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Nicola J. Mutch
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Journal Articles

S100A8/A9 drives the formation of procoagulant platelets through GPIbα

Martina Colicchia, Waltraud C. Schrottmaier, Gina Perrella, Jasmeet S. Reyat, Jenefa Begum, Alexandre Slater, Joshua Price, Joanne C. Clark, Zhaogong Zhi, Megan J. Simpson, Joshua H. Bourne, Natalie S. Poulter, Abdullah O. Khan, Phillip L. R. Nicolson, Matthew Pugh, Paul Harrison, Asif J. Iqbal, George E. Rainger, Steve P. Watson, Mark R. Thomas, Nicola J. Mutch, Alice Assinger, Julie Rayes
Journal: Blood
Blood (2022) 140 (24): 2626–2643.
https://doi.org/10.1182/blood.2021014966
Published: 2022
Includes: Supplemental data
Journal Articles

Exposure of plasminogen and a novel plasminogen receptor, Plg-R KT , on activated human and murine platelets

Claire S. Whyte, Gael B. Morrow, Nagyung Baik, Nuala A. Booth, Mohammed M. Jalal, Robert J. Parmer, Lindsey A. Miles, Nicola J. Mutch
Journal: Blood
Blood (2021) 137 (2): 248–257.
https://doi.org/10.1182/blood.2020007263
Published: 2021
Includes: Multimedia, Supplemental data
Journal Articles

Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery

Bubacarr G. Kaira, Alexandre Slater, Keith R. McCrae, Ingrid Dreveny, Ummay Sumya, Nicola J. Mutch, Mark Searle, Jonas Emsley
Journal: Blood
Blood (2020) 136 (14): 1685–1697.
https://doi.org/10.1182/blood.2020004818
Published: 2020
Includes: Multimedia, Supplemental data
Journal Articles

Regulation of Coagulation by Polyphosphate

Nicola J. Mutch, BSc, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): SCI-18.
https://doi.org/10.1182/blood-2019-121062
Published: 2019
Journal Articles

Polyphosphate colocalizes with factor XII on platelet-bound fibrin and augments its plasminogen activator activity

Joanne L. Mitchell, Ausra S. Lionikiene, Georgi Georgiev, Anja Klemmer, Chelsea Brain, Paul Y. Kim, Nicola J. Mutch
Journal: Blood
Blood (2016) 128 (24): 2834–2845.
https://doi.org/10.1182/blood-2015-10-673285
Published: 2016
Includes: Multimedia, Supplemental data
Journal Articles

Altered fibrinolysis in autosomal dominant thrombomodulin-associated coagulopathy

Brief Report
Kate Burley, Claire S. Whyte, Sarah K. Westbury, Mary Walker, Kathleen E. Stirrups, Ernest Turro, NIHR BioResource, Oliver G. Chapman, Christopher Reilly-Stitt, Nicola J. Mutch, Andrew D. Mumford
Journal: Blood
Blood (2016) 128 (14): 1879–1883.
https://doi.org/10.1182/blood-2016-05-716092
Published: 2016
Includes: Supplemental data
Journal Articles

Plasminogen associates with phosphatidylserine-exposing platelets and contributes to thrombus lysis under flow

Claire S. Whyte, Frauke Swieringa, Tom G. Mastenbroek, Ausra S. Lionikiene, Marcus D. Lancé, Paola E. J. van der Meijden, Johan W. M. Heemskerk, Nicola J. Mutch
Journal: Blood
Blood (2015) 125 (16): 2568–2578.
https://doi.org/10.1182/blood-2014-09-599480
Published: 2015
Includes: Multimedia, Supplemental data
Journal Articles

Functional factor XIII-A is exposed on the stimulated platelet surface

Joanne L. Mitchell, Ausra S. Lionikiene, Steven R. Fraser, Claire S. Whyte, Nuala A. Booth, Nicola J. Mutch
Journal: Blood
Blood (2014) 124 (26): 3982–3990.
https://doi.org/10.1182/blood-2014-06-583070
Published: 2014
Includes: Multimedia, Supplemental data
Journal Articles

Time-dependent degradation and tissue factor addition mask the ability of platelet polyphosphates in activating factor XII–mediated coagulation

Katrin Faye Nickel, Henri M. Spronk, Nicola J. Mutch, Thomas Renné
Journal: Blood
Blood (2013) 122 (23): 3847–3849.
https://doi.org/10.1182/blood-2013-09-525840
Published: 2013
Journal Articles

Factor XIIa regulates the structure of the fibrin clot independently of thrombin generation through direct interaction with fibrin

Joke Konings, José W. P. Govers-Riemslag, Helen Philippou, Nicola J. Mutch, Julian I. Borissoff, Peter Allan, Sumitra Mohan, Guido Tans, Hugo ten Cate, Robert A. S. Ariëns
Journal: Blood
Blood (2011) 118 (14): 3942–3951.
https://doi.org/10.1182/blood-2011-03-339572
Published: 2011
Includes: Supplemental data
Journal Articles

The antifibrinolytic function of factor XIII is exclusively expressed through α 2 -antiplasmin cross-linking

Brief Report
Steven R. Fraser, Nuala A. Booth, Nicola J. Mutch
Journal: Blood
Blood (2011) 117 (23): 6371–6374.
https://doi.org/10.1182/blood-2011-02-333203
Published: 2011
Journal Articles

Polyphosphate modifies the fibrin network and down-regulates fibrinolysis by attenuating binding of tPA and plasminogen to fibrin

Nicola J. Mutch, Ruchira Engel, Shirley Uitte de Willige, Helen Philippou, Robert A. S. Ariëns
Journal: Blood
Blood (2010) 115 (19): 3980–3988.
https://doi.org/10.1182/blood-2009-11-254029
Published: 2010