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Issue Archive

Volume 123, Issue 24
June 12 2014
Issue Cover

Table of Contents

INSIDE BLOOD COMMENTARIES

INSIDE BLOOD COMMENTARY
Paving the road to MRD-guided treatment in CLL
Clinical Trials & Observations
Sebastian Böttcher
View Articletitled, Paving the road to MRD-guided treatment in CLL
INSIDE BLOOD COMMENTARY
An unsung runt 6e isoform for HSC expansion
Motomi Osato
View Articletitled, An unsung runt 6e isoform for HSC expansion
INSIDE BLOOD COMMENTARY
Symptom burden in hematologic malignancies
Charles S. Cleeland,Loretta A. Williams
View Articletitled, Symptom burden in hematologic malignancies
INSIDE BLOOD COMMENTARY
Validation is a dish oft served cold
David B. Wilson
View Articletitled, Validation is a dish oft served cold
INSIDE BLOOD COMMENTARY
Erythroid DAMPs drive inflammation in SCD
Mark T. Gladwin,Solomon F. Ofori-Acquah
View Articletitled, Erythroid DAMPs drive inflammation in SCD
INSIDE BLOOD COMMENTARY
In search of the source of factor VIII
Edward Tuddenham
View Articletitled, In search of the source of factor VIII
INSIDE BLOOD COMMENTARY
JAK inhibitors: a home run for GVHD patients?
Takanori Teshima
View Articletitled, JAK inhibitors: a home run for GVHD patients?

BLOOD WORK

Chance identification of synchronous hairy cell leukemia and plasma cell myeloma in a potential HSC donor
Xiangrong Zhao,Irina Maric
View Articletitled, Chance identification of synchronous hairy cell leukemia and plasma cell myeloma in a potential HSC donor
Bodies of evidence? Lymphoglandular bodies in aspirate smears of bone marrow involved by aggressive large B-cell lymphoma
Michael J. Rauh,David J. Good
View Articletitled, Bodies of evidence? Lymphoglandular bodies in aspirate smears of bone marrow involved by aggressive large B-cell lymphoma

PLENARY PAPER

Murine coagulation factor VIII is synthesized in endothelial cells
Lesley A. Everett,Audrey C. A. Cleuren,Rami N. Khoriaty,David Ginsburg
View Articletitled, Murine coagulation factor VIII is synthesized in endothelial cells
Supplemental data

PLENARY PAPER

A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII
Scot A. Fahs,Matthew T. Hille,Qizhen Shi,Hartmut Weiler,Robert R. Montgomery
View Articletitled, A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII

BLOOD SPOTLIGHT

From Janus kinase 2 to calreticulin: the clinically relevant genomic landscape of myeloproliferative neoplasms
Mario Cazzola,Robert Kralovics
View Articletitled, From Janus kinase 2 to calreticulin: the clinically relevant genomic landscape of myeloproliferative neoplasms

HOW I TREAT

How I treat renal complications in sickle cell disease
Claire C. Sharpe,Swee Lay Thein
View Articletitled, How I treat renal complications in sickle cell disease

CLINICAL TRIALS AND OBSERVATIONS

Eradication of bone marrow minimal residual disease may prompt early treatment discontinuation in CLL
Clinical Trials & Observations
Paolo Strati,Michael J. Keating,Susan M. O'Brien,Jan Burger,Alessandra Ferrajoli,Nitin Jain,Francesco Paolo Tambaro,Zeev Estrov,Jeffrey Jorgensen,Pramoda Challagundla,Stefan H. Faderl,William G. Wierda
View Articletitled, Eradication of bone marrow minimal residual disease may prompt early treatment discontinuation in CLL
Supplemental data
Biomarkers of terminal complement activation confirm the diagnosis of aHUS and differentiate aHUS from TTP
Clinical Trials & Observations
Spero R. Cataland,V. Michael Holers,Susan Geyer,Shangbin Yang,Haifeng M. Wu
View Articletitled, Biomarkers of terminal complement activation confirm the diagnosis of aHUS and differentiate aHUS from TTP
Supplemental data
Oncogenetics and minimal residual disease are independent outcome predictors in adult patients with acute lymphoblastic leukemia
Clinical Trials & Observations
Kheira Beldjord,Sylvie Chevret,Vahid Asnafi,Françoise Huguet,Marie-Laure Boulland,Thibaut Leguay,Xavier Thomas,Jean-Michel Cayuela,Nathalie Grardel,Yves Chalandon,Nicolas Boissel,Beat Schaefer,Eric Delabesse,Hélène Cavé,Patrice Chevallier,Agnès Buzyn,Thierry Fest,Oumedaly Reman,Jean-Paul Vernant,Véronique Lhéritier,Marie C. Béné,Marina Lafage,Elizabeth Macintyre,Norbert Ifrah,Hervé Dombret,on behalf of the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL)
View Articletitled, Oncogenetics and minimal residual disease are independent outcome predictors in adult patients with acute lymphoblastic leukemia
Supplemental data

GENE THERAPY

Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15
Yang Xu,Ming Zhang,Carlos A. Ramos,April Durett,Enli Liu,Olga Dakhova,Hao Liu,Chad J. Creighton,Adrian P. Gee,Helen E. Heslop,Cliona M. Rooney,Barbara Savoldo,Gianpietro Dotti
View Articletitled, Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15
Supplemental data

HEMATOPOIESIS AND STEM CELLS

Runx1 exon 6–related alternative splicing isoforms differentially regulate hematopoiesis in mice
Yukiko Komeno,Ming Yan,Shinobu Matsuura,Kentson Lam,Miao-Chia Lo,Yi-Jou Huang,Daniel G. Tenen,James R. Downing,Dong-Er Zhang
View Articletitled, Runx1 exon 6–related alternative splicing isoforms differentially regulate hematopoiesis in mice
Supplemental data

LYMPHOID NEOPLASIA

CD28-mediated pro-survival signaling induces chemotherapeutic resistance in multiple myeloma
Megan E. Murray,Catherine M. Gavile,Jayakumar R. Nair,Chandana Koorella,Louise M. Carlson,Daniela Buac,Adam Utley,Marta Chesi,P. Leif Bergsagel,Lawrence H. Boise,Kelvin P. Lee
View Articletitled, CD28-mediated pro-survival signaling induces chemotherapeutic resistance in multiple myeloma
Supplemental data
Evaluation of bendamustine in combination with fludarabine in primary chronic lymphocytic leukemia cells
Amal A. El-Mabhouh,Mary L. Ayres,Elizabeth J. Shpall,Veerabhadran Baladandayuthapani,Michael J. Keating,William G. Wierda,Varsha Gandhi
View Articletitled, Evaluation of bendamustine in combination with fludarabine in primary chronic lymphocytic leukemia cells
Supplemental data
Mutations in TLR/MYD88 pathway identify a subset of young chronic lymphocytic leukemia patients with favorable outcome
Alejandra Martínez-Trillos,Magda Pinyol,Alba Navarro,Marta Aymerich,Pedro Jares,Manel Juan,María Rozman,Dolors Colomer,Julio Delgado,Eva Giné,Marcos González-Díaz,Jesús M. Hernández-Rivas,Enrique Colado,Consolación Rayón,Angel R. Payer,Maria José Terol,Blanca Navarro,Victor Quesada,Xosé S. Puente,Ciril Rozman,Carlos López-Otín,Elías Campo,Armando López-Guillermo,Neus Villamor
View Articletitled, Mutations in <em>TLR/MYD88</em> pathway identify a subset of young chronic lymphocytic leukemia patients with favorable outcome
Supplemental data
Stimulation of the B-cell receptor activates the JAK2/STAT3 signaling pathway in chronic lymphocytic leukemia cells
Brief Report
Uri Rozovski,Ji Yuan Wu,David M. Harris,Zhiming Liu,Ping Li,Inbal Hazan-Halevy,Alessandra Ferrajoli,Jan A. Burger,Susan O’Brien,Nitin Jain,Srdan Verstovsek,William G. Wierda,Michael J. Keating,Zeev Estrov
View Articletitled, Stimulation of the B-cell receptor activates the JAK2/STAT3 signaling pathway in chronic lymphocytic leukemia cells
Supplemental data

MYELOID NEOPLASIA

Distinct clustering of symptomatic burden among myeloproliferative neoplasm patients: retrospective assessment in 1470 patients
Holly L. Geyer,Robyn M. Scherber,Amylou C. Dueck,Jean-Jacques Kiladjian,Zhijian Xiao,Stefanie Slot,Sonja Zweegman,Federico Sackmann,Ana Kerguelen Fuentes,Dolores Hernández-Maraver,Konstanze Döhner,Claire N. Harrison,Deepti Radia,Pablo Muxi,Carlos Besses,Francisco Cervantes,Peter L. Johansson,Bjorn Andreasson,Alessandro Rambaldi,Tiziano Barbui,Alessandro M. Vannucchi,Francesco Passamonti,Jan Samuelsson,Gunnar Birgegard,Ruben A. Mesa
View Articletitled, Distinct clustering of symptomatic burden among myeloproliferative neoplasm patients: retrospective assessment in 1470 patients
Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Inherited biallelic CSF3R mutations in severe congenital neutropenia
Alexa Triot,Päivi M. Järvinen,Juan I. Arostegui,Dhaarini Murugan,Naschla Kohistani,José Luis Dapena Díaz,Tomas Racek,Jacek Puchałka,E. Michael Gertz,Alejandro A. Schäffer,Daniel Kotlarz,Dietmar Pfeifer,Cristina Díaz de Heredia Rubio,Mehmet Akif Ozdemir,Turkan Patiroglu,Musa Karakukcu,José Sánchez de Toledo Codina,Jordi Yagüe,Ivo P. Touw,Ekrem Unal,Christoph Klein
View Articletitled, Inherited biallelic <em>CSF3R</em> mutations in severe congenital neutropenia
Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease
Grace Chen,Dachuan Zhang,Tobias A. Fuchs,Deepa Manwani,Denisa D. Wagner,Paul S. Frenette
View Articletitled, Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease
Supplemental data

THROMBOSIS AND HEMOSTASIS

The thromboprotective effect of bortezomib is dependent on the transcription factor Kruppel-like factor 2 (KLF2)
Brief Report
Lalitha Nayak,Hong Shi,G. Brandon Atkins,Zhiyong Lin,Alvin H. Schmaier,Mukesh K. Jain
View Articletitled, The thromboprotective effect of bortezomib is dependent on the transcription factor Kruppel-like factor 2 (<em>KLF2</em>)
Supplemental data

TRANSPLANTATION

Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease
Silvia Spoerl,Nimitha R. Mathew,Michael Bscheider,Annette Schmitt-Graeff,Sophia Chen,Tony Mueller,Mareike Verbeek,Julius Fischer,Vera Otten,Martina Schmickl,Kristina Maas-Bauer,Jürgen Finke,Christian Peschel,Justus Duyster,Hendrik Poeck,Robert Zeiser,Nikolas von Bubnoff
View Articletitled, Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease
Supplemental data
OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues
e-blood
Mark Wunderlich,Ryan A. Brooks,Rushi Panchal,Garrett W. Rhyasen,Gwenn Danet-Desnoyers,James C. Mulloy
View Articletitled, OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues

ERRATA

Zhang F, Michaelson JE, Moshiach S, et al. Tetraspanin CD151 maintains vascular stability by balancing the forces of cell adhesion and cytoskeletal tension. Blood. 2011;118(15):4274-4284.
View Articletitled, Zhang F, Michaelson JE, Moshiach S, et al. Tetraspanin CD151 maintains vascular stability by balancing the forces of cell adhesion and cytoskeletal tension. <em>Blood</em>. 2011;118(15):4274-4284.
Gay F, Magarotto V, Crippa C, et al. Bortezomib induction, reduced-intensity transplantation, and lenalidomide consolidation-maintenance for myeloma: updated results. Blood. 2013;122(8):1376-1383.
View Articletitled, Gay F, Magarotto V, Crippa C, et al. Bortezomib induction, reduced-intensity transplantation, and lenalidomide consolidation-maintenance for myeloma: updated results. <em>Blood</em>. 2013;122(8):1376-1383.
Rowley JW, Oler AJ, Tolley ND, et al. Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes. Blood. 2011;118(14):e101-e111.
View Articletitled, Rowley JW, Oler AJ, Tolley ND, et al. Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes. <em>Blood</em>. 2011;118(14):e101-e111.
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