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David O’Connor
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Journal Articles

Focal deletions of a promoter tether activate the IRX3 oncogene in T-cell acute lymphoblastic leukemia

Sunniyat Rahman, Gianna Bloye, Nadine Farah, Jonas Demeulemeester, Joana R. Costa, David O’Connor, Rachael Pocock, Tanya Rapoz-D’Silva, Adam Turna, Lingyi Wang, SooWah Lee, Adele K. Fielding, Juliette Roels, Roman Jaksik, Małgorzata Dawidowska, Pieter Van Vlierberghe, Suzana Hadjur, Jim R. Hughes, James O. J. Davies, Alejandro Gutierrez, Michelle A. Kelliher, Peter Van Loo, Mark A. Dawson, Marc R. Mansour
Journal: Blood
Blood (2024) 144 (22): 2319–2326.
https://doi.org/10.1182/blood.2024024300
Published: 2024
Includes: Supplemental data
Journal Articles

A Non-Canonical Lymphoblast in Refractory Childhood T-Cell Acute Lymphoblastic Leukemia

Bram S.J. Lim, Holly J. Whitfield, Mi K. Trinh, Gianna Bloye, Rebecca Thomas, Nathaniel D. Anderson, Anna Wenger, Angus Hodder, Taryn D. Treger, Henry Lee-Six, Tim H.H. Coorens, Conor Parks, Toochi Ogbonnah, Petri Pölönen, Charles G. Mullighan, David T. Teachey, Melanie M Hagleitner, Lennart A. Kester, Frank N. van Leeuwen, Gordon Beattie, Marc R. Mansour, Owen Williams, Jack Bartram, Stuart Adams, Laura Jardine, Sam Behjati, David O'Connor
Journal: Blood
Blood (2024) 144 (Supplement 1): 2830.
https://doi.org/10.1182/blood-2024-198354
Published: 2024
Journal Articles

Noncoding mutations drive persistence of a founder preleukemic clone which initiates late relapse in T-ALL

David O’Connor, Jose Espejo Valle-Inclán, Lucia Conde, Gianna Bloye, Sunniyat Rahman, Joana R. Costa, Jack Bartram, Stuart Adams, Gary Wright, Hillary Elrick, Kerry Wall, Sara Dyer, Christopher Howell, Galina Jigoulina, Javier Herrero, Isidro Cortes-Ciriano, Anthony V. Moorman, Marc R. Mansour
Journal: Blood
Blood (2024) 143 (10): 933–937.
https://doi.org/10.1182/blood.2023021906
Published: 2024
Includes: Supplemental data
Journal Articles

Drug Response Profiling Informs Personalized Bridging to Cell Therapy for Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia

Fabio D. Steffen, Andrej Lissat, Julia Alten, Cornelia Eckert, Nicole Bodmer, Bodil E. Thorhauge Als-Nielsen, Adriana Balduzzi, Barbara Buldini, Sarah Elitzur, Andras Kriston, Gergely Nyiri, Imre Västrik, Ferenc Kovacs, Francesco Ceppi, Lucie Sramkova, Larissa Schori, Arianna Arpagaus, Silvia Gutnik, Andishe Attarbaschi, Birgitte Klug Albertsen, Jeanette Greiner, Marc Ansari, Judith M. Boer, Elad Jacoby, Martin Stanulla, Uri Ilan, Peter M. Hoogerbrugge, Tim Lammens, Barbara De Moerloose, Petter Svenberg, Nicolas von der Weid, David O'Connor, Hélène Cavé, Franco Locatelli, Martin Schrappe, André Baruchel, Andreas Kulozik, Kjeld Schmiegelow, Gunnar Cario, Arend von Stackelberg, Peter Horvath, Beat Bornhauser, Jean-Pierre Bourquin
Journal: Blood
Blood (2023) 142 (Supplement 1): 4350.
https://doi.org/10.1182/blood-2023-179306
Published: 2023
Journal Articles

Routine Whole Genome Sequencing for All Children with Hematological Malignancies Defines a New Standard of Care - Data of the First 152 Cases from the NHS England Genomic Medicine Service

Angus Hodder, Sarah Leiter, Aditi Vedi, Phillipa May, Dilys Addy, Phil Ancliff, Julian Cano-Flanagan, Jane Chalker, Danny Cheng, Yasmin Clinch, Caryl Dryden, Sara Ghorashian, David O'Connor, Vesna Pavasovic, Anupama Rao, Sujith Samarasinghe, Iryna Stasevich, Ajay Vora, Michael Hubank, Dame Lyn Chitty, Sam Behjati, Jack Bartram
Journal: Blood
Blood (2023) 142 (Supplement 1): 3656.
https://doi.org/10.1182/blood-2023-186025
Published: 2023
Journal Articles

Pharmacological Modulation of CD21 Antigen Density Enhances Chimeric Antigen Receptor (CAR-T) Cell Function

Nicola C Maciocia, Amy Burley, Malika Hoekx, Thaneswari Karpanasamy, Lydia Lee, David O'Connor, Marc R. Mansour, Asim Khwaja, Paul M Maciocia, Martin Pule
Journal: Blood
Blood (2022) 140 (Supplement 1): 4529–4530.
https://doi.org/10.1182/blood-2022-158973
Published: 2022
Journal Articles

Blinatumomab As Toxicity Sparing First Line Treatment of Children and Young Persons with B-Precursor Acute Lymphoblastic Leukaemia (B-ALL)

Angus Hodder, Avijeet K Mishra, Susan Baird, Ismail Bisho, Denise Bonney, Katherine Clesham, Michelle Cummins, Emmy Dickens, Brenda Gibson, Lindsay George, Danielle Ingham, Galina Jigoulina, Donna Lancaster, Katherine Lindsay, Majid Madni, Andrea Malone, Bethany Mitchell, John Moppett, Jayashree Motwani, Anthony V. Moorman, Katharine Patrick, Lamia Samrin, Sanjay Tewari, Indu Rakesh Thakur, David O'Connor, Ajay Vora, Sujith Samarasinghe
Journal: Blood
Blood (2022) 140 (Supplement 1): 8987–8988.
https://doi.org/10.1182/blood-2022-162475
Published: 2022
Journal Articles

The Clinico-Genomic Landscape of Induction Failure in Childhood and Young Adult T-Cell Acute Lymphoblastic Leukemia (T-ALL)

David O'Connor, Jonas Demeulemeester, Lucia Conde, Amy A. Kirkwood, Kent Fung, Foteini Papaleonidopoulou, Gianna Bloye, Nadine Farah, Sunniyat Rahman, Jeremy Hancock, Caroline Bateman, Sarah Inglott, Jon Mee, Javier Herrero, Peter Van Loo, Anthony V. Moorman, Ajay Vora, Marc R. Mansour
Journal: Blood
Blood (2022) 140 (Supplement 1): 1720–1721.
https://doi.org/10.1182/blood-2022-165308
Published: 2022
Journal Articles

The Hematopoietic Transcription Factor GATA3 Is the Main Activator of Enhancer-Mediated Activation of Oncogenic TAL1 in T-ALL

Joana R Costa, David O'Connor, Nurkaiyisah Anuar, Sunniyat Rahman, Nivedita Singh, Zhaodong China, Tanya Rapoz-D'Silva, Yang Li, Kent Fung, Sara Hyseni, Stephen Henderson, George Morrow, Yanping Guo, Javier Herrero, Richard Jenner, Dennis Keppei, A. Thomas Look, Marc R. Mansour
Journal: Blood
Blood (2022) 140 (Supplement 1): 3046–3047.
https://doi.org/10.1182/blood-2022-166396
Published: 2022
Journal Articles

IRX3 Oncogene Activation in T-ALL through Enhancer Hijacking Caused By fto Intron 8 Deletions

Sunniyat Rahman, Nadine Farah, Jonas Demeulemeester, Joana R Costa, Gianna Bloye, David O'Connor, Rachael Pocock, Adam Turna, SooWah Lee, Adele K. Fielding, Juliette Roels, Małgorzata Dawidowska, Pieter Van Vlierberghe, Suzana Hadjur, Alejandro Gutierrez, Michelle A Kelliher, Simone Riva, Jim R. Hughes, James O.J. Davies, Peter Van Loo, Mark A. Dawson, Marc R. Mansour
Journal: Blood
Blood (2022) 140 (Supplement 1): 1009–1010.
https://doi.org/10.1182/blood-2022-162930
Published: 2022
Journal Articles

Tvt CAR7: Phase 1 Clinical Trial of Base-Edited "Universal” CAR7 T Cells for Paediatric Relapsed/Refractory T-ALL

Robert Chiesa, Christos Georgiadis, Giorgio Ottaviano, Farhatullah Syed, Toni Braybrook, Annie Etuk, Hong Zhan, Soragia Athina Gkazi, Roland Preece, Stuart Adams, Rebecca Thomas, Arnold Awuah, Kimberly Gilmour, Lana Mhaldien, Jan Chu, Danielle Pinner, Agnieszka Kubat, Paul Veys, Kanchan Rao, Giovanna Lucchini, David O'Connor, Ajay Vora, Waseem Qasim
Journal: Blood
Blood (2022) 140 (Supplement 1): 4579–4580.
https://doi.org/10.1182/blood-2022-169114
Published: 2022
Journal Articles

Reduced Intensity Reinduction Followed By Blinatumomab Achieves Excellent MRD Clearance with Reduced Toxicity and Facilitates Timely Transplant in Children and Young People with Relapsed B-Precursor Acute Lymphoblastic Leukemia

Angus Hodder, Avijeet K Mishra, Katherine Clesham, Susan Baird, Kaljit Bhuller, Ismail Bisho, Denise Bonney, Anna Castleton, Michelle Cummins, Emmy Dickens, Lindsay George, Sara Ghorashian, Brenda Gibson, Chris Hasley, Nicholas Heaney, Rachael E Hough, Danielle Ingham, Galina Jigoulina, Katherine Lindsay, Donna Lancaster, Majid Madni, Andrea Malone, Bethany Mitchell, Anthony V. Moorman, John Moppett, Vanessa McLelland, Jayashree Motwani, Emma Nicholson, Caroline Osborne, Katharine Patrick, Lamia Samrin, Sanjay Tewari, Indu Rakesh Thakur, Sujith Samarasinghe, Ajay Vora, David O'Connor
Journal: Blood
Blood (2022) 140 (Supplement 1): 3268–3270.
https://doi.org/10.1182/blood-2022-162565
Published: 2022
Journal Articles

Anti-CCR9 chimeric antigen receptor T cells for T-cell acute lymphoblastic leukemia

Paul M. Maciocia, Patrycja A. Wawrzyniecka, Nicola C. Maciocia, Amy Burley, Thaneswari Karpanasamy, Sam Devereaux, Malika Hoekx, David O’Connor, Theresa Leon, Tanya Rapoz-D’Silva, Rachael Pocock, Sunniyat Rahman, Giuseppe Gritti, Diana C. Yánez, Susan Ross, Tessa Crompton, Owen Williams, Lydia Lee, Martin A. Pule, Marc R. Mansour
Journal: Blood
Blood (2022) 140 (1): 25–37.
https://doi.org/10.1182/blood.2021013648
Published: 2022
Includes: Supplemental data
Journal Articles

Anti-CCR9 CAR-T Cells for T Acute Lymphoblastic Leukemia

Paul M Maciocia, Patrycja Wawrzyniecka, Nicola C Maciocia, Amy Burley, David O'Connor, Theresa E. Leon, Tanya Rapoz-D'Silva, Thaneswari Karpanasamy, Martin Pule, Marc R. Mansour
Journal: Blood
Blood (2021) 138 (Supplement 1): 903.
https://doi.org/10.1182/blood-2021-146565
Published: 2021
Journal Articles

Blinatumomab for infant acute lymphoblastic leukemia

Clinical Trials & Observations
Katherine Clesham, Vasudha Rao, Jack Bartram, Philip Ancliff, Sara Ghorashian, David O’Connor, Vesna Pavasovic, Anupama Rao, Sujith Samarasinghe, Michelle Cummins, Andrea Malone, Katharine Patrick, Denise Bonney, Beki James, Brenda Gibson, Ajay Vora
Journal: Blood
Blood (2020) 135 (17): 1501–1504.
https://doi.org/10.1182/blood.2019004008
Published: 2020
Journal Articles

A validated novel continuous prognostic index to deliver stratified medicine in pediatric acute lymphoblastic leukemia

Clinical Trials & Observations
Amir Enshaei, David O’Connor, Jack Bartram, Jeremy Hancock, Christine J. Harrison, Rachael Hough, Sujith Samarasinghe, Monique L. den Boer, Judith M. Boer, Hester A. de Groot-Kruseman, Hanne V. Marquart, Ulrika Noren-Nystrom, Kjeld Schmiegelow, Claire Schwab, Martin A. Horstmann, Gabriele Escherich, Mats Heyman, Rob Pieters, Ajay Vora, John Moppett, Anthony V. Moorman
Journal: Blood
Blood (2020) 135 (17): 1438–1446.
https://doi.org/10.1182/blood.2019003191
Published: 2020
Includes: Supplemental data
Journal Articles

How I treat newly diagnosed T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma in children

Clinical Trials & Observations
David T. Teachey, David O’Connor
Journal: Blood
Blood (2020) 135 (3): 159–166.
https://doi.org/10.1182/blood.2019001557
Published: 2020
Journal Articles

Trisomy 21 Driven Pro-Inflammatory Signalling in Fetal Bone Marrow May Play a Role in Perturbed B-Lymphopoiesis and Acute Lymphoblastic Leukemia of Down Syndrome

Sorcha Isabella O'Byrne, BSc, Natalina Elliott, PhD, Gemma Buck, BSc, Siobhan Rice, David O'Connor, Jana Oswald, Hannah Fuchs, Ella-Mae Labbett, Nicholas James Fordham, MBBS, BSc, Anindita Roy, MD PhD, Irene Roberts
Journal: Blood
Blood (2019) 134 (Supplement_1): 1206.
https://doi.org/10.1182/blood-2019-130180
Published: 2019
Journal Articles

Excellent Response to Blinatumomab in Children and Young Adults with Refractory B Lineage Acute Lymphoblastic Leukaemia for Persistent MRD or after Debulking Chemotherapy for Higher Disease Burden

Vasudha Rao, MD, Katherine Clesham, Jack Luke Bartram, MD, Phil Ancliff, Sara Ghorashian, FRCPath, PhD, David O'Connor, Vesna Pavasovic, Anupama Rao, MD, Sujith Samarasinghe, Carole Cairns, David Marks, David Taussig, PhD MRCP, FRCPath, Ajay Vora, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5201.
https://doi.org/10.1182/blood-2018-99-117051
Published: 2018
Journal Articles

Refining genetic stratification in T-ALL

Clinical Trials & Observations
David O’Connor
Journal: Blood
Blood (2018) 131 (3): 271–272.
https://doi.org/10.1182/blood-2017-10-812933
Published: 2018