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Journal Articles

Cytokinesis failure in RhoA-deficient mouse erythroblasts involves actomyosin and midbody dysregulation and triggers p53 activation

Diamantis G. Konstantinidis, Katie M. Giger, Mary Risinger, Suvarnamala Pushkaran, Ping Zhou, Phillip Dexheimer, Satwica Yerneni, Paul Andreassen, Ursula Klingmüller, James Palis, Yi Zheng, Theodosia A. Kalfa

Blood (2015) 126 (12): 1473–1482.

https://doi.org/10.1182/blood-2014-12-616169

Published: 2015

Includes: Supplemental data

Journal Articles

Development Of a Comprehensive Rapid Next-Generation Sequencing Assay For The Diagnosis Of Inherited Hemolytic Anemia

Amber Hogart Begtrup, PhD, Neha Dagaonkar, Suvarnamala Pushkaran, M.Sc., Katie M. Giger, PhD, Ammar Husami, Diane Kissell, Clinton H. Joiner, MD, PhD, Mehdi Keddache, Ph.D., Kejian Zhang, M.D., M.B.A., Theodosia A. Kalfa, M.D., Ph.D.

Blood (2013) 122 (21): 949.

https://doi.org/10.1182/blood.V122.21.949.949

Published: 2013

Journal Articles

RhoA Gtpase Regulates Erythroblast Cytokinesis and Enucleation By Dynamic Coordination Of The Microtubule-Actomyosin Machineries For Successful Abscission

Diamantis G. Konstantinidis, PhD, Suvarnamala Pushkaran, M.Sc., Katie M. Giger, PhD, Ping Zhou, B.S., Paul R. Andreassen, PhD, Ursula Klingmuller, PhD, James Palis, M.D., Yi Zheng, PhD, Theodosia A. Kalfa, M.D., Ph.D.

Blood (2013) 122 (21): 311.

https://doi.org/10.1182/blood.V122.21.311.311

Published: 2013

Journal Articles

Erythrocyte NADPH oxidase activity modulated by Rac GTPases, PKC, and plasma cytokines contributes to oxidative stress in sickle cell disease

Alex George, Suvarnamala Pushkaran, Diamantis G. Konstantinidis, Sebastian Koochaki, Punam Malik, Narla Mohandas, Yi Zheng, Clinton H. Joiner, Theodosia A. Kalfa

Blood (2013) 121 (11): 2099–2107.

https://doi.org/10.1182/blood-2012-07-441188

Published: 2013

Includes: Supplemental data

Journal Articles

Next Generation Sequencing for Diagnostic Testing of Erythrocyte Cytoskeleton Disorders

Theodosia A Kalfa, M.D., Ph.D., Mary A. Risinger, Ph.D., Suvarnamala Pushkaran, M.Sc., Phillip Dexheimer, Ammar Husami, Diane Kissell, Clinton H. Joiner, MD, PhD, Mehdi Keddache, Ph.D., Kejian Zhang, M.D., M.B.A.

Blood (2012) 120 (21): 976.

https://doi.org/10.1182/blood.V120.21.976.976

Published: 2012

Journal Articles

Erythroid Specific RhoA Deficiency Causes Dysplastic and Inefficient Fetal Erythropoiesis with Lethal Embryonic Anemia Due to Defects in Erythroblast Cytokinesis and Enucleation

Diamantis Konstantinidis, PhD, Suvarnamala Pushkaran, M.Sc., Ursula Klingmuller, PhD, James Palis, MD, Yi Zheng, PhD, Theodosia A Kalfa, M.D., Ph.D.

Blood (2012) 120 (21): 82.

https://doi.org/10.1182/blood.V120.21.82.82

Published: 2012

Journal Articles

Signaling and cytoskeletal requirements in erythroblast enucleation

Diamantis G. Konstantinidis, Suvarnamala Pushkaran, James F. Johnson, Jose A. Cancelas, Stefanos Manganaris, Chad E. Harris, David A. Williams, Yi Zheng, Theodosia A. Kalfa

Blood (2012) 119 (25): 6118–6127.

https://doi.org/10.1182/blood-2011-09-379263

Published: 2012

Journal Articles

Elevated Reactive Oxygen Species Production In Sickle Erythrocytes Is Modulated by a Pathway Involving Endothelin-1, TGFβ1, PKC, and Rac GTPases

Alex George, M.D., Ph.D., Sebastian Koochaki, Suvarnamala Pushkaran, Narla Mohandas, Ph.D., Yi Zheng, Ph.D., Clinton H. Joiner, MD, PhD, Theodosia A Kalfa, M.D., Ph.D.

Blood (2010) 116 (21): 1634.

https://doi.org/10.1182/blood.V116.21.1634.1634

Published: 2010

Journal Articles

Sickle Erythrocytes Have Increased Adducin Phosphorylation and Increased ROS Production Mediated by Signaling Pathways Involving Protein Kinase C and Rac GTPases.

Theodosia A. Kalfa, MD, PhD, Alex George, MD, PhD, Suvarnamala Pushkaran, MSc, Xiuli An, MD, PhD, Clinton H. Joiner, MD, PhD, Narla Mohandas, DSc, Yi Zheng, PhD

Blood (2009) 114 (22): 901.

https://doi.org/10.1182/blood.V114.22.901.901

Published: 2009

Journal Articles

Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis

Linda Yang, Lei Wang, Theodosia A. Kalfa, Jose A. Cancelas, Xun Shang, Suvarnamala Pushkaran, Jun Mo, David A. Williams, Yi Zheng

Blood (2007) 110 (12): 3853–3861.

https://doi.org/10.1182/blood-2007-03-079582

Published: 2007

Journal Articles

Rac GTPases Regulate Erythropoiesis Both in the Early Steps of Differentiation and in Enucleation.

Theodosia A. Kalfa, MD, PhD, Suvarnamala Pushkaran, Jose A. Cancelas, MD, PhD, James F. Johnson, Deidre Daria, Hartmut Geiger, PhD, David A. Williams, MD, Yi Zheng, PhD

Blood (2007) 110 (11): 1714.

https://doi.org/10.1182/blood.V110.11.1714.1714

Published: 2007

Journal Articles

Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton

Theodosia A. Kalfa, Suvarnamala Pushkaran, Narla Mohandas, John H. Hartwig, Velia M. Fowler, James F. Johnson, Clinton H. Joiner, David A. Williams, Yi Zheng

Blood (2006) 108 (12): 3637–3645.

https://doi.org/10.1182/blood-2006-03-005942

Published: 2006

Journal Articles

Deficiency of Rac1 and Rac2 GTPases Perturbs Erythroid Proliferation and Differentiation but Not Enucleation.

Theodosia A. Kalfa, MD,PhD, Suvarnamala Pushkaran, Jose A. Cancelas, MD, PhD, Michael Jansen, PhD, James F. Johnson, Kristen Hebel, David A. Williams, MD, Yi Zheng, PhD

Blood (2006) 108 (11): 467.

https://doi.org/10.1182/blood.V108.11.467.467

Published: 2006

Journal Articles

Erythrocyte Cytoskeletal Defects Induced in Mice by Deletion of Rac GTPases.

Theodosia A. Kalfa, MD, PhD, Suvarnamala Pushkaran, James F. Johnson, Qian Wei, David A. Williams, MD, Yi Zheng, PhD

Blood (2004) 104 (11): 1573.

https://doi.org/10.1182/blood.V104.11.1573.1573

Published: 2004

NARROW

Cytokinesis failure in RhoA-deficient mouse erythroblasts involves actomyosin and midbody dysregulation and triggers p53 activation

Development Of a Comprehensive Rapid Next-Generation Sequencing Assay For The Diagnosis Of Inherited Hemolytic Anemia

RhoA Gtpase Regulates Erythroblast Cytokinesis and Enucleation By Dynamic Coordination Of The Microtubule-Actomyosin Machineries For Successful Abscission

Erythrocyte NADPH oxidase activity modulated by Rac GTPases, PKC, and plasma cytokines contributes to oxidative stress in sickle cell disease

Next Generation Sequencing for Diagnostic Testing of Erythrocyte Cytoskeleton Disorders

Erythroid Specific RhoA Deficiency Causes Dysplastic and Inefficient Fetal Erythropoiesis with Lethal Embryonic Anemia Due to Defects in Erythroblast Cytokinesis and Enucleation

Signaling and cytoskeletal requirements in erythroblast enucleation

Elevated Reactive Oxygen Species Production In Sickle Erythrocytes Is Modulated by a Pathway Involving Endothelin-1, TGFβ1, PKC, and Rac GTPases

Sickle Erythrocytes Have Increased Adducin Phosphorylation and Increased ROS Production Mediated by Signaling Pathways Involving Protein Kinase C and Rac GTPases.

Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis

Rac GTPases Regulate Erythropoiesis Both in the Early Steps of Differentiation and in Enucleation.

Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton

Deficiency of Rac1 and Rac2 GTPases Perturbs Erythroid Proliferation and Differentiation but Not Enucleation.

Erythrocyte Cytoskeletal Defects Induced in Mice by Deletion of Rac GTPases.

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American Society of Hematology

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American Society of Hematology

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