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Journal Articles

Placental Growth Factor (PlGF) Enhances TLR/MK2 Dependent TNF Gene Transcription and Dissociates miRNAs Targeting TNF Regulatory Transcripts from the Polysome

Laura F. Newell, MD, Nicholas Burwick, MD, Christina A Harrington, PhD, Kristina Vartanian, Julja Burchard, Shernan G. Holtan, MD, Akiko Shimamura, MD PhD, Grover C. Bagby, MD

Blood (2016) 128 (22): 408.

https://doi.org/10.1182/blood.V128.22.408.408

Published: 2016

Journal Articles

The Pro-Inflammatory Cytokine Interleukin-1 Is Essential for Clonal Expansion and Disease Progression in Acute Myeloid Leukemia

Alyssa Carey, BS, Megan M Cleary, B.S., B.A., David K Edwards, V, B.A., B.S., Christopher A. Eide, Elie Traer, MD PhD, Shannon K. McWeeney, PhD, Jeffrey W. Tyner, PhD, Grover C. Bagby, MD, Brian J. Druker, MD, Anupriya Agarwal, PhD

Blood (2015) 126 (23): 866.

https://doi.org/10.1182/blood.V126.23.866.866

Published: 2015

Journal Articles

A Blunted Response to the Anti-Inflammatory Cytokine IL-10 Contributes to Excessive TNF Production in Myeloproliferative Neoplasm

Hew Yeng Lai, BS, Sarah J Morse, MS, BS, Thanh Kim Nguyen, MS PhD, Samuel B Luty, BS, Michael Garbati, PhD BS, Grover C. Bagby, Jr., MD MACP, Brian J. Druker, MD, Angela G Fleischman, MDPhD

Blood (2015) 126 (23): 1632.

https://doi.org/10.1182/blood.V126.23.1632.1632

Published: 2015

Journal Articles

TGF-β Pathway Inhibition Rescues the Function of Hematopoietic Stem and Progenitor Cells Derived from Patients with Fanconi Anemia

Haojian Zhang, PhD, David Kozono, MD PhD, Kevin O'Connor, Alix Rousseau, Lisa Moreau, Emily Gaudiano, BS, Joel S Greenberger, MD, Grover C. Bagby, Jr., MD MACP, Jean Soulier, MD PhD, Markus Grompe, MD, Kalindi Parmar, PhD, Alan D D'Andrea, MD

Blood (2015) 126 (23): 297.

https://doi.org/10.1182/blood.V126.23.297.297

Published: 2015

Journal Articles

Alda-1 Constrains TLR-Induced Cytokine Overproduction By Fanconi Anemia Macrophages By Enhancing ALDH1A1 Activity

Michael Garbati, PhD BS, Winifred Keeble, BS, Wenjin Yang, PhD, Grover C. Bagby, Jr., MD MACP

Blood (2015) 126 (23): 1000.

https://doi.org/10.1182/blood.V126.23.1000.1000

Published: 2015

Journal Articles

Deficiency of the c-JUN Inhibitor DACH1 in FA Macrophages Accounts for the Cytokine Overproduction Phenotype

Michael Garbati, PhD BS, Grover C. Bagby, Jr., MD MACP

Blood (2015) 126 (23): 1002.

https://doi.org/10.1182/blood.V126.23.1002.1002

Published: 2015

Journal Articles

Placental Growth Factor Enhances Toll-like Receptor-Induced Inflammatory Cytokine Gene Expression Transcriptionally in Human Mononuclear Phagocytes

Laura F Newell, MD, Shernan G. Holtan, MD, Jason Rosenzweig, PhD, Jane Yates, Michael Garbati, PhD BS, R. K. Rathbun, Winifred Keeble, BS, Jeffrey W. Tyner, PhD, Irina Burd, MD PhD, Grover C. Bagby, MD

Blood (2015) 126 (23): 1006.

https://doi.org/10.1182/blood.V126.23.1006.1006

Published: 2015

Journal Articles

Oxymetholone Therapy of Fanconi Anemia Induces Hematopoietic Stem Cell Cycling By Suppressing Osteopontin Transcription

Qingshuo Zhang, PhD, Eric Benedetti, Matthew Deater, Kathryn Schubert, Angela Major, Carl Pelz, Soren Impey, Laura Marquez-Loza, Keaney Rathbun, Shigeaki Kato, PhD, Grover C. Bagby, MD MACP, Markus Grompe, MD

Blood (2014) 124 (21): 2949.

https://doi.org/10.1182/blood.V124.21.2949.2949

Published: 2014

Journal Articles

Targeted Suppression of Interleukin-1 Signaling Attenuates Leukemic Cellular Growth and Disease Progression in Primary Human Cells and Murine Models of Acute Myeloid leukemia

Alyssa Carey, B.A., David Edwards, B.A., B.S., Christopher A. Eide, Elie Traer, MD, PhD, Jeffrey W. Tyner, Grover C. Bagby, MD MACP, Brian J. Druker, Anupriya Agarwal

Blood (2014) 124 (21): 702.

https://doi.org/10.1182/blood.V124.21.702.702

Published: 2014

Journal Articles

The Role of Innate Immune Dysfunction in Inherited Bone Marrow Failure

Grover C. Bagby, MD MACP

Blood (2014) 124 (21): SCI-19.

https://doi.org/10.1182/blood.V124.21.SCI-19.SCI-19

Published: 2014

Journal Articles

The Contribution of Toll-like Receptor (TLR) Pathway Hyper-Reactivity to Clonal Selection in Secondary MDS and AML

Laura F. Newell, MD, R. K. Rathbun, Michael R Garbati, PhD, Kim-Hien T. Dao, DO,PhD, Shernan G. Holtan, MD, Rachel J Cook, MD MS, Gabrielle Meyers, MD, Grover C. Bagby, MD MACP

Blood (2014) 124 (21): 4621.

https://doi.org/10.1182/blood.V124.21.4621.4621

Published: 2014

Journal Articles

Exaggerated Response to Toll-like Receptor Agonist Contributes to Excessive TNF Production in Myeloproliferative Neoplasm

Hew Yeng Lai, BS, Sarah J Morse, MS, Samuel B Luty, BS, Michael R Garbati, PhD, J Blair Edmiston, BS, Grover C. Bagby, MD MACP, Brian J. Druker, Angela G Fleischman, MDPhD

Blood (2014) 124 (21): 4584.

https://doi.org/10.1182/blood.V124.21.4584.4584

Published: 2014

Journal Articles

ALDH1A1 Dysfunction in FA-Deficient Macrophages Contributes to Aberrant Activation of the Innate Immune Response

Michael R Garbati, PhD, R. K. Rathbun, Jane E. Yates, Wenjin Yang, PhD, Grover C. Bagby, MD MACP

Blood (2014) 124 (21): 4107.

https://doi.org/10.1182/blood.V124.21.4107.4107

Published: 2014

Journal Articles

Exaggerated Response To Toll-Like Receptor Agonist Contributes To Excessive TNF Production In Myeloproliferative Neoplasm

Angela G. Fleischman, MD, PhD, Samuel B Luty, BS, Michael R Garbati, PhD, J Blair Edmiston, BS, Lacey R Royer, Dorian H LaTocha, BS, Grover C. Bagby, M.D., Brian J. Druker

Blood (2013) 122 (21): 4097.

https://doi.org/10.1182/blood.V122.21.4097.4097

Published: 2013

Journal Articles

Critical Role Of Interleukin Receptor Signaling In Acute Myeloid Leukemia Identified Using An RNAi Functional Screen

Anupriya Agarwal, Ryan J. Meckenzie, B.S., Alyssa Carey, B.A., Monika Davare, Ph.D., Christopher A. Eide, Kevin Watanabe-Smith, B.S., Rita M. Braziel, M.D., Jeffrey W. Tyner, Grover C. Bagby, M.D., Brian J. Druker

Blood (2013) 122 (21): 473.

https://doi.org/10.1182/blood.V122.21.473.473

Published: 2013

Journal Articles

FANCA and FANCC modulate TLR and p38 MAPK–dependent expression of IL-1β in macrophages

Michael R. Garbati, Laura E. Hays, Winifred Keeble, Jane E. Yates, R. Keaney Rathbun, Grover C. Bagby

Blood (2013) 122 (18): 3197–3205.

https://doi.org/10.1182/blood-2013-02-484816

Published: 2013

Includes: Supplemental data

Journal Articles

Regulation of FANCL by Glycogen Synthase Kinase-3beta Links the Fanconi anemia pathway to Self Renewal and Survival Signals

Kim-Hien T. Dao, Michael D. Rotelli, Jane E. Yates, Brieanna Brown, Juha Rantala, Keaney Rathbun, Jeffrey W Tyner, Brian J. Druker, Grover C. Bagby, Jr.

Blood (2012) 120 (21): 1263.

https://doi.org/10.1182/blood.V120.21.1263.1263

Published: 2012

Journal Articles

Fanconi Anemia: Emerging Therapeutic Opportunities

Markus Grompe, MD, John Postlethwait, Professor, Alan D. D'Andrea, MD, Susan B. Olson, Qingshuo Zhang, Grover C. Bagby, Jr.

Blood (2012) 120 (21): SCI-1.

https://doi.org/10.1182/blood.V120.21.SCI-1.SCI-1

Published: 2012

Journal Articles

FANCL ubiquitinates β-catenin and enhances its nuclear function

Kim-Hien T. Dao, Michael D. Rotelli, Curtis L. Petersen, Stefanie Kaech, Whitney D. Nelson, Jane E. Yates, Amy E. Hanlon Newell, Susan B. Olson, Brian J. Druker, Grover C. Bagby

Blood (2012) 120 (2): 323–334.

https://doi.org/10.1182/blood-2011-11-388355

Published: 2012

Includes: Supplemental data

Journal Articles

p38 MAPK inhibition suppresses the TLR-hypersensitive phenotype in FANCC- and FANCA-deficient mononuclear phagocytes

Praveen Anur, Jane Yates, Michael R. Garbati, Scott Vanderwerf, Winifred Keeble, Keaney Rathbun, Laura E. Hays, Jeffrey W. Tyner, Johanna Svahn, Enrico Cappelli, Carlo Dufour, Grover C. Bagby

Blood (2012) 119 (9): 1992–2002.

https://doi.org/10.1182/blood-2011-06-354647

Published: 2012

NARROW

Placental Growth Factor (PlGF) Enhances TLR/MK2 Dependent TNF Gene Transcription and Dissociates miRNAs Targeting TNF Regulatory Transcripts from the Polysome

The Pro-Inflammatory Cytokine Interleukin-1 Is Essential for Clonal Expansion and Disease Progression in Acute Myeloid Leukemia

A Blunted Response to the Anti-Inflammatory Cytokine IL-10 Contributes to Excessive TNF Production in Myeloproliferative Neoplasm

TGF-β Pathway Inhibition Rescues the Function of Hematopoietic Stem and Progenitor Cells Derived from Patients with Fanconi Anemia

Alda-1 Constrains TLR-Induced Cytokine Overproduction By Fanconi Anemia Macrophages By Enhancing ALDH1A1 Activity

Deficiency of the c-JUN Inhibitor DACH1 in FA Macrophages Accounts for the Cytokine Overproduction Phenotype

Placental Growth Factor Enhances Toll-like Receptor-Induced Inflammatory Cytokine Gene Expression Transcriptionally in Human Mononuclear Phagocytes

Oxymetholone Therapy of Fanconi Anemia Induces Hematopoietic Stem Cell Cycling By Suppressing Osteopontin Transcription

Targeted Suppression of Interleukin-1 Signaling Attenuates Leukemic Cellular Growth and Disease Progression in Primary Human Cells and Murine Models of Acute Myeloid leukemia

The Role of Innate Immune Dysfunction in Inherited Bone Marrow Failure

The Contribution of Toll-like Receptor (TLR) Pathway Hyper-Reactivity to Clonal Selection in Secondary MDS and AML

Exaggerated Response to Toll-like Receptor Agonist Contributes to Excessive TNF Production in Myeloproliferative Neoplasm

ALDH1A1 Dysfunction in FA-Deficient Macrophages Contributes to Aberrant Activation of the Innate Immune Response

Exaggerated Response To Toll-Like Receptor Agonist Contributes To Excessive TNF Production In Myeloproliferative Neoplasm

Critical Role Of Interleukin Receptor Signaling In Acute Myeloid Leukemia Identified Using An RNAi Functional Screen

FANCA and FANCC modulate TLR and p38 MAPK–dependent expression of IL-1β in macrophages

Regulation of FANCL by Glycogen Synthase Kinase-3beta Links the Fanconi anemia pathway to Self Renewal and Survival Signals

Fanconi Anemia: Emerging Therapeutic Opportunities

FANCL ubiquitinates β-catenin and enhances its nuclear function

p38 MAPK inhibition suppresses the TLR-hypersensitive phenotype in FANCC- and FANCA-deficient mononuclear phagocytes

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American Society of Hematology

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American Society of Hematology

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