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Journal Articles

Ex-Vivo FT-4202 Treatment Improves Hemoglobin Oxygen Affinity and Membrane Health in Red Blood Cells of Patients with Hemoglobin SS and Hemoglobin SC Disease Irrespective of Prior Hydroxyurea Use

Diamantis G. Konstantinidis, PhD BSc, Rose Fessler, Katie Giger Seu, PhD, Bhargav Patel, Jennifer B Korpik, Keertik Fulzele, PhD, Sylvie Guichard, Theodosia A. Kalfa, MD PhD

Blood (2020) 136 (Supplement 1): 23–24.

https://doi.org/10.1182/blood-2020-139714

Published: 2020

Journal Articles

Angiotensin Signaling Is Essential for Stress Erythropoiesis but Results in Retention of Dysfunctional Mitochondria in Erythrocytes That Generate Excessive Reactive Oxygen Species

Parul Rai, MDMBBS, Swarnava Roy, PhD, Diamantis G. Konstantinidis, PhD BSc, Sithara Raju Ponny, MS, Marthe-sandrine Eiymo Mwa Mpollo, PhD, Archana Shrestha, Theodosia A. Kalfa, MD PhD, Punam Malik, MD

Blood (2020) 136 (Supplement 1): 31–32.

https://doi.org/10.1182/blood-2020-139980

Published: 2020

Journal Articles

Phase 1 Single (SAD) and Multiple Ascending Dose (MAD) Studies of the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of FT-4202, an Allosteric Activator of Pyruvate Kinase-R, in Healthy and Sickle Cell Disease Subjects

Theodosia A. Kalfa, MD PhD, Frans A Kuypers, PhD, Marilyn J. Telen, MD, Punam Malik, MD, Diamantis G. Konstantinidis, PhD BSc, Jeremy H. Estepp, MD, Hyon J. Kim, MD PhD, Santosh L. Saraf, MD, Lindsey Wilson, Maria D Ribadeneira, PhD, Sanjeev Forsyth, Patricia Schroeder, Adam Drake, Olga Polyanskaya, Patrick Kelly, MD, Lukasz Biernat, MD

Blood (2019) 134 (Supplement_1): 616.

https://doi.org/10.1182/blood-2019-121889

Published: 2019

Journal Articles

Cellular Hydration and Oxidation As Phenotype Modifiers in Sickle Cell Anemia

Mary A Risinger, PhD, Neha Dagaonkar, Georgios E Christakopoulos, MD, Jie Liu, PhD, Katie Giger Seu, PhD, Diamantis G Konstantinidis, BSc, PhD, Charles T Quinn, MD, Satheesh Chonat, MD, Clinton H Joiner, MD PhD, Kejian Zhang, MD, Theodosia A Kalfa, MD PhD

Blood (2016) 128 (22): 2446.

https://doi.org/10.1182/blood.V128.22.2446.2446

Published: 2016

Journal Articles

Reactive Oxygen Species Produced by NADPH Oxidase Contribute to Cardiac Pathology in a Mouse Model of Sickle Cell Disease

Georgios E Christakopoulos, MD, Satheesh Chonat, MD, Inigo Valiente-Alandi, PhD, Diamantis G Konstantinidis, BSc, PhD, Amanda Schleper, Nihal Bakeer, MD, Anastacia Loberg, Burns C Blaxall, PhD FAHA, FACC, FAPS, Yi Zheng, PhD, Jeanne James, MD, Punam Malik, MD, Theodosia A Kalfa, MD PhD

Blood (2016) 128 (22): 853.

https://doi.org/10.1182/blood.V128.22.853.853

Published: 2016

Journal Articles

Cytokinesis failure in RhoA-deficient mouse erythroblasts involves actomyosin and midbody dysregulation and triggers p53 activation

Diamantis G. Konstantinidis, Katie M. Giger, Mary Risinger, Suvarnamala Pushkaran, Ping Zhou, Phillip Dexheimer, Satwica Yerneni, Paul Andreassen, Ursula Klingmüller, James Palis, Yi Zheng, Theodosia A. Kalfa

Blood (2015) 126 (12): 1473–1482.

https://doi.org/10.1182/blood-2014-12-616169

Published: 2015

Includes: Supplemental data

Journal Articles

Increased Oxidative Stress In Sickle Cell Disease Activates The Renin-Angiotensin-TGF-β Pathway To Mediate Sickle Nephropathy

Swarnava Roy, PhD, Diamantis G. Konstantinidis, PhD, Tilat Rizvi, PhD, Kyung-Hee Chang, PhD, Nambirajan Sundaram, Michael Wourms, M.Sc., Loberg Anastacia, Lanxi Song, Katie Burke, Tadashi Inagami, PhD, Nancy Ratner, PhD, David Witte, MD, Theodosia A. Kalfa, M.D., Ph.D., Jose A Cancelas, MD, PhD, Shiva Kumar Shanmukhappa, PhD, Punam Malik, MD

Blood (2013) 122 (21): 2211.

https://doi.org/10.1182/blood.V122.21.2211.2211

Published: 2013

Journal Articles

RhoA Gtpase Regulates Erythroblast Cytokinesis and Enucleation By Dynamic Coordination Of The Microtubule-Actomyosin Machineries For Successful Abscission

Diamantis G. Konstantinidis, PhD, Suvarnamala Pushkaran, M.Sc., Katie M. Giger, PhD, Ping Zhou, B.S., Paul R. Andreassen, PhD, Ursula Klingmuller, PhD, James Palis, M.D., Yi Zheng, PhD, Theodosia A. Kalfa, M.D., Ph.D.

Blood (2013) 122 (21): 311.

https://doi.org/10.1182/blood.V122.21.311.311

Published: 2013

Journal Articles

Erythrocyte NADPH oxidase activity modulated by Rac GTPases, PKC, and plasma cytokines contributes to oxidative stress in sickle cell disease

Alex George, Suvarnamala Pushkaran, Diamantis G. Konstantinidis, Sebastian Koochaki, Punam Malik, Narla Mohandas, Yi Zheng, Clinton H. Joiner, Theodosia A. Kalfa

Blood (2013) 121 (11): 2099–2107.

https://doi.org/10.1182/blood-2012-07-441188

Published: 2013

Includes: Supplemental data

Journal Articles

Signaling and cytoskeletal requirements in erythroblast enucleation

Diamantis G. Konstantinidis, Suvarnamala Pushkaran, James F. Johnson, Jose A. Cancelas, Stefanos Manganaris, Chad E. Harris, David A. Williams, Yi Zheng, Theodosia A. Kalfa

Blood (2012) 119 (25): 6118–6127.

https://doi.org/10.1182/blood-2011-09-379263

Published: 2012

NARROW

Ex-Vivo FT-4202 Treatment Improves Hemoglobin Oxygen Affinity and Membrane Health in Red Blood Cells of Patients with Hemoglobin SS and Hemoglobin SC Disease Irrespective of Prior Hydroxyurea Use

Angiotensin Signaling Is Essential for Stress Erythropoiesis but Results in Retention of Dysfunctional Mitochondria in Erythrocytes That Generate Excessive Reactive Oxygen Species

Phase 1 Single (SAD) and Multiple Ascending Dose (MAD) Studies of the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of FT-4202, an Allosteric Activator of Pyruvate Kinase-R, in Healthy and Sickle Cell Disease Subjects

Cellular Hydration and Oxidation As Phenotype Modifiers in Sickle Cell Anemia

Reactive Oxygen Species Produced by NADPH Oxidase Contribute to Cardiac Pathology in a Mouse Model of Sickle Cell Disease

Cytokinesis failure in RhoA-deficient mouse erythroblasts involves actomyosin and midbody dysregulation and triggers p53 activation

Increased Oxidative Stress In Sickle Cell Disease Activates The Renin-Angiotensin-TGF-β Pathway To Mediate Sickle Nephropathy

RhoA Gtpase Regulates Erythroblast Cytokinesis and Enucleation By Dynamic Coordination Of The Microtubule-Actomyosin Machineries For Successful Abscission

Erythrocyte NADPH oxidase activity modulated by Rac GTPases, PKC, and plasma cytokines contributes to oxidative stress in sickle cell disease

Signaling and cytoskeletal requirements in erythroblast enucleation

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American Society of Hematology

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