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Drug-induced thrombotic microangiopathy: a systematic review of published reports
Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3
BCL2 mutations are associated with increased risk of transformation and shortened survival in follicular lymphoma
A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults
Issue Archive
January 22 2015
In this Issue
Table of Contents
INSIDE BLOOD COMMENTARIES
PLENARY PAPER
IMMUNOBIOLOGY
Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations
Joshua D. Milner,Tiphanie P. Vogel,Lisa Forbes,Chi A. Ma,Asbjørg Stray-Pedersen,Julie E. Niemela,Jonathan J. Lyons,Karin R. Engelhardt,Yu Zhang,Nermina Topcagic,Elisha D. O. Roberson,Helen Matthews,James W. Verbsky,Trivikram Dasu,Alexander Vargas-Hernandez,Nidhy Varghese,Kenneth L. McClain,Lina B. Karam,Karen Nahmod,George Makedonas,Emily M. Mace,Hanne S. Sorte,Gøri Perminow,V. Koneti Rao,Michael P. O’Connell,Susan Price,Helen C. Su,Morgan Butrick,Joshua McElwee,Jason D. Hughes,Joseph Willet,David Swan,Yaobo Xu,Mauro Santibanez-Koref,Voytek Slowik,Darrell L. Dinwiddie,Christina E. Ciaccio,Carol J. Saunders,Seth Septer,Stephen F. Kingsmore,Andrew J. White,Andrew J. Cant,Sophie Hambleton,Megan A. Cooper
PERSPECTIVES
The hidden genomic landscape of acute myeloid leukemia: subclonal structure revealed by undetected mutations
Margherita Bodini,Chiara Ronchini,Luciano Giacò,Anna Russo,Giorgio E. M. Melloni,Lucilla Luzi,Domenico Sardella,Sara Volorio,Syed K. Hasan,Tiziana Ottone,Serena Lavorgna,Francesco Lo-Coco,Anna Candoni,Renato Fanin,Eleonora Toffoletti,Ilaria Iacobucci,Giovanni Martinelli,Alessandro Cignetti,Corrado Tarella,Loris Bernard,Pier Giuseppe Pelicci,Laura Riva
HOW I TREAT
CLINICAL TRIALS AND OBSERVATIONS
Drug-induced thrombotic microangiopathy: a systematic review of published reports
Clinical Trials & Observations
Brief Report
HEMATOPOIESIS AND STEM CELLS
IMMUNOBIOLOGY
Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3
Clinical Trials & Observations
Emma M. Haapaniemi,Meri Kaustio,Hanna L. M. Rajala,Arjan J. van Adrichem,Leena Kainulainen,Virpi Glumoff,Rainer Doffinger,Heikki Kuusanmäki,Tarja Heiskanen-Kosma,Luca Trotta,Samuel Chiang,Petri Kulmala,Samuli Eldfors,Riku Katainen,Sanna Siitonen,Marja-Liisa Karjalainen-Lindsberg,Panu E. Kovanen,Timo Otonkoski,Kimmo Porkka,Kaarina Heiskanen,Arno Hänninen,Yenan T. Bryceson,Raija Uusitalo-Seppälä,Janna Saarela,Mikko Seppänen,Satu Mustjoki,Juha Kere
LYMPHOID NEOPLASIA
BCL2 mutations are associated with increased risk of transformation and shortened survival in follicular lymphoma
Clinical Trials & Observations
Cristina Correia,Paula A. Schneider,Haiming Dai,Ahmet Dogan,Matthew J. Maurer,Amy K. Church,Anne J. Novak,Andrew L. Feldman,Xiaosheng Wu,Husheng Ding,X. Wei Meng,James R. Cerhan,Susan L. Slager,William R. Macon,Thomas M. Habermann,Judith E. Karp,Steven D. Gore,Neil E. Kay,Diane F. Jelinek,Thomas E. Witzig,Grzegorz S. Nowakowski,Scott H. Kaufmann
A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults
Clinical Trials & Observations
Virginia Perez-Andreu,Kathryn G. Roberts,Heng Xu,Colton Smith,Hui Zhang,Wenjian Yang,Richard C. Harvey,Debbie Payne-Turner,Meenakshi Devidas,I-Ming Cheng,William L. Carroll,Nyla A. Heerema,Andrew J. Carroll,Elizabeth A. Raetz,Julie M. Gastier-Foster,Guido Marcucci,Clara D. Bloomfield,Krzysztof Mrózek,Jessica Kohlschmidt,Wendy Stock,Steven M. Kornblau,Marina Konopleva,Elisabeth Paietta,Jacob M. Rowe,Selina M. Luger,Martin S. Tallman,Michael Dean,Esteban G. Burchard,Dara G. Torgerson,Feng Yue,Yanli Wang,Ching-Hon Pui,Sima Jeha,Mary V. Relling,William E. Evans,Daniela S. Gerhard,Mignon L. Loh,Cheryl L. Willman,Stephen P. Hunger,Charles G. Mullighan,Jun J. Yang
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS
PLATELETS AND THROMBOPOIESIS
RED CELLS, IRON, AND ERYTHROPOIESIS
THROMBOSIS AND HEMOSTASIS
TRANSPLANTATION
CMV promotes recipient T-cell immunity following reduced-intensity T-cell–depleted HSCT, significantly modulating chimerism status
Rob S. Sellar,Frederick Arce Vargas,Jake Y. Henry,Stephanie Verfuerth,Sarah Charrot,Brendan Beaton,Ronjon Chakraverty,Sergio A. Quezada,Stephen Mackinnon,Kirsty J. Thomson,Karl S. Peggs
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Cover Image
Cover Image
Does the contact activation defect in prekallikrein deficiency protect from collagen/epinephrine (Col/Epi)-induced pulmonary emboli? This immunofluorescence image is of pulmonary microthrombi from prekallikrein-null (Klkb1−/−) mice following treatment with intravenous Col/Epi. The green color stains fibrin (Mab 59D8), the red color stains platelets (Mab anti-CD42c), and the orange color reflects their colocalization. Klkb1−/− mice have microvessel fibrin-platelet pulmonary emboli identical to those of wild-type mice (not shown), indicating that the mechanism for thrombosis observed is not mediated through contact activation. See the article by Stavrou et al on page 710.
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