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Journal Articles

FXII inhibition: multipronged benefits

Helen Philippou

Blood (2021) 138 (2): 107–109.

https://doi.org/10.1182/blood.2021011032

Published: 2021

Journal Articles

Heavy chain of FXII: not an innocent bystander!

Helen Philippou

Blood (2019) 133 (10): 1008–1009.

https://doi.org/10.1182/blood-2019-01-895110

Published: 2019

Journal Articles

The interaction between fibrinogen and zymogen FXIII-A 2 B 2 is mediated by fibrinogen residues γ390-396 and the FXIII-B subunits

James R. Byrnes, Clare Wilson, Anthony M. Boutelle, Chase B. Brandner, Matthew J. Flick, Helen Philippou, Alisa S. Wolberg

Blood (2016) 128 (15): 1969–1978.

https://doi.org/10.1182/blood-2016-04-712323

Published: 2016

Includes: Supplemental data

Journal Articles

Ranking reactive glutamines in the fibrinogen αC region that are targeted by blood coagulant factor XIII

Kelly Njine Mouapi, Jacob D. Bell, Kerrie A. Smith, Robert A. S. Ariëns, Helen Philippou, Muriel C. Maurer

Blood (2016) 127 (18): 2241–2248.

https://doi.org/10.1182/blood-2015-09-672303

Published: 2016

Includes: Supplemental data

Journal Articles

Thrombin and fibrinogen γ′ impact clot structure by marked effects on intrafibrillar structure and protofibril packing

Marco M. Domingues, Fraser L. Macrae, Cédric Duval, Helen R. McPherson, Katherine I. Bridge, Ramzi A. Ajjan, Victoria C. Ridger, Simon D. Connell, Helen Philippou, Robert A. S. Ariëns

Blood (2016) 127 (4): 487–495.

https://doi.org/10.1182/blood-2015-06-652214

Published: 2016

Includes: Multimedia, Supplemental data

Journal Articles

Unexplained bleeding: another player to look out for!

Helen Philippou

Blood (2014) 124 (12): 1850–1851.

https://doi.org/10.1182/blood-2014-08-592550

Published: 2014

Journal Articles

Diabetes is associated with posttranslational modifications in plasminogen resulting in reduced plasmin generation and enzyme-specific activity

Ramzi A. Ajjan, Toby Gamlen, Kristina F. Standeven, Salihah Mughal, Katharina Hess, Kerrie A. Smith, Emma J. Dunn, M. Maqsud Anwar, Naila Rabbani, Paul J. Thornalley, Helen Philippou, Peter J. Grant

Blood (2013) 122 (1): 134–142.

https://doi.org/10.1182/blood-2013-04-494641

Published: 2013

Journal Articles

The activation peptide cleft exposed by thrombin cleavage of FXIII-A 2 contains a recognition site for the fibrinogen α chain

Kerrie A. Smith, Richard J. Pease, Craig A. Avery, Jane M. Brown, Penelope J. Adamson, Esther J. Cooke, Søs Neergaard-Petersen, Paul A. Cordell, Robert A. S. Ariëns, Colin W. G. Fishwick, Helen Philippou, Peter J. Grant

Blood (2013) 121 (11): 2117–2126.

https://doi.org/10.1182/blood-2012-07-446393

Published: 2013

Includes: Supplemental data

Journal Articles

Factor XIIa regulates the structure of the fibrin clot independently of thrombin generation through direct interaction with fibrin

Joke Konings, José W. P. Govers-Riemslag, Helen Philippou, Nicola J. Mutch, Julian I. Borissoff, Peter Allan, Sumitra Mohan, Guido Tans, Hugo ten Cate, Robert A. S. Ariëns

Blood (2011) 118 (14): 3942–3951.

https://doi.org/10.1182/blood-2011-03-339572

Published: 2011

Includes: Supplemental data

Journal Articles

Proteolytic and genetic variation of the alpha-2-antiplasmin C-terminus in myocardial infarction

Shirley Uitte de Willige, Megan Miedzak, Angela M. Carter, Ton Lisman, Frits R. Rosendaal, Peter J. Grant, Helen Philippou, Robert A. S. Ariëns

Blood (2011) 117 (24): 6694–6701.

https://doi.org/10.1182/blood-2010-11-320325

Published: 2011

Journal Articles

Interactions between factor XIII and the αC region of fibrinogen

Kerrie A. Smith, Penelope J. Adamson, Richard J. Pease, Jane M. Brown, Anthony J. Balmforth, Paul A. Cordell, Robert A. S. Ariëns, Helen Philippou, Peter J. Grant

Blood (2011) 117 (12): 3460–3468.

https://doi.org/10.1182/blood-2010-10-313601

Published: 2011

Includes: Supplemental data

Journal Articles

Polyphosphate modifies the fibrin network and down-regulates fibrinolysis by attenuating binding of tPA and plasminogen to fibrin

Nicola J. Mutch, Ruchira Engel, Shirley Uitte de Willige, Helen Philippou, Robert A. S. Ariëns

Blood (2010) 115 (19): 3980–3988.

https://doi.org/10.1182/blood-2009-11-254029

Published: 2010

Journal Articles

The pleiotropic role of the fibrinogen γ′ chain in hemostasis

Shirley Uitte de Willige, Kristina F. Standeven, Helen Philippou, Robert A. S. Ariëns

Blood (2009) 114 (19): 3994–4001.

https://doi.org/10.1182/blood-2009-05-217968

Published: 2009

Journal Articles

Directing thrombin

David A. Lane, Helen Philippou, James A. Huntington

Blood (2005) 106 (8): 2605–2612.

https://doi.org/10.1182/blood-2005-04-1710

Published: 2005

Journal Articles

The factor XIII V34L polymorphism accelerates thrombin activation of factor XIII and affects cross-linked fibrin structure

Robert A. S. Ariëns, Helen Philippou, Chandrasekaran Nagaswami, John W. Weisel, David A. Lane, Peter J. Grant

Blood (2000) 96 (3): 988–995.

https://doi.org/10.1182/blood.V96.3.988

Published: 2000

Journal Articles

A Novel Specific Immunoassay for Plasma Two-Chain Factor VIIa: Investigation of FVIIa Levels in Normal Individuals and in Patients With Acute Coronary Syndromes

Helen Philippou, Antonella Adami, Rajiv A. Amersey, Peter J. Stubbs, David A. Lane

Blood (1997) 89 (3): 767–775.

https://doi.org/10.1182/blood.V89.3.767

Published: 1997

NARROW

FXII inhibition: multipronged benefits

Heavy chain of FXII: not an innocent bystander!

The interaction between fibrinogen and zymogen FXIII-A 2 B 2 is mediated by fibrinogen residues γ390-396 and the FXIII-B subunits

Ranking reactive glutamines in the fibrinogen αC region that are targeted by blood coagulant factor XIII

Thrombin and fibrinogen γ′ impact clot structure by marked effects on intrafibrillar structure and protofibril packing

Unexplained bleeding: another player to look out for!

Diabetes is associated with posttranslational modifications in plasminogen resulting in reduced plasmin generation and enzyme-specific activity

The activation peptide cleft exposed by thrombin cleavage of FXIII-A 2 contains a recognition site for the fibrinogen α chain

Factor XIIa regulates the structure of the fibrin clot independently of thrombin generation through direct interaction with fibrin

Proteolytic and genetic variation of the alpha-2-antiplasmin C-terminus in myocardial infarction

Interactions between factor XIII and the αC region of fibrinogen

Polyphosphate modifies the fibrin network and down-regulates fibrinolysis by attenuating binding of tPA and plasminogen to fibrin

The pleiotropic role of the fibrinogen γ′ chain in hemostasis

Directing thrombin

The factor XIII V34L polymorphism accelerates thrombin activation of factor XIII and affects cross-linked fibrin structure

A Novel Specific Immunoassay for Plasma Two-Chain Factor VIIa: Investigation of FVIIa Levels in Normal Individuals and in Patients With Acute Coronary Syndromes

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American Society of Hematology

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ASH Publications

American Society of Hematology

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