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Issue Archive

Volume 114, Issue 13
September 24 2009
Issue Cover

Table of Contents

INSIDE BLOOD

IMMUNOBIOLOGY
NK antibody therapy: KIR-ative intent
Nina Shah,Elizabeth J. Shpall
View Articletitled, NK antibody therapy: KIR-ative intent
INSIDE BLOOD
“Tax-ing” the cancer stem cell
Gerold Feuer
View Articletitled, “Tax-ing” the cancer stem cell
MYELOID NEOPLASIA
Missteps in “tango” for epigenome targeting
Keith D. Robertson,Kapil N. Bhalla
View Articletitled, Missteps in “tango” for epigenome targeting
PHAGOCYTES & GRANULOCYTES
HIV: getting to the heart of DARCness
Robert J. B. Nibbs
View Articletitled, HIV: getting to the heart of DARCness
PLATELETS & THROMBOPOIESIS
Platelet integrin signaling: wherefore art thou?
Alec A. Schmaier,Mark L. Kahn
View Articletitled, Platelet integrin signaling: wherefore art thou?
VASCULAR BIOLOGY
Super factor B-gets atypical HUS
Edward M. Conway
View Articletitled, Super factor B-gets atypical HUS

PERSPECTIVE

Defining prior therapy in myelodysplastic syndromes and criteria for relapsed and refractory disease: implications for clinical trial design and enrollment
Mikkael A. Sekeres,David P. Steensma
View Articletitled, Defining prior therapy in myelodysplastic syndromes and criteria for relapsed and refractory disease: implications for clinical trial design and enrollment

REVIEW ARTICLES

Allogeneic hematopoietic cell transplantation for chronic lymphocytic leukemia: ready for prime time?
Julio Delgado,Donald W. Milligan,Peter Dreger
View Articletitled, Allogeneic hematopoietic cell transplantation for chronic lymphocytic leukemia: ready for prime time?

CLINICAL TRIALS AND OBSERVATIONS

Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): dissecting the contribution of 17p deletion, TP53 mutation, p53-p21 dysfunction, and miR34a in a prospective clinical trial
Clinical Trials & Observations
Thorsten Zenz,Sonja Häbe,Tina Denzel,Julia Mohr,Dirk Winkler,Andreas Bühler,Antonio Sarno,Silja Groner,Daniel Mertens,Raymonde Busch,Michael Hallek,Hartmut Döhner,Stephan Stilgenbauer
View Articletitled, Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): dissecting the contribution of 17p deletion, <em>TP53</em> mutation, p53-p21 dysfunction, and miR34a in a prospective clinical trial
Supplemental data
Determining the rise in BCR-ABL RNA that optimally predicts a kinase domain mutation in patients with chronic myeloid leukemia on imatinib
Clinical Trials & Observations
Richard D. Press,Stephanie G. Willis,Jennifer Laudadio,Michael J. Mauro,Michael W. N. Deininger
View Articletitled, Determining the rise in BCR-ABL RNA that optimally predicts a kinase domain mutation in patients with chronic myeloid leukemia on imatinib
Donor, recipient, and transplant characteristics as risk factors after unrelated donor PBSC transplantation: beneficial effects of higher CD34+ cell dose
Clinical Trials & Observations
Michael A. Pulsipher,Pintip Chitphakdithai,Brent R. Logan,Susan F. Leitman,Paolo Anderlini,John P. Klein,Mary M. Horowitz,John P. Miller,Roberta J. King,Dennis L. Confer
View Articletitled, Donor, recipient, and transplant characteristics as risk factors after unrelated donor PBSC transplantation: beneficial effects of higher CD34<sup>+</sup> cell dose
Supplemental data
The importance of bone marrow examination in determining complete response to therapy in patients with multiple myeloma
Brief Report
Cheng E. Chee,Shaji Kumar,Dirk R. Larson,Robert A. Kyle,Angela Dispenzieri,Morie A. Gertz,Colin L. Colby,S. Vincent Rajkumar
View Articletitled, The importance of bone marrow examination in determining complete response to therapy in patients with multiple myeloma

GENE THERAPY

Restoration of NET formation by gene therapy in CGD controls aspergillosis
Brief Report
Matteo Bianchi,Abdul Hakkim,Volker Brinkmann,Ulrich Siler,Reinhard A. Seger,Arturo Zychlinsky,Janine Reichenbach
View Articletitled, Restoration of NET formation by gene therapy in CGD controls aspergillosis
Supplemental data

IMMUNOBIOLOGY

Dynamic accumulation of plasmacytoid dendritic cells in lymph nodes is regulated by interferon-β
Yunfei Gao,Beata Majchrzak-Kita,Eleanor N. Fish,Jennifer L. Gommerman
View Articletitled, Dynamic accumulation of plasmacytoid dendritic cells in lymph nodes is regulated by interferon-β
Supplemental data
Mesenchymal stromal cells cross-present soluble exogenous antigens as part of their antigen-presenting cell properties
Moïra François,Raphaëlle Romieu-Mourez,Sophie Stock-Martineau,Marie-Noëlle Boivin,Jonathan L. Bramson,Jacques Galipeau
View Articletitled, Mesenchymal stromal cells cross-present soluble exogenous antigens as part of their antigen-presenting cell properties
Mast cells counteract regulatory T-cell suppression through interleukin-6 and OX40/OX40L axis toward Th17-cell differentiation
Silvia Piconese,Giorgia Gri,Claudio Tripodo,Silvia Musio,Andrea Gorzanelli,Barbara Frossi,Rosetta Pedotti,Carlo E. Pucillo,Mario P. Colombo
View Articletitled, Mast cells counteract regulatory T-cell suppression through interleukin-6 and OX40/OX40L axis toward Th17-cell differentiation
Supplemental data
Pneumoviruses infect eosinophils and elicit MyD88-dependent release of chemoattractant cytokines and interleukin-6
Kimberly D. Dyer,Caroline M. Percopo,Elizabeth R. Fischer,Stanislaw J. Gabryszewski,Helene F. Rosenberg
View Articletitled, Pneumoviruses infect eosinophils and elicit MyD88-dependent release of chemoattractant cytokines and interleukin-6
Supplemental data
Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors
Yenan T. Bryceson,Hans-Gustaf Ljunggren,Eric O. Long
View Articletitled, Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors
Supplemental data
Preclinical characterization of 1-7F9, a novel human anti–KIR receptor therapeutic antibody that augments natural killer–mediated killing of tumor cells
Francois Romagné,Pascale André,Pieter Spee,Stefan Zahn,Nicolas Anfossi,Laurent Gauthier,Marusca Capanni,Loredana Ruggeri,Don M. Benson, Jr,Bradley W. Blaser,Mariella Della Chiesa,Alessandro Moretta,Eric Vivier,Michael A. Caligiuri,Andrea Velardi,Nicolai Wagtmann
View Articletitled, Preclinical characterization of 1-7F9, a novel human anti–KIR receptor therapeutic antibody that augments natural killer–mediated killing of tumor cells
Supplemental data

LYMPHOID NEOPLASIA

Mer receptor tyrosine kinase is a novel therapeutic target in pediatric B-cell acute lymphoblastic leukemia
Rachel M. A. Linger,Deborah DeRyckere,Luis Brandão,Kelly K. Sawczyn,Kristen M. Jacobsen,Xiayuan Liang,Amy K. Keating,Douglas K. Graham
View Articletitled, Mer receptor tyrosine kinase is a novel therapeutic target in pediatric B-cell acute lymphoblastic leukemia
Supplemental data
Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia
Lisa J. Russell,Melania Capasso,Inga Vater,Takashi Akasaka,Olivier A. Bernard,Maria Jose Calasanz,Thiruppavaii Chandrasekaran,Elise Chapiro,Stephan Gesk,Mike Griffiths,David S. Guttery,Claudia Haferlach,Lana Harder,Olaf Heidenreich,Julie Irving,Lyndal Kearney,Florence Nguyen-Khac,Lee Machado,Lynne Minto,Aneela Majid,Anthony V. Moorman,Heather Morrison,Vikki Rand,Jonathan C. Strefford,Claire Schwab,Holger Tönnies,Martin J. S. Dyer,Reiner Siebert,Christine J. Harrison
View Articletitled, Deregulated expression of cytokine receptor gene, <em>CRLF2</em>, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia
Supplemental data
Aurora kinase A is a target of Wnt/β-catenin involved in multiple myeloma disease progression
Jui Dutta-Simmons,Yunyu Zhang,Gullu Gorgun,Moshe Gatt,Mala Mani,Teru Hideshima,Kohichi Takada,Nicole E. Carlson,Daniel E. Carrasco,Yu-Tzu Tai,Noopur Raje,Anthony G. Letai,Kenneth C. Anderson,Daniel R. Carrasco
View Articletitled, Aurora kinase A is a target of Wnt/β-catenin involved in multiple myeloma disease progression
Supplemental data
Identification of cancer stem cells in a Tax-transgenic (Tax-Tg) mouse model of adult T-cell leukemia/lymphoma
Jumpei Yamazaki,Takuo Mizukami,Kazuya Takizawa,Madoka Kuramitsu,Haruka Momose,Atsuko Masumi,Yasushi Ami,Hideki Hasegawa,William W. Hall,Hajime Tsujimoto,Isao Hamaguchi,Kazunari Yamaguchi
View Articletitled, Identification of cancer stem cells in a Tax-transgenic (Tax-Tg) mouse model of adult T-cell leukemia/lymphoma
Therapeutic potential of an anti-CD79b antibody–drug conjugate, anti–CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma
David Dornan,Fiona Bennett,Yvonne Chen,Mark Dennis,Dan Eaton,Kristi Elkins,Dorothy French,Mary Ann T. Go,Andrew Jack,Jagath R. Junutula,Hartmut Koeppen,Jeffrey Lau,Jacqueline McBride,Andy Rawstron,Xiaoyan Shi,Nancy Yu,Shang-Fan Yu,Peng Yue,Bing Zheng,Allen Ebens,Andrew G. Polson
View Articletitled, Therapeutic potential of an anti-CD79b antibody–drug conjugate, anti–CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma
Supplemental data
A prospective study of serum soluble CD30 concentration and risk of non-Hodgkin lymphoma
Brief Report
Mark P. Purdue,Qing Lan,Otoniel Martinez-Maza,Martin M. Oken,William Hocking,Wen-Yi Huang,Dalsu Baris,Betty Conde,Nathaniel Rothman
View Articletitled, A prospective study of serum soluble CD30 concentration and risk of non-Hodgkin lymphoma
Supplemental data

MYELOID NEOPLASIA

Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells
Warren Fiskus,Yongchao Wang,Arun Sreekumar,Kathleen M. Buckley,Huidong Shi,Anand Jillella,Celalettin Ustun,Rekha Rao,Pravina Fernandez,Jianguang Chen,Ramesh Balusu,Sanjay Koul,Peter Atadja,Victor E. Marquez,Kapil N. Bhalla
View Articletitled, Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells
Supplemental data
RUNX1 regulates phosphoinositide 3-kinase/AKT pathway: role in chemotherapy sensitivity in acute megakaryocytic leukemia
Holly Edwards,Chengzhi Xie,Katherine M. LaFiura,Alan A. Dombkowski,Steven A. Buck,Julie L. Boerner,Jeffrey W. Taub,Larry H. Matherly,Yubin Ge
View Articletitled, RUNX1 regulates phosphoinositide 3-kinase/AKT pathway: role in chemotherapy sensitivity in acute megakaryocytic leukemia
Supplemental data
Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome
Diane C. Cabelof,Hiral V. Patel,Qing Chen,Holly van Remmen,Larry H. Matherly,Yubin Ge,Jeffrey W. Taub
View Articletitled, Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome
Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies
Tamer E. Fandy,James G. Herman,Patrick Kerns,Anchalee Jiemjit,Elizabeth A. Sugar,Si-Ho Choi,Allen S. Yang,Timothy Aucott,Tianna Dauses,Rosalie Odchimar-Reissig,Jonathan Licht,Melanie J. McConnell,Chris Nasrallah,Marianne K. H. Kim,Weijia Zhang,Yezou Sun,Anthony Murgo,Igor Espinoza-Delgado,Katharine Oteiza,Ibitayo Owoeye,Lewis R. Silverman,Steven D. Gore,Hetty E. Carraway
View Articletitled, Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner
Leah C. Kottyan,Ann R. Collier,Khanh H. Cao,Kathryn A. Niese,Megan Hedgebeth,Caius G. Radu,Owen N. Witte,Gurjit K. Khurana Hershey,Marc E. Rothenberg,Nives Zimmermann
View Articletitled, Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner
Supplemental data
The Duffy-null state is associated with a survival advantage in leukopenic HIV-infected persons of African ancestry
Hemant Kulkarni,Vincent C. Marconi,Weijing He,Michael L. Landrum,Jason F. Okulicz,Judith Delmar,Dickran Kazandjian,John Castiblanco,Seema S. Ahuja,Edwina J. Wright,Robin A. Weiss,Robert A. Clark,Matthew J. Dolan,Sunil K. Ahuja
View Articletitled, The Duffy-null state is associated with a survival advantage in leukopenic HIV-infected persons of African ancestry
Supplemental data

PLATELETS AND THROMBOPOIESIS

Distinct spatio-temporal Ca2+ signaling elicited by integrin α2β1 and glycoprotein VI under flow
Mario Mazzucato,Maria Rita Cozzi,Monica Battiston,Martine Jandrot-Perrus,Maurizio Mongiat,Patrizia Marchese,Thomas J. Kunicki,Zaverio M. Ruggeri,Luigi De Marco
View Articletitled, Distinct spatio-temporal Ca<sup>2+</sup> signaling elicited by integrin α2β1 and glycoprotein VI under flow

THROMBOSIS AND HEMOSTASIS

Enhanced efficacy of recombinant FVIII in noncovalent complex with PEGylated liposome in hemophilia A mice
Junliang Pan,Tongyao Liu,Ji-Yun Kim,Daguang Zhu,Chandra Patel,Zhi-Hua Cui,Xin Zhang,James O. Newgren,Aaron Reames,Dodie Canivel,Gary Jesmok,Glenn F. Pierce,Jurg M. Sommer,Haiyan Jiang
View Articletitled, Enhanced efficacy of recombinant FVIII in noncovalent complex with PEGylated liposome in hemophilia A mice
Thrombin induces the expression of oncostatin M via AP-1 activation in human macrophages: a link between coagulation and inflammation
Stefan P. Kastl,Walter S. Speidl,Katharina M. Katsaros,Christoph Kaun,Gersina Rega,Afshin Assadian,Georg W. Hagmueller,Martina Hoeth,Rainer de Martin,Yongsheng Ma,Gerald Maurer,Kurt Huber,Johann Wojta
View Articletitled, Thrombin induces the expression of oncostatin M via AP-1 activation in human macrophages: a link between coagulation and inflammation
A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF
Sara Zanardelli,Alain C. K. Chion,Evelyn Groot,Peter J. Lenting,Thomas A. J. McKinnon,Mike A. Laffan,Michelle Tseng,David A. Lane
View Articletitled, A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF

TRANSPLANTATION

Selective depletion of alloreactive T cells by targeted therapy of heat shock protein 90: a novel strategy for control of graft-versus-host disease
Claudia Stuehler,Stephan Mielke,Manik Chatterjee,Johannes Duell,Sarah Lurati,Florian Rueckert,Hermann Einsele,Ralf C. Bargou,Max S. Topp
View Articletitled, Selective depletion of alloreactive T cells by targeted therapy of heat shock protein 90: a novel strategy for control of graft-versus-host disease

VASCULAR BIOLOGY

Hyperfunctional C3 convertase leads to complement deposition on endothelial cells and contributes to atypical hemolytic uremic syndrome
Lubka T. Roumenina,Mathieu Jablonski,Christophe Hue,Jacques Blouin,Jordan D. Dimitrov,Marie-Agnes Dragon-Durey,Mathieu Cayla,Wolf H. Fridman,Marie-Alice Macher,David Ribes,Luc Moulonguet,Lionel Rostaing,Simon C. Satchell,Peter W. Mathieson,Catherine Sautes-Fridman,Chantal Loirat,Catherine H. Regnier,Lise Halbwachs-Mecarelli,Veronique Fremeaux-Bacchi
View Articletitled, Hyperfunctional C3 convertase leads to complement deposition on endothelial cells and contributes to atypical hemolytic uremic syndrome
Supplemental data

CORRESPONDENCE

Role of TNFRSF13B variants in patients with common variable immunodeficiency
Natalia Martínez-Pomar,Drahomíra Detková,Juan I. Arostegui,Antonio Alvarez,Pere Soler-Palacín,Antonio Vidaller,Teresa Espanol,Almudena Sampalo,Javier de Gracia,Manuel Hernandez,Jordi Yagüe,Nuria Matamoros
View Articletitled, Role of <em>TNFRSF13B</em> variants in patients with common variable immunodeficiency
Identification of monoclonal B-cell lymphocytosis among sibling transplant donors for chronic lymphocytic leukemia patients
Ilaria Del Giudice,Francesca Romana Mauro,Maria Stefania De Propris,Irene Della Starza,Daniele Armiento,Anna Paola Iori,Giovanni Fernando Torelli,Anna Guarini,Robin Foà
View Articletitled, Identification of monoclonal B-cell lymphocytosis among sibling transplant donors for chronic lymphocytic leukemia patients
The role of CBFβ in AML1-ETO's activity
Sangho Park,Nancy A. Speck,John H. Bushweller
View Articletitled, The role of CBFβ in AML1-ETO's activity

ERRATUM

Ambrogio et al. p130Cas mediates the transforming properties of the anaplastic lymphoma kinase. Blood. 2005;106(12):3907–3916.
View Articletitled, Ambrogio et al. p130Cas mediates the transforming properties of the anaplastic lymphoma kinase. <em>Blood</em>. 2005;106(12):3907–3916.
Nolte-'t Hoen et al. Activated T cells recruit exosomes secreted by dendritic cells via LFA-1. Blood. 2009;113(9):1977–1981.
View Articletitled, Nolte-'t Hoen et al. Activated T cells recruit exosomes secreted by dendritic cells via LFA-1. <em>Blood</em>. 2009;113(9):1977–1981.
Tai et al. CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf–mediated interactions with bone marrow stromal cells. Blood. 2009;113(18):4309–4318.
View Articletitled, Tai et al. CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf–mediated interactions with bone marrow stromal cells. <em>Blood</em>. 2009;113(18):4309–4318.
  • Cover Image

    Cover Image

    issue cover

    It is unclear how neutrophils control Aspergillus species in healthy persons. Due to their large size, Aspergillus hyphae (red) cannot be phagocytosed by neutrophils (green). Bianchi et al show in this issue that recently discovered NADPH oxidase–dependent microbicidal pathways through neutrophil extracellular traps (NETs) are efficient against Aspergillus conidia and hyphae in vitro, and that restoration of NET formation by gene therapy of NADPH oxidase–deficient X-linked chronic granulomatous disease aided clearing severe invasive Aspergillus nidulans infection in vivo, underlining the role of functional NADPH oxidase in NET formation and antifungal activity. See the article by Bianchi et al on page 2619.

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