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Issue Archive

Volume 121, Issue 11
March 14 2013
Issue Cover

Table of Contents

Inside Blood

CLINICAL TRIALS & OBSERVATIONS
Acute promyelocytic leukemia: progress far and wide
Clinical Trials & Observations
Bayard L. Powell
View Articletitled, Acute promyelocytic leukemia: progress far and wide
CLINICAL TRIALS & OBSERVATIONS
“IM iD”eally treating multiple myeloma
Clinical Trials & Observations
Martha Q. Lacy
View Articletitled, “IM iD”eally treating multiple myeloma
CLINICAL TRIALS & OBSERVATIONS
ITP: hematology’s Cosette from Les Misérables
Clinical Trials & Observations
V. Koneti Rao
View Articletitled, ITP: hematology’s Cosette from <em>Les Misérables</em>
INSIDE BLOOD
Too much or too little, how much HDAC activity is good for you?
Patrick Matthias
View Articletitled, Too much or too little, how much HDAC activity is good for you?
THROMBOSIS & HEMOSTASIS
Interaction between FXIII and fibrinogen
Hans P. Kohler
View Articletitled, Interaction between FXIII and fibrinogen
THROMBOSIS & HEMOSTASIS
Heparin – not only thinning the blood
Sascha Drewlo
View Articletitled, Heparin – not only thinning the blood

Blood Work

Leukemic phase of ALK-positive anaplastic large cell lymphoma
Rong He,David S. Viswanatha
View Articletitled, Leukemic phase of ALK-positive anaplastic large cell lymphoma

Plenary Paper

Improving acute promyelocytic leukemia (APL) outcome in developing countries through networking, results of the International Consortium on APL
Eduardo M. Rego,Haesook T. Kim,Guillermo J. Ruiz-Argüelles,Maria Soledad Undurraga,Maria del Rosario Uriarte,Rafael H. Jacomo,Homero Gutiérrez-Aguirre,Raul A. M. Melo,Rosane Bittencourt,Ricardo Pasquini,Katia Pagnano,Evandro M. Fagundes,Maria de Lourdes Chauffaille,Carlos S. Chiattone,Lem Martinez,Luis A. Meillón,David Gómez-Almaguer,Hau C. Kwaan,Javier Garcés-Eisele,Robert Gallagher,Charlotte M. Niemeyer,Stanley L. Schrier,Martin Tallman,David Grimwade,Arnold Ganser,Nancy Berliner,Raul C. Ribeiro,Francesco Lo-Coco,Bob Löwenberg,Miguel A. Sanz
View Articletitled, Improving acute promyelocytic leukemia (APL) outcome in developing countries through networking, results of the International Consortium on APL
Supplemental data

Perspectives

Thrombin generation and whole blood viscoelastic assays in the management of hemophilia: current state of art and future perspectives
Guy Young,Benny Sørensen,Yesim Dargaud,Claude Negrier,Kathleen Brummel-Ziedins,Nigel S. Key
View Articletitled, Thrombin generation and whole blood viscoelastic assays in the management of hemophilia: current state of art and future perspectives

Review Article

The CD300 molecules: an emerging family of regulators of the immune system
Francisco Borrego
View Articletitled, The CD300 molecules: an emerging family of regulators of the immune system

Clinical Trials and Observations

Phase 1 study of pomalidomide MTD, safety, and efficacy in patients with refractory multiple myeloma who have received lenalidomide and bortezomib
Clinical Trials & Observations
Paul G. Richardson,David Siegel,Rachid Baz,Susan L. Kelley,Nikhil C. Munshi,Jacob Laubach,Daniel Sullivan,Melissa Alsina,Robert Schlossman,Irene M. Ghobrial,Deborah Doss,Nora Loughney,Laura McBride,Elizabeth Bilotti,Palka Anand,Lisa Nardelli,Sandra Wear,Gail Larkins,Min Chen,Mohamad H. Zaki,Christian Jacques,Kenneth C. Anderson
View Articletitled, Phase 1 study of pomalidomide MTD, safety, and efficacy in patients with refractory multiple myeloma who have received lenalidomide and bortezomib
Pomalidomide plus low-dose dexamethasone is active and well tolerated in bortezomib and lenalidomide–refractory multiple myeloma: Intergroupe Francophone du Myélome 2009-02
Clinical Trials & Observations
Xavier Leleu,Michel Attal,Bertrand Arnulf,Philippe Moreau,Catherine Traulle,Gerald Marit,Claire Mathiot,Marie Odile Petillon,Margaret Macro,Murielle Roussel,Brigitte Pegourie,Brigitte Kolb,Anne Marie Stoppa,Bernadette Hennache,Sabine Bréchignac,Nathalie Meuleman,Beatrice Thielemans,Laurent Garderet,Bruno Royer,Cyrille Hulin,Lotfi Benboubker,Olivier Decaux,Martine Escoffre-Barbe,Mauricette Michallet,Denis Caillot,Jean Paul Fermand,Hervé Avet-Loiseau,Thierry Facon,on behalf of Intergroupe Francophone du Myélome
View Articletitled, Pomalidomide plus low-dose dexamethasone is active and well tolerated in bortezomib and lenalidomide–refractory multiple myeloma: Intergroupe Francophone du Myélome 2009-02
Supplemental data
Rituximab and dexamethasone vs dexamethasone monotherapy in newly diagnosed patients with primary immune thrombocytopenia
Clinical Trials & Observations
Sif Gudbrandsdottir,Henrik Sverre Birgens,Henrik Frederiksen,Bjarne Anker Jensen,Morten Krogh Jensen,Lars Kjeldsen,Tobias Wirenfeldt Klausen,Herdis Larsen,Hans Torben Mourits-Andersen,Claus Henrik Nielsen,Ove Juul Nielsen,Torben Plesner,Stanislaw Pulczynski,Inge Helleberg Rasmussen,Dorthe Rønnov-Jessen,Hans Carl Hasselbalch
View Articletitled, Rituximab and dexamethasone vs dexamethasone monotherapy in newly diagnosed patients with primary immune thrombocytopenia
Supplemental data
BiRd (clarithromycin, lenalidomide, dexamethasone): an update on long-term lenalidomide therapy in previously untreated patients with multiple myeloma
Brief Report
Adriana Rossi,Tomer Mark,David Jayabalan,Paul Christos,Faiza Zafar,Karen Pekle,Roger Pearse,Selina Chen-Kiang,Morton Coleman,Ruben Niesvizky
View Articletitled, <strong>BiRd (clarithromycin, lenalidomide, dexamethasone): an update on long-term lenalidomide therapy in previously untreated patients with multiple myeloma</strong>
Supplemental data

Hematopoiesis and Stem Cells

The function of hematopoietic stem cells is altered by both genetic and inflammatory factors in lupus mice
Haitao Niu,Guoqiang Fang,Yiting Tang,Luokun Xie,Huan Yang,Laurence Morel,Betty Diamond,Yong-Rui Zou
View Articletitled, The function of hematopoietic stem cells is altered by both genetic and inflammatory factors in lupus mice
Prostaglandin E2 regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells
Yoshiko Matsumoto Ikushima,Fumio Arai,Kentaro Hosokawa,Hirofumi Toyama,Keiyo Takubo,Tomoyuki Furuyashiki,Shuh Narumiya,Toshio Suda
View Articletitled, Prostaglandin E<sub>2</sub> regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells
Supplemental data
Fetal origins of hematopoietic failure in a murine model of Fanconi anemia
Brief Report
Ashley N. Kamimae-Lanning,Natalya A. Goloviznina,Peter Kurre
View Articletitled, Fetal origins of hematopoietic failure in a murine model of Fanconi anemia

Immunobiology

Therapeutic preparations of IVIg contain naturally occurring anti–HLA-E antibodies that react with HLA-Ia (HLA-A/-B/-Cw) alleles
Mepur H. Ravindranath,Paul I. Terasaki,Tho Pham,Vadim Jucaud,Satoru Kawakita
View Articletitled, Therapeutic preparations of IVIg contain naturally occurring anti–HLA-E antibodies that react with HLA-Ia (HLA-A/-B/-Cw) alleles
Blood cell mRNAs and microRNAs: optimized protocols for extraction and preservation
e-blood
Michael Eikmans,Niels V. Rekers,Jacqueline D. H. Anholts,Sebastiaan Heidt,Frans H. J. Claas
View Articletitled, Blood cell mRNAs and microRNAs: optimized protocols for extraction and preservation

Lymphoid Neoplasia

Markedly additive antitumor activity with the combination of a selective survivin suppressant YM155 and alemtuzumab in adult T-cell leukemia
Jing Chen,Cynthia A. Pise-Masison,Joanna H. Shih,John C. Morris,John E. Janik,Kevin C. Conlon,Anne Keating,Thomas A. Waldmann
View Articletitled, Markedly additive antitumor activity with the combination of a selective survivin suppressant YM155 and alemtuzumab in adult T-cell leukemia
Supplemental data
Dosage-dependent tumor suppression by histone deacetylases 1 and 2 through regulation of c-Myc collaborating genes and p53 function
Marinus R. Heideman,Roel H. Wilting,Eva Yanover,Arno Velds,Johann de Jong,Ron M. Kerkhoven,Heinz Jacobs,Lodewyk F. Wessels,Jan-Hermen Dannenberg
View Articletitled, Dosage-dependent tumor suppression by histone deacetylases 1 and 2 through regulation of c-Myc collaborating genes and p53 function
Supplemental data
MYD88 L265P in Waldenström macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction
Lian Xu,Zachary R. Hunter,Guang Yang,Yangsheng Zhou,Yang Cao,Xia Liu,Enrica Morra,Alessandra Trojani,Antonino Greco,Luca Arcaini,Marzia Varettoni,Jennifer R. Brown,Yu-Tzu Tai,Kenneth C. Anderson,Nikhil C. Munshi,Christopher J. Patterson,Robert J. Manning,Christina K. Tripsas,Neal I. Lindeman,Steven P. Treon
View Articletitled, MYD88 L265P in Waldenström macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction
Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis
Brief Report
Aparna Vasanthakumar,Janet B. Lepore,Matthew H. Zegarek,Masha Kocherginsky,Mahi Singh,Elizabeth M. Davis,Petra A. Link,John Anastasi,Michelle M. Le Beau,Adam R. Karpf,Lucy A. Godley
View Articletitled, <em>Dnmt3b</em> is a haploinsufficient tumor suppressor gene in <em>Myc</em>-induced lymphomagenesis
Supplemental data

Myeloid Neoplasia

Inhibition of the receptor tyrosine kinase Axl impedes activation of the FLT3 internal tandem duplication in human acute myeloid leukemia: implications for Axl as a potential therapeutic target
Il-Kyoo Park,Anjali Mishra,Jason Chandler,Susan P. Whitman,Guido Marcucci,Michael A. Caligiuri
View Articletitled, Inhibition of the receptor tyrosine kinase Axl impedes activation of the FLT3 internal tandem duplication in human acute myeloid leukemia: implications for Axl as a potential therapeutic target
Supplemental data

Phagocytes, Granulocytes, and Myelopoiesis

Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans
Shigeharu Ueki,Rossana C. N. Melo,Ionita Ghiran,Lisa A. Spencer,Ann M. Dvorak,Peter F. Weller
View Articletitled, Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans
Supplemental data
Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b β2-integrin–dependent signaling
Sarah J. McMillan,Ritu S. Sharma,Emma J. McKenzie,Hannah E. Richards,Jiquan Zhang,Alan Prescott,Paul R. Crocker
View Articletitled, Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b β2-integrin–dependent signaling
Supplemental data

Platelets and Thrombopoiesis

MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP)
Brief Report
Margareta Jernås,Intawat Nookaew,Hans Wadenvik,Bob Olsson
View Articletitled, MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP)
Supplemental data

Red Cells, Iron, and Erythropoiesis

Erythrocyte NADPH oxidase activity modulated by Rac GTPases, PKC, and plasma cytokines contributes to oxidative stress in sickle cell disease
Alex George,Suvarnamala Pushkaran,Diamantis G. Konstantinidis,Sebastian Koochaki,Punam Malik,Narla Mohandas,Yi Zheng,Clinton H. Joiner,Theodosia A. Kalfa
View Articletitled, Erythrocyte NADPH oxidase activity modulated by Rac GTPases, PKC, and plasma cytokines contributes to oxidative stress in sickle cell disease
Supplemental data

Thrombosis and Hemostasis

A novel B-domain O-glycoPEGylated FVIII (N8-GP) demonstrates full efficacy and prolonged effect in hemophilic mice models
Henning R. Stennicke,Marianne Kjalke,Ditte M. Karpf,Kristoffer W. Balling,Peter B. Johansen,Torben Elm,Kristine Øvlisen,Flemming Möller,Heidi L. Holmberg,Charlotte N. Gudme,Egon Persson,Ida Hilden,Hermann Pelzer,Henrik Rahbek-Nielsen,Christina Jespersgaard,Are Bogsnes,Anette A. Pedersen,Anne K. Kristensen,Bernd Peschke,Wendy Kappers,Frederik Rode,Lars Thim,Mikael Tranholm,Mirella Ezban,Eva H. N. Olsen,Søren E. Bjørn
View Articletitled, A novel B-domain <em>O</em>-glycoPEGylated FVIII (N8-GP) demonstrates full efficacy and prolonged effect in hemophilic mice models
Supplemental data
The activation peptide cleft exposed by thrombin cleavage of FXIII-A2 contains a recognition site for the fibrinogen α chain
Kerrie A. Smith,Richard J. Pease,Craig A. Avery,Jane M. Brown,Penelope J. Adamson,Esther J. Cooke,Søs Neergaard-Petersen,Paul A. Cordell,Robert A. S. Ariëns,Colin W. G. Fishwick,Helen Philippou,Peter J. Grant
View Articletitled, The activation peptide cleft exposed by thrombin cleavage of FXIII-A<sub>2</sub> contains a recognition site for the fibrinogen α chain
Supplemental data
Heparin rescues factor V Leiden–associated placental failure independent of anticoagulation in a murine high-risk pregnancy model
Jianzhong An,Magarya S. Waitara,Michelle Bordas,Vidhyalakshmi Arumugam,Raymond G. Hoffmann,Brian G. Petrich,Uma Sinha,Paula E. North,Rashmi Sood
View Articletitled, Heparin rescues factor V Leiden–associated placental failure independent of anticoagulation in a murine high-risk pregnancy model
Supplemental data
Mutations in the A3 domain of Von Willebrand factor inducing combined qualitative and quantitative defects in the protein
Paulette Legendre,Ana-Maria Navarrete,Julie Rayes,Caterina Casari,Pierre Boisseau,Catherine Ternisien,Claudine Caron,Edith Fressinaud,Jenny Goudemand,Agnès Veyradier,Cécile V. Denis,Peter J. Lenting,Olivier D. Christophe
View Articletitled, Mutations in the A3 domain of Von Willebrand factor inducing combined qualitative and quantitative defects in the protein
Supplemental data

Transplantation

Intrathymic progenitor cell transplantation across histocompatibility barriers results in the persistence of early thymic progenitors and T-cell differentiation
Stéphanie C. de Barros,Rita Vicente,Karim Chebli,Chantal Jacquet,Valérie S. Zimmermann,Naomi Taylor
View Articletitled, Intrathymic progenitor cell transplantation across histocompatibility barriers results in the persistence of early thymic progenitors and T-cell differentiation

Vascular Biology

The vascular permeabilizing factors histamine and serotonin induce angiogenesis through TR3/Nur77 and subsequently truncate it through thrombospondin-1
Liuliang Qin,Dezheng Zhao,Jianfeng Xu,Xianghui Ren,Ernest F. Terwilliger,Sareh Parangi,Jack Lawler,Harold F. Dvorak,Huiyan Zeng
View Articletitled, The vascular permeabilizing factors histamine and serotonin induce angiogenesis through TR3/Nur77 and subsequently truncate it through thrombospondin-1
Supplemental data
  • Cover Image

    Cover Image

    issue cover

    Wright-Giemsa stained bone marrow aspirate smear of acute promyelocytic leukemia (APL) demonstrating numerous myeloblasts and promyelocytes containing abundant cytoplasmic granules and Auer rods. Advances in survival of APL in South/Central America made possible by the development of the International Consortium on APL (IC-APL), a network for sharing data, information, and expertise. Median survival increased to a level similar to that seen in the US and Western Europe. Image courtesy of Michael W. Beaty, MD, Department of Pathology, Wake Forest School of Medicine. See the article by Powell on page 1925 and by Rego et al on page 1935.

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