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Clinical regressions and broad immune activation following combination therapy targeting human NKT cells in myeloma
Stem cell transplantation can provide durable disease control in blastic plasmacytoid dendritic cell neoplasm: a retrospective study from the European Group for Blood and Marrow Transplantation
The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial
Phase 1 trial of IL-15 trans presentation blockade using humanized Mik-Beta-1 mAb in patients with T-cell large granular lymphocytic leukemia
Tyrosine kinome sequencing of pediatric acute lymphoblastic leukemia: a report from the Children's Oncology Group TARGET Project
Safety and efficacy of eltrombopag for treatment of chronic immune thrombocytopenia: results of the long-term, open-label EXTEND study
Issue Archive
January 17 2013
In this Issue
Table of Contents
Inside Blood
Blood Work
Plenary Paper
PLENARY PAPER
Clinical regressions and broad immune activation following combination therapy targeting human NKT cells in myeloma
Clinical Trials & Observations
Joshua Richter,Natalia Neparidze,Lin Zhang,Shiny Nair,Tamara Monesmith,Ranjini Sundaram,Fred Miesowicz,Kavita M. Dhodapkar,Madhav V. Dhodapkar
Review Article
Clinical Trials and Observations
Stem cell transplantation can provide durable disease control in blastic plasmacytoid dendritic cell neoplasm: a retrospective study from the European Group for Blood and Marrow Transplantation
Clinical Trials & Observations
Damien Roos-Weil,Sascha Dietrich,Ariane Boumendil,Emmanuelle Polge,Dominique Bron,Enric Carreras,Arturo Iriondo Atienza,William Arcese,Dietrich W. Beelen,Jan J. Cornelissen,Nicolaus Kröger,Giuseppe Milone,Giuseppe Rossi,Fabrice Jardin,Christina Peters,Vanderson Rocha,Anna Sureda,Mohamad Mohty,Peter Dreger,on behalf of the European Group for Blood and Marrow Transplantation Lymphoma, Pediatric Diseases, and Acute Leukemia Working Parties,on behalf of the European Group for Blood and Marrow Transplantation Lymphoma, Pediatric Diseases, and Acute Leukemia Working Parties,on behalf of the European Group for Blood and Marrow Transplantation Lymphoma, Pediatric Diseases, and Acute Leukemia Working Parties,on behalf of the European Group for Blood and Marrow Transplantation Lymphoma, Pediatric Diseases, and Acute Leukemia Working Parties,on behalf of the European Group for Blood and Marrow Transplantation Lymphoma, Pediatric Diseases, and Acute Leukemia Working Parties,on behalf of the European Group for Blood and Marrow Transplantation Lymphoma, Pediatric Diseases, and Acute Leukemia Working Parties,on behalf of the European Group for Blood and Marrow Transplantation Lymphoma, Pediatric Diseases, and Acute Leukemia Working Parties,on behalf of the European Group for Blood and Marrow Transplantation Lymphoma, Pediatric Diseases, and Acute Leukemia Working Parties,on behalf of the European Group for Blood and Marrow Transplantation Lymphoma, Pediatric Diseases, and Acute Leukemia Working Parties,on behalf of the European Group for Blood and Marrow Transplantation Lymphoma, Pediatric Diseases, and Acute Leukemia Working Parties,on behalf of the European Group for Blood and Marrow Transplantation Lymphoma, Pediatric Diseases, and Acute Leukemia Working Parties,on behalf of the European Group for Blood and Marrow Transplantation Lymphoma, Pediatric Diseases, and Acute Leukemia Working Parties,on behalf of the European Group for Blood and Marrow Transplantation Lymphoma, Pediatric Diseases, and Acute Leukemia Working Parties,on behalf of the European Group for Blood and Marrow Transplantation Lymphoma, Pediatric Diseases, and Acute Leukemia Working Parties,on behalf of the European Group for Blood and Marrow Transplantation Lymphoma, Pediatric Diseases, and Acute Leukemia Working Parties,on behalf of the European Group for Blood and Marrow Transplantation Lymphoma, Pediatric Diseases, and Acute Leukemia Working Parties,on behalf of the European Group for Blood and Marrow Transplantation Lymphoma, Pediatric Diseases, and Acute Leukemia Working Parties,on behalf of the European Group for Blood and Marrow Transplantation Lymphoma, Pediatric Diseases, and Acute Leukemia Working Parties,on behalf of the European Group for Blood and Marrow Transplantation Lymphoma, Pediatric Diseases, and Acute Leukemia Working Parties
Hematopoiesis and Stem Cells
Immunobiology
Human plasmacytoid dendritic cells efficiently cross-present exogenous Ags to CD8+ T cells despite lower Ag uptake than myeloid dendritic cell subsets
Jurjen Tel,Gerty Schreibelt,Simone P. Sittig,Till S. M. Mathan,Sonja I. Buschow,Luis J. Cruz,Annechien J. A. Lambeck,Carl G. Figdor,I. Jolanda M. de Vries
Lymphoid Neoplasia
The clinical significance of NOTCH1 and SF3B1 mutations in the UK LRF CLL4 trial
CME
Clinical Trials & Observations
David G. Oscier,Matthew J. J. Rose-Zerilli,Nils Winkelmann,David Gonzalez de Castro,Belen Gomez,Jade Forster,Helen Parker,Anton Parker,Anne Gardiner,Andrew Collins,Monica Else,Nicholas C. P. Cross,Daniel Catovsky,Jonathan C. Strefford
Phase 1 trial of IL-15 trans presentation blockade using humanized Mik-Beta-1 mAb in patients with T-cell large granular lymphocytic leukemia
Clinical Trials & Observations
Thomas A. Waldmann,Kevin C. Conlon,Donn M. Stewart,TatYana A. Worthy,John E. Janik,Thomas A. Fleisher,Paul S. Albert,William D. Figg,Shawn D. Spencer,Mark Raffeld,Jean R. Decker,Carolyn K. Goldman,Bonita R. Bryant,Michael N. Petrus,Stephen P. Creekmore,John C. Morris
Tyrosine kinome sequencing of pediatric acute lymphoblastic leukemia: a report from the Children's Oncology Group TARGET Project
Brief Report
Mignon L. Loh,Jinghui Zhang,Richard C. Harvey,Kathryn Roberts,Debbie Payne-Turner,Huining Kang,Gang Wu,Xiang Chen,Jared Becksfort,Michael Edmonson,Kenneth H. Buetow,William L. Carroll,I-Ming Chen,Brent Wood,Michael J. Borowitz,Meenakshi Devidas,Daniela S. Gerhard,Paul Bowman,Eric Larsen,Naomi Winick,Elizabeth Raetz,Malcolm Smith,James R. Downing,Cheryl L. Willman,Charles G. Mullighan,Stephen P. Hunger
Myeloid Neoplasia
BCR-ABL1 compound mutations in tyrosine kinase inhibitor–resistant CML: frequency and clonal relationships
Jamshid S. Khorashad,Todd W. Kelley,Philippe Szankasi,Clinton C. Mason,Simona Soverini,Lauren T. Adrian,Christopher A. Eide,Matthew S. Zabriskie,Thoralf Lange,Johanna C. Estrada,Anthony D. Pomicter,Anna M. Eiring,Ira L. Kraft,David J. Anderson,Zhimin Gu,Mary Alikian,Alistair G. Reid,Letizia Foroni,David Marin,Brian J. Druker,Thomas O'Hare,Michael W. Deininger
Epigenetic silencing of microRNA-193a contributes to leukemogenesis in t(8;21) acute myeloid leukemia by activating the PTEN/PI3K signal pathway
Yonghui Li,Li Gao,Xufeng Luo,Lili Wang,Xiaoning Gao,Wei Wang,Junzhong Sun,Liping Dou,Jingxin Li,Chengwang Xu,Lixin Wang,Minhang Zhou,Mengmeng Jiang,Jihao Zhou,Michael A. Caligiuri,Clara Nervi,Clara D. Bloomfield,Guido Marcucci,Li Yu
Phagocytes, Granulocytes, and Myelopoiesis
Platelets and Thrombopoiesis
Safety and efficacy of eltrombopag for treatment of chronic immune thrombocytopenia: results of the long-term, open-label EXTEND study
Clinical Trials & Observations
Mansoor N. Saleh,James B. Bussel,Gregory Cheng,Oliver Meyer,Christine K. Bailey,Michael Arning,Andres Brainsky,on behalf of the EXTEND Study Group,on behalf of the EXTEND Study Group,on behalf of the EXTEND Study Group,on behalf of the EXTEND Study Group,on behalf of the EXTEND Study Group,on behalf of the EXTEND Study Group,on behalf of the EXTEND Study Group
Red Cells, Iron, and Erythropoiesis
Abnormal properties of red blood cells suggest a role in the pathophysiology of Gaucher disease
Melanie Franco,Emmanuel Collec,Philippe Connes,Emile van den Akker,Thierry Billette de Villemeur,Nadia Belmatoug,Marieke von Lindern,Nejma Ameziane,Olivier Hermine,Yves Colin,Caroline Le Van Kim,Cyril Mignot
Transplantation
Continuing Medical Education (CME) questions
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Cover Image
Cover Image
![issue cover]()
Representative immunofluoresence microscopy image of double-layer mouse mesentery exhibiting strong IL-33 expression (red) in a majority of the cells. Endothelial cells, CD31, is labeled (green), and DAPI (blue) is used for nuclear staining. See the article by Enoksson et al on page 530.
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