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Issue Archive

Volume 123, Issue 25
June 19 2014
Blood Cover Image for Volume 123, Issue 25

Table of Contents

EDITORIAL

Clinical trials have a home in Blood
Clinical Trials & Observations
Jorge Cortes,Nancy Berliner,Bob Löwenberg
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INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Red cell island dances: switching hands
Kathleen E. McGrath
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INSIDE BLOOD COMMENTARY
Can Treg elimination enhance NK cell therapy for AML?
Clinical Trials & Observations
Cliona M. Rooney
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INSIDE BLOOD COMMENTARY
A GVHD kill switch helps immune reconstitution
Clinical Trials & Observations
Jeffrey J. Molldrem,Sijie Lu
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INSIDE BLOOD COMMENTARY
Distinguishing CML LSCs from HSCs using CD26
Xiaoyan Jiang
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BLOOD WORK

Acute myeloid leukemia pretreated with filgastrim mimicking acute promyelocytic leukemia
Jamen R. Bartlett,John H. Lunde
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A thirsty child
Shyamali Dutta,Ankita Majumder
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PLENARY PAPER

Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein
Clinical Trials & Observations
Veronika Bachanova,Sarah Cooley,Todd E. Defor,Michael R. Verneris,Bin Zhang,David H. McKenna,Julie Curtsinger,Angela Panoskaltsis-Mortari,Dixie Lewis,Keli Hippen,Philip McGlave,Daniel J. Weisdorf,Bruce R. Blazar,Jeffrey S. Miller
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Supplemental data

PLENARY PAPER

Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine β-thalassemia
Rajasekhar N. V. S. Suragani,Sharon M. Cawley,Robert Li,Samantha Wallner,Mark J. Alexander,Aaron W. Mulivor,Sara Gardenghi,Stefano Rivella,Asya V. Grinberg,R. Scott Pearsall,Ravindra Kumar
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REVIEW ARTICLE

Practice guidelines for the diagnosis and management of microcytic anemias due to genetic disorders of iron metabolism or heme synthesis
CME
Albertine E. Donker,Reinier A. P. Raymakers,L. Thom Vlasveld,Teus van Barneveld,Rieneke Terink,Natasja Dors,Paul P. T. Brons,Nine V. A. M. Knoers,Dorine W. Swinkels
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CLINICAL TRIALS AND OBSERVATIONS

A randomized trial of avatrombopag, an investigational thrombopoietin-receptor agonist, in persistent and chronic immune thrombocytopenia
Clinical Trials & Observations
James B. Bussel,David J. Kuter,Louis M. Aledort,Craig M. Kessler,Adam Cuker,Kelly B. Pendergrass,Shande Tang,Joe McIntosh
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Supplemental data
Long-term outcome after haploidentical stem cell transplant and infusion of T cells expressing the inducible caspase 9 safety transgene
Clinical Trials & Observations
Xiaoou Zhou,Antonio Di Stasi,Siok-Keen Tey,Robert A. Krance,Caridad Martinez,Kathryn S. Leung,April G. Durett,Meng-Fen Wu,Hao Liu,Ann M. Leen,Barbara Savoldo,Yu-Feng Lin,Bambi J. Grilley,Adrian P. Gee,David M. Spencer,Cliona M. Rooney,Helen E. Heslop,Malcolm K. Brenner,Gianpietro Dotti
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Eltrombopag and high-dose dexamethasone as frontline treatment of newly diagnosed immune thrombocytopenia in adults
Clinical Trials & Observations Brief Report
David Gómez-Almaguer,Miguel A. Herrera-Rojas,José C. Jaime-Pérez,Andrés Gómez-De León,Olga G. Cantú-Rodríguez,César H. Gutiérrez-Aguirre,Luz Tarín-Arzaga,Jesús Hernández-Reyes,Guillermo J. Ruiz-Arguelles
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HEMATOPOIESIS AND STEM CELLS

Posttranscriptional regulation of c-Myc expression in adult murine HSCs during homeostasis and interferon-α-induced stress response
Brief Report
Armin Ehninger,Tobias Boch,Hannah Uckelmann,Marieke A. Essers,Katja Müdder,Barry P. Sleckman,Andreas Trumpp
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LYMPHOID NEOPLASIA

A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis
Tobias Berg,Silvia Thoene,Damian Yap,Tracee Wee,Nathalie Schoeler,Patty Rosten,Emilia Lim,Misha Bilenky,Andrew J. Mungall,Thomas Oellerich,Sherry Lee,Courteney K. Lai,Patricia Umlandt,Anisa Salmi,Harry Chang,Lisa Yue,David Lai,S.-W. Grace Cheng,Ryan D. Morin,Martin Hirst,Hubert Serve,Marco A. Marra,Gregg B. Morin,Randy D. Gascoyne,Samuel A. Aparicio,R. Keith Humphries
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The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma
Lucy B. Cook,Anat Melamed,Heather Niederer,Mikel Valganon,Daniel Laydon,Letizia Foroni,Graham P. Taylor,Masao Matsuoka,Charles R. M. Bangham
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MYELOID NEOPLASIA

Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells
Fumio Nakahara,Jiro Kitaura,Tomoyuki Uchida,Chiemi Nishida,Katsuhiro Togami,Daichi Inoue,Toshihiro Matsukawa,Yuki Kagiyama,Yutaka Enomoto,Kimihito C. Kawabata,Lai Chen-Yi,Yukiko Komeno,Kumi Izawa,Toshihiko Oki,Genta Nagae,Yuka Harada,Hironori Harada,Makoto Otsu,Hiroyuki Aburatani,Beate Heissig,Koichi Hattori,Toshio Kitamura
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Loss of Stat1 decreases megakaryopoiesis and favors erythropoiesis in a JAK2-V617F–driven mouse model of MPNs
Adrian Duek,Pontus Lundberg,Takafumi Shimizu,Jean Grisouard,Axel Karow,Lucia Kubovcakova,Hui Hao-Shen,Stephan Dirnhofer,Radek C. Skoda
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Dipeptidylpeptidase IV (CD26) defines leukemic stem cells (LSC) in chronic myeloid leukemia
Harald Herrmann,Irina Sadovnik,Sabine Cerny-Reiterer,Thomas Rülicke,Gabriele Stefanzl,Michael Willmann,Gregor Hoermann,Martin Bilban,Katharina Blatt,Susanne Herndlhofer,Matthias Mayerhofer,Berthold Streubel,Wolfgang R. Sperr,Tessa L. Holyoake,Christine Mannhalter,Peter Valent
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RED CELLS, IRON, AND ERYTHROPOIESIS

MerTK-mediated engulfment of pyrenocytes by central macrophages in erythroblastic islands
Satoshi Toda,Katsumori Segawa,Shigekazu Nagata
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THROMBOSIS AND HEMOSTASIS

Predictors of venous thromboembolism recurrence and bleeding among active cancer patients: a population-based cohort study
Cheng E. Chee,Aneel A. Ashrani,Randolph S. Marks,Tanya M. Petterson,Kent R. Bailey,L. Joseph Melton, III,John A. Heit
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TFPI cofactor function of protein S: essential role of the protein S SHBG-like domain
Natalia Reglińska-Matveyev,Helena M. Andersson,Suely M. Rezende,Björn Dahlbäck,James T. B. Crawley,David A. Lane,Josefin Ahnström
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TRANSPLANTATION

Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans
Ryan Flynn,Jing Du,Rachelle G. Veenstra,Dawn K. Reichenbach,Angela Panoskaltsis-Mortari,Patricia A. Taylor,Gordon J. Freeman,Jonathan S. Serody,William J. Murphy,David H. Munn,Stefanie Sarantopoulos,Leo Luznik,Ivan Maillard,John Koreth,Corey Cutler,Robert J. Soiffer,Joseph H. Antin,Jerome Ritz,Jason A. Dubovsky,John C. Byrd,Kelli P. MacDonald,Geoff R. Hill,Bruce R. Blazar
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CORRESPONDENCE

Survival trends in Waldenström macroglobulinemia: an analysis of the Surveillance, Epidemiology and End Results database
Clinical Trials & Observations
Jorge J. Castillo,Adam J. Olszewski,Angel M. Cronin,Zachary R. Hunter,Steven P. Treon
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Supplemental data
CD20 antibodies induce production and release of reactive oxygen species by neutrophils
Olle Werlenius,Rebecca E. Riise,Maria Simpanen,Johan Aurelius,Fredrik B. Thorén
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Novel severe hemophilia A and moyamoya (SHAM) syndrome caused by Xq28 deletions encompassing F8 and BRCC3 genes
Szymon Janczar,Anna Fogtman,Marta Koblowska,Dobromila Baranska,Agata Pastorczak,Olga Wegner,Magdalena Kostrzewska,Pawel Laguna,Maciej Borowiec,Wojciech Mlynarski
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CONTINUING MEDICAL EDUCATION (CME) QUESTIONS

Rare inherited iron and heme-related anemias
CME
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  • Cover Image

    Cover Image

    issue cover

    Red blood cells differentiate in association with a macrophage at the center of erythroblastic islands. At the final stage, pyrenocytes, nuclei covered by plasma membrane, are expelled from erythroblasts and engulfed by the macrophage. This process was reproduced in vitro by culturing erythroblastic islands in methylcellulose-containing medium. The image shows the central macrophages carrying many engulfed propidium iodide-positive pyrenocytes. See the article by Toda et al on page 3963.

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