Skip to Main Content

Advertisement intended for health care professionals

Umbrella Alt Text
Cart
header search
Search
Skip Nav Destination

Issue Archive

Volume 117, Issue 10
March 10 2011
Issue Cover

Table of Contents

Inside Blood

CLINICAL TRIALS
Erdheim-Chester: beyond the lesion
Carl E. Allen,Kenneth L. McClain
View Articletitled, Erdheim-Chester: beyond the lesion
CLINICAL TRIALS
The power of 1 in HIV therapeutics
Raphaelle Parker,Irini Sereti
View Articletitled, The power of 1 in HIV therapeutics
IMMUNOBIOLOGY
Oncogenic Ras scales the ALPS
Kevin Shannon,Qing Li
View Articletitled, Oncogenic Ras scales the ALPS
INSIDE BLOOD
Notch, a T-ALL order
Barbara A. Osborne
View Articletitled, Notch, a T-ALL order
INSIDE BLOOD
A new face of BCL-2 inhibition in CLL
Anthony Letai
View Articletitled, A new face of BCL-2 inhibition in CLL
TRANSPLANTATION
Balancing act for Treg immunotherapy
Vu H. Nguyen
View Articletitled, Balancing act for Treg immunotherapy

Editorial

Patients, hematologists, and time
Lawrence A. Solberg, Jr,Cynthia E. Dunbar
View Articletitled, Patients, hematologists, and time

Review Article

Management of RSV infections in adult recipients of hematopoietic stem cell transplantation
Jharna N. Shah,Roy F. Chemaly
View Articletitled, Management of RSV infections in adult recipients of hematopoietic stem cell transplantation

How I Treat

How I treat LGL leukemia
Thierry Lamy,Thomas P. Loughran, Jr
View Articletitled, How I treat LGL leukemia

Blood Consult

Blood consult: acute myeloid leukemia and the t(8;21)(q22;22)
Clinical Trials & Observations
Jae H. Park,Cyrus V. Hedvat,Martin S. Tallman
View Articletitled, <em>Blood</em> consult: acute myeloid leukemia and the t(8;21)(q22;22)

Gene therapy

Therapeutic levels of fetal hemoglobin in erythroid progeny of β-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer
Andrew Wilber,Phillip W. Hargrove,Yoon-Sang Kim,Janice M. Riberdy,Vijay G. Sankaran,Eleni Papanikolaou,Maria Georgomanoli,Nicholas P. Anagnou,Stuart H. Orkin,Arthur W. Nienhuis,Derek A. Persons
View Articletitled, Therapeutic levels of fetal hemoglobin in erythroid progeny of β-thalassemic CD34<sup>+</sup> cells after lentiviral vector-mediated gene transfer
Supplemental data

Hematopoiesis and Stem Cells

Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells
Mathias Leddin,Chiara Perrod,Maarten Hoogenkamp,Saeed Ghani,Salam Assi,Sven Heinz,Nicola K. Wilson,George Follows,Jörg Schönheit,Lena Vockentanz,Ali M. Mosammam,Wei Chen,Daniel G. Tenen,David R. Westhead,Berthold Göttgens,Constanze Bonifer,Frank Rosenbauer
View Articletitled, Two distinct auto-regulatory loops operate at the <em>PU.1</em> locus in B cells and myeloid cells
Supplemental data

Immunobiology

Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation
Clinical Trials & Observations
Kristina Allers,Gero Hütter,Jörg Hofmann,Christoph Loddenkemper,Kathrin Rieger,Eckhard Thiel,Thomas Schneider
View Articletitled, Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation
Epigenetic modification of the human CCR6 gene is associated with stable CCR6 expression in T cells
Svenja Steinfelder,Stefan Floess,Dirk Engelbert,Barbara Haeringer,Udo Baron,Laura Rivino,Bodo Steckel,Andreas Gruetzkau,Sven Olek,Jens Geginat,Jochen Huehn,Alf Hamann
View Articletitled, Epigenetic modification of the human <em>CCR6</em> gene is associated with stable CCR6 expression in T cells
Supplemental data
IRF8 and IRF3 cooperatively regulate rapid interferon-β induction in human blood monocytes
Peng Li,Joyce Jing-Yi Wong,Calvin Sum,Wei-Xiang Sin,Kok-Quan Ng,Mickey B. C. Koh,Keh-Chuang Chin
View Articletitled, IRF8 and IRF3 cooperatively regulate rapid interferon-β induction in human blood monocytes
Supplemental data
IκBζ augments IL-12– and IL-18–mediated IFN-γ production in human NK cells
Yashaswini Kannan,Jianhua Yu,Raquel M. Raices,Sudarshan Seshadri,Min Wei,Michael A. Caligiuri,Mark D. Wewers
View Articletitled, IκBζ augments IL-12– and IL-18–mediated IFN-γ production in human NK cells
Supplemental data
Up-regulation of cytolytic functions of human Vδ2− γδ T lymphocytes through engagement of ILT2 expressed by tumor target cells
Christelle Harly,Marie-Alix Peyrat,Sonia Netzer,Julie Déchanet-Merville,Marc Bonneville,Emmanuel Scotet
View Articletitled, Up-regulation of cytolytic functions of human Vδ2<sup>−</sup> γδ T lymphocytes through engagement of ILT2 expressed by tumor target cells
Supplemental data
Impact of β2 integrin deficiency on mouse natural killer cell development and function
Karine Crozat,Céline Eidenschenk,Baptiste N. Jaeger,Philippe Krebs,Sophie Guia,Bruce Beutler,Eric Vivier,Sophie Ugolini
View Articletitled, Impact of β2 integrin deficiency on mouse natural killer cell development and function
Supplemental data

Lymphoid Neoplasia

The combination of bendamustine, bortezomib, and rituximab for patients with relapsed/refractory indolent and mantle cell non-Hodgkin lymphoma
Clinical Trials & Observations
Jonathan W. Friedberg,Julie M. Vose,Jennifer L. Kelly,Faith Young,Steven H. Bernstein,Derick Peterson,Lynn Rich,Susan Blumel,Nicole K. Proia,Jane Liesveld,Richard I. Fisher,James O. Armitage,Steven Grant,John P. Leonard
View Articletitled, The combination of bendamustine, bortezomib, and rituximab for patients with relapsed/refractory indolent and mantle cell non-Hodgkin lymphoma
Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis
Brief Report
Julie E. Niemela,Lianghao Lu,Thomas A. Fleisher,Joie Davis,Iusta Caminha,Marc Natter,Laurel A. Beer,Kennichi C. Dowdell,Stefania Pittaluga,Mark Raffeld,V. Koneti Rao,João B. Oliveira
View Articletitled, Somatic <em>KRAS</em> mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis
Supplemental data
Autoimmune lymphoproliferative syndrome–like disease with somatic KRAS mutation
Brief Report
Masatoshi Takagi,Kunihiro Shinoda,Jinhua Piao,Noriko Mitsuiki,Mari Takagi,Kazuyuki Matsuda,Hideki Muramatsu,Sayoko Doisaki,Masayuki Nagasawa,Tomohiro Morio,Yoshihito Kasahara,Kenichi Koike,Seiji Kojima,Akira Takao,Shuki Mizutani
View Articletitled, Autoimmune lymphoproliferative syndrome–like disease with somatic <em>KRAS</em> mutation
Supplemental data
Notch/HES1-mediated PARP1 activation: a cell type–specific mechanism for tumor suppression
Sankaranarayanan Kannan,Wendy Fang,Guangchun Song,Charles G. Mullighan,Richard Hammitt,John McMurray,Patrick A. Zweidler-McKay
View Articletitled, Notch/HES1-mediated PARP1 activation: a cell type–specific mechanism for tumor suppression
Supplemental data
Notch is oncogenic dominant in T-cell acute lymphoblastic leukemia
Renée M. Demarest,Nadia Dahmane,Anthony J. Capobianco
View Articletitled, Notch is oncogenic dominant in T-cell acute lymphoblastic leukemia
HDAC11 plays an essential role in regulating OX40 ligand expression in Hodgkin lymphoma
Daniela Buglio,Noor M. Khaskhely,Kui Shin Voo,Hector Martinez-Valdez,Yong-Jun Liu,Anas Younes
View Articletitled, HDAC11 plays an essential role in regulating OX40 ligand expression in Hodgkin lymphoma
Hyperphosphorylated paratarg-7: a new molecularly defined risk factor for monoclonal gammopathy of undetermined significance of the IgM type and Waldenström macroglobulinemia
Sandra Grass,Klaus-Dieter Preuss,Alexandra Wikowicz,Evangelos Terpos,Marita Ziepert,Diana Nikolaus,Yin Yang,Natalie Fadle,Evi Regitz,Meletios A. Dimopoulos,Steven P. Treon,Zachary R. Hunter,Michael Pfreundschuh
View Articletitled, Hyperphosphorylated paratarg-7: a new molecularly defined risk factor for monoclonal gammopathy of undetermined significance of the IgM type and Waldenström macroglobulinemia
Supplemental data
Induction of Ca2+-driven apoptosis in chronic lymphocytic leukemia cells by peptide-mediated disruption of Bcl-2–IP3 receptor interaction
Fei Zhong,Michael W. Harr,Geert Bultynck,Giovanni Monaco,Jan B. Parys,Humbert De Smedt,Yi-Ping Rong,Jason K. Molitoris,Minh Lam,Christopher Ryder,Shigemi Matsuyama,Clark W. Distelhorst
View Articletitled, Induction of Ca<sup>2+</sup>-driven apoptosis in chronic lymphocytic leukemia cells by peptide-mediated disruption of Bcl-2–IP<sub>3</sub> receptor interaction

Myeloid Neoplasia

Molecular and clinical features of the myeloproliferative neoplasm associated with JAK2 exon 12 mutations
Brief Report
Francesco Passamonti,Chiara Elena,Susanne Schnittger,Radek C. Skoda,Anthony R. Green,François Girodon,Jean-Jacques Kiladjian,Mary Frances McMullin,Marco Ruggeri,Carles Besses,Alessandro M. Vannucchi,Eric Lippert,Heinz Gisslinger,Elisa Rumi,Thomas Lehmann,Christina A. Ortmann,Daniela Pietra,Cristiana Pascutto,Torsten Haferlach,Mario Cazzola
View Articletitled, Molecular and clinical features of the myeloproliferative neoplasm associated with <em>JAK2</em> exon 12 mutations
Supplemental data
Novel imatinib-sensitive PDGFRA-activating point mutations in hypereosinophilic syndrome induce growth factor independence and leukemia-like disease
Christian Elling,Philipp Erben,Christoph Walz,Marie Frickenhaus,Mirle Schemionek,Martin Stehling,Hubert Serve,Nicholas C. P. Cross,Andreas Hochhaus,Wolf-Karsten Hofmann,Wolfgang E. Berdel,Carsten Müller-Tidow,Andreas Reiter,Steffen Koschmieder
View Articletitled, Novel imatinib-sensitive PDGFRA-activating point mutations in hypereosinophilic syndrome induce growth factor independence and leukemia-like disease

Phagocytes, Granulocytes, and Myelopoiesis

CNS involvement and treatment with interferon-α are independent prognostic factors in Erdheim-Chester disease: a multicenter survival analysis of 53 patients
Clinical Trials & Observations
Laurent Arnaud,Baptiste Hervier,Antoine Néel,Mohamed A. Hamidou,Jean-Emmanuel Kahn,Bertrand Wechsler,Gemma Pérez-Pastor,Bjørn Blomberg,Jean-Gabriel Fuzibet,François Dubourguet,António Marinho,Catherine Magnette,Violaine Noel,Michel Pavic,Jochen Casper,Anne-Bérangère Beucher,Nathalie Costedoat-Chalumeau,Laurent Aaron,Juan Salvatierra,Carlos Graux,Patrice Cacoub,Véronique Delcey,Claudia Dechant,Pascal Bindi,Christiane Herbaut,Giorgio Graziani,Zahir Amoura,Julien Haroche
View Articletitled, CNS involvement and treatment with interferon-α are independent prognostic factors in Erdheim-Chester disease: a multicenter survival analysis of 53 patients
Systemic perturbation of cytokine and chemokine networks in Erdheim-Chester disease: a single-center series of 37 patients
Clinical Trials & Observations
Laurent Arnaud,Guy Gorochov,Frédéric Charlotte,Virginie Lvovschi,Christophe Parizot,Martin Larsen,Pascale Ghillani-Dalbin,Baptiste Hervier,Jean-Emmanuel Kahn,Claire Deback,Lucile Musset,Zahir Amoura,Julien Haroche
View Articletitled, Systemic perturbation of cytokine and chemokine networks in Erdheim-Chester disease: a single-center series of 37 patients
The nerve growth factor reduces APOBEC3G synthesis and enhances HIV-1 transcription and replication in human primary macrophages
Thiago Moreno L. Souza,Diego Q. Rodrigues,Caroline P. B. Passaes,Victor Barreto-de-Souza,Renato S. Aguiar,Jairo R. Temerozo,Mariza G. Morgado,Carlos Frederico L. Fontes,Elizabeth G. Araujo,Dumith Chequer Bou-Habib
View Articletitled, The nerve growth factor reduces APOBEC3G synthesis and enhances HIV-1 transcription and replication in human primary macrophages
Supplemental data

Red Cells, Iron, and Erythropoiesis

Prevalence of 25-hydroxyvitamin D deficiency in subgroups of elderly persons with anemia: association with anemia of inflammation
Clinical Trials & Observations
Todd S. Perlstein,Reena Pande,Nancy Berliner,Gary J. Vanasse
View Articletitled, Prevalence of 25-hydroxyvitamin D deficiency in subgroups of elderly persons with anemia: association with anemia of inflammation
Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project
Alberto Piperno,Stefania Galimberti,Raffaella Mariani,Sara Pelucchi,Giulia Ravasi,Carolina Lombardi,Grzegorz Bilo,Miriam Revera,Andrea Giuliano,Andrea Faini,Veronica Mainini,Mark Westerman,Tomas Ganz,Maria Grazia Valsecchi,Giuseppe Mancia,Gianfranco Parati,for the HIGHCARE investigators
View Articletitled, Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project
Supplemental data
Blunted hepcidin response to inflammation in the absence of Hfe and transferrin receptor 2
Daniel F. Wallace,Cameron J. McDonald,Lesa Ostini,V. Nathan Subramaniam
View Articletitled, Blunted hepcidin response to inflammation in the absence of Hfe and transferrin receptor 2

Thrombosis and Hemostasis

Functional study of the vitamin K cycle in mammalian cells
Jian-Ke Tie,Da-Yun Jin,David L. Straight,Darrel W. Stafford
View Articletitled, Functional study of the vitamin K cycle in mammalian cells

Transplantation

Immune reconstitution is preserved in hematopoietic stem cell transplantation coadministered with regulatory T cells for GVHD prevention
Aline Gaidot,Dan Avi Landau,Gaëlle Hélène Martin,Olivia Bonduelle,Yenkel Grinberg-Bleyer,Diana Matheoud,Sylvie Grégoire,Claude Baillou,Béhazine Combadière,Eliane Piaggio,José Laurent Cohen
View Articletitled, Immune reconstitution is preserved in hematopoietic stem cell transplantation coadministered with regulatory T cells for GVHD prevention
Supplemental data
All Issues

Advertisement intended for health care professionals

NK cells with adhesion defects and reduced cytotoxic functions are associated with a poor prognosis in Multiple Myeloma.
Early-life infection depletes preleukemic cells in a mouse model of hyperdiploid B-cell acute lymphoblastic leukemia
COping with acute sickle cell hemolysis
Unrelated donor selection with PTCy
What WAS disease risk then versus now?

Advertisement intended for health care professionals

Advertisement intended for health care professionals

  • American Society of Hematology
  • 2021 L Street NW, Suite 900
  • Washington, DC 20036
  • TEL +1 202-776-0544
  • FAX +1 202-776-0545

ASH Publications

American Society of Hematology

Copyright 2024 by American Society of Hematology
 
Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal

Advertisement intended for health care professionals