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Journal Articles

Results from an Association-Scan of the Extended MHC-Class-II Region Using Novel Association-Based Statistical Methods Establish That DQ Allotypes and Race Independently Influence the Risk of Factor VIII Inhibitor Development in Hemophilia-A Patients

Paola Ibarra, Marcio A. Almeida, Vincent P. Diego, Bernadette W. Luu, Kevin R. Viel, Raja Rajalingam, Afshin Ameri, Meera Chitlur, Benjamin Kim, Grecia Castillo, Jerry S. Powell, Juan M. Peralta, Miguel A. Escobar, Sarah Williams-Blangero, John Blangero, Carol K. Kasper, Laura Almasy, Tom E. Howard

Blood (2023) 142 (Supplement 1): 1247.

https://doi.org/10.1182/blood-2023-191140

Published: 2023

Journal Articles

A Nonsynonymous-Single-Nucleotide Polymorphism (ns-SNP) in TFPI , the Gene Encoding Tissue Factor Pathway Inhibitor (TFPI), is Pleiotropically Associated with Increased Plasma TFPI Levels and a Decreased Risk of Type 2 Diabetes (T2D) in Mexican Americans of South Texas

Alberto D. Lopez, Vincent P. Diego, Kanisha Patel, Marcio A. Almeida, Joanne E. Curran, Miguel Escobar, Jerry S. Powell, Donna M. Lehman, Ralph A DeFronzo, Sarah Williams-Blangero, Ravi Duggirala, Laura Almasy, John Blangero, Tom E. Howard

Blood (2022) 140 (Supplement 1): 8536–8537.

https://doi.org/10.1182/blood-2022-171201

Published: 2022

Journal Articles

The Nonsynonymous-Single-Nucleotide Polymorphism (ns-SNP) 353 R>q in the Coagulation Factor VII (FVII) Gene, F7 , is Associated with Decreased Plasma FVII Levels and a Decreased Risk of Coronary Heart Disease (CHD) in Mexican Americans of South Texas

Kanisha Patel, Vincent P. Diego, Alberto D. Lopez, Marcio A. Almeida, Joanne E. Curran, Miguel Escobar, Jerry S. Powell, Donna M. Lehman, Ralph A DeFronzo, Sarah Williams-Blangero, Ravi Duggirala, Laura Almasy, John Blangero, Tom E. Howard

Blood (2022) 140 (Supplement 1): 2799–2800.

https://doi.org/10.1182/blood-2022-168478

Published: 2022

Journal Articles

On the Role of Hemostasis Variables in Cardiometabolic Outcomes

Alberto D. Lopez, Kanisha Patel, Vincent P. Diego, Marcio A. Almeida, John Blangero, Jerry S. Powell, Tom E. Howard

Blood (2021) 138 (Supplement 1): 4266.

https://doi.org/10.1182/blood-2021-154441

Published: 2021

Journal Articles

The G505A Nonsynonymous Single-Nucleotide Polymorphism (SNP) in TAFI , the Gene Encoding Thrombin-Activatable Fibrinolysis Inhibitor (TAFI) Is Pleiotropically Associated with TAFI Antigen Levels and Coronary Heart Disease (CHD) in Mexican Americans of South Texas

Shuchita Jhaveri, Vincent P. Diego, Hoang Anh Thi Nguyen, Satish Kumar, Marcio A. Almeida, Juan M Peralta, Joanne E. Curran, Bernadette W. Luu, Donna M. Lehman, Ralph A DeFronzo, Miguel A. Escobar, Sarah Williams-Blangero, Ravi Duggirala, Jerry S. Powell, Laura Almasy, John Blangero, Tom E. Howard

Blood (2021) 138 (Supplement 1): 3217.

https://doi.org/10.1182/blood-2021-151968

Published: 2021

Journal Articles

The Factor II (FII) Expression Quantitative Trait Locus (eQTL) Prothrombin G20210A Is Pleiotropically Associated with Plasma Fibrinogen Levels and Has a Profound Effect on Obesity in Mexican Americans of South Texas

Hoang Anh Thi Nguyen, Vincent P. Diego, Shuchita Jhaveri, Marcio A. Almeida, Satish Kumar, Juan M Peralta, Joanne E. Curran, Bernadette W. Luu, Donna M. Lehman, Ralph A DeFronzo, Miguel A. Escobar, Sarah Williams-Blangero, Ravi Duggirala, Jerry S. Powell, Laura Almasy, John Blangero, Tom E. Howard

Blood (2021) 138 (Supplement 1): 1059.

https://doi.org/10.1182/blood-2021-154338

Published: 2021

Journal Articles

Specific Correction of the Intron-22 Inverted Factor VIII Gene in Autologous Blood Outgrowth Endothelial Cells from Patients with Severe Hemophilia A

Long V. Dinh, PhD, Eli Fine, PhD, Afshin Ameri, MD, Bernadette W. Luu, B.S., M.T. (CLS), Satish Kumar, PhD, Vincent P. Diego, PhD, Joanne E. Curran, PhD, Juan M Peralta, M.S., Henry Mead, M.B.A., M.P.H., Miguel A. Escobar, MD, Sarah Williams-Blangero, PhD, John Blangero, PhD, Jerry S. Powell, MD, Timothy C. Nichols, MD, Robert P. Hebbel, MD, Tom E. Howard, MD, PhD

Blood (2020) 136 (Supplement 1): 30–31.

https://doi.org/10.1182/blood-2020-142679

Published: 2020

Journal Articles

Disentangling the Effects of HLA DRB115:01 and DQB106:02 to Establish the True HLA Risk Allele for Inhibitor Development in the Treatment of Hemophilia A

Vincent P. Diego, PhD, Bernadette W. Luu, B.S., M.T. (CLS), Alexis Garza, B.S., Marco Hofmann, M.S., Marcio A. Almeida, PhD, Jerry S. Powell, MD, Long V. Dinh, PhD, Raja Rajalingam, PhD, Juan M Peralta, M.S., Satish Kumar, PhD, Eli Fine, PhD, Joanne E. Curran, PhD, Miguel A. Escobar, MD, Sarah Williams-Blangero, PhD, Eugene Maraskovsky, PhD, John Blangero, PhD, Tom E. Howard, MD, PhD

Blood (2020) 136 (Supplement 1): 1–2.

https://doi.org/10.1182/blood-2020-142716

Published: 2020

Journal Articles

N-Linked Glycans on Therapeutic Factor VIII (FVIII) Proteins Attenuate Immunogenicity Potential: Evidence from Independent HLA-Class-II/FVIII (HLAcII/FVIII) Peptidomes

Vincent P. Diego, PhD, Bernadette W. Luu, B.S., M.T. (CLS), Hari Movva, B.S., Marco Hofmann, M.S., Marcio A. Almeida, PhD, Long V. Dinh, PhD, Jerry S. Powell, MD, Raja Rajalingam, PhD, Juan M Peralta, M.S., Henry Mead, M.B.A., M.P.H., Satish Kumar, PhD, Joanne E. Curran, PhD, Miguel A. Escobar, MD, Sarah Williams-Blangero, PhD, Eugene Maraskovsky, PhD, John Blangero, PhD, Tom E. Howard, MD, PhD

Blood (2020) 136 (Supplement 1): 29–30.

https://doi.org/10.1182/blood-2020-142493

Published: 2020

Journal Articles

The Dendritic Cell HLA-Class-II/Therapeutic Factor VIII (FVIII) Peptidome Is Influenced in Unanticipated Ways By the B-Domain of FVIII and the FVIII Chaperon Protein, Von Willebrand Factor: The Outrigger and Glycosylation-Umbrella (GUMB) Hypotheses

Tom E. Howard, MD, PhD, Bernadette W. Luu, B.S., M.T. (CLS), Marco Hofmann, M.S., Marcio A. Almeida, PhD, Satish Kumar, PhD, Long V. Dinh, PhD, Henry Mead, M.B.A., M.P.H., Jerry S. Powell, MD, Miguel A. Escobar, MD, Raja Rajalingam, PhD, Sarah Williams-Blangero, PhD, John Blangero, PhD, Maraskovsky Eugene, PhD, Vincent P. Diego, PhD

Blood (2019) 134 (Supplement_1): 161.

https://doi.org/10.1182/blood-2019-131727

Published: 2019

Journal Articles

On the Role of F8 Sequence Mismatch and Class-II Human Leukocyte Antigen Binding in the Development of Neutralizing Antibodies ("Inhibitors") Directed Against Therapeutic Factor VIII Proteins (tFVIIIs): Evidence from the PATH Study

Vincent P. Diego, PhD, Bernadette W. Luu, B.S., M.T. (CLS), Afshin Ameri, MD, Meera B. Chitlur, MD, Marcio A. Almeida, PhD, Karin Haack, PhD, Satish Kumar, PhD, Long V. Dinh, PhD, Henry Mead, M.B.A., M.P.H., Jerry S. Powell, MD, Miguel A. Escobar, MD, Raja Rajalingam, PhD, Sarah Williams-Blangero, PhD, Carol K. Kasper, MD, Laura Almasy, PhD, Shelley Cole, PhD, John Blangero, PhD, Tom E. Howard, MD, PhD

Blood (2019) 134 (Supplement_1): 2393.

https://doi.org/10.1182/blood-2019-132218

Published: 2019

Journal Articles

Genetics of Factor VIII Inhibitor Development in Hemophilia Patients: Novel Statistical Approaches in the PATH Study

Vincent P. Diego, PhD, Marcio A. Almeida, PhD, Bernadette W. Luu, BS, MT/CLS, Karin Haack, PhD, Meera B. Chitlur, MD, Afshin Ameri, MD, Long V. Dinh, PhD, Raja Rajalingam, PhD, Jerry S. Powell, MD, John Blangero, PhD, Laura Almasy, PhD, Shelley Cole, PhD, Tom E. Howard

Blood (2018) 132 (Supplement 1): 1199.

https://doi.org/10.1182/blood-2018-99-120021

Published: 2018

Journal Articles

The Role of Class II Human Leukocyte Antigens (cII-HLAs) in Determining the Immunogenic Potential of Therapeutic Factor VIII Proteins in Hemophilia Patients: The "Gate Keeper" Hypothesis

Vincent P. Diego, PhD, Bernadette W. Luu, BS, MT/CLS, Marco Hofmann, MS, Marcio A. Almeida, PhD, Jose Antonio G. Hernandez, PhD, Juan Peralta, MS, Joanne Curran, PhD, Jerry S. Powell, MD, Raja Rajalingam, PhD, Long V. Dinh, PhD, Sarah Williams-Blangero, PhD, Miguel A Escobar, MD, Eugene Maraskovsky, PhD, John Blangero, PhD, Tom E. Howard

Blood (2018) 132 (Supplement 1): 5022.

https://doi.org/10.1182/blood-2018-99-115537

Published: 2018

Journal Articles

Characterization of the HLA-Class-II (HLAcII)/Therapeutic Factor VIII (FVIII)-Derived Peptidome By FVIII Domain and HLAcII Isomer

Marcio Almeida, PhD, Vincent P. Diego, PhD, Bernadette W. Luu, B.S., Marco Hofmann, M.S., Jose Antonio G. Hernandez, PhD, Juan Peralta, Joanne Curran, Miguel A Escobar, MD, Rajalingam Raja, PhD, LV Dinh, Jerry S. Powell, MD, Sarah Williams-Blangero, John Blangero, Eugene Maraskovsky, Tom Howard

Blood (2017) 130 (Supplement 1): 2352.

https://doi.org/10.1182/blood.V130.Suppl_1.2352.2352

Published: 2017

Journal Articles

Recombinant Fusion Protein Linking Coagulation Factor IX with Albumin (RIX-FP) in Previously Treated Children < 12 Years of Age with Hemophilia B: Long-Term Efficacy and Safety from an Ongoing Phase 3b Extension Clinical Trial

Gili Kenet, MD, Andres Brainsky, MD, Jerry S. Powell, MD, Yanyan Li, PhD, Wilfried Seifert, PhD

Blood (2017) 130 (Supplement 1): 2370.

https://doi.org/10.1182/blood.V130.Suppl_1.2370.2370

Published: 2017

Journal Articles

Recombinant Fusion Protein Linking Coagulation Factor IX with Albumin (RIX-FP) in Previously Treated Adolescents/Adults with Hemophilia B: Long-Term Efficacy and Safety from an Ongoing Phase 3b Extension Clinical Trial

Ingrid Pabinger, MD, Elena Santagostino, Andres Brainsky, MD, Jerry S. Powell, MD, Yanyan Li, PhD, Wilfried Seifert, PhD

Blood (2017) 130 (Supplement 1): 3690.

https://doi.org/10.1182/blood.V130.Suppl_1.3690.3690

Published: 2017

Journal Articles

Profiling and Comparing the Immunogenicity of a Novel Single-Chain FVIII Molecule (rVIII-SingleChain) for the Treatment of Hemophilia a

Eugene Maraskovsky, PhD, Anne Verhagen, PhD, Huy Huynh, BS, Adriana Baz Morelli, PhD, Stefan Schmidbauer, BS, Sabine Zollner, PhD, Jerry S. Powell, Katie St Ledger, Alex Veldman, MD, Marco Hofmann, MS

Blood (2016) 128 (22): 4960.

https://doi.org/10.1182/blood.V128.22.4960.4960

Published: 2016

Journal Articles

Human Chorionic Villus Stem Cells May Contribute to Endogenous Factor VIII Production during Gestation

Maricel G. Miguelino, MD, Priyadarsini Kumar, PhD, Jerry S. Powell, MD, Aijun Wang, PhD

Blood (2015) 126 (23): 1082.

https://doi.org/10.1182/blood.V126.23.1082.1082

Published: 2015

Journal Articles

Liver Tropism and Factor VIII Transgene Expression after Intrauterine Chorionic Villus Stem Cell Transplantation

Maricel G. Miguelino, MD, Priyadarsini Kumar, PhD, Christopher Pivetti, M.Sc., Lee Lanford, M.A., Jerry S. Powell, MD, Aijun Wang, PhD

Blood (2015) 126 (23): 3508.

https://doi.org/10.1182/blood.V126.23.3508.3508

Published: 2015

Journal Articles

Predicting FIX Activity in Prophylaxis Patients Using Recombinant FIX Fc Fusion Protein for Treatment of Bleeding Episodes

Jerry S Powell, MD, Margareth Ozelo, MD PhD, Margaret V. Ragni, MD MPH, John Pasi, MBChB, PhD FRCP, FRCPath, David J. Perry, MD PhD FRCP, FRCPath, Ying Zhu, MPH, Baisong Mei, MD PhD, Glenn F Pierce, MD PhD, Lian Li, PhD, Brian Robinson, MD

Blood (2014) 124 (21): 2842.

https://doi.org/10.1182/blood.V124.21.2842.2842

Published: 2014

NARROW

Results from an Association-Scan of the Extended MHC-Class-II Region Using Novel Association-Based Statistical Methods Establish That DQ Allotypes and Race Independently Influence the Risk of Factor VIII Inhibitor Development in Hemophilia-A Patients

A Nonsynonymous-Single-Nucleotide Polymorphism (ns-SNP) in TFPI , the Gene Encoding Tissue Factor Pathway Inhibitor (TFPI), is Pleiotropically Associated with Increased Plasma TFPI Levels and a Decreased Risk of Type 2 Diabetes (T2D) in Mexican Americans of South Texas

The Nonsynonymous-Single-Nucleotide Polymorphism (ns-SNP) 353 R>q in the Coagulation Factor VII (FVII) Gene, F7 , is Associated with Decreased Plasma FVII Levels and a Decreased Risk of Coronary Heart Disease (CHD) in Mexican Americans of South Texas

On the Role of Hemostasis Variables in Cardiometabolic Outcomes

The G505A Nonsynonymous Single-Nucleotide Polymorphism (SNP) in TAFI , the Gene Encoding Thrombin-Activatable Fibrinolysis Inhibitor (TAFI) Is Pleiotropically Associated with TAFI Antigen Levels and Coronary Heart Disease (CHD) in Mexican Americans of South Texas

The Factor II (FII) Expression Quantitative Trait Locus (eQTL) Prothrombin G20210A Is Pleiotropically Associated with Plasma Fibrinogen Levels and Has a Profound Effect on Obesity in Mexican Americans of South Texas

Specific Correction of the Intron-22 Inverted Factor VIII Gene in Autologous Blood Outgrowth Endothelial Cells from Patients with Severe Hemophilia A

Disentangling the Effects of HLA DRB115:01 and DQB106:02 to Establish the True HLA Risk Allele for Inhibitor Development in the Treatment of Hemophilia A

N-Linked Glycans on Therapeutic Factor VIII (FVIII) Proteins Attenuate Immunogenicity Potential: Evidence from Independent HLA-Class-II/FVIII (HLAcII/FVIII) Peptidomes

The Dendritic Cell HLA-Class-II/Therapeutic Factor VIII (FVIII) Peptidome Is Influenced in Unanticipated Ways By the B-Domain of FVIII and the FVIII Chaperon Protein, Von Willebrand Factor: The Outrigger and Glycosylation-Umbrella (GUMB) Hypotheses

On the Role of F8 Sequence Mismatch and Class-II Human Leukocyte Antigen Binding in the Development of Neutralizing Antibodies ("Inhibitors") Directed Against Therapeutic Factor VIII Proteins (tFVIIIs): Evidence from the PATH Study

Genetics of Factor VIII Inhibitor Development in Hemophilia Patients: Novel Statistical Approaches in the PATH Study

The Role of Class II Human Leukocyte Antigens (cII-HLAs) in Determining the Immunogenic Potential of Therapeutic Factor VIII Proteins in Hemophilia Patients: The "Gate Keeper" Hypothesis

Characterization of the HLA-Class-II (HLAcII)/Therapeutic Factor VIII (FVIII)-Derived Peptidome By FVIII Domain and HLAcII Isomer

Recombinant Fusion Protein Linking Coagulation Factor IX with Albumin (RIX-FP) in Previously Treated Children < 12 Years of Age with Hemophilia B: Long-Term Efficacy and Safety from an Ongoing Phase 3b Extension Clinical Trial

Recombinant Fusion Protein Linking Coagulation Factor IX with Albumin (RIX-FP) in Previously Treated Adolescents/Adults with Hemophilia B: Long-Term Efficacy and Safety from an Ongoing Phase 3b Extension Clinical Trial

Profiling and Comparing the Immunogenicity of a Novel Single-Chain FVIII Molecule (rVIII-SingleChain) for the Treatment of Hemophilia a

Human Chorionic Villus Stem Cells May Contribute to Endogenous Factor VIII Production during Gestation

Liver Tropism and Factor VIII Transgene Expression after Intrauterine Chorionic Villus Stem Cell Transplantation

Predicting FIX Activity in Prophylaxis Patients Using Recombinant FIX Fc Fusion Protein for Treatment of Bleeding Episodes

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American Society of Hematology

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American Society of Hematology

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