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Journal Articles

Chromosome 9p Duplication Promotes T-Cell Exhaustion and Enhances Stem Cell Clonogenic Potential in JAK2-Mutant Myeloproliferative Neoplasms

Blood (2023) 142 (Supplement 1): 1780.

https://doi.org/10.1182/blood-2023-182420

Published: 2023

Journal Articles

Peripheral Blood Cytotoxic T Cells from Myelofibrosis Patients Show Early Exhausted Features Targetable By CTLA-4 Inhibition

Lara Tavernari, Sebastiano Rontauroli, Monica Maccaferri, Barbara Mora, Elia Venturelli, Elisa Bianchi, Sandra Parenti, Elena Genovese, Paola Guglielmelli, Chiara Carretta, Margherita Mirabile, Stefano Sartini, Corrado Colasante, Leonardo Potenza, Francesco Passamonti, Enrico Tagliafico, Mario Luppi, Alessandro M. Vannucchi, Rossella Manfredini

Blood (2022) 140 (Supplement 1): 9600–9601.

https://doi.org/10.1182/blood-2022-167161

Published: 2022

Journal Articles

Single Cell Mutation Analysis Delineates Clonal Architecture in Leukemic Transformation of Myeloproliferative Neoplasms

Paola Guglielmelli, Laura Calabresi, Chiara Carretta, Giada Rotunno, Sandra Parenti, Simone Romagnoli, Selene Mallia, Niccolò Bartalucci, Sebastiano Rontauroli, Chiara Chiereghin, Sara Castellano, Francesco Mannelli, Matteo G. Della Porta, Rossella Manfredini, Alessandro Vannucchi

Blood (2021) 138 (Supplement 1): 56.

https://doi.org/10.1182/blood-2021-148315

Published: 2021

Journal Articles

Spectrum of ASXL1 mutations in primary myelofibrosis: prognostic impact of the ASXL1 p.G646Wfs*12 mutation

Giada Rotunno, Carmela Mannarelli, Giada Brogi, Annalisa Pacilli, Francesca Gesullo, Francesco Mannelli, Sara Fiaccabrino, Benedetta Sordi, Chiara Paoli, Ilaria Marone, Elisa Rumi, Rossella Manfredini, Giovanni Barosi, Mario Cazzola, Alessandro M. Vannucchi, Paola Guglielmelli

Blood (2019) 133 (26): 2802–2808.

https://doi.org/10.1182/blood.2018879536

Published: 2019

Includes: Supplemental data

Journal Articles

Calreticulin Ins5 and Del52 Mutations Impair Unfolded Protein and Oxidative Stress Responses in Hematopoietic Cells

Simona Salati, PhD, Elena Genovese, BSc, Zelia Prudente, BSc, PhD, Chiara Carretta, Niccolò Bartalucci, PhD BSc, Valentina Pennucci, PhD, Samantha Ruberti, BSc, PhD, Chiara Rossi, PharmD, Sebastiano Rontauroli, BSc, Carmela Mannarelli, PhD, Roberta Zini, BSc, PhD, Elisa Bianchi, BSc, PhD, Paola Guglielmelli, MD PhD, Enrico Tagliafico, MDPhD, Alessandro M. Vannucchi, MD, Rossella Manfredini, PhD

Blood (2018) 132 (Supplement 1): 4332.

https://doi.org/10.1182/blood-2018-99-112550

Published: 2018

Journal Articles

Comparative Genomic and Expression Analysis of Chronic and Blast-Phase Cells in Patients with Myeloproliferative Neoplasms

Paola Guglielmelli, MD PhD, Tiziana Fanelli, BiSc, Valentina Ariu, BSci, Giada Rotunno, PhD, Annalisa Pacilli, PhD, Elisa Contini, PhD, Alberto Magi, PhD, Roberto Semeraro, Simona Salati, PhD, Alberto Bosi, MD, Francesco Mannelli, MD, Rossella Manfredini, PhD, Alessandro M. Vannucchi, MD

Blood (2018) 132 (Supplement 1): 1777.

https://doi.org/10.1182/blood-2018-99-112894

Published: 2018

Journal Articles

Absence of Calreticulin Phenocopies Cellular Abnormalities Induced By Calreticulin Exon-9 Mutation in Myeloproliferative Neoplasms

Laura Calabresi, PhD BSc, Manjola Balliu, PhD BSc, Niccolò Bartalucci, PhDBSc, Simona Salati, PhD, Laura Maggi, PhD, Francesco Annunziato, PhD, Rossella Manfredini, PhD, Paola Guglielmelli, MD PhD, Alessandro M. Vannucchi, MD

Blood (2018) 132 (Supplement 1): 1780.

https://doi.org/10.1182/blood-2018-99-113266

Published: 2018

Journal Articles

Bone marrow–specific loss of ABI1 induces myeloproliferative neoplasm with features resembling human myelofibrosis

Blood (2018) 132 (19): 2053–2066.

https://doi.org/10.1182/blood-2018-05-848408

Published: 2018

Includes: Supplemental data

Journal Articles

The Role of the Axis TGF-β1/Mir-382-5p/SOD2 in the Induction of Oxidative Stress in CD34+ Hematopoietic Stem/Progenitor Cells from Primary Myelofibrosis

Chiara Rossi, PharmD, Roberta Zini, BSc, PhD, Samantha Ruberti, BSc, PhD, Sebastiano Rontauroli, BSc, Zelia Prudente, BSc, PhD, Greta Barbieri, BSc, Elisa Bianchi, BSc, PhD, Simona Salati, BSc, PhD, Elena Genovese, BSc, Carmela Mannarelli, MSc, PhD, Paola Guglielmelli, MD PhD, Enrico Tagliafico, MDPhD, Vittorio Rosti, MD, Giovanni Barosi, MD, Alessandro M. Vannucchi, Rossella Manfredini, BSc, PhD

Blood (2017) 130 (Supplement 1): 1655.

https://doi.org/10.1182/blood.V130.Suppl_1.1655.1655

Published: 2017

Journal Articles

Beyond JAK-STAT: Contribution of Abi-1, STAT3, and NF-κB Signaling to Pathogenesis of Myeloproliferative Neoplasms

Anna Dorota Chorzalska, PhD, John Morgan, PhD, Diana Olguta Treaba, MD, Adam J Olszewski, MD, Kara Lombardo, Roberta Zini, BSc, PhD, Annalisa Pacilli, PhD, Alexander Tepper, John L. Reagan, MD, Leszek Kotula, MD, Peter J. Quesenberry, MD, Philip Gruppuso, MD, Rossella Manfredini, BSc, PhD, Alessandro M. Vannucchi, Patrycja Dubielecka, PhD

Blood (2017) 130 (Supplement 1): 4210.

https://doi.org/10.1182/blood.V130.Suppl_1.4210.4210

Published: 2017

Journal Articles

MiR-494-3p Overexpression Leads to SOCS6 Downregulation and Supports Megakaryocytopoiesis in Primary Myelofibrosis CD34+ Hematopoietic Stem/Progenitor Cells

Sebastiano Rontauroli, BSc, Ruggiero Norfo, PhD, Valentina Pennucci, PhD, Roberta Zini, PhD, Samantha Ruberti, BSc, Elisa Bianchi, PhD, Simona Salati, PhD, Zelia Prudente, PhD, Chiara Rossi, BSc, Vittorio Rosti, Paola Guglielmelli, MD PhD, Giovanni Barosi, Alessandro M. Vannucchi, MD, Enrico Tagliafico, MD PhD, Rossella Manfredini, PhDBSc

Blood (2016) 128 (22): 4272.

https://doi.org/10.1182/blood.V128.22.4272.4272

Published: 2016

Journal Articles

Bone Marrow-Specific Loss of ABI1 Induces Myelofibrosis through a Mechanism Involving Activation of NFκB

Blood (2016) 128 (22): 1203.

https://doi.org/10.1182/blood.V128.22.1203.1203

Published: 2016

Journal Articles

MAF Induces Inflammatory Mediators Involved in the Pathogenesis of Primary Myelofibrosis

Samantha Ruberti, BSc, Elisa Bianchi, PhD, Tiziana Fanelli, MSc, Sebastiano Rontauroli, BSc, Valentina Pennucci, PhD, Giuditta Corbizzi Fattori, BSc, Carmela Mannarelli, MSc, PhD, Ruggiero Norfo, PhD, Chiara Rossi, BSc, Roberta Zini, PhD, Simona Salati, PhD, Zelia Prudente, PhD, Enrico Tagliafico, MDPhD, Paola Guglielmelli, MD PhD, Alessandro M. Vannucchi, MD, Rossella Manfredini, PhDBSc

Blood (2016) 128 (22): 3132.

https://doi.org/10.1182/blood.V128.22.3132.3132

Published: 2016

Journal Articles

Genomic landscape of megakaryopoiesis and platelet function defects

Elisa Bianchi, Ruggiero Norfo, Valentina Pennucci, Roberta Zini, Rossella Manfredini

Blood (2016) 127 (10): 1249–1259.

https://doi.org/10.1182/blood-2015-07-607952

Published: 2016

Journal Articles

Integrative Analysis of Copy Number and Gene Expression Data Suggests Novel Pathogenetic Mechanisms in Primary Myelofibrosis

Blood (2015) 126 (23): 2830.

https://doi.org/10.1182/blood.V126.23.2830.2830

Published: 2015

Journal Articles

C-Myb Restrains Megakaryopoiesis through the Hsa-MiR-486-3p-Driven Down-Regulation of C-Maf

Elisa Bianchi, PhD, Jenny Bulgarelli, PhD, Giorgia Sacchi, BiSci, Samantha Ruberti, BiSci, Ruggiero Norfo, PhD, Sebastiano Rontauroli, BiSci, Valentina Pennucci, PhD, Roberta Zini, PhD, Simona Salati, PhD, Zelia Prudente, BiSci, Sergio Ferrari, MD, Alessandro M. Vannucchi, MD, Rossella Manfredini, PhD

Blood (2014) 124 (21): 5124.

https://doi.org/10.1182/blood.V124.21.5124.5124

Published: 2014

Journal Articles

Impact of Mutation Status of ASXL1, EZH2, SRSF2, IDH1/2 on Clinical Phenotype and Prognosis in Patients with Post-Polycythemia and Post-Essential Thrombocythemia Myelofibrosis: An AGIMM Study

Blood (2014) 124 (21): 1867.

https://doi.org/10.1182/blood.V124.21.1867.1867

Published: 2014

Journal Articles

Mutation-Enhanced International Prognostic Scoring System (MIPSS) for Primary Myelofibrosis: An AGIMM & IWG-MRT Project

Blood (2014) 124 (21): 405.

https://doi.org/10.1182/blood.V124.21.405.405

Published: 2014

Journal Articles

miRNA-mRNA integrative analysis in primary myelofibrosis CD34 + cells: role of miR-155/JARID2 axis in abnormal megakaryopoiesis

Blood (2014) 124 (13): e21–e32.

https://doi.org/10.1182/blood-2013-12-544197

Published: 2014

Includes: Supplemental data

Journal Articles

Impact of mutational status on outcomes in myelofibrosis patients treated with ruxolitinib in the COMFORT-II study

Paola Guglielmelli, Flavia Biamonte, Giada Rotunno, Valentina Artusi, Lucia Artuso, Isabella Bernardis, Elena Tenedini, Lisa Pieri, Chiara Paoli, Carmela Mannarelli, Rajmonda Fjerza, Elisa Rumi, Viktoriya Stalbovskaya, Matthew Squires, Mario Cazzola, Rossella Manfredini, Claire Harrison, Enrico Tagliafico, Alessandro M. Vannucchi

Blood (2014) 123 (14): 2157–2160.

https://doi.org/10.1182/blood-2013-11-536557

Published: 2014

Includes: Supplemental data

NARROW

Chromosome 9p Duplication Promotes T-Cell Exhaustion and Enhances Stem Cell Clonogenic Potential in JAK2-Mutant Myeloproliferative Neoplasms

Peripheral Blood Cytotoxic T Cells from Myelofibrosis Patients Show Early Exhausted Features Targetable By CTLA-4 Inhibition

Single Cell Mutation Analysis Delineates Clonal Architecture in Leukemic Transformation of Myeloproliferative Neoplasms

Spectrum of ASXL1 mutations in primary myelofibrosis: prognostic impact of the ASXL1 p.G646Wfs*12 mutation

Calreticulin Ins5 and Del52 Mutations Impair Unfolded Protein and Oxidative Stress Responses in Hematopoietic Cells

Comparative Genomic and Expression Analysis of Chronic and Blast-Phase Cells in Patients with Myeloproliferative Neoplasms

Absence of Calreticulin Phenocopies Cellular Abnormalities Induced By Calreticulin Exon-9 Mutation in Myeloproliferative Neoplasms

Bone marrow–specific loss of ABI1 induces myeloproliferative neoplasm with features resembling human myelofibrosis

The Role of the Axis TGF-β1/Mir-382-5p/SOD2 in the Induction of Oxidative Stress in CD34+ Hematopoietic Stem/Progenitor Cells from Primary Myelofibrosis

Beyond JAK-STAT: Contribution of Abi-1, STAT3, and NF-κB Signaling to Pathogenesis of Myeloproliferative Neoplasms

MiR-494-3p Overexpression Leads to SOCS6 Downregulation and Supports Megakaryocytopoiesis in Primary Myelofibrosis CD34+ Hematopoietic Stem/Progenitor Cells

Bone Marrow-Specific Loss of ABI1 Induces Myelofibrosis through a Mechanism Involving Activation of NFκB

MAF Induces Inflammatory Mediators Involved in the Pathogenesis of Primary Myelofibrosis

Genomic landscape of megakaryopoiesis and platelet function defects

Integrative Analysis of Copy Number and Gene Expression Data Suggests Novel Pathogenetic Mechanisms in Primary Myelofibrosis

C-Myb Restrains Megakaryopoiesis through the Hsa-MiR-486-3p-Driven Down-Regulation of C-Maf

Impact of Mutation Status of ASXL1, EZH2, SRSF2, IDH1/2 on Clinical Phenotype and Prognosis in Patients with Post-Polycythemia and Post-Essential Thrombocythemia Myelofibrosis: An AGIMM Study

Mutation-Enhanced International Prognostic Scoring System (MIPSS) for Primary Myelofibrosis: An AGIMM & IWG-MRT Project

miRNA-mRNA integrative analysis in primary myelofibrosis CD34 + cells: role of miR-155/JARID2 axis in abnormal megakaryopoiesis

Impact of mutational status on outcomes in myelofibrosis patients treated with ruxolitinib in the COMFORT-II study

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American Society of Hematology

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