Yoav H. Messinger,for the Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Consortium,Paul S. Gaynon,for the Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Consortium,Richard Sposto,for the Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Consortium,Jeannette van der Giessen,for the Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Consortium,Elena Eckroth,for the Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Consortium,Jemily Malvar,for the Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Consortium,Bruce C. Bostrom,for the Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Consortium

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Predictive value of early molecular response in patients with chronic myeloid leukemia treated with first-line dasatinib
Brief Report

David Marin,Corinne Hedgley,Richard E. Clark,Jane Apperley,Letizia Foroni,Dragana Milojkovic,Christopher Pocock,John M. Goldman,Stephen O'Brien

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Hematopoiesis and Stem Cells

N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells

Adam M. Greenbaum,Leila D. Revollo,Jill R. Woloszynek,Roberto Civitelli,Daniel C. Link

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Osteoblastic N-cadherin is not required for microenvironmental support and regulation of hematopoietic stem and progenitor cells

Olga Bromberg,Benjamin J. Frisch,Jonathan M. Weber,Rebecca L. Porter,Roberto Civitelli,Laura M. Calvi

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FANCL ubiquitinates β-catenin and enhances its nuclear function

Kim-Hien T. Dao,Michael D. Rotelli,Curtis L. Petersen,Stefanie Kaech,Whitney D. Nelson,Jane E. Yates,Amy E. Hanlon Newell,Susan B. Olson,Brian J. Druker,Grover C. Bagby

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Lymphoid Neoplasia

Essential role of TAK1 in regulating mantle cell lymphoma survival

Daniela Buglio,Sangeetha Palakurthi,Kate Byth,Francisco Vega,Dorin Toader,Jamal Saeh,Sattva S. Neelapu,Anas Younes

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The degree of BCR and NFAT activation predicts clinical outcomes in chronic lymphocytic leukemia

Christine Le Roy,Pierre-Antoine Deglesne,Nathalie Chevallier,Taoufik Beitar,Virginie Eclache,Maude Quettier,Marouane Boubaya,Rémi Letestu,Vincent Lévy,Florence Ajchenbaum-Cymbalista,Nadine Varin-Blank

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APOBEC3G enhances lymphoma cell radioresistance by promoting cytidine deaminase-dependent DNA repair

Roni Nowarski,Ofer I. Wilner,Ori Cheshin,Or D. Shahar,Edan Kenig,Leah Baraz,Elena Britan-Rosich,Arnon Nagler,Reuben S. Harris,Michal Goldberg,Itamar Willner,Moshe Kotler

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Drug response in a genetically engineered mouse model of multiple myeloma is predictive of clinical efficacy

Marta Chesi,Geoffrey M. Matthews,Victoria M. Garbitt,Stephen E. Palmer,Jake Shortt,Marcus Lefebure,A. Keith Stewart,Ricky W. Johnstone,P. Leif Bergsagel

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Myeloid Neoplasia

Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation

Michael Roth,Britta Will,Guillermo Simkin,Swathi Narayanagari,Laura Barreyro,Boris Bartholdy,Roni Tamari,Constantine S. Mitsiades,Amit Verma,Ulrich Steidl

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GATA2 zinc finger 1 mutations associated with biallelic CEBPA mutations define a unique genetic entity of acute myeloid leukemia

Philipp A. Greif,Annika Dufour,Nikola P. Konstandin,Bianka Ksienzyk,Evelyn Zellmeier,Belay Tizazu,Jutta Sturm,Tobias Benthaus,Tobias Herold,Marjan Yaghmaie,Petra Dörge,Karl-Peter Hopfner,Andreas Hauser,Alexander Graf,Stefan Krebs,Helmut Blum,Purvi M. Kakadia,Stephanie Schneider,Eva Hoster,Friederike Schneider,Martin Stanulla,Jan Braess,Maria Cristina Sauerland,Wolfgang E. Berdel,Thomas Büchner,Bernhard J. Woermann,Wolfgang Hiddemann,Karsten Spiekermann,Stefan K. Bohlander

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Platelets and Thrombopoiesis

SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models

Ronghua Meng,Yuhuan Wang,Yu Yao,Zhe Zhang,Dawn C. Harper,Harry F. G. Heijnen,Anand Sitaram,Wei Li,Graça Raposo,Mitchell J. Weiss,Mortimer Poncz,Michael S. Marks

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Calpain inhibition stabilizes the platelet proteome and reactivity in diabetes

Voahanginirina Randriamboavonjy,Johann Isaak,Amro Elgheznawy,Frank Pistrosch,Timo Frömel,Xiaoke Yin,Klaus Badenhoop,Heinrich Heide,Manuel Mayr,Ingrid Fleming

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Red Cells, Iron, and Erythropoiesis

Dual actions of Meis1 inhibit erythroid progenitor development and sustain general hematopoietic cell proliferation

Mi Cai,Ellen M. Langer,Jennifer G. Gill,Ansuman T. Satpathy,Jörn C. Albring,Wumesh KC,Theresa L. Murphy,Kenneth M. Murphy

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Quantitative assessment of sensing and sequestration of spherocytic erythrocytes by the human spleen

Innocent Safeukui,Pierre A. Buffet,Guillaume Deplaine,Sylvie Perrot,Valentine Brousse,Alioune Ndour,Marie Nguyen,Odile Mercereau-Puijalon,Peter H. David,Geneviève Milon,Narla Mohandas

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Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling

Céline Besson-Fournier,Chloé Latour,Léon Kautz,Jessica Bertrand,Tomas Ganz,Marie-Paule Roth,Hélène Coppin

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Thrombosis and Hemostasis

Residual plasmatic activity of ADAMTS13 is correlated with phenotype severity in congenital thrombotic thrombocytopenic purpura

Luca A. Lotta,Haifeng M. Wu,Ian J. Mackie,Marina Noris,Agnes Veyradier,Marie A. Scully,Giuseppe Remuzzi,Paul Coppo,Ri Liesner,Roberta Donadelli,Chantal Loirat,Richard A. Gibbs,April Horne,Shangbin Yang,Isabella Garagiola,Khaled M. Musallam,Flora Peyvandi

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Sequence and structure relationships within von Willebrand factor

Yan-Feng Zhou,Edward T. Eng,Jieqing Zhu,Chafen Lu,Thomas Walz,Timothy A. Springer

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Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism

Wei Li,James A. Huntington

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Transplantation

Detectable minimal residual disease before hematopoietic cell transplantation is prognostic but does not preclude cure for children with very-high-risk leukemia

Wing Leung,Ching-Hon Pui,Elaine Coustan-Smith,Jie Yang,Deqing Pei,Kwan Gan,Ashok Srinivasan,Christine Hartford,Brandon M. Triplett,Mari Dallas,Asha Pillai,David Shook,Jeffrey E. Rubnitz,John T. Sandlund,Sima Jeha,Hiroto Inaba,Raul C. Ribeiro,Rupert Handgretinger,Joseph H. Laver,Dario Campana

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Allogeneic hematopoietic stem cell transplantation in thalassemia major: results of a reduced-toxicity conditioning regimen based on the use of treosulfan
Brief Report

Maria Ester Bernardo,Eugenia Piras,Adriana Vacca,Giovanna Giorgiani,Marco Zecca,Alice Bertaina,Daria Pagliara,Benedetta Contoli,Rita Maria Pinto,Giovanni Caocci,Angela Mastronuzzi,Giorgio La Nasa,Franco Locatelli

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Vascular Biology

GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment

Christophe Lancrin,Milena Mazan,Monika Stefanska,Rahima Patel,Monika Lichtinger,Guilherme Costa,Özge Vargel,Nicola K. Wilson,Tarik Möröy,Constanze Bonifer,Berthold Göttgens,Valerie Kouskoff,Georges Lacaud

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Supplemental data

Hedgehog signaling via a calcitonin receptor-like receptor can induce arterial differentiation independently of VEGF signaling in zebrafish

Robert N. Wilkinson,Marco J. Koudijs,Roger K. Patient,Philip W. Ingham,Stefan Schulte-Merker,Fredericus J. M. van Eeden

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CDP-diacylglycerol synthetase-controlled phosphoinositide availability limits VEGFA signaling and vascular morphogenesis

Weijun Pan,Van N. Pham,Amber N. Stratman,Daniel Castranova,Makoto Kamei,Kameha R. Kidd,Brigid D. Lo,Kenna M. Shaw,Jesus Torres-Vazquez,Constantinos M. Mikelis,J. Silvio Gutkind,George E. Davis,Brant M. Weinstein

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Cover Image

Cover Image

PTH treatment alters the bone marrow microarchitecture. A representative image of hematoxylin and eosin–stained paraffin section from the distal femur of a PTH-treated mouse. The increased trabecular structures (in pink) are surrounded by the hematopoietic marrow cells (in blue). See the article by Bromberg et al on page 303.
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