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Journal Articles

Epigenetic silencing of microRNA-193a contributes to leukemogenesis in t(8;21) acute myeloid leukemia by activating the PTEN /PI3K signal pathway

Yonghui Li, Li Gao, Xufeng Luo, Lili Wang, Xiaoning Gao, Wei Wang, Junzhong Sun, Liping Dou, Jingxin Li, Chengwang Xu, Lixin Wang, Minhang Zhou, Mengmeng Jiang, Jihao Zhou, Michael A. Caligiuri, Clara Nervi, Clara D. Bloomfield, Guido Marcucci, Li Yu

Blood (2013) 121 (3): 499–509.

https://doi.org/10.1182/blood-2012-07-444729

Published: 2013

Includes: Supplemental data

Journal Articles

Polycombs and microRNA-223 regulate human granulopoiesis by transcriptional control of target gene expression

Giuseppe Zardo, Alberto Ciolfi, Laura Vian, Linda M. Starnes, Monia Billi, Serena Racanicchi, Carmen Maresca, Francesco Fazi, Lorena Travaglini, Nelida Noguera, Marco Mancini, Mauro Nanni, Giuseppe Cimino, Francesco Lo-Coco, Francesco Grignani, Clara Nervi

Blood (2012) 119 (17): 4034–4046.

https://doi.org/10.1182/blood-2011-08-371344

Published: 2012

Includes: Supplemental data

Journal Articles

NFI-A directs the fate of hematopoietic progenitors to the erythroid or granulocytic lineage and controls β-globin and G-CSF receptor expression

Linda Marie Starnes, Antonio Sorrentino, Elvira Pelosi, Monica Ballarino, Ornella Morsilli, Mauro Biffoni, Simona Santoro, Nadia Felli, Germana Castelli, Maria Laura De Marchis, Gianfranco Mastroberardino, Marco Gabbianelli, Alessandro Fatica, Irene Bozzoni, Clara Nervi, Cesare Peschle

Blood (2009) 114 (9): 1753–1763.

https://doi.org/10.1182/blood-2008-12-196196

Published: 2009

Includes: Supplemental data

Journal Articles

Treatment with Sequential Valproic Acid (VPA) +/− Low Doses All Trans Retinoic Acid (LoATRA) and Low Doses Ara-C (LoDAC) for “De Novo” or Relapsed Acute Myeloid Leukaemia (AML).

Susanna Fenu, MD, Clara Nervi, Carolina Nobile, MD, Anna Chierichini, MD, Paola Anticoli Borza, MD, Barbara Anaclerico, MD, Velia Bongarzoni, MD, Loredana Bove, MD, Stefania Cortese, MD, Fulivio Pauselli, MD, Carla Tozzi, MD, Su Ellen Vignetti, MD, Giuseppe G. Cimino, Luciana Annino, MD

Blood (2007) 110 (11): 4362.

https://doi.org/10.1182/blood.V110.11.4362.4362

Published: 2007

Journal Articles

Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemia

Francesco Fazi, Giuseppe Zardo, Vania Gelmetti, Lorena Travaglini, Alberto Ciolfi, Luciano Di Croce, Alessandro Rosa, Irene Bozzoni, Francesco Grignani, Francesco Lo-Coco, Pier Giuseppe Pelicci, Clara Nervi

Blood (2007) 109 (10): 4432–4440.

https://doi.org/10.1182/blood-2006-09-045781

Published: 2007

Journal Articles

Targeting the Tetramerization by a Specific Peptide Abrogates the Transformation Potential of BCR/ABL and Some of Its Imatinib-Resistant Mutants.

Tim Beissert, Alena Hundertmark, Velina Kaburova, Afsar A. Mian, Lorena Travaglini, Oliver G. Ottmann, Dieter Hoelzer, Clara Nervi, Martin Ruthardt

Blood (2006) 108 (11): 2186.

https://doi.org/10.1182/blood.V108.11.2186.2186

Published: 2006

Journal Articles

Expression of SMRTβ promotes ligand-induced activation of mutated and wild-type retinoid receptors

Sylvie Côté, Suzan McNamara, Daria Brambilla, Andrea Bianchini, Giovanni Rizzo, Sonia Victoria del Rincón, Francesco Grignani, Clara Nervi, Wilson H. Miller, Jr

Blood (2004) 104 (13): 4226–4235.

https://doi.org/10.1182/blood-2003-10-3583

Published: 2004

Journal Articles

Targeting of the N-terminal coiled coil oligomerization interface of BCR interferes with the transformation potential of BCR-ABL and increases sensitivity to STI571

Tim Beissert, Elena Puccetti, Andrea Bianchini, Saskia Güller, Simone Boehrer, Dieter Hoelzer, Oliver Gerhard Ottmann, Clara Nervi, Martin Ruthardt

Blood (2003) 102 (8): 2985–2993.

https://doi.org/10.1182/blood-2003-03-0811

Published: 2003

Journal Articles

Response to histone deacetylase inhibition of novel PML/RARα mutants detected in retinoic acid–resistant APL cells

Sylvie Côté, Angelika Rosenauer, Andrea Bianchini, Karen Seiter, Jonathan Vandewiele, Clara Nervi, Wilson H. Miller, Jr

Blood (2002) 100 (7): 2586–2596.

https://doi.org/10.1182/blood-2002-02-0614

Published: 2002

Journal Articles

Complete remission through blast cell differentiation in PLZF/RARα -positive acute promyelocytic leukemia: in vitro and in vivo studies

Maria C. Petti, Francesco Fazi, Massimo Gentile, Daniela Diverio, Paolo De Fabritiis, M. Stefania De Propris, Roberto Fiorini, Maria A. Aloe Spiriti, Fabrizio Padula, Pier Giuseppe Pelicci, Clara Nervi, Francesco Lo Coco

Blood (2002) 100 (3): 1065–1067.

https://doi.org/10.1182/blood-2001-12-0368

Published: 2002

Journal Articles

Altered ligand binding and transcriptional regulation by mutations in the PML/RARα ligand-binding domain arising in retinoic acid–resistant patients with acute promyelocytic leukemia

Sylvie Côté, Dacheng Zhou, Andrea Bianchini, Clara Nervi, Robert E. Gallagher, Wilson H. Miller, Jr

Blood (2000) 96 (9): 3200–3208.

https://doi.org/10.1182/blood.V96.9.3200

Published: 2000

Journal Articles

Genetic Diagnosis and Molecular Monitoring in the Management of Acute Promyelocytic Leukemia

Francesco Lo Coco, Daniela Diverio, Brunangelo Falini, Andrea Biondi, Clara Nervi, Pier Giuseppe Pelicci

Blood (1999) 94 (1): 12–22.

https://doi.org/10.1182/blood.V94.1.12.413a44_12_22

Published: 1999

Journal Articles

Constitutive Degradation of PML/RAR Through the Proteasome Pathway Mediates Retinoic Acid Resistance

Mirco Fanelli, Saverio Minucci, Vania Gelmetti, Clara Nervi, Carlo Gambacorti-Passerini, Pier Giuseppe Pelicci

Blood (1999) 93 (5): 1477–1481.

https://doi.org/10.1182/blood.V93.5.1477

Published: 1999

Journal Articles

Caspases Mediate Retinoic Acid–Induced Degradation of the Acute Promyelocytic Leukemia PML/RARα Fusion Protein

Clara Nervi, Fabiana F. Ferrara, Mirco Fanelli, Maria Rita Rippo, Barbara Tomassini, Pier Francesco Ferrucci, Martin Ruthardt, Vania Gelmetti, Carlo Gambacorti-Passerini, Daniela Diverio, Francesco Grignani, Pier Giuseppe Pelicci, Roberto Testi

Blood (1998) 92 (7): 2244–2251.

https://doi.org/10.1182/blood.V92.7.2244

Published: 1998

Journal Articles

Characterization of the Retinoid Binding Properties of the Major Fusion Products Present in Acute Promyelocytic Leukemia Cells

Laura Benedetti, Arthur A. Levin, Bianca M. Scicchitano, Francesco Grignani, Gary Allenby, Daniela Diverio, Francesco Lo Coco, Giuseppe Avvisati, Martin Ruthardt, Sergio Adamo, Pier Giuseppe Pelicci, Clara Nervi

Blood (1997) 90 (3): 1175–1185.

https://doi.org/10.1182/blood.V90.3.1175

Published: 1997

Journal Articles

A Retinoid-Resistant Acute Promyelocytic Leukemia Subclone Expresses a Dominant Negative PML-RARα Mutation

Wenlin Shao, Laura Benedetti, William W. Lamph, Clara Nervi, Wilson H. Miller, Jr

Blood (1997) 89 (12): 4282–4289.

https://doi.org/10.1182/blood.V89.12.4282

Published: 1997

NARROW

Epigenetic silencing of microRNA-193a contributes to leukemogenesis in t(8;21) acute myeloid leukemia by activating the PTEN /PI3K signal pathway

Polycombs and microRNA-223 regulate human granulopoiesis by transcriptional control of target gene expression

NFI-A directs the fate of hematopoietic progenitors to the erythroid or granulocytic lineage and controls β-globin and G-CSF receptor expression

Treatment with Sequential Valproic Acid (VPA) +/− Low Doses All Trans Retinoic Acid (LoATRA) and Low Doses Ara-C (LoDAC) for “De Novo” or Relapsed Acute Myeloid Leukaemia (AML).

Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemia

Targeting the Tetramerization by a Specific Peptide Abrogates the Transformation Potential of BCR/ABL and Some of Its Imatinib-Resistant Mutants.

Expression of SMRTβ promotes ligand-induced activation of mutated and wild-type retinoid receptors

Targeting of the N-terminal coiled coil oligomerization interface of BCR interferes with the transformation potential of BCR-ABL and increases sensitivity to STI571

Response to histone deacetylase inhibition of novel PML/RARα mutants detected in retinoic acid–resistant APL cells

Complete remission through blast cell differentiation in PLZF/RARα -positive acute promyelocytic leukemia: in vitro and in vivo studies

Altered ligand binding and transcriptional regulation by mutations in the PML/RARα ligand-binding domain arising in retinoic acid–resistant patients with acute promyelocytic leukemia

Genetic Diagnosis and Molecular Monitoring in the Management of Acute Promyelocytic Leukemia

Constitutive Degradation of PML/RAR Through the Proteasome Pathway Mediates Retinoic Acid Resistance

Caspases Mediate Retinoic Acid–Induced Degradation of the Acute Promyelocytic Leukemia PML/RARα Fusion Protein

Characterization of the Retinoid Binding Properties of the Major Fusion Products Present in Acute Promyelocytic Leukemia Cells

A Retinoid-Resistant Acute Promyelocytic Leukemia Subclone Expresses a Dominant Negative PML-RARα Mutation

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American Society of Hematology

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American Society of Hematology

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