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Journal Articles

Inhibition of EZH2 Depletes MLL Fusion Leukemia Stem Cells Through Restoration of p16 Expression

Koki Ueda, Akihide Yoshimi, Masahiro Nakagawa, Satoshi Nishikawa, Victor E Marquez, Keiki Kumano, Mineo Kurokawa, M.D.

Blood (2012) 120 (21): 3510.

https://doi.org/10.1182/blood.V120.21.3510.3510

Published: 2012

Journal Articles

Silencing c-Myc Using Myc Inhibitor JQ1 and EZH2 Inhibitor DZNep Blocks Converging Survival Signals in Aggressive B-Cell Lymphomas

Xiaohong Zhao, PhD, Tint Lwin, MD, PhD, Xinwei Zhang, MD, Andy Huang, Jian Wang, Victor E. Marquez, PhD, Selina Chen-Kiang, PhD, James E Bradner, MD, William S. Dalton, PhD, MD, Eduardo M. Sotomayor, MD, Jianguo Tao, MD, PhD

Blood (2012) 120 (21): 4618.

https://doi.org/10.1182/blood.V120.21.4618.4618

Published: 2012

Journal Articles

Histone Methyltransferase Ezh2 Controls T-Cell Immunity by Regulating Bioenergetic Metabolism

Shan He, PhD, Fang Xie, MD, Qing Tong, MS, Kazuhiro Mochizuki, MD, PhD, Yongnian Liu, MS, Philip E Lapinski, PhD, Shin Mineishi, Ram Shankar Mani, MD, Victor E Marquez, Arul M. Chinnaiyan, MD, PhD, Philip D King, PhD, Yi Zhang, MD, PhD

Blood (2012) 120 (21): 953.

https://doi.org/10.1182/blood.V120.21.953.953

Published: 2012

Journal Articles

Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells

Shan He, Jina Wang, Koji Kato, Fang Xie, Sooryanarayana Varambally, Shin Mineishi, Rork Kuick, Kazuhiro Mochizuki, Yongnian Liu, Evelyn Nieves, Ram-Shankar Mani, Arul M. Chinnaiyan, Victor E. Marquez, Yi Zhang

Blood (2012) 119 (5): 1274–1282.

https://doi.org/10.1182/blood-2011-06-364422

Published: 2012

Includes: Supplemental data

Journal Articles

Inhibition of Histone Methylation Arrests Ongoing Graft-Versus-Host Diseases in Mice by Selectively Inducing Apoptosis of Alloreactive Effector T Cells

Shan He, PhD, Jina Wang, MD, Koji Kato, MD, PhD, Fang Xie, MD, Sooryanarayana Varambally, MD, Shin Mineishi, MD, Rork Kuick, MS, Kazuhiro Mochizuki, MD, Yongnian Liu, MS, Evelyn Nieves, PhD, Ram Mani, MD, Arul M. Chinnaiyan, MD, PhD, Victor E. Marquez, PhD, Yi Zhang, MD, PhD

Blood (2011) 118 (21): 820.

https://doi.org/10.1182/blood.V118.21.820.820

Published: 2011

Journal Articles

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

Damian B. Yap, Justin Chu, Tobias Berg, Matthieu Schapira, S.-W. Grace Cheng, Annie Moradian, Ryan D. Morin, Andrew J. Mungall, Barbara Meissner, Merrill Boyle, Victor E. Marquez, Marco A. Marra, Randy D. Gascoyne, R. Keith Humphries, Cheryl H. Arrowsmith, Gregg B. Morin, Samuel A. J. R. Aparicio

Blood (2011) 117 (8): 2451–2459.

https://doi.org/10.1182/blood-2010-11-321208

Published: 2011

Includes: Supplemental data

Journal Articles

Methylation of Specific Microrna Genes In MLL -Rearranged Infant Acute Lymphoblastic Leukemia: - Major Matters at a Micro Scale -

Dominique JPM Stumpel, Diana Schotte, Ellen AM Lange-Turenhout, Pauline Schneider, Lidija Seslija, Renee X de Menezes, Victor E Marquez, Rob Pieters, MD, PhD, Monique L. Den Boer, Ronald Stam, PhD

Blood (2010) 116 (21): 2483.

https://doi.org/10.1182/blood.V116.21.2483.2483

Published: 2010

Journal Articles

Alloreactive CD8 + Effector T Cells Proliferate and Persist Upon Chronic Exposure to Alloantigens through Reactivation of Stem Cell Transcriptional Programs.

Koji Kato, MD, Shuaiying Cui, Rork Kuick, Shin Mineishi, MD, Elizabeth Hexner, MD, James LM Ferrara, MD, DSc, Victor E Marquez, PhD, Stephen G. Emerson, MD, PhD, Yi Zhang, MD, PhD

Blood (2009) 114 (22): 2444.

https://doi.org/10.1182/blood.V114.22.2444.2444

Published: 2009

Journal Articles

Modulation of Histone H3K4 and H3K27 Methylation Levels Via Pharmacological Inhibition of LSD1 and Degradation of the EZH2-Containing Polycomb Repressive Complex 2 Stimulates ATRA-Mediated Differentiation of AML Cells.

Kevin R. Petrie, PhD, Tino Schenk, PhD, Manuel Boix Chornet, PhD, Louise Howell, John E Dick, PhD, Victor E Marquez, PhD, Laurence J Marton, MD, Patrick M Woster, PhD, Robert A Casero, Jr., PhD, Arthur Zelent, PhD

Blood (2009) 114 (22): 1046.

https://doi.org/10.1182/blood.V114.22.1046.1046

Published: 2009

Journal Articles

Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells

Warren Fiskus, Yongchao Wang, Arun Sreekumar, Kathleen M. Buckley, Huidong Shi, Anand Jillella, Celalettin Ustun, Rekha Rao, Pravina Fernandez, Jianguang Chen, Ramesh Balusu, Sanjay Koul, Peter Atadja, Victor E. Marquez, Kapil N. Bhalla

Blood (2009) 114 (13): 2733–2743.

https://doi.org/10.1182/blood-2009-03-213496

Published: 2009

Includes: Supplemental data

NARROW

Inhibition of EZH2 Depletes MLL Fusion Leukemia Stem Cells Through Restoration of p16 Expression

Silencing c-Myc Using Myc Inhibitor JQ1 and EZH2 Inhibitor DZNep Blocks Converging Survival Signals in Aggressive B-Cell Lymphomas

Histone Methyltransferase Ezh2 Controls T-Cell Immunity by Regulating Bioenergetic Metabolism

Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells

Inhibition of Histone Methylation Arrests Ongoing Graft-Versus-Host Diseases in Mice by Selectively Inducing Apoptosis of Alloreactive Effector T Cells

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

Methylation of Specific Microrna Genes In MLL -Rearranged Infant Acute Lymphoblastic Leukemia: - Major Matters at a Micro Scale -

Alloreactive CD8 + Effector T Cells Proliferate and Persist Upon Chronic Exposure to Alloantigens through Reactivation of Stem Cell Transcriptional Programs.

Modulation of Histone H3K4 and H3K27 Methylation Levels Via Pharmacological Inhibition of LSD1 and Degradation of the EZH2-Containing Polycomb Repressive Complex 2 Stimulates ATRA-Mediated Differentiation of AML Cells.

Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells

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American Society of Hematology

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ASH Publications

American Society of Hematology

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