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Journal Articles

Final Results of a Phase 2 Study of Modified Lenalidomide, Bortezomib, and Dexamethasone (RVD lite) in Transplant-Ineligible Multiple Myeloma

Elizabeth O'Donnell, MD, Jacob Laubach, MD, Andrew J Yee, MD, Tianqi Chen, Carol Ann Huff, MD, Frank G. Basile, MD, Philip Wade, MD, Claudia Paba-Prada, MD, Irene M. Ghobrial, MD, Robert Schlossman, MD, Jill Burke, Harrington Cynthia, Kathleen Lively, Hannah Lyons, Nikhil Munshi, MD, Lorenzo Trippa, PhD, Kenneth C Anderson, MD, Paul G Richardson, MD, Noopur Raje, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3126.
https://doi.org/10.1182/blood.V130.Suppl_1.3126.3126
Published: 2017
Journal Articles

Next Generation Sequencing Identifies Smoldering Multiple Myeloma Patients with a High Risk of Disease Progression

Mark Bustoros, Jihye Park, PhD, Karma Ziad Salem, MD, Chia-Jen Liu, MD PhD, Marzia Capelletti, PhD, Daisy Huynh, BS, MS, Yu-Tzu Tai, PhD, Tarek H Mouhieddine, MD, Samuel Freeman, Gavin Ha, PhD, Justin Rhoades, Sarah Reed, Gregory Gydush, Denisse Rotem, Adriana Perilla Glen, Patrick Henrick, BS, Aaron Caola, Bradley Rivotto, BS, Alexandra Savell, BS, Kimberly Noonan, NP, Kaitlen Reyes, NP, Antonio Sacco, Cody J Boehner, Houry Leblebjian, PharmD, David Liu, MD MPH, MS, Elizabeth A Morgan, MD, Aldo M. Roccaro, Claudia Paba-Prada, MD, Eliezer Van Allen, MD, Christopher Love, Viktor Adalsteinsson, PhD, Jacob Laubach, MD, Robert Schlossman, MD, Nikhil Munshi, MD, Paul G Richardson, MD, Kenneth C Anderson, MD, Shaji K Kumar, MD, Gad Getz, PhD, Irene M Ghobrial, MD, Salomon Manier, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 392.
https://doi.org/10.1182/blood.V130.Suppl_1.392.392
Published: 2017
Journal Articles

Phase 1 study of pomalidomide MTD, safety, and efficacy in patients with refractory multiple myeloma who have received lenalidomide and bortezomib

Clinical Trials & Observations
Paul G. Richardson, David Siegel, Rachid Baz, Susan L. Kelley, Nikhil C. Munshi, Jacob Laubach, Daniel Sullivan, Melissa Alsina, Robert Schlossman, Irene M. Ghobrial, Deborah Doss, Nora Loughney, Laura McBride, Elizabeth Bilotti, Palka Anand, Lisa Nardelli, Sandra Wear, Gail Larkins, Min Chen, Mohamad H. Zaki, Christian Jacques, Kenneth C. Anderson
Journal: Blood
Blood (2013) 121 (11): 1961–1967.
https://doi.org/10.1182/blood-2012-08-450742
Published: 2013
Journal Articles

Biomarkers of Bone Remodeling in Multiple Myeloma Patients to Tailor Bisphosphonate Therapy

Chirayu Patel, Andrew Yee, Tyler A. Scullen, Neeharika Nemani, Loredana Santo, Anuj Mahindra, Paul G. Richardson, MD, Jacob P. Laubach, MD, Irene M. Ghobrial, MD, Robert Schlossman, MD, Kenneth C. Anderson, Nikhil C Munshi, MD, Noopur Raje
Journal: Blood
Blood (2012) 120 (21): 3965.
https://doi.org/10.1182/blood.V120.21.3965.3965
Published: 2012
Journal Articles

PANORAMA 2: Panobinostat Combined with Bortezomib and Dexamethasone in Patients with Relapsed and Bortezomib-Refractory Multiple Myeloma

Paul G. Richardson, MD, Melissa Alsina, MD, Donna Weber, MD, Steven E. Coutre, MD, Sagar Lonial, MD, Cristina Gasparetto, MD, Sutapa Mukhopadhyay, PhD, Michael Ondovik, PharmD, MBA, Mahmudul Khan, PhD, Carole Paley, MD, Robert Schlossman, MD
Journal: Blood
Blood (2012) 120 (21): 1852.
https://doi.org/10.1182/blood.V120.21.1852.1852
Published: 2012
Journal Articles

Phase II Study of the Pan-Deacetylase Inhibitor Panobinostat in Combination with Bortezomib and Dexamethasone in Relapsed and Bortezomib-Refractory Multiple Myeloma (PANORAMA 2)

Paul G. Richardson, MD, Melissa Alsina, MD, Donna M. Weber, MD, Steven E. Coutre, MD, Sagar Lonial, MD, Cristina Gasparetto, MD, Ghulam Warsi, PhD, Michael Ondovik, PharmD, MBA, Sutapa Mukhopadhyay, PhD, Susan Snodgrass, MD, Robert Schlossman, MD
Journal: Blood
Blood (2011) 118 (21): 814.
https://doi.org/10.1182/blood.V118.21.814.814
Published: 2011
Journal Articles

Perifosine Plus Bortezomib and Dexamethasone in Relapsed/Refractory Multiple Myeloma Patients Previously Treated with Bortezomib: Final Results of a Phase I/II Trial

Paul G. Richardson, MD, Jeffrey Lee Wolf, MD, Andrzej J. Jakubowiak, MD, PhD, Jeffrey A. Zonder, MD, Sagar Lonial, MD, David Irwin, MD, John Densmore, MD, PhD, Amrita Krishnan, MD, Noopur S. Raje, MD, Michael H. Bar, MD, Robert Schlossman, MD, Irene M. Ghobrial, MD, Nikhil C. Munshi, MD, Thomas Martin, MD, Jacob P. Laubach, MD, Jeffrey P Allerton, MD, Teru Hideshima, MD, PhD, Peter Sportelli, Lesa Gardner, RN, Kenneth C. Anderson, MD
Journal: Blood
Blood (2011) 118 (21): 815.
https://doi.org/10.1182/blood.V118.21.815.815
Published: 2011
Journal Articles

Update on a Phase III Study of Panobinostat with Bortezomib and Dexamethasone in Patients with Relapsed Multiple Myeloma: PANORAMA 1,

Jesús F. San-Miguel, MD, PhD, Vânia Tietsche de Moraes Hungria, MD, PhD, Sung-Soo Yoon, MD, PhD, Wieslaw Wiktor-Jedrzejczak, MD, PhD, Ashraf Elghandour, MD, Noppadol Siritanaratkul, MD, Meletios Athanasios Dimopoulos, MD, Paolo Corradini, MD, Thanyaphong Na Nakorn, MD, PhD, Tatiana Shelekhova, MD, Andreas Günther, MD, Kwee Yong, PhD, Robert Schlossman, MD, Monika Wroclawska-Swacha, MD, MBA, Hans-Jochen Weber, PhD, Priscille Bourquelot, MD, Jian Hou, MD, Hermann Einsele, MD, Jae Hoon Lee, MD, Philippe Moreau, MD, Sagar Lonial, MD, Paul G. Richardson, MD
Journal: Blood
Blood (2011) 118 (21): 3976.
https://doi.org/10.1182/blood.V118.21.3976.3976
Published: 2011
Journal Articles

Biomarker Correlation with Outcomes in Patients with Relapsed or Refractory Multiple Myeloma on a Phase I Study of Everolimus in Combination with Lenalidomide,

Andrew J. Yee, MD, Anuj K. Mahindra, MD, Paul G. Richardson, MD, Diana D. Cirstea, MD, Tyler A. Scullen, BA, Scott J. Rodig, MD, PhD, Teru Hideshima, MD, PhD, Parameswaran Hari, MBBS, MD, MRCP, Jacob P. Laubach, MD, Irene M. Ghobrial, MD, Robert Schlossman, MD, Nikhil C. Munshi, MD, Edie A. Weller, PhD, Kenneth C. Anderson, MD, Noopur S. Raje, MD
Journal: Blood
Blood (2011) 118 (21): 3966.
https://doi.org/10.1182/blood.V118.21.3966.3966
Published: 2011
Journal Articles

RVD Induction Followed by Consolidation with ASCT in Patients with Newly Diagnosed Multiple Myeloma,

Marlise R Luskin, MD, Federico Campigotto, MS, Paul G. Richardson, MD, John Koreth, MBBS, DPhil, Irene M. Ghobrial, MD, Robert Schlossman, MD, Robert J Soiffer, MD, Nikhil C. Munshi, MD, Diane Warren, Muriel Gannon, RN, Kathleen Finn, RN, Kenneth C Anderson, MD, Edie Weller, PhD, Jacob P. Laubach, MD
Journal: Blood
Blood (2011) 118 (21): 4134.
https://doi.org/10.1182/blood.V118.21.4134.4134
Published: 2011
Journal Articles

Phase I/II Results of a Multicenter Trial of Perifosine (KRX-0401) + Bortezomib in Patients with Relapsed or Relapsed/Refractory Multiple Myeloma Who Were Previously Relapsed from or Refractory to Bortezomib

Paul Richardson, MD, Jeffrey Wolf, MD, Andrzej Jakubowiak, MD, PhD, Jeffrey Zonder, MD, Sagar Lonial, MD, David H Irwin, MD, John Densmore, MD, PhD, Amrita Krishnan, MD, FACP, Noopur Raje, MD, Michael H. Bar, MD, Jeffrey P. Allerton, MD, Robert Schlossman, Irene M. Ghobrial, M.D., Nikhil C. Munshi, MD, Thomas Martin, MD, Jacob Laubach, MD, Kathy Colson, RN, Sarah Dean, Deanna Tocco, Elizabeth Steinfield, RN, Tara Kendall, PA, Kimberly O’Riley, RN, Teru Hideshima, MD, PhD, Peter Sportelli, Lesa Gardner, RN, Kenneth C. Anderson, MD
Journal: Blood
Blood (2008) 112 (11): 870.
https://doi.org/10.1182/blood.V112.11.870.870
Published: 2008
Journal Articles

Phase II Trial of Combination of Bortezomib and Rituximab in Relapsed and/or Refractory Waldenstrom Macroglobulinemia

Irene M. Ghobrial, M.D., Jeffrey Matous, MD, Swaminathan Padmanabhan, MD, Ashraf Badros, MD, Robert Schlossman, MD, Stacey Chuma, RN, Renee Leduc1, Marybeth Nelson, PA, Kelly O’Connor, Amy Sam, Brianna Harris, Jacob Soumerai, Diane Warren, Ann Birner, Nikhil Munshi, MD, Steven P. Treon, MD, PhD, Kenneth C. Anderson, MD, Paul Richardson, MD
Journal: Blood
Blood (2008) 112 (11): 832.
https://doi.org/10.1182/blood.V112.11.832.832
Published: 2008
Journal Articles

Phase I Trial of CCI-779 (Temsirolimus) and Weekly Bortezomib in Relapsed and/or Refractory Multiple Myeloma

Irene M. Ghobrial, M.D., Nikhil Munshi, MD, Robert Schlossman, MD, Stacey Chuma, RN, Renee Leduc, Marybeth Nelson, PA, Amy Sam, Kelly O’Connor, Brianna Harris, Diane Warren, Akari M. Dollard, Jacob Laubach, MD, Ravi Vij, MD, Erica Campagnaro, MD, Ann Birner, Virginia Dixon-Lipscomb, Kenneth C. Anderson, Paul G. Richardson
Journal: Blood
Blood (2008) 112 (11): 3696.
https://doi.org/10.1182/blood.V112.11.3696.3696
Published: 2008
Journal Articles

In Vitro and In Vivo Anti-Myeloma Activity of PRLX, an Orally-Bioavailable Agent Against Cells with Constitutive Activation of Ras or Its Downstream Pathway.

Steffen Klippel, Jana Jakubikova, Lauren Jenkins, Joseph M. Negri, Yevgenia Tesmenitsky, Melissa Rooney, Jake Delmore, Douglas W. McMillin, R. Selliah, P. Robbins, Nicholas Mitsiades, Robert Schlossman, Sudhir Sahasrabudhe, Kenneth C. Anderson, Paul G. Richardson, Constantine S. Mitsiades
Journal: Blood
Blood (2007) 110 (11): 540.
https://doi.org/10.1182/blood.V110.11.540.540
Published: 2007
Journal Articles

Compartment-Specific Bioluminescence Imaging (CS-BLI): A High-Throughput Approach To Identify Novel Anti-Neoplastic Therapies That Overcome the Protection of Stromal Cells.

Douglas W. McMillin, Joseph M. Negri, Patrick Hayden, Ellen Weisberg, Steffen Klippel, Robert Schlossman, Nikhil C. Munshi, Nicholas Mitsiades, Paul G. Richardson, Kenneth C. Anderson, Constantine S. Mitsiades
Journal: Blood
Blood (2007) 110 (11): 536.
https://doi.org/10.1182/blood.V110.11.536.536
Published: 2007
Journal Articles

Activity of New Heat Shock Protein 90 (hsp90) Inhibitor NVP-AUY922 Against Myeloma Cells Sensitive and Resistant to Conventional Agents.

Douglas W. McMillin, Joseph Negri, Jake Delmore, Patrick Hayden, Melissa Ooi, Nicholas Mitsiades, Robert Schlossman, Paul G. Richardson, Nikhil C. Munshi, Michael R. Jensen, Cornelia Quadt, Patrick Chène, Joseph Schoepfer, Carlos García-Echeverría, Kenneth C. Anderson, Constantine S. Mitsiades
Journal: Blood
Blood (2007) 110 (11): 1587.
https://doi.org/10.1182/blood.V110.11.1587.1587
Published: 2007
Journal Articles

Combination of Proteasome Inhibitors Bortezomib and NPI-0052 Trigger In Vivo Synergistic Cytotoxicity in Multiple Myeloma.

Dharminder Chauhan, PhD, Ajita Singh, Ph.D, Mohan Brahmandam, M.S, Klaus Podar, Ph.D, Teru Hideshima, M.D., Robert Schlossman, M.D., Paul Richardson, M.D., Nikhil Munshi, M.D., Michael Palladino, Ph.D, Kenneth C. Anderson, M.D.
Journal: Blood
Blood (2007) 110 (11): 2524.
https://doi.org/10.1182/blood.V110.11.2524.2524
Published: 2007
Journal Articles

Acquisition of New In Vivo Genomic Change over Time in Multiple Myeloma.

Yu-Tzu Tai, PhD, Leutz Buon, M.S., Benjamin King, B.S., Cheng Li Cheng Li, Ph.D., Peter Burger Peter Burger, B.S., Xian-Feng Li, M.S., Weihua Song, M.D., Robert Schlossman, M.D., Paul Richardson, M.D., Kenneth C. Anderson, M.D., Nikhil Munshi, M.D.
Journal: Blood
Blood (2007) 110 (11): 2481.
https://doi.org/10.1182/blood.V110.11.2481.2481
Published: 2007
Journal Articles

Lenalidomide, Bortezomib, and Dexamethasone (Rev/Vel/Dex) in Patients with Relapsed or Relapsed/Refractory Multiple Myeloma (MM): Preliminary Results of a Phase II Study.

Paul Richardson, Sundar Jagannath, Noopur Raje, Andrzej Jakubowiak, Sagar Lonial, Irene Ghobrial, Robert Schlossman, Amitabha Mazumder, Nikhil Munshi, Kathleen Colson, Mary McKenney, Melissa Farrell, Laura Lunde, Lawrence Giove, Sarah Kaster, Constantine Mitsiades, Teru Hideshima, Robert Knight, Dixie-Lee Esseltine, Kenneth Anderson
Journal: Blood
Blood (2007) 110 (11): 2714.
https://doi.org/10.1182/blood.V110.11.2714.2714
Published: 2007
Journal Articles

Anti-Myeloma Activity of Selective PI-3K/PDK/mTOR Inhibitor BEZ235.

Douglas W. McMillin, Joseph Negri, Jake Delmore, Patrick Hayden, Nicholas Mitsiades, Paul G. Richardson, Nikhil C. Munshi, Robert Schlossman, Saveur-Michel Maira, Carlos García-Echeverría, Kenneth C. Anderson, Constantine S. Mitsiades
Journal: Blood
Blood (2007) 110 (11): 1185.
https://doi.org/10.1182/blood.V110.11.1185.1185
Published: 2007