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Journal Articles

NG2 is a target gene of MLL-AF4 and underlies glucocorticoid resistance in MLLr B-ALL by regulating NR3C1 expression

Blood (2024) 144 (19): 2002–2017.

https://doi.org/10.1182/blood.2023022050

Published: 2024

Includes: Supplemental data

Journal Articles

KMT2A -Rearranged ALL Requires DYRK1A for Regulation of ERK Signaling and Cell Proliferation

Venkata Sesha Sai Abhinav Ayyadevara, Gerald Wertheim, John Chukinas, Joseph Loftus, Sung June Lee, Anil Kumar, Srividya Swaminathan, Rahul S Bhansali, Wayne Childers, Huimin Geng, Thomas A Milne, Xianxin Hua, Kathrin M. Bernt, Thierry Besson, Junwei Shi, John D. Crispino, Martin P Carroll, Sarah K. Tasian, Christian Hurtz

Blood (2024) 144 (Supplement 1): 1455.

https://doi.org/10.1182/blood-2024-206134

Published: 2024

Journal Articles

Differential Gene Expression in KMT2A::AFF1 Leukemia Is Driven By Enhancer Heterogeneity

Alastair L Smith, Nicholas Denny, Catherine M Chahrour, Natalina Elliott, Thomas Jackson, Joe Harman, Huimin Geng, Irene Roberts, Nicholas Crump, James Oliver Davies, Anindita Roy, Thomas A Milne

Blood (2024) 144 (Supplement 1): 201.

https://doi.org/10.1182/blood-2024-208035

Published: 2024

Journal Articles

First-in-Class Targeted Protein Degrader of MLLT1/3 for the Treatment of Advanced AML and ALL Including Menin Inhibitor Resistant / Refractory Disease

John Pollard, Graham Craggs, Gillian Farnie, Matthew Fawkes, Fenella Gross, Joe Harman, Marta Llorca-Cardenosa, Sarah Major, Alison Maloney, Thomas A Milne, Iain Simpson

Blood (2024) 144 (Supplement 1): 2772.

https://doi.org/10.1182/blood-2024-210052

Published: 2024

Journal Articles

The Fetal Specific Gene LIN28B Is Essential for Human Fetal B-Lymphopoiesis and Initiation of KMT2A-AFF1+ Infant Acute Lymphoblastic Leukemia

Rebecca E Ling, Thomas Jackson, Natalina Elliott, Joe W Cross, Lucy Hamer, Arundhati S Wuppalapati, Alastair L Smith, Catherine M Chahrour, Okan Sevim, Deena Iskander, Guanlin Wang, Sorcha I O'Byrne, Siobhan Rice, Joe R Harman, Bethan Psaila, Rhys G Morgan, Irene Roberts, Thomas A Milne, Anindita Roy

Blood (2024) 144 (Supplement 1): 199.

https://doi.org/10.1182/blood-2024-198819

Published: 2024

Journal Articles

Identification of a Novel Chromatin Structure Associated with the Transcriptional Response to Menin Inhibitors in AML

Pablo R Freire, Brandon Regalado, Elizabeth Ener, Jevon Cutler, Christian Marinaccio, Vassilena Sharlandjieva, Thomas A Milne, Scott A Armstrong

Blood (2024) 144 (Supplement 1): 952.

https://doi.org/10.1182/blood-2024-211004

Published: 2024

Journal Articles

A human genome editing–based MLL :: AF4 ALL model recapitulates key cellular and molecular leukemogenic features

Blood (2023) 142 (20): 1752–1756.

https://doi.org/10.1182/blood.2023020858

Published: 2023

Includes: Supplemental data

Journal Articles

PPARG and ASS1: Targets of Metabolic Alteration in Venetoclax / Decitabine Resistant Acute Myeloid Leukemia

Kotoko Yamatani, Tatsuro Watanabe, Kaori Saito, Abhishek Maiti, Satoshi Yamashita, Abdullah Khasawneh, Faith Jessica Paran, Kala Hayes, Gautam Borthakur, Joe R Harman, Shinya Kimura, Courtney D. DiNardo, Thomas A Milne, Michael Andreeff, Yoko Tabe, Marina Y. Konopleva

Blood (2023) 142 (Supplement 1): 4162.

https://doi.org/10.1182/blood-2023-178554

Published: 2023

Journal Articles

Molecular Profiling of Response and Resistance to Venetoclax-Decitabine Therapy in Acute Myeloid Leukemia

Abdullah Khasawneh, Faith Jessica Paran, Rieko Oyama, Abhishek Maiti, Hussein A Abbas, Bofei Wang, Poonam N Desai, Kala Hayes, Joe R Harman, Xiaoping Su, Courtney D. DiNardo, Michael Andreeff, Thomas A Milne, Marina Y. Konopleva, Yoko Tabe

Blood (2023) 142 (Supplement 1): 4159.

https://doi.org/10.1182/blood-2023-180463

Published: 2023

Journal Articles

Establishment and Characterization of a Model of Acquired Resistance to DOT1L Inhibition in KMT2A -Rearranged Acute Lymphoblastic Leukemia Cells

Pauline Schneider, Susan T.C.J.M. Arentsen-Peters, Nicholas T. Crump, Alastair Smith, Rico Hagelaar, Fabienne R.S. Adriaanse, Romy S. Bos, Kirsten S. Vrenken, Dedeke rockx-Brouwer, Ziqin Tang, Wilbert P. Vermeij, Anja De Jong, Bianca Koopmans, M.Emmy M. Dolman, Thomas A. Milne, Rob Pieters, Ronald W. Stam

Blood (2022) 140 (Supplement 1): 8760–8761.

https://doi.org/10.1182/blood-2022-166310

Published: 2022

Journal Articles

Dysregulation of Stem-Progenitor and Differentiation Programmes through Modulation of Bivalent Chromatin Drives Leukemogenesis in Mutant IDH2 Acute Myeloid Leukaemia

Douglas RA RA Silveira, Prodromos Chatzikyriakou, Maria del Pilar Casares Alaez, Sarah Mackie, Roan Hulks, Olena Yavorska, Paulina Siejka-Zielinska, Marlen Metzner, Alastair Smith, Batchimeg Usukhbayar, Virginie Penard-Lacronique, Chunxiao Song, Anita K. Gandhi, Maroof Hasan, Paresh Vyas, Thomas A. Milne, Skirmantas Kriaucionis, Lynn Quek

Blood (2022) 140 (Supplement 1): 8698–8699.

https://doi.org/10.1182/blood-2022-165898

Published: 2022

Journal Articles

Repressed Chromatin Drives Leukaemogenesis in Mutant IDH2 Acute Myeloid Leukaemia Via Inhibition of Granulocyte Differentiation and Cell Cycle Progression

Douglas RA Silveira, Prodromos Chatzikyriakou, Olena Yavorska, Sarah Mackie, Roan Hulks, Paulina Siejka-Zielinska, Anna Corby, Alastair Smith, Benjamin Brown, Marlen Metzner, Thomas A. Milne, Virginie Penard-Lacronique, Chunxiao Song, Maroof Hasan, Anjan Thakurta, Paresh Vyas, Skirmantas Kriaucionis, Lynn Quek

Blood (2021) 138 (Supplement 1): 3467.

https://doi.org/10.1182/blood-2021-149519

Published: 2021

Journal Articles

The BET inhibitor CPI203 promotes ex vivo expansion of cord blood long-term repopulating HSCs and megakaryocytes

Peng Hua, Joanna Hester, George Adigbli, Rong Li, Bethan Psaila, Anindita Roy, Carole J. R. Bataille, Graham M. Wynne, Thomas Jackson, Thomas A. Milne, Angela J. Russell, James Davies, Irene Roberts, Fadi Issa, Suzanne M. Watt

Blood (2020) 136 (21): 2410–2415.

https://doi.org/10.1182/blood.2020005357

Published: 2020

Includes: Supplemental data

Journal Articles

Pharmacological Induction of NOXA Sensitizes High-Risk B Cell Acute Lymphoblastic Leukemia Cells to Venetoclax

Klaudyna Fidyt, MSc, Julia Cyran, Agata Pastorczak, Nicholas T. Crump, Angelika Muchowicz, Agnieszka Goral, Krzysztof Domka, Lukasz Komorowski, Karolina Siudakowska, Agnieszka Graczyk-Jarzynka, Elzbieta Patkowska, Magdalena Winiarska, Jakub Golab, Thomas A. Milne, Malgorzata Firczuk, PhD

Blood (2020) 136 (Supplement 1): 17–18.

https://doi.org/10.1182/blood-2020-139318

Published: 2020

Journal Articles

Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs

Blood (2019) 134 (13): 1059–1071.

https://doi.org/10.1182/blood.2019001289

Published: 2019

Includes: Supplemental data

Journal Articles

LEDGF: a leukemia-specific target

Thomas A. Milne

Blood (2018) 131 (1): 4–5.

https://doi.org/10.1182/blood-2017-11-815449

Published: 2018

Journal Articles

Mouse models of MLL leukemia: recapitulating the human disease

Thomas A. Milne

Blood (2017) 129 (16): 2217–2223.

https://doi.org/10.1182/blood-2016-10-691428

Published: 2017

Journal Articles

Interaction of MLL Amino Terminal Sequences with Menin Is Required for Transformation.

Jay L. Hess, MD, PhD, Zhaohai Yang, MD, PhD, Haoren Wang, Ya-Xiong Chen, PhD, Thomas A. Milne, PhD, Mary Ellen Martin, MD, Robert K. Slany, PhD, Xianxin Hua, MD, PhD

Blood (2005) 106 (11): 664.

https://doi.org/10.1182/blood.V106.11.664.664

Published: 2005

Journal Articles

Leukemogenic MLL Fusion Proteins Promote MLL Association with HOX Loci Resulting in Persistent Expression.

Thomas A. Milne, Mary Ellen Martin, M.D., Robert K. Slany, Ph.D., Jay L. Hess, M.D., Ph.D.

Blood (2004) 104 (11): 386.

https://doi.org/10.1182/blood.V104.11.386.386

Published: 2004

Journal Articles

Failure of recombinant human granulocyte-macrophage colony-stimulating factor therapy in aplastic anemia patients with very severe neutropenia

C Nissen, A Tichelli, A Gratwohl, B Speck, A Milne, EC Gordon-Smith, J Schaedelin

Blood (1988) 72 (6): 2045–2047.

https://doi.org/10.1182/blood.V72.6.2045.2045

Published: 1988

NARROW

NG2 is a target gene of MLL-AF4 and underlies glucocorticoid resistance in MLLr B-ALL by regulating NR3C1 expression

KMT2A -Rearranged ALL Requires DYRK1A for Regulation of ERK Signaling and Cell Proliferation

Differential Gene Expression in KMT2A::AFF1 Leukemia Is Driven By Enhancer Heterogeneity

First-in-Class Targeted Protein Degrader of MLLT1/3 for the Treatment of Advanced AML and ALL Including Menin Inhibitor Resistant / Refractory Disease

The Fetal Specific Gene LIN28B Is Essential for Human Fetal B-Lymphopoiesis and Initiation of KMT2A-AFF1+ Infant Acute Lymphoblastic Leukemia

Identification of a Novel Chromatin Structure Associated with the Transcriptional Response to Menin Inhibitors in AML

A human genome editing–based MLL :: AF4 ALL model recapitulates key cellular and molecular leukemogenic features

PPARG and ASS1: Targets of Metabolic Alteration in Venetoclax / Decitabine Resistant Acute Myeloid Leukemia

Molecular Profiling of Response and Resistance to Venetoclax-Decitabine Therapy in Acute Myeloid Leukemia

Establishment and Characterization of a Model of Acquired Resistance to DOT1L Inhibition in KMT2A -Rearranged Acute Lymphoblastic Leukemia Cells

Dysregulation of Stem-Progenitor and Differentiation Programmes through Modulation of Bivalent Chromatin Drives Leukemogenesis in Mutant IDH2 Acute Myeloid Leukaemia

Repressed Chromatin Drives Leukaemogenesis in Mutant IDH2 Acute Myeloid Leukaemia Via Inhibition of Granulocyte Differentiation and Cell Cycle Progression

The BET inhibitor CPI203 promotes ex vivo expansion of cord blood long-term repopulating HSCs and megakaryocytes

Pharmacological Induction of NOXA Sensitizes High-Risk B Cell Acute Lymphoblastic Leukemia Cells to Venetoclax

Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs

LEDGF: a leukemia-specific target

Mouse models of MLL leukemia: recapitulating the human disease

Interaction of MLL Amino Terminal Sequences with Menin Is Required for Transformation.

Leukemogenic MLL Fusion Proteins Promote MLL Association with HOX Loci Resulting in Persistent Expression.

Failure of recombinant human granulocyte-macrophage colony-stimulating factor therapy in aplastic anemia patients with very severe neutropenia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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