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Issue Archive

Volume 125, Issue 4
January 22 2015
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
STAT3: too much may be worse than not enough!
Elie Haddad
View Articletitled, STAT3: too much may be worse than not enough!
INSIDE BLOOD COMMENTARY
Myeloid disorders arise in Dnmt3a-null marrow
Ruud Delwel
View Articletitled, Myeloid disorders arise in Dnmt3a-null marrow
INSIDE BLOOD COMMENTARY
Enhancing BCR signals at the cell membrane
Joseph R. Slupsky
View Articletitled, Enhancing BCR signals at the cell membrane
INSIDE BLOOD COMMENTARY
Mutations and microenvironment collude in FL
Sattva S. Neelapu
View Articletitled, Mutations and microenvironment collude in FL
INSIDE BLOOD COMMENTARY
The vascular side of plasma kallikrein
Thomas Renné
View Articletitled, The vascular side of plasma kallikrein

PLENARY PAPER

IMMUNOBIOLOGY
Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations
Joshua D. Milner,Tiphanie P. Vogel,Lisa Forbes,Chi A. Ma,Asbjørg Stray-Pedersen,Julie E. Niemela,Jonathan J. Lyons,Karin R. Engelhardt,Yu Zhang,Nermina Topcagic,Elisha D. O. Roberson,Helen Matthews,James W. Verbsky,Trivikram Dasu,Alexander Vargas-Hernandez,Nidhy Varghese,Kenneth L. McClain,Lina B. Karam,Karen Nahmod,George Makedonas,Emily M. Mace,Hanne S. Sorte,Gøri Perminow,V. Koneti Rao,Michael P. O’Connell,Susan Price,Helen C. Su,Morgan Butrick,Joshua McElwee,Jason D. Hughes,Joseph Willet,David Swan,Yaobo Xu,Mauro Santibanez-Koref,Voytek Slowik,Darrell L. Dinwiddie,Christina E. Ciaccio,Carol J. Saunders,Seth Septer,Stephen F. Kingsmore,Andrew J. White,Andrew J. Cant,Sophie Hambleton,Megan A. Cooper
View Articletitled, Early-onset lymphoproliferation and autoimmunity caused by germline <em>STAT3</em> gain-of-function mutations
Supplemental data

PERSPECTIVES

The hidden genomic landscape of acute myeloid leukemia: subclonal structure revealed by undetected mutations
Margherita Bodini,Chiara Ronchini,Luciano Giacò,Anna Russo,Giorgio E. M. Melloni,Lucilla Luzi,Domenico Sardella,Sara Volorio,Syed K. Hasan,Tiziana Ottone,Serena Lavorgna,Francesco Lo-Coco,Anna Candoni,Renato Fanin,Eleonora Toffoletti,Ilaria Iacobucci,Giovanni Martinelli,Alessandro Cignetti,Corrado Tarella,Loris Bernard,Pier Giuseppe Pelicci,Laura Riva
View Articletitled, The hidden genomic landscape of acute myeloid leukemia: subclonal structure revealed by undetected mutations
Supplemental data

HOW I TREAT

How we treat chronic graft-versus-host disease
Mary E. D. Flowers,Paul J. Martin
View Articletitled, How we treat chronic graft-versus-host disease
Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Drug-induced thrombotic microangiopathy: a systematic review of published reports
Clinical Trials & Observations Brief Report
Zayd L. Al-Nouri,Jessica A. Reese,Deirdra R. Terrell,Sara K. Vesely,James N. George
View Articletitled, Drug-induced thrombotic microangiopathy: a systematic review of published reports
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation
Hamza Celik,Cates Mallaney,Alok Kothari,Elizabeth L. Ostrander,Elizabeth Eultgen,Andrew Martens,Christopher A. Miller,Jasreet Hundal,Jeffery M. Klco,Grant A. Challen
View Articletitled, Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation
Supplemental data
Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation
Allison Mayle,Liubin Yang,Benjamin Rodriguez,Ting Zhou,Edmund Chang,Choladda V. Curry,Grant A. Challen,Wei Li,David Wheeler,Vivienne I. Rebel,Margaret A. Goodell
View Articletitled, <em>Dnmt3a</em> loss predisposes murine hematopoietic stem cells to malignant transformation
Supplemental data

IMMUNOBIOLOGY

Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3
Clinical Trials & Observations
Emma M. Haapaniemi,Meri Kaustio,Hanna L. M. Rajala,Arjan J. van Adrichem,Leena Kainulainen,Virpi Glumoff,Rainer Doffinger,Heikki Kuusanmäki,Tarja Heiskanen-Kosma,Luca Trotta,Samuel Chiang,Petri Kulmala,Samuli Eldfors,Riku Katainen,Sanna Siitonen,Marja-Liisa Karjalainen-Lindsberg,Panu E. Kovanen,Timo Otonkoski,Kimmo Porkka,Kaarina Heiskanen,Arno Hänninen,Yenan T. Bryceson,Raija Uusitalo-Seppälä,Janna Saarela,Mikko Seppänen,Satu Mustjoki,Juha Kere
View Articletitled, Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in <em>STAT3</em>
Supplemental data
HGAL localization to cell membrane regulates B-cell receptor signaling
Xiaoqing Lu,Renaud Sicard,Xiaoyu Jiang,Jessica N. Stockus,George McNamara,Midhat Abdulreda,Vincent T. Moy,Ralf Landgraf,Izidore S. Lossos
View Articletitled, HGAL localization to cell membrane regulates B-cell receptor signaling
Supplemental data

LYMPHOID NEOPLASIA

BCL2 mutations are associated with increased risk of transformation and shortened survival in follicular lymphoma
Clinical Trials & Observations
Cristina Correia,Paula A. Schneider,Haiming Dai,Ahmet Dogan,Matthew J. Maurer,Amy K. Church,Anne J. Novak,Andrew L. Feldman,Xiaosheng Wu,Husheng Ding,X. Wei Meng,James R. Cerhan,Susan L. Slager,William R. Macon,Thomas M. Habermann,Judith E. Karp,Steven D. Gore,Neil E. Kay,Diane F. Jelinek,Thomas E. Witzig,Grzegorz S. Nowakowski,Scott H. Kaufmann
View Articletitled, <em>BCL2</em> mutations are associated with increased risk of transformation and shortened survival in follicular lymphoma
Supplemental data
Activating STAT6 mutations in follicular lymphoma
Mehmet Yildiz,Hongxiu Li,Denzil Bernard,Nisar A. Amin,Peter Ouillette,Siân Jones,Kamlai Saiya-Cork,Brian Parkin,Kathryn Jacobi,Kerby Shedden,Shaomeng Wang,Alfred E. Chang,Mark S. Kaminski,Sami N. Malek
View Articletitled, Activating STAT6 mutations in follicular lymphoma
Supplemental data
A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults
Clinical Trials & Observations
Virginia Perez-Andreu,Kathryn G. Roberts,Heng Xu,Colton Smith,Hui Zhang,Wenjian Yang,Richard C. Harvey,Debbie Payne-Turner,Meenakshi Devidas,I-Ming Cheng,William L. Carroll,Nyla A. Heerema,Andrew J. Carroll,Elizabeth A. Raetz,Julie M. Gastier-Foster,Guido Marcucci,Clara D. Bloomfield,Krzysztof Mrózek,Jessica Kohlschmidt,Wendy Stock,Steven M. Kornblau,Marina Konopleva,Elisabeth Paietta,Jacob M. Rowe,Selina M. Luger,Martin S. Tallman,Michael Dean,Esteban G. Burchard,Dara G. Torgerson,Feng Yue,Yanli Wang,Ching-Hon Pui,Sima Jeha,Mary V. Relling,William E. Evans,Daniela S. Gerhard,Mignon L. Loh,Cheryl L. Willman,Stephen P. Hunger,Charles G. Mullighan,Jun J. Yang
View Articletitled, A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

ST3Gal-4 is the primary sialyltransferase regulating the synthesis of E-, P-, and L-selectin ligands on human myeloid leukocytes
Nandini Mondal,Alexander Buffone, Jr,Gino Stolfa,Aristotelis Antonopoulos,Joseph T. Y. Lau,Stuart M. Haslam,Anne Dell,Sriram Neelamegham
View Articletitled, ST3Gal-4 is the primary sialyltransferase regulating the synthesis of E-, P-, and L-selectin ligands on human myeloid leukocytes
Supplemental data

PLATELETS AND THROMBOPOIESIS

Visualization of nitric oxide production by individual platelets during adhesion in flowing blood
Maria Rita Cozzi,Giuseppe Guglielmini,Monica Battiston,Stefania Momi,Elisabetta Lombardi,Edward Cole Miller,Denise De Zanet,Mario Mazzucato,Paolo Gresele,Luigi De Marco
View Articletitled, Visualization of nitric oxide production by individual platelets during adhesion in flowing blood
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Telomere attrition and candidate gene mutations preceding monosomy 7 in aplastic anemia
Brief Report
Bogdan Dumitriu,Xingmin Feng,Danielle M. Townsley,Yasutaka Ueda,Tetsuichi Yoshizato,Rodrigo T. Calado,Yanqin Yang,Yoshiyuki Wakabayashi,Sachiko Kajigaya,Seishi Ogawa,Jun Zhu,Neal S. Young
View Articletitled, Telomere attrition and candidate gene mutations preceding monosomy 7 in aplastic anemia
Supplemental data

THROMBOSIS AND HEMOSTASIS

Reduced thrombosis in Klkb1−/− mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor
Evi X. Stavrou,Chao Fang,Alona Merkulova,Omar Alhalabi,Nadja Grobe,Silvio Antoniak,Nigel Mackman,Alvin H. Schmaier
View Articletitled, Reduced thrombosis in <em>Klkb1</em><sup><em>−/−</em></sup> mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor
Supplemental data
EphB2 regulates contact-dependent and contact-independent signaling to control platelet function
Sakthivel Vaiyapuri,Tanya Sage,Rekha H. Rana,Michael P. Schenk,Marfoua S. Ali,Amanda J. Unsworth,Chris I. Jones,Alexander R. Stainer,Neline Kriek,Leonardo A. Moraes,Jonathan M. Gibbins
View Articletitled, EphB2 regulates contact-dependent and contact-independent signaling to control platelet function
Supplemental data

TRANSPLANTATION

CMV promotes recipient T-cell immunity following reduced-intensity T-cell–depleted HSCT, significantly modulating chimerism status
Rob S. Sellar,Frederick Arce Vargas,Jake Y. Henry,Stephanie Verfuerth,Sarah Charrot,Brendan Beaton,Ronjon Chakraverty,Sergio A. Quezada,Stephen Mackinnon,Kirsty J. Thomson,Karl S. Peggs
View Articletitled, CMV promotes recipient T-cell immunity following reduced-intensity T-cell–depleted HSCT, significantly modulating chimerism status
Supplemental data
  • Cover Image

    Cover Image

    issue cover

    Does the contact activation defect in prekallikrein deficiency protect from collagen/epinephrine (Col/Epi)-induced pulmonary emboli? This immunofluorescence image is of pulmonary microthrombi from prekallikrein-null (Klkb1−/−) mice following treatment with intravenous Col/Epi. The green color stains fibrin (Mab 59D8), the red color stains platelets (Mab anti-CD42c), and the orange color reflects their colocalization. Klkb1−/− mice have microvessel fibrin-platelet pulmonary emboli identical to those of wild-type mice (not shown), indicating that the mechanism for thrombosis observed is not mediated through contact activation. See the article by Stavrou et al on page 710.

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