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Journal Articles

CLL Cell-Derived Exosomes Impair Immune Function and Normal Hematopoiesis in CLL

Blood (2023) 142 (Supplement 1): 3264.

https://doi.org/10.1182/blood-2023-190712

Published: 2023

Journal Articles

Constitutively Activated STAT3 Induces the Expression of Gli1 in Chronic Lymphocytic Leukemia Cells

Uri Rozovski, MD, David M. Harris, PhD, Ping Li, PhD, Zhiming Liu, BS, Taghi Manshouri, PhD, Ivo Veletic, MD, Preetesh Jain, MBBS,MDDM,PhD, Alessandra Ferrajoli, MD, Jan A. Burger, MD PhD, Prithviraj Bose, MD, Philip A. Thompson, MBBS, Nitin Jain, MD, Srdan Verstovsek, MD PhD, William G. Wierda, MD PhD, Michael J Keating, MBBS, Zeev E. Estrov, MD

Blood (2019) 134 (Supplement_1): 3018.

https://doi.org/10.1182/blood-2019-124014

Published: 2019

Journal Articles

STAT3-Induced Gli1 Promotes the Differentiation and Maturation of Myelofibrosis Fibrocytes

Taghi Manshouri, PhD, Ivo Veletic, MD, Ying Zhang, MD MS, Joseph E. Bove, IV, BS, Ping Li, PhD, David M. Harris, PhD, Zhiming Liu, BS, Evan N. Cohen, PhD, Srdan Verstovsek, MD PhD, Zeev E. Estrov, MD

Blood (2019) 134 (Supplement_1): 2961.

https://doi.org/10.1182/blood-2019-132054

Published: 2019

Journal Articles

Constitutively Activated STAT3 Induces the Production of PTX3 That Contributes to the Induction of Bone Marrow Reticulin Fibrosis in Patient with CLL

Blood (2019) 134 (Supplement_1): 3024.

https://doi.org/10.1182/blood-2019-124183

Published: 2019

Journal Articles

Endogenous STAT3-Activated Wnt5a Provides CLL Cells with Survival Advantage

Uri Rozovski, Ping Li, PhD, David M. Harris, Zhiming Liu, Preetesh Jain, MBBS, MDDM, PhD, Alessandra Ferrajoli, MD, Jan A. Burger, MD PhD, Prithviraj Bose, MD, Philip A. Thompson, MBBS, Nitin Jain, MD, William G. Wierda, MD PhD, Michael J. Keating, MD, Zeev E. Estrov, MD

Blood (2018) 132 (Supplement 1): 4398.

https://doi.org/10.1182/blood-2018-99-111960

Published: 2018

Journal Articles

CLL Cells with 13q- Are Characterized By High BCL2 Levels and CLL Cells with Trisomy-12 By Increased Activation of STAT3 and NF-κB

Uri Rozovski, David M. Harris, Ping Li, PhD, Zhiming Liu, Preetesh Jain, MBBS, MDDM, PhD, Alessandra Ferrajoli, MD, Jan A. Burger, MD PhD, Prithviraj Bose, MD, Philip A. Thompson, MBBS, Nitin Jain, MD, William G. Wierda, MD PhD, Michael J. Keating, MD, Zeev E. Estrov, MD

Blood (2018) 132 (Supplement 1): 4411.

https://doi.org/10.1182/blood-2018-99-114909

Published: 2018

Journal Articles

CLL Cell-Derived Exosomes Promote Bone Marrow Fibrosis and Inhibit Normal Hematopoietic Colony Proliferation

Uri Rozovski, MD, David M. Harris, Ping Li, PhD, Zhiming Liu, Taghi Manshouri, Ivo Veletic, MD, Carlos Bueso-Ramos, MD PhD, Preetesh Jain, MBBS,MDDM,PhD, Srdan Verstovsek, MD PhD, Alessandra Ferrajoli, MD, Jan A. Burger, MD PhD, Prithviraj Bose, MD, Philip A Thompson, MBBS, Nitin Jain, MD, William G Wierda, MD PhD, Michael J. Keating, MD, Zeev Estrov, MD

Blood (2017) 130 (Supplement 1): 1728.

https://doi.org/10.1182/blood.V130.Suppl_1.1728.1728

Published: 2017

Journal Articles

Overexpression of CD36, Driven By STAT3, Mediates Free Fatty Acid Uptake in CLL Cells

Uri Rozovski, MD, David M. Harris, Ping Li, PhD, Zhiming Liu, Preetesh Jain, MBBS,MDDM,PhD, Alessandra Ferrajoli, MD, Jan A. Burger, MD PhD, Prithviraj Bose, MD, Philip A Thompson, MBBS, Nitin Jain, MD, William G Wierda, MD PhD, Michael J. Keating, MD, Zeev Estrov, MD

Blood (2017) 130 (Supplement 1): 4301.

https://doi.org/10.1182/blood.V130.Suppl_1.4301.4301

Published: 2017

Journal Articles

Ibrutinib Disrupts the Metabolic Program of CLL Cells in-Vivo

Uri Rozovski, MD, David M. Harris, Ping LI, PhD, Zhiming Liu, Preetesh Jain, MBBS, MDDM,PhD, Alessandra Ferrajoli, MD, Jan A. Burger, MD PhD, Susan M. O'Brien, MD, Prithviraj Bose, MD, Philip A. Thompson, MBBS, Nitin Jain, MD, William G. Wierda, MD PhD, Michael Keating, MBBS, Zeev Estrov, MD

Blood (2016) 128 (22): 4348.

https://doi.org/10.1182/blood.V128.22.4348.4348

Published: 2016

Journal Articles

Casein Kinase-2 Induces Constitutive Phosphorylation of STAT3 in CLL Cells

Uri Rozovski, MD, David M. Harris, Ping LI, PhD, Zhiming Liu, Preetesh Jain, MBBS, MDDM, PhD, Alessandra Ferrajoli, MD, Jan A. Burger, MD PhD, Susan M. O'Brien, MD, Prithviraj Bose, MD, Philip A. Thompson, MBBS, Nitin Jain, MD, William G. Wierda, MD PhD, Michael Keating, MBBS, Zeev Estrov, MD

Blood (2016) 128 (22): 4374.

https://doi.org/10.1182/blood.V128.22.4374.4374

Published: 2016

Journal Articles

Stimulation of the B-Cell Receptor (BCR) Induces Successive Activation of STAT3 and Nuclear Factor-Kappa-B in CLL Cells

Uri Rozovski, MD, David M. Harris, Ping LI, PhD, Zhiming Liu, Alessandra Ferrajoli, MD, Jan A Burger, MD PhD, Philip Thompson, MBBS, Nitin Jain, MD, William Wierda, MD PhD, Michael Keating, MBBS, Zeev Estrov, MD

Blood (2015) 126 (23): 4125.

https://doi.org/10.1182/blood.V126.23.4125.4125

Published: 2015

Journal Articles

P300 Acetylates STAT3 and Increases Its Constitutive Transcriptional Activity in CLL Cells

Blood (2015) 126 (23): 4143.

https://doi.org/10.1182/blood.V126.23.4143.4143

Published: 2015

Journal Articles

Ruxolitinib Reduces Cytokine/Chemokine Levels and Improves Fatigue and Chronic Lymphocytic Leukemia (CLL)-Related Symptoms in CLL Patients Not Requiring Systemic Therapy

Preetesh Jain, MBBS,MDDM,PhD, Michael J. Keating, MD, Charles Cleeland, Sarah Renner, Huang Xuelin, Graciela Nogueras Gonzalez, David M. Harris, William Wierda, MD PhD, Courtney DiNardo, MD, Naveen Pemmaraju, Nitin Jain, MD, Philip Thompson, MBBS, Alessandra Ferrajoli, MD, Jan A. Burger, MD PhD, Hagop M. Kantarjian, MD, Srdan Verstovsek, MD, Zeev Estrov, MD

Blood (2015) 126 (23): 2943.

https://doi.org/10.1182/blood.V126.23.2943.2943

Published: 2015

Journal Articles

STAT3-Driven, Aberrantly Expressed Lipoprotein Lipase Mediates Free Fatty Acid Metabolism in Chronic Lymphocytic Leukemia Cells

Uri Rozovski, MD, Srdana Grgurevic, Carlos E. Bueso-Ramos, MD PhD, David M. Harris, Ping Li, PhD, Zhiming Liu, JI Yuan Wu, MD, William Wierda, MD PhD, Jan A. Burger, MD PhD, Susan O'Brien, MD, Nitin Jain, MD, Alessandra Ferrajoli, MD, Michael Keating, MBBS, Zeev Estrov, MD

Blood (2014) 124 (21): 3304.

https://doi.org/10.1182/blood.V124.21.3304.3304

Published: 2014

Journal Articles

Stimulation of the B-cell receptor activates the JAK2/STAT3 signaling pathway in chronic lymphocytic leukemia cells

Uri Rozovski, Ji Yuan Wu, David M. Harris, Zhiming Liu, Ping Li, Inbal Hazan-Halevy, Alessandra Ferrajoli, Jan A. Burger, Susan O’Brien, Nitin Jain, Srdan Verstovsek, William G. Wierda, Michael J. Keating, Zeev Estrov

Blood (2014) 123 (24): 3797–3802.

https://doi.org/10.1182/blood-2013-10-534073

Published: 2014

Includes: Supplemental data

Journal Articles

Janus Kinase (JAK)-2 Does Not Play a Role in Bcr-Abl Signaling in Philadelphia Chromosome (Ph)-Positive (p190) Acute Lymphoblastic Leukemia (ALL) Cells.

Stefan H. Faderl, MD, Quin Van, BS, Patricia E. Koch, MS, David M. Harris, BS, Inbal Hallevi, PhD, Zhiming Liu, BS, Yongtao Wang, MD, Alessandra Ferrajoli, MD, Zeev Estrov, MD

Blood (2007) 110 (11): 4241.

https://doi.org/10.1182/blood.V110.11.4241.4241

Published: 2007

Journal Articles

The Synthetic Hest Shock Protein (Hsp) 90 Inhibitor EC141 Induces Degradation of the Bcr-Abl p190 Protein and Apoptosis of Philadelphia Chromosome (Ph)-Positive Acute Lymphoblastic Leukemia (ALL) Cells.

Alessandra Ferrajoli, MD, Yongtao Wang, MD, Susan M. O’Brien, MD, Stefan H. Faderl, MD, David M. Harris, BS, Quin Van, BS, Inbal Hallevi, PhD, Zhiming Liu, BS, Patricia E. Koch, MS, John Sensintaffar, MS, Francis Burrows, PhD, Hagop M. Kantarjian, MD, Michael J. Keating, MB, BS, Zeev Estrov, MD

Blood (2007) 110 (11): 2784.

https://doi.org/10.1182/blood.V110.11.2784.2784

Published: 2007

Journal Articles

WP-1066, a Next-Generation Member of JAK-Stat Inhibitors, Induces Cell Cycle Arrest, Abrogates Proliferation, and Induces Apoptosis of Acute Myeloid Leukemia (AML) Cells.

Alessandra Ferrajoli, M.D., Stefan Faderl, M.D., Quin Van, B.S., David M. Harris, B.S., Waldemar Priebe, Ph.D., Hagop M. Kantarjian, M.D., Moshe Talpaz, M.D., Zeev Estrov, M.D.

Blood (2004) 104 (11): 1169.

https://doi.org/10.1182/blood.V104.11.1169.1169

Published: 2004

NARROW

CLL Cell-Derived Exosomes Impair Immune Function and Normal Hematopoiesis in CLL

Constitutively Activated STAT3 Induces the Expression of Gli1 in Chronic Lymphocytic Leukemia Cells

STAT3-Induced Gli1 Promotes the Differentiation and Maturation of Myelofibrosis Fibrocytes

Constitutively Activated STAT3 Induces the Production of PTX3 That Contributes to the Induction of Bone Marrow Reticulin Fibrosis in Patient with CLL

Endogenous STAT3-Activated Wnt5a Provides CLL Cells with Survival Advantage

CLL Cells with 13q- Are Characterized By High BCL2 Levels and CLL Cells with Trisomy-12 By Increased Activation of STAT3 and NF-κB

CLL Cell-Derived Exosomes Promote Bone Marrow Fibrosis and Inhibit Normal Hematopoietic Colony Proliferation

Overexpression of CD36, Driven By STAT3, Mediates Free Fatty Acid Uptake in CLL Cells

Ibrutinib Disrupts the Metabolic Program of CLL Cells in-Vivo

Casein Kinase-2 Induces Constitutive Phosphorylation of STAT3 in CLL Cells

Stimulation of the B-Cell Receptor (BCR) Induces Successive Activation of STAT3 and Nuclear Factor-Kappa-B in CLL Cells

P300 Acetylates STAT3 and Increases Its Constitutive Transcriptional Activity in CLL Cells

Ruxolitinib Reduces Cytokine/Chemokine Levels and Improves Fatigue and Chronic Lymphocytic Leukemia (CLL)-Related Symptoms in CLL Patients Not Requiring Systemic Therapy

STAT3-Driven, Aberrantly Expressed Lipoprotein Lipase Mediates Free Fatty Acid Metabolism in Chronic Lymphocytic Leukemia Cells

Stimulation of the B-cell receptor activates the JAK2/STAT3 signaling pathway in chronic lymphocytic leukemia cells

Janus Kinase (JAK)-2 Does Not Play a Role in Bcr-Abl Signaling in Philadelphia Chromosome (Ph)-Positive (p190) Acute Lymphoblastic Leukemia (ALL) Cells.

The Synthetic Hest Shock Protein (Hsp) 90 Inhibitor EC141 Induces Degradation of the Bcr-Abl p190 Protein and Apoptosis of Philadelphia Chromosome (Ph)-Positive Acute Lymphoblastic Leukemia (ALL) Cells.

WP-1066, a Next-Generation Member of JAK-Stat Inhibitors, Induces Cell Cycle Arrest, Abrogates Proliferation, and Induces Apoptosis of Acute Myeloid Leukemia (AML) Cells.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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