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Journal Articles

IMiDs Synergize with EP300 Inhibition to Disrupt the Ikzf/MYC/IRF4 Axis in Multiple Myeloma

Seth J Welsh, Benjamin G Barwick, Erin Meermeier, Daniel Riggs, Chang-Xin Shi, Yuan Xiao Zhu, Meaghen E Sharik, Megan T Du, Victoria Marie Garbitt, Caleb K Stein, Joachim L Petit, Nathalie Meurice, Rodrigo Fonseca, Kennedi Todd, Sochilt Brown, Yuliza Tafoya Alvarado, Zachary Hammond, Nicklus Cuc, Courtney Wittenberg, Camille Herzog, Lawrence H. Boise, Nizar J. Bahlis, Paola Neri, W. Michael Kuehl, Marta Chesi, P. Leif Bergsagel
Journal: Blood
Blood (2022) 140 (Supplement 1): 12997.
https://doi.org/10.1182/blood-2022-169920
Published: 2022
Journal Articles

Disrupting Ectopic Super-Enhancers to Treat Multiple Myeloma

Seth Welsh, Daniel Riggs, Erin Meermeier, Chang-Xin Shi, Victoria Garbitt, Meaghen E Sharik, Megan Du, Kennedi Todd, Zachary Hammond, Sochilt Brown, Caleb K Stein, Paola Neri, Nizar J. Bahlis, Benjamin G Barwick, Larry H. Boise, W. Michael Kuehl, Marta Chesi, P. Leif Bergsagel
Journal: Blood
Blood (2021) 138 (Supplement 1): 1593.
https://doi.org/10.1182/blood-2021-147551
Published: 2021
Journal Articles

Detailing the genomic landscape of myeloma

P. Leif Bergsagel, W. Michael Kuehl
Journal: Blood
Blood (2018) 132 (6): 554–555.
https://doi.org/10.1182/blood-2018-06-857508
Published: 2018
Journal Articles

Promiscuous Cryptic Rearrangements of the MYC Locus Cis-Dysregulate MYC Expression and Are Present in the Majority of Patients with Hyperdiploid Myeloma

P Leif Bergsagel, MD, Maurizio Affer, PhD, Oleg K Glebov, PhD, Wei-Dong D Chen, PhD, Jonathan J Keats, PhD, Leslie A Brents, Marta Chesi, PhD, Scott Van Wier, Sandra K Badar, Rafael Fonseca, MD, W Michael Kuehl, MD
Journal: Blood
Blood (2012) 120 (21): 724.
https://doi.org/10.1182/blood.V120.21.724.724
Published: 2012
Journal Articles

MYC addiction: a potential therapeutic target in MM

W. Michael Kuehl, P. Leif Bergsagel
Journal: Blood
Blood (2012) 120 (12): 2351–2352.
https://doi.org/10.1182/blood-2012-08-445262
Published: 2012
Journal Articles

Mouse models can predict cancer therapy

W. Michael Kuehl
Journal: Blood
Blood (2012) 120 (2): 238–240.
https://doi.org/10.1182/blood-2012-04-422501
Published: 2012
Journal Articles

A mechanistic rationale for MEK inhibitor therapy in myeloma based on blockade of MAF oncogene expression

Christina M. Annunziata, Lidia Hernandez, R. Eric Davis, Adriana Zingone, Laurence Lamy, Lloyd T. Lam, Elaine M. Hurt, Arthur L. Shaffer, W. Michael Kuehl, Louis M. Staudt
Journal: Blood
Blood (2011) 117 (8): 2396–2404.
https://doi.org/10.1182/blood-2010-04-278788
Published: 2011
Includes: Supplemental data
Journal Articles

Classical and/or alternative NF-κB pathway activation in multiple myeloma

Yulia N. Demchenko, Oleg K. Glebov, Adriana Zingone, Jonathan J. Keats, P. Leif Bergsagel, W. Michael Kuehl
Journal: Blood
Blood (2010) 115 (17): 3541–3552.
https://doi.org/10.1182/blood-2009-09-243535
Published: 2010
Journal Articles

A monoclonal gammopathy precedes multiple myeloma in most patients

Clinical Trials & Observations
Brendan M. Weiss, Jude Abadie, Pramvir Verma, Robin S. Howard, W. Michael Kuehl
Journal: Blood
Blood (2009) 113 (22): 5418–5422.
https://doi.org/10.1182/blood-2008-12-195008
Published: 2009
Journal Articles

WSU-WM and BCWM.1 should not be assumed to represent Waldenström macroglobulinemia cell lines

P. Leif Bergsagel, W. Michael Kuehl
Journal: Blood
Blood (2008) 112 (3): 917.
https://doi.org/10.1182/blood-2008-05-154831
Published: 2008
Journal Articles

A Simple and Reliable Method To Verify the Authenticity and Purity of Human Myeloma Cell Lines.

Jonathan J. Keats, PhD, Marta Chesi, PhD, W. Michael Kuehl, MD, P. Leif Bergsagel, MD
Journal: Blood
Blood (2007) 110 (11): 2485.
https://doi.org/10.1182/blood.V110.11.2485.2485
Published: 2007
Journal Articles

CKS1B , overexpressed in aggressive disease, regulates multiple myeloma growth and survival through SKP2- and p27 Kip1 -dependent and -independent mechanisms

Fenghuang Zhan, Simona Colla, Xiaosong Wu, Bangzheng Chen, James P. Stewart, W. Michael Kuehl, Bart Barlogie, John D. Shaughnessy, Jr
Journal: Blood
Blood (2007) 109 (11): 4995–5001.
https://doi.org/10.1182/blood-2006-07-038703
Published: 2007
Journal Articles

Aberrant Immunoglobulin Class Switch Recombination and Switch Translocations in Activated B Cell-Like Diffuse Large B-Cell Lymphoma.

Georg Lenz, MD, Inga Nagel, PhD, Reiner Siebert, MD, Warren Sanger, MD, George W. Wright, PhD, Hong Zhao, Andreas Rosenwald, MD, Hans-Konrad Muller-Hermelink, MD, Randy D. Gascoyne, MD, Elias Campo, MD, Elaine S. Jaffe, MD, Erlend B. Smeland, MD, Richard I. Fisher, MD, W. Michael Kuehl, MD, Wing C. Chan, MD, Louis M. Staudt, MD, PhD
Journal: Blood
Blood (2006) 108 (11): 356.
https://doi.org/10.1182/blood.V108.11.356.356
Published: 2006
Journal Articles

Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma

P. Leif Bergsagel, W. Michael Kuehl, Fenghuang Zhan, Jeffrey Sawyer, Bart Barlogie, John Shaughnessy, Jr
Journal: Blood
Blood (2005) 106 (1): 296–303.
https://doi.org/10.1182/blood-2005-01-0034
Published: 2005
Includes: Supplemental data
Journal Articles

Advances in biology of multiple myeloma: clinical applications

Teru Hideshima, P. Leif Bergsagel, W. Michael Kuehl, Kenneth C. Anderson
Journal: Blood
Blood (2004) 104 (3): 607–618.
https://doi.org/10.1182/blood-2004-01-0037
Published: 2004
Journal Articles

Waldenström macroglobulinemia neoplastic cells lack immunoglobulin heavy chain locus translocations but have frequent 6q deletions

Roelandt F. J. Schop, W. Michael Kuehl, Scott A. Van Wier, Gregory J. Ahmann, Tammy Price-Troska, Richard J. Bailey, Syed M. Jalal, Ying Qi, Robert A. Kyle, Philip R. Greipp, Rafael Fonseca
Journal: Blood
Blood (2002) 100 (8): 2996–3001.
https://doi.org/10.1182/blood.V100.8.2996
Published: 2002
Journal Articles

Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma

Marta Chesi, Leslie A. Brents, Sarah A. Ely, Carlos Bais, Davide F. Robbiani, Enrique A. Mesri, W. Michael Kuehl, P. Leif Bergsagel
Journal: Blood
Blood (2001) 97 (3): 729–736.
https://doi.org/10.1182/blood.V97.3.729
Published: 2001
Journal Articles

Concurrent activation of a novel putative transforming gene, myeov , and cyclin D1 in a subset of multiple myeloma cell lines with t(11;14)(q13;q32)

Johannes W. G. Janssen, Jan-Willem Vaandrager, Tanja Heuser, Anna Jauch, Philip M. Kluin, Erik Geelen, P. Leif Bergsagel, W. Michael Kuehl, Hans G. Drexler, Takemi Otsuki, Claus R. Bartram, Ed Schuuring
Journal: Blood
Blood (2000) 95 (8): 2691–2698.
https://doi.org/10.1182/blood.V95.8.2691
Published: 2000
Journal Articles

The t(4;14) Translocation in Myeloma Dysregulates Both FGFR3 and a Novel Gene, MMSET , Resulting in IgH/MMSET Hybrid Transcripts

Marta Chesi, Elena Nardini, Robert S.C. Lim, Kerrington D. Smith, W. Michael Kuehl, P. Leif Bergsagel
Journal: Blood
Blood (1998) 92 (9): 3025–3034.
https://doi.org/10.1182/blood.V92.9.3025
Published: 1998
Journal Articles

Frequent Dysregulation of the c- maf Proto-Oncogene at 16q23 by Translocation to an Ig Locus in Multiple Myeloma

Marta Chesi, P. Leif Bergsagel, Oluwatoyin O. Shonukan, Maria Luisa Martelli, Leslie A. Brents, Theresa Chen, Evelin Schröck, Thomas Ried, W. Michael Kuehl
Journal: Blood
Blood (1998) 91 (12): 4457–4463.
https://doi.org/10.1182/blood.V91.12.4457
Published: 1998