sliozberg, Jenna Maurer, Armida Faella, Shangzhen Zhou, MD, Katherine A. High, MD, Charles T Esmon, PhD, C. Arnold Spek, PhD, Valder R Arruda, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3350.
https://doi.org/10.1182/blood.V120.21.3350.3350
Published: 2012
Journal Articles

Eradication of neutralizing antibodies to factor VIII in canine hemophilia A after liver gene therapy

Jonathan D. Finn, Margareth C. Ozelo, Denise E. Sabatino, Helen W. G. Franck, Elizabeth P. Merricks, Julie M. Crudele, Shangzhen Zhou, Haig H. Kazazian, David Lillicrap, Timothy C. Nichols, Valder R. Arruda
Journal: Blood
Blood (2010) 116 (26): 5842–5848.
https://doi.org/10.1182/blood-2010-06-288001
Published: 2010