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Journal Articles

Regulated Natural Killer Cell Expansion and Anti-Tumor Activity with Inducible MyD88/CD40

Xiaomei Wang, PhD, Wei-Chun Chang, PhD, Daniel L. Jasinski, PhD, Jan L. Medina, BS, Ming Zhang, BS, Aaron Foster, PhD, David M. Spencer, PhD, J. Henri Bayle, PhD

Blood (2018) 132 (Supplement 1): 4550.

https://doi.org/10.1182/blood-2018-99-120151

Published: 2018

Journal Articles

Characterization of Allogeneic T Cells Expressing Inducible Caspase-9 Following Adoptive Transfer in Children Receiving an HLA-Haploidentical Hematopoietic Stem Cell Transplant for the Treatment of Myeloid Malignancies

Joanne Shaw, PhD, Xiaoou Zhou, MD PhD, An Lu, Valentina Bertaina, Daria Pagliara, MD PhD, Melissa Aldinger, PharmD, David M. Spencer, PhD, Franco Locatelli, Aaron Foster, PhD

Blood (2018) 132 (Supplement 1): 4534.

https://doi.org/10.1182/blood-2018-99-119779

Published: 2018

Journal Articles

Differential Expression of Inducible Caspase-9 (iC9) in Allogeneic T Cells Allows Selective Depletion of Activated T Cells Following Exposure to Rimiducid and Permits In Vivo Allodepletion

Xiaoou Zhou, MD PhD, An Lu, Kelly L Sharp, Margie Harris, Madhavi Anumula, MS, J. Bayle, PhD, David M. Spencer, PhD, Aaron Foster, PhD, Joanne Shaw, PhD

Blood (2018) 132 (Supplement 1): 3496.

https://doi.org/10.1182/blood-2018-99-119285

Published: 2018

Journal Articles

Inducible MyD88/CD40 (iMC) Costimulation Enhances Polyclonal Epstein-Barr Virus-Specific Cytotoxic T Lymphocyte (EBV-CTL) Proliferation and Anti-Tumor Activity

Mariam Khalil, Eric Yvon, S., Aruna Mahendravada, David M. Spencer, Aaron Foster

Blood (2017) 130 (Supplement 1): 3337.

https://doi.org/10.1182/blood.V130.Suppl_1.3337.3337

Published: 2017

Journal Articles

Dual-Switch CAR-T Cells: Orthogonal Molecular Switches to Control Activation and Elimination of CAR-T Cells to Target CD123 + Cancer

J. Henri Bayle, PhD, MyLinh T Duong, PhD, An Lu, Eva Morschl, PhD, Matthew R. Collinson-Pautz, PhD, Kelly L Sharp, Slawomir Szymanski, PhD, Mary E. Brandt, Kevin M. Slawin, MD, Steven Toler, PhD, Eric Yvon, S., Aaron Foster, David M. Spencer

Blood (2017) 130 (Supplement 1): 3184.

https://doi.org/10.1182/blood.V130.Suppl_1.3184.3184

Published: 2017

Journal Articles

Donor T Cells Genetically Modified with a Novel Suicide Gene (inducible Caspase 9, iC9) Expand and Persist over Time after Post-Allograft Infusion in Patients Given αβ T-Cell and B-Cell Depleted HLA-Haploidentical Allogeneic Stem Cell Transplantation (αβ haplo-HSCT) Contributing to Accelerate Immune Recovery

Pietro Merli, MD, Valentina Bertaina, Federica Galaverna, MD, Mattia Algeri, MD, Matilde Sinibaldi, Luisa Strocchio, Giuseppina Li Pira, Daria Pagliara, Sonia De Murtas, Giuseppe Palumbo, Vincent O'Neill, David M. Spencer, Aaron Foster, Alice Bertaina, MD PhD, Franco Locatelli, MD PhD

Blood (2017) 130 (Supplement 1): 211.

https://doi.org/10.1182/blood.V130.Suppl_1.211.211

Published: 2017

Journal Articles

Single-Cell Multiplex Proteomics Reveals Synergistic Impact of Antigen and Rimiducid-Dependent Stimulatory Signals on Promoting Polyfunctional GoCAR-T Cells Targeting Prostate Stem Cell Antigen (PSCA)

Sean Mackay, Brianna Flynn, Kevin Morse, Colin Ng, Kyle Gallatin, Patrick Paczkowski, Aruna Mahendravada, Nicholas Shinners, David M. Spencer, Aaron Foster, Jing Zhou

Blood (2017) 130 (Supplement 1): 2281.

https://doi.org/10.1182/blood.V130.Suppl_1.2281.2281

Published: 2017

Journal Articles

MyD88/CD40 Enhanced CD19-Specific CAR-T Cells Maintain Therapeutic Efficacy Following Resolution of Cytokine-Related Toxicity Using Inducible Caspase-9

Aaron Foster, Pei-Yi Lin, PhD, An Lu, Wei-Chun Chang, PhD, Nicholas Shinners, Mariam Khalil, Jeannette Crisostomo, Aruna Mahendravada, Kevin M. Slawin, MD, David M. Spencer

Blood (2017) 130 (Supplement 1): 4615.

https://doi.org/10.1182/blood.V130.Suppl_1.4615.4615

Published: 2017

Journal Articles

Inducible MyD88/CD40 (iMC) Enhances Proliferation and Survival of Tumor-Specific TCR-Modified T Cells and Improves Anti-Tumor Efficacy in Myeloma

Tsvetelina Pentcheva-Hoang, PhD, David Torres, Tania Rodriguez, PhD, Ana Korngold, PhD, An Lu, Jeannette Crisostomo, Annemarie Moseley, MD PhD, Lorenz Jahn, Mirjam H.M. Heemskerk, PhD, Kevin M Slawin, MD, David M Spencer, PhD, Aaron E Foster, PhD

Blood (2016) 128 (22): 4550.

https://doi.org/10.1182/blood.V128.22.4550.4550

Published: 2016

Journal Articles

Inducible MyD88/CD40 (iMC) Costimulation Provides Ligand-Dependent Tumor Eradication By CD123-Specific Chimeric Antigen Receptor T Cells

Aaron E Foster, PhD, MyLinh Duong, PhD, An Lu, Peter Chang, PhD, Aruna Mahendravada, Nicholas Shinners, PhD, Kevin M Slawin, MD, J. Henri Bayle, PhD, David M Spencer, PhD

Blood (2016) 128 (22): 4551.

https://doi.org/10.1182/blood.V128.22.4551.4551

Published: 2016

Journal Articles

Inducible MyD88/CD40 Enhances Proliferation and Survival of PRAME-Specific TCR-Engineered T Cells and Increases Anti-Tumor Effects in Myeloma

Tsvetalina Hoang, PhD, Aaron Foster, PhD, Jeannette Crisostomo, An Lu, Annemarie Moseley, MDPhD, Mirjam H.M. Heemskerk, PhD, Kevin M Slawin, MD, David M Spencer, PhD

Blood (2015) 126 (23): 1886.

https://doi.org/10.1182/blood.V126.23.1886.1886

Published: 2015

Journal Articles

Inducible MyD88/CD40 Allows Rimiducid-Dependent Activation to Control Proliferation and Survival of Chimeric Antigen Receptor-Modified T Cells

Aaron Foster, PhD, Aruna Mahendravada, Nicholas P Shinners, PhD, Peter Chang, PhD, An Lu, Eva Morschl, PhD, Joanne Shaw, PhD, Sunandan Saha, PhD, Kevin M Slawin, MD, David M Spencer, PhD

Blood (2015) 126 (23): 4295.

https://doi.org/10.1182/blood.V126.23.4295.4295

Published: 2015

Journal Articles

Expression of MyD88/CD40 Drives In Vivo Activation and Proliferation of Chimeric Antigen Receptor-Modified T Cells That Can be Effectively Regulated By Inducible Caspase-9

Aaron Foster, PhD, Peter Chang, PhD, Pei-Yi Lin, PhD, Jeannette Crisostomo, Aruna Mahendravada, An Lu, Mariam Khalil, Sunandan Saha, PhD, Joanne Shaw, PhD, Eva Morschl, PhD, Kevin M Slawin, MD, David M Spencer, PhD

Blood (2015) 126 (23): 851.

https://doi.org/10.1182/blood.V126.23.851.851

Published: 2015

Journal Articles

Inducible caspase-9 suicide gene controls adverse effects from alloreplete T cells after haploidentical stem cell transplantation

Xiaoou Zhou, Gianpietro Dotti, Robert A. Krance, Caridad A. Martinez, Swati Naik, Rammurti T. Kamble, April G. Durett, Olga Dakhova, Barbara Savoldo, Antonio Di Stasi, David M. Spencer, Yu-Feng Lin, Hao Liu, Bambi J. Grilley, Adrian P. Gee, Cliona M. Rooney, Helen E. Heslop, Malcolm K. Brenner

Blood (2015) 125 (26): 4103–4113.

https://doi.org/10.1182/blood-2015-02-628354

Published: 2015

Includes: Supplemental data

Journal Articles

Long-term outcome after haploidentical stem cell transplant and infusion of T cells expressing the inducible caspase 9 safety transgene

Xiaoou Zhou, Antonio Di Stasi, Siok-Keen Tey, Robert A. Krance, Caridad Martinez, Kathryn S. Leung, April G. Durett, Meng-Fen Wu, Hao Liu, Ann M. Leen, Barbara Savoldo, Yu-Feng Lin, Bambi J. Grilley, Adrian P. Gee, David M. Spencer, Cliona M. Rooney, Helen E. Heslop, Malcolm K. Brenner, Gianpietro Dotti

Blood (2014) 123 (25): 3895–3905.

https://doi.org/10.1182/blood-2014-01-551671

Published: 2014

Includes: Supplemental data

Journal Articles

Genetic Modification of Multi Leukemia Antigen-Specific Cytotoxic T Lymphocytes (CTL) to Enhance In Vivo Safety and Persistency

Fabian Zohren, MD, Maria R Imperato, Anurathapan Usanarat, MD, David M Spencer, PhD, Helen E. Heslop, MD, Malcolm K. Brenner, MB, PhD, FRCP, FRCPath, Cliona M. Rooney, PhD, Ann M. Leen, PhD, Juan F Vera, MD, Ulrike Gerdemann, MD

Blood (2011) 118 (21): 644.

https://doi.org/10.1182/blood.V118.21.644.644

Published: 2011

Journal Articles

T cells redirected against CD70 for the immunotherapy of CD70-positive malignancies

Donald R. Shaffer, Barbara Savoldo, Zhongzhen Yi, Kevin K. H. Chow, Sunitha Kakarla, David M. Spencer, Gianpietro Dotti, Meng-Fen Wu, Hao Liu, Shannon Kenney, Stephen Gottschalk

Blood (2011) 117 (16): 4304–4314.

https://doi.org/10.1182/blood-2010-04-278218

Published: 2011

Includes: Supplemental data

Journal Articles

CASPALLO: Phase I Clinical Trial of Allodepleted T Cells Transduced with Inducible Caspase 9 Suicide Gene After Haploidentical Stem Cell Transplantation

Blood (2010) 116 (21): 559.

https://doi.org/10.1182/blood.V116.21.559.559

Published: 2010

Journal Articles

An inducible caspase 9 safety switch for T-cell therapy

Karin C. Straathof, Martin A. Pulè, Patricia Yotnda, Gianpietro Dotti, Elio F. Vanin, Malcolm K. Brenner, Helen E. Heslop, David M. Spencer, Cliona M. Rooney

Blood (2005) 105 (11): 4247–4254.

https://doi.org/10.1182/blood-2004-11-4564

Published: 2005

Includes: Supplemental data

Journal Articles

Inducible Caspase 9 as a Safety Switch in Genetically Modified Cytotoxic T Cells.

Karin C. Straathof, MD, Martin A. Pule, MD, Patricia Yotnda, PhD, Gianpietro Dotti, MD, Elio F. Vanin, PhD, Malcolm K. Brenner, MD, PhD, Helen E. Heslop, MD, PhD, David M. Spencer, PhD, Cliona M. Rooney, PhD

Blood (2004) 104 (11): 1743.

https://doi.org/10.1182/blood.V104.11.1743.1743

Published: 2004

NARROW

Regulated Natural Killer Cell Expansion and Anti-Tumor Activity with Inducible MyD88/CD40

Characterization of Allogeneic T Cells Expressing Inducible Caspase-9 Following Adoptive Transfer in Children Receiving an HLA-Haploidentical Hematopoietic Stem Cell Transplant for the Treatment of Myeloid Malignancies

Differential Expression of Inducible Caspase-9 (iC9) in Allogeneic T Cells Allows Selective Depletion of Activated T Cells Following Exposure to Rimiducid and Permits In Vivo Allodepletion

Inducible MyD88/CD40 (iMC) Costimulation Enhances Polyclonal Epstein-Barr Virus-Specific Cytotoxic T Lymphocyte (EBV-CTL) Proliferation and Anti-Tumor Activity

Dual-Switch CAR-T Cells: Orthogonal Molecular Switches to Control Activation and Elimination of CAR-T Cells to Target CD123 + Cancer

Single-Cell Multiplex Proteomics Reveals Synergistic Impact of Antigen and Rimiducid-Dependent Stimulatory Signals on Promoting Polyfunctional GoCAR-T Cells Targeting Prostate Stem Cell Antigen (PSCA)

MyD88/CD40 Enhanced CD19-Specific CAR-T Cells Maintain Therapeutic Efficacy Following Resolution of Cytokine-Related Toxicity Using Inducible Caspase-9

Inducible MyD88/CD40 (iMC) Enhances Proliferation and Survival of Tumor-Specific TCR-Modified T Cells and Improves Anti-Tumor Efficacy in Myeloma

Inducible MyD88/CD40 (iMC) Costimulation Provides Ligand-Dependent Tumor Eradication By CD123-Specific Chimeric Antigen Receptor T Cells

Inducible MyD88/CD40 Enhances Proliferation and Survival of PRAME-Specific TCR-Engineered T Cells and Increases Anti-Tumor Effects in Myeloma

Inducible MyD88/CD40 Allows Rimiducid-Dependent Activation to Control Proliferation and Survival of Chimeric Antigen Receptor-Modified T Cells

Expression of MyD88/CD40 Drives In Vivo Activation and Proliferation of Chimeric Antigen Receptor-Modified T Cells That Can be Effectively Regulated By Inducible Caspase-9

Inducible caspase-9 suicide gene controls adverse effects from alloreplete T cells after haploidentical stem cell transplantation

Long-term outcome after haploidentical stem cell transplant and infusion of T cells expressing the inducible caspase 9 safety transgene

Genetic Modification of Multi Leukemia Antigen-Specific Cytotoxic T Lymphocytes (CTL) to Enhance In Vivo Safety and Persistency

T cells redirected against CD70 for the immunotherapy of CD70-positive malignancies

CASPALLO: Phase I Clinical Trial of Allodepleted T Cells Transduced with Inducible Caspase 9 Suicide Gene After Haploidentical Stem Cell Transplantation

An inducible caspase 9 safety switch for T-cell therapy

Inducible Caspase 9 as a Safety Switch in Genetically Modified Cytotoxic T Cells.

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American Society of Hematology

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American Society of Hematology

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