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Journal Articles

Poor Treatment Outcomes of Young (<60 Years) African American Patients (Pts) Diagnosed with Acute Myeloid Leukemia (AML) (Alliance)

Blood (2020) 136 (Supplement 1): 5–7.

https://doi.org/10.1182/blood-2020-140999

Published: 2020

Journal Articles

Meta-Analysis of Genome-Wide Association Studies of Acute Myeloid Leukemia (AML) Patients Identifies Variants Associated with Risk of 11q23/ KMT2A -Translocated and Core-Binding Factor (CBF) AML and Suggests a Role for Transcription Elongation in Leukemogenesis

Blood (2020) 136 (Supplement 1): 29–30.

https://doi.org/10.1182/blood-2020-141653

Published: 2020

Journal Articles

The 2017 European Leukemianet Genetic Risk Classification Performs Poorly in Older Patients with Acute Myeloid Leukemia (AML) and Should be Refined to Identify Patients Requiring Additional or Alternative Treatment

Ann-Kathrin Eisfeld, MD, Jessica Kohlschmidt, PhD, Krzysztof Mrózek, MD PhD, Deedra Nicolet, MS, Alice S. Mims, MD, Dimitrios Papaioannou, MD, Christopher J. Walker, PhD, James S. Blachly, MD, Sophia E. Maharry, Andrew J. Carroll, PhD, Richard M. Stone, MD, Bayard L Powell, MD, Albert de la Chapelle, MD PhD, Eunice S. Wang, MD, Jonathan E. Kolitz, MD, John C. Byrd, MD, Clara D. Bloomfield, MD

Blood (2019) 134 (Supplement_1): 2681.

https://doi.org/10.1182/blood-2019-130076

Published: 2019

Journal Articles

Distinct Gene Expression Profiles and Mutations Associate with Outcome in Younger Adults with De Novo Cytogenetically Normal Acute Myeloid Leukemia (CN-AML) (Alliance)

Christopher J. Walker, PhD, Ann-Kathrin Eisfeld, MD, Hatice G Ozer, PhD, Jessica Kohlschmidt, PhD, Deedra Nicolet, Krzysztof Mrózek, MD PhD, Dimitrios Papaioannou, MD, Luke K Genutis, BS, Bayard L Powell, MD, Geoffrey L. Uy, MD, Jonathan E. Kolitz, MD, Andrew J. Carroll, PhD, Richard Stone, MD, Ramiro Garzon, MD, John C. Byrd, MD, Albert de la Chapelle, MD PhD, Clara D. Bloomfield, MD

Blood (2019) 134 (Supplement_1): 1247.

https://doi.org/10.1182/blood-2019-127478

Published: 2019

Journal Articles

Additional Gene Mutations Refine the 2017 European Leukemianet (ELN) Classification of Adult Patients (Pts) with De Novo Acute Myeloid Leukemia (AML) Aged <60 Years: An Analysis of Alliance for Clinical Trials in Oncology (Alliance) Studies

Ann-Kathrin Eisfeld, MD, Jessica Kohlschmidt, PhD, Krzysztof Mrózek, MD PhD, Alice S. Mims, MD, Christopher J. Walker, PhD, Deedra Nicolet, MS, James S. Blachly, MD, Andrew J. Carroll, PhD, Jonathan E. Kolitz, MD, Bayard L. Powell, MD, Richard M. Stone, MD, Albert de la Chapelle, MD PhD, John C. Byrd, MD, Clara D. Bloomfield, MD

Blood (2018) 132 (Supplement 1): 2740.

https://doi.org/10.1182/blood-2018-99-119994

Published: 2018

Journal Articles

Uniparental Disomies (UPD) of Chromosome 13q Is Associated with Shorter Disease-Free Survival in Adult Patients (Pts) with De Novo Cytogenetically Normal Acute Myeloid Leukemia (CN-AML)

Christopher J. Walker, PhD, Jessica Kohlschmidt, PhD, Ann-Kathrin Eisfeld, MD, Krzysztof Mrózek, MD PhD, Deedra Nicolet, MS, James S. Blachly, MD, Christopher C. Oakes, Shelley Orwick, BS, Dimitrios Papaioannou, MD, Bayard L. Powell, MD, Jonathan E. Kolitz, MD, Andrew J. Carroll, PhD, Richard M. Stone, MD, John C. Byrd, MD, Albert de la Chapelle, MD PhD, Clara D. Bloomfield, MD

Blood (2018) 132 (Supplement 1): 2777.

https://doi.org/10.1182/blood-2018-99-115389

Published: 2018

Journal Articles

Genome-Wide Association Study (GWAS) Identifies a Significant Acute Myeloid Leukemia (AML) Susceptibility Locus Near BICRA

Blood (2018) 132 (Supplement 1): 85.

https://doi.org/10.1182/blood-2018-99-115170

Published: 2018

Journal Articles

Mutations in Genes Associated with Familial Predisposition to Myeloid Neoplasms: Their Frequency and Associations with Pretreatment Characteristics in Adult Patients (Pts) with Presumably Sporadic De Novo Acute Myeloid Leukemia (AML)

Ann-Kathrin Eisfeld, MD, Jessica Kohlschmidt, PhD, Krzysztof Mrózek, MD PhD, Alice S. Mims, MD, Christopher J. Walker, PhD, Deedra Nicolet, MS, James S. Blachly, MD, Luke K Genutis, BS, Andrew J. Carroll, PhD, Bayard L. Powell, MD, Jonathan E. Kolitz, MD, Richard M. Stone, MD, Albert de la Chapelle, MD PhD, John C. Byrd, MD, Clara D. Bloomfield, MD

Blood (2018) 132 (Supplement 1): 1478.

https://doi.org/10.1182/blood-2018-99-120085

Published: 2018

Journal Articles

Mutational Landscape and Clinical Outcome Associated with Different Rearrangements Involving 11q23/ MLL in De Novo Acute Myeloid Leukemia (AML)

Marius Bill, MD PhD, Ann-Kathrin Eisfeld, MD, Krzysztof Mrózek, MDPhD, Jessica Kohlschmidt, PhD, Deedra Nicolet, MS, Christopher J. Walker, PhD, James S. Blachly, MD, Andrew Carroll, PhD, Jonathan E. Kolitz, MD, Eunice S. Wang, MD, Bayard L. Powell, MD, Richard M. Stone, MD, Albert de la Chapelle, MD PhD, John C. Byrd, MD, Clara D. Bloomfield, MD

Blood (2017) 130 (Supplement 1): 3960.

https://doi.org/10.1182/blood.V130.Suppl_1.3960.3960

Published: 2017

Journal Articles

Neurofibromin 1 gene Mutations Are Recurrent Events in Adult Patients with Acute Myeloid Leukemia (AML), Associate with Poor Outcome and Refine the Adverse European Leukemianet (ELN) Risk Category

Ann-Kathrin Eisfeld, MD, Jessica Kohlschmidt, PhD, Krzysztof Mrózek, MDPhD, Alice S. Mims, MD MSCR, Christopher J. Walker, PhD, James S. Blachly, MD, Deedra Nicolet, MS, Shelley Orwick, BS, Sofia E. Maharry, Andrew Carroll, PhD, Bayard L. Powell, MD, Jonathan E. Kolitz, MD, Eunice S. Wang, MD, Richard M. Stone, MD, Albert de la Chapelle, MD PhD, John C. Byrd, MD, Clara D. Bloomfield, MD

Blood (2017) 130 (Supplement 1): 186.

https://doi.org/10.1182/blood.V130.Suppl_1.186.186

Published: 2017

Journal Articles

Mutation Patterns Identify Adult Patients with De Novo Acute Myeloid Leukemia (AML) Aged 60 Years or Older Who Respond Favorably to Standard Chemotherapy: an Analysis of Alliance Studies

Ann-Kathrin Eisfeld, MD, Jessica Kohlschmidt, PhD, Krzysztof Mrózek, MDPhD, James S. Blachly, MD, Christopher J. Walker, PhD, Deedra Nicolet, MS, Shelley Orwick, BS, Andrew Carroll, PhD, Richard M. Stone, MD, Eunice S. Wang, MD, Jonathan E. Kolitz, MD, Bayard L. Powell, MD, Albert de la Chapelle, MD PhD, John C. Byrd, MD, Clara D. Bloomfield, MD

Blood (2017) 130 (Supplement 1): 103.

https://doi.org/10.1182/blood.V130.Suppl_1.103.103

Published: 2017

Journal Articles

The Mutational Patterns Associated with Cytogenetic Subsets of De Novo Acute Myeloid Leukemia (AML): A Study of 1603 Adult Patients (Pts)

Ann-Kathrin Eisfeld, MD, Krzysztof Mrózek, MD PhD, Jessica Kohlschmidt, PhD BS, MS, Deedra Nicolet, Shelley Orwick, BS, Karl Kroll, James S. Blachly, MD, Andrew J. Carroll, PhD, Jonathan E. Kolitz, MD, Bayard L Powell, MD, Eunice S. Wang, MD, Richard M. Stone, MD, Albert de la Chapelle, John C. Byrd, MD, Clara D. Bloomfield, MD

Blood (2016) 128 (22): 287.

https://doi.org/10.1182/blood.V128.22.287.287

Published: 2016

Journal Articles

CCND1 and CCND2 Mutations Are Frequent in Adults with Core-Binding Factor Acute Myeloid Leukemia (CBF-AML) with t(8;21)(q22;q22)

Ann-Kathrin Eisfeld, MD, Jessica Kohlschmidt, PhD BS, MS, Sebastian Schwind, MD, Deedra Nicolet, James S. Blachly, MD, Shelley Orwick, BS, Chandni Shah, Maryam Bainazar, Karl Kroll, Christopher J Walker, Andrew J. Carroll, PhD, Bayard L Powell, MD, Richard M. Stone, MD, Jonathan E. Kolitz, MD, Maria R. Baer, MD, Albert de la Chapelle, Krzysztof Mrózek, MD PhD, John C. Byrd, MD, Clara D. Bloomfield, MD

Blood (2016) 128 (22): 2740.

https://doi.org/10.1182/blood.V128.22.2740.2740

Published: 2016

Journal Articles

Micro RNA-3662 Located within the Major Hematopoietic Differentiation Quantitative Trait Locus on Chromosome 6q23 Acts As a Tumor Suppressor By Direct Targeting of the NF-ĸB Transcriptional Activation Pathway

Sophia E. Maharry, Sujay Mehta, Sandya Liyanarachchi, MS, Christopher J. Walker, PhD, Clara D. Bloomfield, MD, Albert de la Chapelle, MD PhD, Ann-Kathrin Eisfeld, MD

Blood (2014) 124 (21): 2216.

https://doi.org/10.1182/blood.V124.21.2216.2216

Published: 2014

Journal Articles

miR-3151 interplays with its host gene BAALC and independently affects outcome of patients with cytogenetically normal acute myeloid leukemia

Blood (2012) 120 (2): 249–258.

https://doi.org/10.1182/blood-2012-02-408492

Published: 2012

Includes: Supplemental data

Journal Articles

MiR-3151 , a Novel MicroRNA Embedded in BAALC , Is Only Weakly Co-Expressed with Its Host Gene and Independently Impacts on the Clinical Outcome of Older Patients (Pts) with De Novo Cytogenetically Normal Acute Myeloid Leukemia (CN-AML)

Blood (2011) 118 (21): 1462.

https://doi.org/10.1182/blood.V118.21.1462.1462

Published: 2011

Journal Articles

High BAALC expression associates with other molecular prognostic markers, poor outcome, and a distinct gene-expression signature in cytogenetically normal patients younger than 60 years with acute myeloid leukemia: a Cancer and Leukemia Group B (CALGB) study

Christian Langer, Michael D. Radmacher, Amy S. Ruppert, Susan P. Whitman, Peter Paschka, Krzysztof Mrózek, Claudia D. Baldus, Tamara Vukosavljevic, Chang-Gong Liu, Mary E. Ross, Bayard L. Powell, Albert de la Chapelle, Jonathan E. Kolitz, Richard A. Larson, Guido Marcucci, Clara D. Bloomfield

Blood (2008) 111 (11): 5371–5379.

https://doi.org/10.1182/blood-2007-11-124958

Published: 2008

Includes: Supplemental data

Journal Articles

Amnionless function is required for cubilin brush-border expression and intrinsic factor-cobalamin (vitamin B 12 ) absorption in vivo

Qianchuan He, Mette Madsen, Adam Kilkenney, Brittany Gregory, Erik I. Christensen, Henrik Vorum, Peter Højrup, Alejandro A. Schäffer, Ewen F. Kirkness, Stephan M. Tanner, Albert de la Chapelle, Urs Giger, Søren K. Moestrup, John C. Fyfe

Blood (2005) 106 (4): 1447–1453.

https://doi.org/10.1182/blood-2005-03-1197

Published: 2005

Journal Articles

Significant Down-Regulation of BAALC during Lineage Specific Hematopoietic Differentiation.

Claudia D. Baldus, MD, Martina Komor, MS, Dieter Hoelzer, MD, Albert de la Chapelle, MD PhD, Eckhard Thiel, MD, Wolf-Karsten Hofmann, MD

Blood (2004) 104 (11): 4189.

https://doi.org/10.1182/blood.V104.11.4189.4189

Published: 2004

Journal Articles

The functional cobalamin (vitamin B 12 )–intrinsic factor receptor is a novel complex of cubilin and amnionless

John C. Fyfe, Mette Madsen, Peter Højrup, Erik I. Christensen, Stephan M. Tanner, Albert de la Chapelle, Qianchuan He, Søren K. Moestrup

Blood (2004) 103 (5): 1573–1579.

https://doi.org/10.1182/blood-2003-08-2852

Published: 2004

NARROW

Poor Treatment Outcomes of Young (<60 Years) African American Patients (Pts) Diagnosed with Acute Myeloid Leukemia (AML) (Alliance)

Meta-Analysis of Genome-Wide Association Studies of Acute Myeloid Leukemia (AML) Patients Identifies Variants Associated with Risk of 11q23/ KMT2A -Translocated and Core-Binding Factor (CBF) AML and Suggests a Role for Transcription Elongation in Leukemogenesis

The 2017 European Leukemianet Genetic Risk Classification Performs Poorly in Older Patients with Acute Myeloid Leukemia (AML) and Should be Refined to Identify Patients Requiring Additional or Alternative Treatment

Distinct Gene Expression Profiles and Mutations Associate with Outcome in Younger Adults with De Novo Cytogenetically Normal Acute Myeloid Leukemia (CN-AML) (Alliance)

Additional Gene Mutations Refine the 2017 European Leukemianet (ELN) Classification of Adult Patients (Pts) with De Novo Acute Myeloid Leukemia (AML) Aged <60 Years: An Analysis of Alliance for Clinical Trials in Oncology (Alliance) Studies

Uniparental Disomies (UPD) of Chromosome 13q Is Associated with Shorter Disease-Free Survival in Adult Patients (Pts) with De Novo Cytogenetically Normal Acute Myeloid Leukemia (CN-AML)

Genome-Wide Association Study (GWAS) Identifies a Significant Acute Myeloid Leukemia (AML) Susceptibility Locus Near BICRA

Mutations in Genes Associated with Familial Predisposition to Myeloid Neoplasms: Their Frequency and Associations with Pretreatment Characteristics in Adult Patients (Pts) with Presumably Sporadic De Novo Acute Myeloid Leukemia (AML)

Mutational Landscape and Clinical Outcome Associated with Different Rearrangements Involving 11q23/ MLL in De Novo Acute Myeloid Leukemia (AML)

Neurofibromin 1 gene Mutations Are Recurrent Events in Adult Patients with Acute Myeloid Leukemia (AML), Associate with Poor Outcome and Refine the Adverse European Leukemianet (ELN) Risk Category

Mutation Patterns Identify Adult Patients with De Novo Acute Myeloid Leukemia (AML) Aged 60 Years or Older Who Respond Favorably to Standard Chemotherapy: an Analysis of Alliance Studies

The Mutational Patterns Associated with Cytogenetic Subsets of De Novo Acute Myeloid Leukemia (AML): A Study of 1603 Adult Patients (Pts)

CCND1 and CCND2 Mutations Are Frequent in Adults with Core-Binding Factor Acute Myeloid Leukemia (CBF-AML) with t(8;21)(q22;q22)

Micro RNA-3662 Located within the Major Hematopoietic Differentiation Quantitative Trait Locus on Chromosome 6q23 Acts As a Tumor Suppressor By Direct Targeting of the NF-ĸB Transcriptional Activation Pathway

miR-3151 interplays with its host gene BAALC and independently affects outcome of patients with cytogenetically normal acute myeloid leukemia

MiR-3151 , a Novel MicroRNA Embedded in BAALC , Is Only Weakly Co-Expressed with Its Host Gene and Independently Impacts on the Clinical Outcome of Older Patients (Pts) with De Novo Cytogenetically Normal Acute Myeloid Leukemia (CN-AML)

High BAALC expression associates with other molecular prognostic markers, poor outcome, and a distinct gene-expression signature in cytogenetically normal patients younger than 60 years with acute myeloid leukemia: a Cancer and Leukemia Group B (CALGB) study

Amnionless function is required for cubilin brush-border expression and intrinsic factor-cobalamin (vitamin B 12 ) absorption in vivo

Significant Down-Regulation of BAALC during Lineage Specific Hematopoietic Differentiation.

The functional cobalamin (vitamin B 12 )–intrinsic factor receptor is a novel complex of cubilin and amnionless

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American Society of Hematology

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