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Journal Articles

γ-Glutamyl carboxylase mutations differentially affect the biological function of vitamin K–dependent proteins

Zhenyu Hao, Da-Yun Jin, Xuejie Chen, Leon J. Schurgers, Darrel W. Stafford, Jian-Ke Tie

Blood (2021) 137 (4): 533–543.

https://doi.org/10.1182/blood.2020006329

Published: 2021

Includes: Supplemental data

Journal Articles

A cell-based high-throughput screen identifies drugs that cause bleeding disorders by off-targeting the vitamin K cycle

Xuejie Chen, Caihong Li, Da-Yun Jin, Brian Ingram, Zhenyu Hao, Xue Bai, Darrel W. Stafford, Keping Hu, Jian-Ke Tie

Blood (2020) 136 (7): 898–908.

https://doi.org/10.1182/blood.2019004234

Published: 2020

Includes: Supplemental data

Journal Articles

Dysfunctional endogenous FIX impairs prophylaxis in a mouse hemophilia B model

Brian Cooley, George J. Broze, Jr, David M. Mann, Feng-Chang Lin, Lee G. Pedersen, Darrel W. Stafford

Blood (2019) 133 (22): 2445–2451.

https://doi.org/10.1182/blood.2018884015

Published: 2019

Journal Articles

Evaluation of oral anticoagulants with vitamin K epoxide reductase in its native milieu

Xuejie Chen, Da-Yun Jin, Darrel W. Stafford, Jian-Ke Tie

Blood (2018) 132 (18): 1974–1984.

https://doi.org/10.1182/blood-2018-05-846592

Published: 2018

Includes: Supplemental data

Journal Articles

Warfarin and vitamin K epoxide reductase: a molecular accounting for observed inhibition

Sangwook Wu, Xuejie Chen, Da-Yun Jin, Darrel W. Stafford, Lee G. Pedersen, Jian-Ke Tie

Blood (2018) 132 (6): 647–657.

https://doi.org/10.1182/blood-2018-01-830901

Published: 2018

Includes: Multimedia, Supplemental data

Journal Articles

Molecular basis of the first reported clinical case of congenital combined deficiency of coagulation factors

Da-Yun Jin, Brian O. Ingram, Darrel W. Stafford, Jian-Ke Tie

Blood (2017) 130 (7): 948–951.

https://doi.org/10.1182/blood-2017-05-782367

Published: 2017

Includes: Supplemental data

Journal Articles

Prophylactic efficacy of BeneFIX vs Alprolix in hemophilia B mice

Brian Cooley, William Funkhouser, Dougald Monroe, Ashley Ezzell, David M. Mann, Feng-Chang Lin, Paul E. Monahan, Darrel W. Stafford

Blood (2016) 128 (2): 286–292.

https://doi.org/10.1182/blood-2016-01-696104

Published: 2016

Journal Articles

Characterization of vitamin K–dependent carboxylase mutations that cause bleeding and nonbleeding disorders

Jian-Ke Tie, Jorge D. A. Carneiro, Da-Yun Jin, Ciro D. Martinhago, Cees Vermeer, Darrel W. Stafford

Blood (2016) 127 (15): 1847–1855.

https://doi.org/10.1182/blood-2015-10-677633

Published: 2016

Includes: Supplemental data

Journal Articles

At Equal Doses FIXFc (Alprolix) Is Not Significanly Better in a Saphenous Vein Bleeding Model Than Recombinant FIX (BeneFix) Seven Days Post-Infusion

Brian Cooley, PhD, David M Mann, PhD, Dougald Monroe, PhD, Feng-Chang Lin, Paul E. Monahan, MD, Darrel W. Stafford, PhD

Blood (2015) 126 (23): 3490.

https://doi.org/10.1182/blood.V126.23.3490.3490

Published: 2015

Journal Articles

FVIIa as used pharmacologically is not TF dependent in hemophilia B mice

Dengmin Feng, Herbert Whinna, Dougald Monroe, Darrel W. Stafford

Blood (2014) 123 (11): 1764–1766.

https://doi.org/10.1182/blood-2013-08-522987

Published: 2014

Journal Articles

Hemophilia B Mouse Lines Doubly Humanized for Human F9 and MHC Class II Genes Advance Specificity of Inhibitor Study

Genlin Hu, PhD, Tong Gui, PhD, Junjiang Sun, MD, Darrel W. Stafford, PhD, R. Jude Samulski, PhD, Paul E. Monahan, MD

Blood (2011) 118 (21): 200.

https://doi.org/10.1182/blood.V118.21.200.200

Published: 2011

Journal Articles

Functional study of the vitamin K cycle in mammalian cells

Jian-Ke Tie, Da-Yun Jin, David L. Straight, Darrel W. Stafford

Blood (2011) 117 (10): 2967–2974.

https://doi.org/10.1182/blood-2010-08-304303

Published: 2011

Journal Articles

Vitamin K supplementation during oral anticoagulation: cautions

Darrel W. Stafford, Harold R. Roberts, Cees Vermeer

Blood (2007) 109 (8): 3607.

https://doi.org/10.1182/blood-2006-12-061200

Published: 2007

Journal Articles

Purification of a Single Peptide with Vitamin K Epoxide to Vitamin K and Vitamin K to Vitamin KH2 Activity.

Pei-hsuan Chu, MS, Teng-yi Huang, MS, Jason Williams, PhD, Darrel W. Stafford, PhD

Blood (2006) 108 (11): 331.

https://doi.org/10.1182/blood.V108.11.331.331

Published: 2006

Journal Articles

Expression of a Two Chain Gamma-Glutamyl Carboxylase: Importance of Disulfide Bond Formation and Transmembrane Domain Interactions.

Jian-Kie Tie, PhD, Mei-Yan Zheng, B.S., Darrel W. Stafford, Ph.D, David L. Straight, Ph.D

Blood (2006) 108 (11): 1694.

https://doi.org/10.1182/blood.V108.11.1694.1694

Published: 2006

Journal Articles

Mutational Analysis of VKOR.

Da-Yun Jin, MS, Jian-Ke Tie, PhD, Darrel W. Stafford, PhD

Blood (2006) 108 (11): 1628.

https://doi.org/10.1182/blood.V108.11.1628.1628

Published: 2006

Journal Articles

Vitamin K epoxide reductase significantly improves carboxylation in a cell line overexpressing factor X

Yan-Mei Sun, Da-Yun Jin, Rodney M. Camire, Darrel W. Stafford

Blood (2005) 106 (12): 3811–3815.

https://doi.org/10.1182/blood-2005-06-2495

Published: 2005

Journal Articles

Hemophilia B Gene Therapy Modelled in Null and Missense Mutant Mice: Kinetics of Transgenic Factor IX Expression Influences Tolerance to a Greater Extent Than Dose or Serotype of Adeno-Associated Virus (AAV) Vector.

Paul E. Monahan, MD, Tai-Ping Zhang, MD, Da-Yun Jin, Tong Gui, MD, PhD, Darrel W. Stafford, PhD

Blood (2005) 106 (11): 5526.

https://doi.org/10.1182/blood.V106.11.5526.5526

Published: 2005

Journal Articles

Factor IX variants improve gene therapy efficacy for hemophilia B

Joerg Schuettrumpf, Roland W. Herzog, Alexander Schlachterman, Antje Kaufhold, Darrel W. Stafford, Valder R. Arruda

Blood (2005) 105 (6): 2316–2323.

https://doi.org/10.1182/blood-2004-08-2990

Published: 2005

Journal Articles

Creation of a mouse expressing defective human factor IX

Da-Yun Jin, Tai-Ping Zhang, Tong Gui, Darrel W. Stafford, Paul E. Monahan

Blood (2004) 104 (6): 1733–1739.

https://doi.org/10.1182/blood-2004-01-0138

Published: 2004

NARROW

γ-Glutamyl carboxylase mutations differentially affect the biological function of vitamin K–dependent proteins

A cell-based high-throughput screen identifies drugs that cause bleeding disorders by off-targeting the vitamin K cycle

Dysfunctional endogenous FIX impairs prophylaxis in a mouse hemophilia B model

Evaluation of oral anticoagulants with vitamin K epoxide reductase in its native milieu

Warfarin and vitamin K epoxide reductase: a molecular accounting for observed inhibition

Molecular basis of the first reported clinical case of congenital combined deficiency of coagulation factors

Prophylactic efficacy of BeneFIX vs Alprolix in hemophilia B mice

Characterization of vitamin K–dependent carboxylase mutations that cause bleeding and nonbleeding disorders

At Equal Doses FIXFc (Alprolix) Is Not Significanly Better in a Saphenous Vein Bleeding Model Than Recombinant FIX (BeneFix) Seven Days Post-Infusion

FVIIa as used pharmacologically is not TF dependent in hemophilia B mice

Hemophilia B Mouse Lines Doubly Humanized for Human F9 and MHC Class II Genes Advance Specificity of Inhibitor Study

Functional study of the vitamin K cycle in mammalian cells

Vitamin K supplementation during oral anticoagulation: cautions

Purification of a Single Peptide with Vitamin K Epoxide to Vitamin K and Vitamin K to Vitamin KH2 Activity.

Expression of a Two Chain Gamma-Glutamyl Carboxylase: Importance of Disulfide Bond Formation and Transmembrane Domain Interactions.

Mutational Analysis of VKOR.

Vitamin K epoxide reductase significantly improves carboxylation in a cell line overexpressing factor X

Hemophilia B Gene Therapy Modelled in Null and Missense Mutant Mice: Kinetics of Transgenic Factor IX Expression Influences Tolerance to a Greater Extent Than Dose or Serotype of Adeno-Associated Virus (AAV) Vector.

Factor IX variants improve gene therapy efficacy for hemophilia B

Creation of a mouse expressing defective human factor IX

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American Society of Hematology

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American Society of Hematology

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