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Melanie J. McConnell
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Journal Articles

Comprehensive genomic screens identify a role for PLZF-RARα as a positive regulator of cell proliferation via direct regulation of c-MYC

Kim L. Rice, Itsaso Hormaeche, Sergei Doulatov, Jared M. Flatow, David Grimwade, Ken I. Mills, Magdalena Leiva, Julien Ablain, Charuta Ambardekar, Melanie J. McConnell, John E. Dick, Jonathan D. Licht
Journal: Blood
Blood (2009) 114 (27): 5499–5511.
https://doi.org/10.1182/blood-2009-03-206524
Published: 2009
Includes: Supplemental data
Journal Articles

Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies

Tamer E. Fandy, James G. Herman, Patrick Kerns, Anchalee Jiemjit, Elizabeth A. Sugar, Si-Ho Choi, Allen S. Yang, Timothy Aucott, Tianna Dauses, Rosalie Odchimar-Reissig, Jonathan Licht, Melanie J. McConnell, Chris Nasrallah, Marianne K. H. Kim, Weijia Zhang, Yezou Sun, Anthony Murgo, Igor Espinoza-Delgado, Katharine Oteiza, Ibitayo Owoeye, Lewis R. Silverman, Steven D. Gore, Hetty E. Carraway
Journal: Blood
Blood (2009) 114 (13): 2764–2773.
https://doi.org/10.1182/blood-2009-02-203547
Published: 2009
Includes: Supplemental data
Journal Articles

Comprehensive Genomic Screens Reveal Multiple Modes of Action of the PLZF-RAR-α Oncoprotein

Kim L. Rice, Ph.D., Itsaso Hormaeche, Ph.D., Melanie J. McConnell, Ph.D., Sergei Doulatov, B.S., Jared Flatow, M.S., David Grimwade, Ken I Mills, Ph.D., FRCPath, John E. Dick, PhD, Jonathan D. Licht, MD
Journal: Blood
Blood (2008) 112 (11): 686.
https://doi.org/10.1182/blood.V112.11.686.686
Published: 2008
Journal Articles

PLZF-RARα Utilizes the Histone Methyl Transferase G9a/GLP and the Histone Demethylase LSD1 to Repress RARα Target Genes and Block Myeloid Differentiation

Itsaso Hormaeche, PhD, Kim L. Rice, Ph.D., Arthur Zelent, PhD, Melanie J. McConnell, Ph.D., Jonathan D. Licht, MD
Journal: Blood
Blood (2008) 112 (11): 198.
https://doi.org/10.1182/blood.V112.11.198.198
Published: 2008
Journal Articles

Myelodysplastic Syndrome (MDS) Displays Profound and Functionally Significant Epigenetic Deregulation Compared to Acute Myeloid Leukemia (AML) and Normal Bone Marrow Cells.

Maria E. Figueroa, MD, Tamer Fandy, MSC PhD, Melanie J. McConnell, PhD, Windy Berkofsky-Fessler, PhD, Chris Nasrallah, MS, Hetty Carraway, MD, Jonathan Licht, MD, Steven D. Gore, MD, Ari M. Melnick, MD
Journal: Blood
Blood (2007) 110 (11): 345.
https://doi.org/10.1182/blood.V110.11.345.345
Published: 2007
Journal Articles

The Transcriptional Profile of PV Displays Limited Similarity to EPO Stimulated Progenitor Cells: Evidence That JAK2 V617F Confers a Novel Program to Malignant Hematopoietic Stem Cells.

Windy Berkofsky-Fessler, MPhil, Melanie J. McConnell, PhD, Kai Huang, Monica L. Bailey, Dwayne L. Barber, PhD, Ross L. Levine, MD, Donna S. Neuberg, DSc, D. Gary Gilliland, MD, PhD, Jonathan D. Licht, MD
Journal: Blood
Blood (2005) 106 (11): 120.
https://doi.org/10.1182/blood.V106.11.120.120
Published: 2005
Journal Articles

The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT

Shinichiro Takahashi, Melanie J. McConnell, Hideo Harigae, Mitsuo Kaku, Takeshi Sasaki, Ari M. Melnick, Jonathan D. Licht
Journal: Blood
Blood (2004) 103 (12): 4650–4658.
https://doi.org/10.1182/blood-2003-08-2759
Published: 2004
Journal Articles

The acute promyelocytic leukemia–associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D 3 –induced monocytic differentiation of U937 cells through a physical interaction with vitamin D 3 receptor

Jeremy O. Ward, Melanie J. McConnell, Graeme W. Carlile, Pier Paolo Pandolfi, Jonathan D. Licht, Leonard P. Freedman
Journal: Blood
Blood (2001) 98 (12): 3290–3300.
https://doi.org/10.1182/blood.V98.12.3290
Published: 2001
Journal Articles

AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein

Ari Melnick, Graeme W. Carlile, Melanie J. McConnell, Adam Polinger, Scott W. Hiebert, Jonathan D. Licht
Journal: Blood
Blood (2000) 96 (12): 3939–3947.
https://doi.org/10.1182/blood.V96.12.3939
Published: 2000