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Journal Articles

Pharmacokinetics and Pharmacodynamics of Novel Long-Acting Pegylated Recombinant Asparaginase Comparing with Pegaspargase: A Dose-Escalation, Phase Ia Trial in Chinese Healthy Subjects

Kai Fan, Qing Chen, Yunfeng He, Guanghui Tang, Liexing Xu, Jing Sun

Blood (2024) 144 (Supplement 1): 5905.

https://doi.org/10.1182/blood-2024-201156

Published: 2024

Journal Articles

Efficacy and Safety of Pegylated Peptide Agonist of Thrombopoietin Receptor (PN20) in Secondary Prevention of Chemotherapy-Induced Thrombocytopenias: A Multicenter, Single Arm, Phase Ib Trial

Kai Fan, Qing Chen, Shehui Hu, Xin Zeng, Xiaolan Qin, Jing Sun

Blood (2024) 144 (Supplement 1): 1190.

https://doi.org/10.1182/blood-2024-202698

Published: 2024

Journal Articles

Extended Follow up and Immune Alterations in Patients with Classic Hodgkin Lymphoma (cHL) Treated with Frontline Single Agent Pembrolizumab Followed By AVD Chemotherapy

Pamela B. Allen, Latifa Bazzi, Bin Zhang, Qing Chen, Liron Barnea Slonim, Hatice Savas, Ranjana H. Advani, Andrew M Evens, Barbara Pro, Reem Karmali, Eric Mou, Robert Eisner, Robert Bayer, Leo I. Gordon, Jane N. Winter

Blood (2024) 144 (Supplement 1): 1664.

https://doi.org/10.1182/blood-2024-208680

Published: 2024

Journal Articles

Inhibiting CARD11 translation during BCR activation by targeting the eIF4A RNA helicase

Blood (2014) 124 (25): 3758–3767.

https://doi.org/10.1182/blood-2014-07-589689

Published: 2014

Includes: Supplemental data

Journal Articles

Investigation Of p210 Bcr-Abl Rhogef Activity In The Progression Of Chronic Myelogenous Leukemia

Bryan T Ciccarelli, MA, Ilona Tala, PhD, Tinghui Hu, PhD, Dan Li, BS, Ru Chen, PhD, Qing Chen, PhD, Ian P Whitehead, PhD

Blood (2013) 122 (21): 3802.

https://doi.org/10.1182/blood.V122.21.3802.3802

Published: 2013

Journal Articles

Lack of Response of Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML) to Decitabine After Failure of Azacitidine

Bhavana Bhatnagar, DO, Dan P. Zandberg, M.D., Emily J. Vannorsdall, M.D., Alison P. Duffy, Pharm.D., Michael L. Tidwell, C.R.N.P., Yi Ning, Qing Chen, M.D., Maria R. Baer, M.D.

Blood (2012) 120 (21): 3858.

https://doi.org/10.1182/blood.V120.21.3858.3858

Published: 2012

Journal Articles

A p210 BCR/ABL Mutant That Lacks Guanine Nucleotide Exchange Factor Activity Induces Erythroleukemia in a Murine Bone Marrow Transplantation Model,

Ilona Tala, Ru Chen, PhD, Qing Chen, PhD, Ian Whitehead, PhD

Blood (2011) 118 (21): 3756.

https://doi.org/10.1182/blood.V118.21.3756.3756

Published: 2011

Journal Articles

Altered Folate Metabolism Maybeo the Develop Linked tment of Acute Lymphoblastic Leukemia in African American Children.

Qing Chen, MD, Nancy Fassinger, RD, PhD, Ronald Thomas, PhD, Ana C. Xavier, MD, Yubin Ge, PhD, Larry H. Matherly, PhD, Jeffrey W. Taub, MD

Blood (2009) 114 (22): 4118.

https://doi.org/10.1182/blood.V114.22.4118.4118

Published: 2009

Journal Articles

Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome

Diane C. Cabelof, Hiral V. Patel, Qing Chen, Holly van Remmen, Larry H. Matherly, Yubin Ge, Jeffrey W. Taub

Blood (2009) 114 (13): 2753–2763.

https://doi.org/10.1182/blood-2008-11-190330

Published: 2009

Journal Articles

Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors

Deborah J. Kuhn, Sally A. Hunsucker, Qing Chen, Peter M. Voorhees, Marian Orlowski, Robert Z. Orlowski

Blood (2009) 113 (19): 4667–4676.

https://doi.org/10.1182/blood-2008-07-171637

Published: 2009

Includes: Supplemental data

Journal Articles

Analysis of Clonal T-Cell Receptor Gamma Gene Rearrangements, NOTCH1, FBW7 and PTEN Mutations in Paired Pediatric T-Cell Acute Lymphoblastic Leukemia Samples at Diagnosis and Relapse Reveals Evidence of Relapse in New Leukemic Clones.

Qing Chen, MD, Amanda Larson Gedman, Larry H. Matherly, PhD, Jeffrey W. Taub, MD

Blood (2008) 112 (11): 1488.

https://doi.org/10.1182/blood.V112.11.1488.1488

Published: 2008

Journal Articles

Targeting the p27 E3 ligase SCF Skp2 results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy

Qing Chen, Weilin Xie, Deborah J. Kuhn, Peter M. Voorhees, Antonia Lopez-Girona, Derek Mendy, Laura G. Corral, Veronique Plantevin Krenitsky, Weiming Xu, Laure Moutouh-de Parseval, David R. Webb, Frank Mercurio, Keiichi I. Nakayama, Keiko Nakayama, Robert Z. Orlowski

Blood (2008) 111 (9): 4690–4699.

https://doi.org/10.1182/blood-2007-09-112904

Published: 2008

Includes: Supplemental data

Journal Articles

Ciprofloxacin Inhibits Bortezomib-Mediated Apoptosis in Multiple Myeloma Models in Association with Induction of Heme Oxygenase-1.

Qing Chen, PhD, Dixie-Lee Esseltine, MD, Rachel B. Neuwirth, PhD, Paul G. Richardson, MD, Robert Z. Orlowski, MD, PhD

Blood (2007) 110 (11): 2365.

https://doi.org/10.1182/blood.V110.11.2365.2365

Published: 2007

Journal Articles

Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma

Deborah J. Kuhn, Qing Chen, Peter M. Voorhees, John S. Strader, Kevin D. Shenk, Congcong M. Sun, Susan D. Demo, Mark K. Bennett, Fijs W. B. van Leeuwen, Asher A. Chanan-Khan, Robert Z. Orlowski

Blood (2007) 110 (9): 3281–3290.

https://doi.org/10.1182/blood-2007-01-065888

Published: 2007

Includes: Supplemental data

Journal Articles

Vaccination of Leukemia Patients with Autologous In Vitro Cultured Leukemia Dendritic Cells.

Lu Yue, MD, Qi-Rong Geng, MD, Jian-Chuan Xia, MD, Hui-jie Fan, MD, Hai- Xu, MD, PengXiao-qing Chen, MD

Blood (2006) 108 (11): 5190.

https://doi.org/10.1182/blood.V108.11.5190.5190

Published: 2006

Journal Articles

Targeting the p27 Kip1 E3 Ubiquitin Ligase for the Treatment of Multiple Myeloma and Other Hematological Malignancies.

Qing Chen, PhD, Weilin Xie, PhD, Deborah J. Kuhn, PhD, Peter M. Voorhees, MD, Derek Mendy, MD, Antonia Lopez-Girona, PhD, Veronique Plantevin, PhD, Weiming Xu, PhD, Laura De Parseval, PhD, Laura G. Corral, PhD, Emilia Glezer, PhD, Kyle Chan, PhD, Frank Mercurio, PhD, Robert Z. Orlowski, MD, PhD

Blood (2006) 108 (11): 372.

https://doi.org/10.1182/blood.V108.11.372.372

Published: 2006

Journal Articles

Enhancing Activity of Bortezomib Against Multiple Myeloma (MM) through Inhibition of Interleukin (IL)-6 Signaling: A Role for Repression of Myeloid Cell Leukemia (Mcl)-1.

Peter M. Voorhees, George W. Small, Deborah J. Kuhn, Qing Chen, Sally A. Hunsucker, Robert Corringham, Carlos A. Garay, Mohamed H. Zaki, Jeffrey Nemeth, Robert Z. Orlowski

Blood (2006) 108 (11): 3414.

https://doi.org/10.1182/blood.V108.11.3414.3414

Published: 2006

Journal Articles

Development of Immunoproteasome-Specific Inhibitors as Novel Anti-Cancer Drugs.

Deborah J. Kuhn, PhD, Peter M. Voorhees, MD, Qing Chen, PhD, John S. Strader, Frank Bruzzese, PhD, Jeffrey P. Ciavarri, PhD, Zhigen Hu, PhD, Robert Z. Orlowski, MD, PhD

Blood (2006) 108 (11): 3458.

https://doi.org/10.1182/blood.V108.11.3458.3458

Published: 2006

Journal Articles

The Novel, Irreversible Proteasome Inhibitor PR-171 Demonstrates Potent Anti-Tumor Activity in Pre-Clinical Models of Multiple Myeloma, and Overcomes Bortezomib Resistance.

Deborah J. Kuhn, PhD, Qing Chen, PhD, Peter M. Voorhees, MD, John S. Strader, Kevin D. Shenk, PhD, Congcong M. Sun, PhD, Susan D. Demo, PhD, Mark K. Bennett, PhD, Fred W. van Leeuwen, PhD, Robert Z. Orlowski, MD, PhD

Blood (2006) 108 (11): 3461.

https://doi.org/10.1182/blood.V108.11.3461.3461

Published: 2006

Journal Articles

Inhibition of Kinesin Spindle Protein Induces Apoptosis and Overcomes Drug Resistance in Models of Multiple Myeloma.

Qing Chen, PhD, Vishwan Pamarthi, Deborah J. Kuhn, PhD, Peter M. Voorhees, MD, John S. Strader, Robert Z. Orlowski, MD, PhD

Blood (2006) 108 (11): 3425.

https://doi.org/10.1182/blood.V108.11.3425.3425

Published: 2006

NARROW

Pharmacokinetics and Pharmacodynamics of Novel Long-Acting Pegylated Recombinant Asparaginase Comparing with Pegaspargase: A Dose-Escalation, Phase Ia Trial in Chinese Healthy Subjects

Efficacy and Safety of Pegylated Peptide Agonist of Thrombopoietin Receptor (PN20) in Secondary Prevention of Chemotherapy-Induced Thrombocytopenias: A Multicenter, Single Arm, Phase Ib Trial

Extended Follow up and Immune Alterations in Patients with Classic Hodgkin Lymphoma (cHL) Treated with Frontline Single Agent Pembrolizumab Followed By AVD Chemotherapy

Inhibiting CARD11 translation during BCR activation by targeting the eIF4A RNA helicase

Investigation Of p210 Bcr-Abl Rhogef Activity In The Progression Of Chronic Myelogenous Leukemia

Lack of Response of Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML) to Decitabine After Failure of Azacitidine

A p210 BCR/ABL Mutant That Lacks Guanine Nucleotide Exchange Factor Activity Induces Erythroleukemia in a Murine Bone Marrow Transplantation Model,

Altered Folate Metabolism Maybeo the Develop Linked tment of Acute Lymphoblastic Leukemia in African American Children.

Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome

Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors

Analysis of Clonal T-Cell Receptor Gamma Gene Rearrangements, NOTCH1, FBW7 and PTEN Mutations in Paired Pediatric T-Cell Acute Lymphoblastic Leukemia Samples at Diagnosis and Relapse Reveals Evidence of Relapse in New Leukemic Clones.

Targeting the p27 E3 ligase SCF Skp2 results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy

Ciprofloxacin Inhibits Bortezomib-Mediated Apoptosis in Multiple Myeloma Models in Association with Induction of Heme Oxygenase-1.

Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma

Vaccination of Leukemia Patients with Autologous In Vitro Cultured Leukemia Dendritic Cells.

Targeting the p27 Kip1 E3 Ubiquitin Ligase for the Treatment of Multiple Myeloma and Other Hematological Malignancies.

Enhancing Activity of Bortezomib Against Multiple Myeloma (MM) through Inhibition of Interleukin (IL)-6 Signaling: A Role for Repression of Myeloid Cell Leukemia (Mcl)-1.

Development of Immunoproteasome-Specific Inhibitors as Novel Anti-Cancer Drugs.

The Novel, Irreversible Proteasome Inhibitor PR-171 Demonstrates Potent Anti-Tumor Activity in Pre-Clinical Models of Multiple Myeloma, and Overcomes Bortezomib Resistance.

Inhibition of Kinesin Spindle Protein Induces Apoptosis and Overcomes Drug Resistance in Models of Multiple Myeloma.

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American Society of Hematology

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American Society of Hematology

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