Kheira Beldjord,on behalf of the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL),Sylvie Chevret,on behalf of the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL),Vahid Asnafi,on behalf of the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL),Françoise Huguet,on behalf of the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL),Marie-Laure Boulland,on behalf of the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL),Thibaut Leguay,on behalf of the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL),Xavier Thomas,on behalf of the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL),Jean-Michel Cayuela,on behalf of the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL),Nathalie Grardel,on behalf of the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL),Yves Chalandon,on behalf of the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL),Nicolas Boissel,on behalf of the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL),Beat Schaefer,on behalf of the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL),Eric Delabesse,on behalf of the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL),Hélène Cavé,on behalf of the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL),Patrice Chevallier,on behalf of the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL),Agnès Buzyn,on behalf of the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL),Thierry Fest,on behalf of the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL),Oumedaly Reman,on behalf of the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL),Jean-Paul Vernant,on behalf of the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL),Véronique Lhéritier,on behalf of the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL),Marie C. Béné,on behalf of the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL),Marina Lafage,on behalf of the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL),Elizabeth Macintyre,on behalf of the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL),Norbert Ifrah,on behalf of the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL),Hervé Dombret,on behalf of the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL)

View Articletitled, Oncogenetics and minimal residual disease are independent outcome predictors in adult patients with acute lymphoblastic leukemia

Supplemental data

GENE THERAPY

Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15

Yang Xu,Ming Zhang,Carlos A. Ramos,April Durett,Enli Liu,Olga Dakhova,Hao Liu,Chad J. Creighton,Adrian P. Gee,Helen E. Heslop,Cliona M. Rooney,Barbara Savoldo,Gianpietro Dotti

View Articletitled, Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15

Supplemental data

HEMATOPOIESIS AND STEM CELLS

Runx1 exon 6–related alternative splicing isoforms differentially regulate hematopoiesis in mice

Yukiko Komeno,Ming Yan,Shinobu Matsuura,Kentson Lam,Miao-Chia Lo,Yi-Jou Huang,Daniel G. Tenen,James R. Downing,Dong-Er Zhang

View Articletitled, Runx1 exon 6–related alternative splicing isoforms differentially regulate hematopoiesis in mice

Supplemental data

LYMPHOID NEOPLASIA

CD28-mediated pro-survival signaling induces chemotherapeutic resistance in multiple myeloma

Megan E. Murray,Catherine M. Gavile,Jayakumar R. Nair,Chandana Koorella,Louise M. Carlson,Daniela Buac,Adam Utley,Marta Chesi,P. Leif Bergsagel,Lawrence H. Boise,Kelvin P. Lee

View Articletitled, CD28-mediated pro-survival signaling induces chemotherapeutic resistance in multiple myeloma

Supplemental data

Evaluation of bendamustine in combination with fludarabine in primary chronic lymphocytic leukemia cells

Amal A. El-Mabhouh,Mary L. Ayres,Elizabeth J. Shpall,Veerabhadran Baladandayuthapani,Michael J. Keating,William G. Wierda,Varsha Gandhi

View Articletitled, Evaluation of bendamustine in combination with fludarabine in primary chronic lymphocytic leukemia cells

Supplemental data

Mutations in TLR/MYD88 pathway identify a subset of young chronic lymphocytic leukemia patients with favorable outcome

Alejandra Martínez-Trillos,Magda Pinyol,Alba Navarro,Marta Aymerich,Pedro Jares,Manel Juan,María Rozman,Dolors Colomer,Julio Delgado,Eva Giné,Marcos González-Díaz,Jesús M. Hernández-Rivas,Enrique Colado,Consolación Rayón,Angel R. Payer,Maria José Terol,Blanca Navarro,Victor Quesada,Xosé S. Puente,Ciril Rozman,Carlos López-Otín,Elías Campo,Armando López-Guillermo,Neus Villamor

View Articletitled, Mutations in TLR/MYD88 pathway identify a subset of young chronic lymphocytic leukemia patients with favorable outcome

Supplemental data

Stimulation of the B-cell receptor activates the JAK2/STAT3 signaling pathway in chronic lymphocytic leukemia cells
Brief Report

Uri Rozovski,Ji Yuan Wu,David M. Harris,Zhiming Liu,Ping Li,Inbal Hazan-Halevy,Alessandra Ferrajoli,Jan A. Burger,Susan O’Brien,Nitin Jain,Srdan Verstovsek,William G. Wierda,Michael J. Keating,Zeev Estrov

View Articletitled, Stimulation of the B-cell receptor activates the JAK2/STAT3 signaling pathway in chronic lymphocytic leukemia cells

Supplemental data

MYELOID NEOPLASIA

Distinct clustering of symptomatic burden among myeloproliferative neoplasm patients: retrospective assessment in 1470 patients

Holly L. Geyer,Robyn M. Scherber,Amylou C. Dueck,Jean-Jacques Kiladjian,Zhijian Xiao,Stefanie Slot,Sonja Zweegman,Federico Sackmann,Ana Kerguelen Fuentes,Dolores Hernández-Maraver,Konstanze Döhner,Claire N. Harrison,Deepti Radia,Pablo Muxi,Carlos Besses,Francisco Cervantes,Peter L. Johansson,Bjorn Andreasson,Alessandro Rambaldi,Tiziano Barbui,Alessandro M. Vannucchi,Francesco Passamonti,Jan Samuelsson,Gunnar Birgegard,Ruben A. Mesa

View Articletitled, Distinct clustering of symptomatic burden among myeloproliferative neoplasm patients: retrospective assessment in 1470 patients

Supplemental data

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

Inherited biallelic CSF3R mutations in severe congenital neutropenia

Alexa Triot,Päivi M. Järvinen,Juan I. Arostegui,Dhaarini Murugan,Naschla Kohistani,José Luis Dapena Díaz,Tomas Racek,Jacek Puchałka,E. Michael Gertz,Alejandro A. Schäffer,Daniel Kotlarz,Dietmar Pfeifer,Cristina Díaz de Heredia Rubio,Mehmet Akif Ozdemir,Turkan Patiroglu,Musa Karakukcu,José Sánchez de Toledo Codina,Jordi Yagüe,Ivo P. Touw,Ekrem Unal,Christoph Klein

View Articletitled, Inherited biallelic CSF3R mutations in severe congenital neutropenia

Supplemental data

RED CELLS, IRON, AND ERYTHROPOIESIS

Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease

Grace Chen,Dachuan Zhang,Tobias A. Fuchs,Deepa Manwani,Denisa D. Wagner,Paul S. Frenette

View Articletitled, Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease

Supplemental data

THROMBOSIS AND HEMOSTASIS

The thromboprotective effect of bortezomib is dependent on the transcription factor Kruppel-like factor 2 (KLF2)
Brief Report

Lalitha Nayak,Hong Shi,G. Brandon Atkins,Zhiyong Lin,Alvin H. Schmaier,Mukesh K. Jain

View Articletitled, The thromboprotective effect of bortezomib is dependent on the transcription factor Kruppel-like factor 2 (KLF2)

Supplemental data

TRANSPLANTATION

Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease

Silvia Spoerl,Nimitha R. Mathew,Michael Bscheider,Annette Schmitt-Graeff,Sophia Chen,Tony Mueller,Mareike Verbeek,Julius Fischer,Vera Otten,Martina Schmickl,Kristina Maas-Bauer,Jürgen Finke,Christian Peschel,Justus Duyster,Hendrik Poeck,Robert Zeiser,Nikolas von Bubnoff

View Articletitled, Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease

Supplemental data

OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues
e-blood

Mark Wunderlich,Ryan A. Brooks,Rushi Panchal,Garrett W. Rhyasen,Gwenn Danet-Desnoyers,James C. Mulloy

View Articletitled, OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues

ERRATA

Zhang F, Michaelson JE, Moshiach S, et al. Tetraspanin CD151 maintains vascular stability by balancing the forces of cell adhesion and cytoskeletal tension. Blood. 2011;118(15):4274-4284.

View Articletitled, Zhang F, Michaelson JE, Moshiach S, et al. Tetraspanin CD151 maintains vascular stability by balancing the forces of cell adhesion and cytoskeletal tension. Blood. 2011;118(15):4274-4284.

Gay F, Magarotto V, Crippa C, et al. Bortezomib induction, reduced-intensity transplantation, and lenalidomide consolidation-maintenance for myeloma: updated results. Blood. 2013;122(8):1376-1383.

View Articletitled, Gay F, Magarotto V, Crippa C, et al. Bortezomib induction, reduced-intensity transplantation, and lenalidomide consolidation-maintenance for myeloma: updated results. Blood. 2013;122(8):1376-1383.

Rowley JW, Oler AJ, Tolley ND, et al. Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes. Blood. 2011;118(14):e101-e111.

View Articletitled, Rowley JW, Oler AJ, Tolley ND, et al. Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes. Blood. 2011;118(14):e101-e111.

Cover Image

Cover Image

Immunofluorescence image of DNA (green) and citrullinated histone H3 (red) of NETs generated by TNF-α primed wild-type neutrophils, stimulated with heme. See the article by Chen et al on page 3818.
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Table of Contents

INSIDE BLOOD COMMENTARIES

Paving the road to MRD-guided treatment in CLL Clinical Trials & Observations

BLOOD WORK

PLENARY PAPER

PLENARY PAPER

BLOOD SPOTLIGHT

HOW I TREAT

CLINICAL TRIALS AND OBSERVATIONS

Eradication of bone marrow minimal residual disease may prompt early treatment discontinuation in CLL Clinical Trials & Observations

Biomarkers of terminal complement activation confirm the diagnosis of aHUS and differentiate aHUS from TTP Clinical Trials & Observations

Oncogenetics and minimal residual disease are independent outcome predictors in adult patients with acute lymphoblastic leukemia Clinical Trials & Observations

GENE THERAPY

HEMATOPOIESIS AND STEM CELLS

LYMPHOID NEOPLASIA

Stimulation of the B-cell receptor activates the JAK2/STAT3 signaling pathway in chronic lymphocytic leukemia cells Brief Report

MYELOID NEOPLASIA

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS

RED CELLS, IRON, AND ERYTHROPOIESIS

THROMBOSIS AND HEMOSTASIS

The thromboprotective effect of bortezomib is dependent on the transcription factor Kruppel-like factor 2 (KLF2) Brief Report

TRANSPLANTATION

OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues e-blood

ERRATA

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ASH Publications

American Society of Hematology

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Paving the road to MRD-guided treatment in CLL
Clinical Trials & Observations

Eradication of bone marrow minimal residual disease may prompt early treatment discontinuation in CLL
Clinical Trials & Observations

Biomarkers of terminal complement activation confirm the diagnosis of aHUS and differentiate aHUS from TTP
Clinical Trials & Observations

Oncogenetics and minimal residual disease are independent outcome predictors in adult patients with acute lymphoblastic leukemia
Clinical Trials & Observations

Stimulation of the B-cell receptor activates the JAK2/STAT3 signaling pathway in chronic lymphocytic leukemia cells
Brief Report

The thromboprotective effect of bortezomib is dependent on the transcription factor Kruppel-like factor 2 (KLF2)
Brief Report

OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues
e-blood