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Journal Articles

Access to Gene Therapy in Sickle Cell Disease

Payal C. Desai, Alex George, Ferdous Ahmed, Michelle L. Wallander, Nicole Serapin, Jennifer Saunders, Amina Rafique, Deborah Boger

Blood (2024) 144 (Supplement 1): 7674.

https://doi.org/10.1182/blood-2024-209630

Published: 2024

Journal Articles

Exploring the Experiences of Pediatric Patients with Sickle Cell Disease and Their Families

Anna A. Avinger, Alex George, Deborah Boger, Frances R. Bosch, Thomas W. McLean

Blood (2023) 142 (Supplement 1): 7205.

https://doi.org/10.1182/blood-2023-183017

Published: 2023

Journal Articles

Splenic Complications in Sickle Cell Disease: A Retrospective Cohort Review

Alex George, Shannon E. Conneely, Ross Mangum, Philip J. Lupo, Michael E. Scheurer

Blood (2021) 138 (Supplement 1): 766.

https://doi.org/10.1182/blood-2021-148027

Published: 2021

Journal Articles

Ndepth: A Randomized Controlled Trial of a Novel Dose-Prediction Equation to Determine Maximum Tolerated Dose for Hydroxyurea Therapy in Pediatric Patients with Sickle Cell Anemia

Alex George, MD PhD, Bogdan Dinu, MD, Norma Estrada, Charles Minard, PhD, Richard L Hurwitz, MD, Donald Mahoney, MD, Amber M Yates, MD, Mary Vaughan, FNP - C, Alaundra Carmouche, FNP - C, Gladstone Airewele, MDMPH, Kirk E Susan, P.A., Titilope Adenike Fasipe, MD PhD, Precious Uwaezuoke, FNP, Russell E. Ware, MD PhD

Blood (2019) 134 (Supplement_1): 2267.

https://doi.org/10.1182/blood-2019-127414

Published: 2019

Journal Articles

Safety and Efficacy of Dose-Escalation Hydroxyurea Therapy in Infants and Young Children: A Retrospective Cohort Study

Alex George, MD PhD, Jennifer Nguyen Tran, DO

Blood (2018) 132 (Supplement 1): 3658.

https://doi.org/10.1182/blood-2018-99-112586

Published: 2018

Journal Articles

Metformin Induction of Fetal Hemoglobin

Yankai Zhang, PhD, Alireza Paikari, MD, Pavel Sumazin, PhD, Alex George, MD, PhD, Bogdan Dinu, MD, Carly Summarell, MS, Mitchell J Weiss, MD PhD, Vivien Sheehan, MD PhD

Blood (2017) 130 (Supplement 1): 359.

https://doi.org/10.1182/blood.V130.Suppl_1.359.359

Published: 2017

Journal Articles

12-Month Full Donor Chimerism Is Associated with Low-Grade Acute Graft Versus Host Disease (aGVHD) and Predicts Superior Outcomes in Reduced Intensity (RIC) Alemtuzumab-Based Transplants for MDS and AML

Alex George Kanellopoulos, MD, Shankaranarayana Paneesha, MD, Evgenia Xenou, MD, Iman Qureshi, MBBS, MRCP, Dewi Tomos Eden, MRCP,MB,FRCPath, David John Sutton, MBBChir, MRCP, BSc, Rebecca Pryor, MB, MRCP, Lorna Cain, Carolina Arbuthnot, Richard Lovell, Anton Borg, MDFRCP,FRCPath, Katie Randall, MB, FRCPath, Kathy Holder, Julie Suhr, Lynda Baker, Lynn Ryan, Maria Kaparou, Bhuvan Kishore, MBBS, MRCP, FRCPath, Emmanouil Nikolousis, PhD MBBS, FRCPath, MBA

Blood (2016) 128 (22): 5764.

https://doi.org/10.1182/blood.V128.22.5764.5764

Published: 2016

Journal Articles

Iron Unloading By Therapeutic Phlebotomy in Previously Transfused Children with Sickle Cell Anemia: The Twitch Experience

Banu Aygun, MD, Nicole Mortier, PA-C, Zora R. Rogers, MD, William Owen, MD, Beng Fuh, MD, Alex George, MD, PhD, Theodosia A. Kalfa, MD PhD, Janet Kwiatkowski, MD, Margaret Lee, MD, Hamayun Imran, MD, Scott T. Miller, MD, John C Wood, MD PhD, Alan R. Cohen, MD, Sara L Pressel, MS, Russell E. Ware, MD PhD

Blood (2016) 128 (22): 1018.

https://doi.org/10.1182/blood.V128.22.1018.1018

Published: 2016

Journal Articles

Efficacy and Safety of Melphalan 140mg/m 2 Conditioned Autologous Stem Cell Transplantation in Elderly Pre-Dialysis and Dialysis Patients with Multiple Myeloma

Hatem Ali, MBBS, Baharani Jyoti, MBBS, FRCP, Shankaranarayana Paneesha, MD, Richard Lovell, Alex George Kanellopoulos, MD, Evgenia Xenou, MD, Iman Qureshi, MBBS, MRCP, Lorna Cain, Maria Kaparou, David John Sutton, MBBChir, MRCP, BSc, Rebecca Pryor, MB, MRCP, Emmanouil Nikolousis, PhDMBBS,FRCPath,MBA, Bhuvan Kishore, MBBS, MRCP, FRCPath

Blood (2016) 128 (22): 5822.

https://doi.org/10.1182/blood.V128.22.5822.5822

Published: 2016

Journal Articles

Changes in Extrahepatic Iron Load in Response to Iron Chelation Versus Phlebotomy: Observations from the Twitch Trial

John C Wood, MD PhD, Alvarez Ofelia, MD, Matthew M Heeney, MD, Alex George, MD PhD, Cynthia Gauger, MD, Beng Fuh, MD, Stephen C Nelson, MD, Carla W Roberts, MD, Melissa Rhodes, MD, Jamie Coleman, MD, Russell E. Ware, MD PhD

Blood (2016) 128 (22): 202.

https://doi.org/10.1182/blood.V128.22.202.202

Published: 2016

Journal Articles

A Multi-Center, Phase-2 Trial of Losartan for the Nephropathy of Sickle Cell Anemia

Charles T. Quinn, MD MS, Santosh L. Saraf, MD, Victor R. Gordeuk, MD, Courtney D. Fitzhugh, MD, Susan E Creary, MD MSc, Prasad Bodas, MD, Alex George, MD, PhD, Ashok Raj, MD, Alecia C. Nero, MD, Catherine Terrell, BS, Lisa McCord, BS, Omar Niss, MD, Rubina Dosani, MS, Michael D. Taylor, MD, Prasad Devarajan, MD, Punam Malik, MD

Blood (2016) 128 (22): 265.

https://doi.org/10.1182/blood.V128.22.265.265

Published: 2016

Journal Articles

Effects of Genetic Polymorphisms on Leukocyte and Neutrophil Counts and Maximum Tolerated Dose of Hydroxyurea in Children with Sickle Cell Anemia

Beverly A Schaefer, MD, Jonathan M Flanagan, PhD, Thad A. Howard, MS, Kerri A Nottage, MD MPH, Connie M. Piccone, MD, Scott T. Miller, MD, Alex George, MD, PhD, Beatrice E. Gee, MD, Barry R Davis, MDPhD, Russell E. Ware, MD PhD

Blood (2015) 126 (23): 2165.

https://doi.org/10.1182/blood.V126.23.2165.2165

Published: 2015

Journal Articles

Blood Antioxidant Defenses and Sickle Cell Disease: Analyzing Cytochrome b Reductase 1 Protein Levels and Structure in Erythrocyte Membranes

Richard J Kulmacz, PhD, Wen Liu, PhD, Vladimir Berka, PhD, Mohammad H. Rahbar, PhD, Modupe Idowu, MD, Alex George, MD, PhD, Harinder S. Juneja, MD

Blood (2015) 126 (23): 2170.

https://doi.org/10.1182/blood.V126.23.2170.2170

Published: 2015

Journal Articles

Ndepth: Novel Dose Escalation to Predict Treatment with Hydroxyurea

Alex George, MD, PhD, Bogdan R. Dinu, MD, Russell E. Ware, MD PhD

Blood (2015) 126 (23): 3419.

https://doi.org/10.1182/blood.V126.23.3419.3419

Published: 2015

Journal Articles

Initial Clinical Validation of a Rapid, Low-Cost, Paper-Based Diagnostic Test for Sickle Cell Anemia As a Tool to Facilitate Newborn Screening in Resource-Limited Settings

Nathaniel Z. Piety, Alex George, MD, PhD, Sonia Serrano, Maria Rosa Lanzi, Palka R. Patel, MD, Maria Paz Noli, MD, Damian Nirenberg, MD, Joao Camanda, Gladstone Airewele, M.B.B.S., M.P.H., Sergey S. Shevkoplyas, PhD

Blood (2015) 126 (23): 979.

https://doi.org/10.1182/blood.V126.23.979.979

Published: 2015

Journal Articles

TCD with Transfusions Changing to Hydroxyurea (TWiTCH): Hydroxyurea Therapy As an Alternative to Transfusions for Primary Stroke Prevention in Children with Sickle Cell Anemia

Russell E. Ware, MD PhD, Barry R Davis, MD PhD, William H Schultz, MHS PA, Clark Brown, MD PhD, Banu Aygun, MD, Sharada A. Sarnaik, MD, Isaac Odame, MD, Beng Fuh, MD, Alex George, MD, PhD, William Owen, MD, Lori Luchtman-Jones, MD, Zora R. Rogers, MD, Lee Hilliard, MD, Cynthia Gauger, MD, Connie M. Piccone, MD, Margaret T. Lee, MD, Janet Kwiatkowski, MD, Sherron Jackson, MD, Scott T. Miller, MD, Carla W Roberts, MD, Matthew M. Heeney, MD FRCP(C), Theodosia A. Kalfa, MD PhD, Stephen C Nelson, MD, Hamayun Imran, MD, Kerri A Nottage, MD MPH, Ofelia A. Alvarez, MD, Melissa Rhodes, MD, Alexis A. Thompson, MD, Jennifer Rothman, MD, Kathleen J. Helton, MD, Donna Roberts, MD, Jamie Coleman, MD, Melanie J Bonner, PhD, Abdullah Kutlar, MD, Niren Patel, MD, John C Wood, MD PhD, Linda Piller, MD, Peng Wei, PhD, Judy Luden, CCRP, Nicole A. Mortier, MHS, PA-C, Susan Stuber, MA, Naomi L.C. Luban, MD, Alan R. Cohen, MD, Sara L Pressel, MS, Robert J. Adams, MD MS

Blood (2015) 126 (23): 3.

https://doi.org/10.1182/blood.V126.23.3.3

Published: 2015

Journal Articles

Comparison of Clinical Outcomes Between Adult and Pediatric Patients (pts) with Sickle Cell Disease (SCD): 3-Year (y) Follow-up in a Prospective, Longitudinal, Noninterventional Registry Trial

Matthew M. Heeney, MD FRCP(C), Brad Baltz, MD, Patricia Adams-Graves, MD, Elizabeth Yang, MD PhD, Carole Paley, MD, Jason Esposito, MSHS, Katie McNamara, MSHS, CCRA, Elliott Vichinsky, MD, Alex George, MD, PhD

Blood (2014) 124 (21): 4890.

https://doi.org/10.1182/blood.V124.21.4890.4890

Published: 2014

Journal Articles

Paper-Based Assay for Quantification of HbS in Blood of Sickle Cell Disease Patients

Nathaniel Z. Piety, Xiaoxi Yang, PhD, Bogdan R. Dinu, MD, Alex George, MD, PhD, Sergey S. Shevkoplyas, PhD

Blood (2014) 124 (21): 1371.

https://doi.org/10.1182/blood.V124.21.1371.1371

Published: 2014

Journal Articles

Erythrocyte NADPH oxidase activity modulated by Rac GTPases, PKC, and plasma cytokines contributes to oxidative stress in sickle cell disease

Alex George, Suvarnamala Pushkaran, Diamantis G. Konstantinidis, Sebastian Koochaki, Punam Malik, Narla Mohandas, Yi Zheng, Clinton H. Joiner, Theodosia A. Kalfa

Blood (2013) 121 (11): 2099–2107.

https://doi.org/10.1182/blood-2012-07-441188

Published: 2013

Includes: Supplemental data

Journal Articles

Elevated Reactive Oxygen Species Production In Sickle Erythrocytes Is Modulated by a Pathway Involving Endothelin-1, TGFβ1, PKC, and Rac GTPases

Alex George, M.D., Ph.D., Sebastian Koochaki, Suvarnamala Pushkaran, Narla Mohandas, Ph.D., Yi Zheng, Ph.D., Clinton H. Joiner, MD, PhD, Theodosia A Kalfa, M.D., Ph.D.

Blood (2010) 116 (21): 1634.

https://doi.org/10.1182/blood.V116.21.1634.1634

Published: 2010

NARROW

Access to Gene Therapy in Sickle Cell Disease

Exploring the Experiences of Pediatric Patients with Sickle Cell Disease and Their Families

Splenic Complications in Sickle Cell Disease: A Retrospective Cohort Review

Ndepth: A Randomized Controlled Trial of a Novel Dose-Prediction Equation to Determine Maximum Tolerated Dose for Hydroxyurea Therapy in Pediatric Patients with Sickle Cell Anemia

Safety and Efficacy of Dose-Escalation Hydroxyurea Therapy in Infants and Young Children: A Retrospective Cohort Study

Metformin Induction of Fetal Hemoglobin

12-Month Full Donor Chimerism Is Associated with Low-Grade Acute Graft Versus Host Disease (aGVHD) and Predicts Superior Outcomes in Reduced Intensity (RIC) Alemtuzumab-Based Transplants for MDS and AML

Iron Unloading By Therapeutic Phlebotomy in Previously Transfused Children with Sickle Cell Anemia: The Twitch Experience

Efficacy and Safety of Melphalan 140mg/m 2 Conditioned Autologous Stem Cell Transplantation in Elderly Pre-Dialysis and Dialysis Patients with Multiple Myeloma

Changes in Extrahepatic Iron Load in Response to Iron Chelation Versus Phlebotomy: Observations from the Twitch Trial

A Multi-Center, Phase-2 Trial of Losartan for the Nephropathy of Sickle Cell Anemia

Effects of Genetic Polymorphisms on Leukocyte and Neutrophil Counts and Maximum Tolerated Dose of Hydroxyurea in Children with Sickle Cell Anemia

Blood Antioxidant Defenses and Sickle Cell Disease: Analyzing Cytochrome b Reductase 1 Protein Levels and Structure in Erythrocyte Membranes

Ndepth: Novel Dose Escalation to Predict Treatment with Hydroxyurea

Initial Clinical Validation of a Rapid, Low-Cost, Paper-Based Diagnostic Test for Sickle Cell Anemia As a Tool to Facilitate Newborn Screening in Resource-Limited Settings

TCD with Transfusions Changing to Hydroxyurea (TWiTCH): Hydroxyurea Therapy As an Alternative to Transfusions for Primary Stroke Prevention in Children with Sickle Cell Anemia

Comparison of Clinical Outcomes Between Adult and Pediatric Patients (pts) with Sickle Cell Disease (SCD): 3-Year (y) Follow-up in a Prospective, Longitudinal, Noninterventional Registry Trial

Paper-Based Assay for Quantification of HbS in Blood of Sickle Cell Disease Patients

Erythrocyte NADPH oxidase activity modulated by Rac GTPases, PKC, and plasma cytokines contributes to oxidative stress in sickle cell disease

Elevated Reactive Oxygen Species Production In Sickle Erythrocytes Is Modulated by a Pathway Involving Endothelin-1, TGFβ1, PKC, and Rac GTPases

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American Society of Hematology

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American Society of Hematology

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