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Rolf T. Urbanus
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Journal Articles

Pharmacokinetic-Guided Reduction of Emicizumab in Patients with Congenital Hemophilia a in the Netherlands: Interim Analysis from the Dosemi Study

Konrad Van Der Zwet, Marjon H. Cnossen, Floor CJI Moenen, Saskia EM Schols, Paula F Ypma, Paul L. den Exter, Louise Hooimeijer, Michiel Coppens, Ron A.A. Mathôt, Anouk A.M.T. Donners, Alexander Janssen, Ilmar Kruis, Eduard J. Van Beers, Corien L. Eckhardt, Rolf T. Urbanus, Lize Fie Ditteke Van Vulpen, Roger EG Schutgens, Kathelijn Fischer
Journal: Blood
Blood (2024) 144 (Supplement 1): 127.
https://doi.org/10.1182/blood-2024-193995
Published: 2024
Journal Articles

Evaluating the Clinical Relevance of Thrombin Generation Potential during Emicizumab Therapy

Konrad Van Der Zwet, Mark Roest, Dana Huskens, Eduard J. Van Beers, Kathelijn Fischer, Lize Fie Ditteke Van Vulpen, Roger EG Schutgens, Rolf T. Urbanus
Journal: Blood
Blood (2024) 144 (Supplement 1): 3960.
https://doi.org/10.1182/blood-2024-204587
Published: 2024
Journal Articles

Prothrombin forced into an awkward position

Rolf T. Urbanus
Journal: Blood
Blood (2024) 143 (19): 1888–1890.
https://doi.org/10.1182/blood.2024024240
Published: 2024
Journal Articles

Domain Specificity of Anti-Prothrombin Antibodies That Express Lupus Anticoagulant Activity

Rachel Gehlen, Tessa Noordermeer, Arne Vandevelde, Walid Chayoua, Marisa Ninivaggi, Romy De Laat-Kremers, Mark Roest, Philip G. De Groot, Katrien M.J. Devreese, Rolf T. Urbanus, Bas De Laat
Journal: Blood
Blood (2023) 142 (Supplement 1): 5529.
https://doi.org/10.1182/blood-2023-185610
Published: 2023
Journal Articles

Diversity of Plasmatic Thrombin Pools Regulate Thrombin Generation and Blood Clotting: Interference By a Novel Nanobody

Siyu Sun, Joke Konings, Rolf T. Urbanus, Dana Huskens, Frauke Swieringa, Romy De Laat-Kremers, Jinmi Zou, Philip G. De Groot, Mark Roest, Johan W. M. Heemskerk, Bas De Laat
Journal: Blood
Blood (2023) 142 (Supplement 1): 3978.
https://doi.org/10.1182/blood-2023-185665
Published: 2023
Journal Articles

Microlyse: a thrombolytic agent that targets VWF for clearance of microvascular thrombosis

Steven de Maat, Chantal C. Clark, Arjan D. Barendrecht, Simone Smits, Nadine D. van Kleef, Hinde El Otmani, Manon Waning, Marc van Moorsel, Michael Szardenings, Nicolas Delaroque, Kristof Vercruysse, Rolf T. Urbanus, Silvie Sebastian, Peter J. Lenting, Christoph Hagemeyer, Thomas Renné, Karen Vanhoorelbeke, Claudia Tersteeg, Coen Maas
Journal: Blood
Blood (2022) 139 (4): 597–607.
https://doi.org/10.1182/blood.2021011776
Published: 2022
Includes: Supplemental data
Journal Articles

Small Angle X-Ray Scattering Reveals the Conformation of β 2 glycoprotein I and the Conformational Binding Epitopes of Autoantibodies

Seung J. Kim, PhD, Jacob H. Rand, MD PhD, Philip G. de Groot, PhD, Rolf T. Urbanus, PhD, Dina Schneidman, PhD, Man K. Chan, PhD, Hilde Kelchtermans, PhD, Bas De Laat, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2378.
https://doi.org/10.1182/blood.V130.Suppl_1.2378.2378
Published: 2017
Journal Articles

The significance of autoantibodies against β 2 -glycoprotein I

Philip G. de Groot, Rolf T. Urbanus
Journal: Blood
Blood (2012) 120 (2): 266–274.
https://doi.org/10.1182/blood-2012-03-378646
Published: 2012
Journal Articles

β 2 -Glycoprotein I: a novel component of innate immunity

Çetin Ağar, Philip G. de Groot, Matthias Mörgelin, Stephanie D. D. C. Monk, Gwendolyn van Os, Johannes H. M. Levels, Bas de Laat, Rolf T. Urbanus, Heiko Herwald, Tom van der Poll, Joost C. M. Meijers
Journal: Blood
Blood (2011) 117 (25): 6939–6947.
https://doi.org/10.1182/blood-2010-12-325951
Published: 2011
Journal Articles

Apolipoprotein E receptor 2 is involved in the thrombotic complications in a murine model of the antiphospholipid syndrome

Zurina Romay-Penabad, Renan Aguilar-Valenzuela, Rolf T. Urbanus, Ronald H. W. M. Derksen, Maarten T. T. Pennings, Elizabeth Papalardo, Tuya Shilagard, Gracie Vargas, Yong Hwang, Philip G. de Groot, Silvia S. Pierangeli
Journal: Blood
Blood (2011) 117 (4): 1408–1414.
https://doi.org/10.1182/blood-2010-07-299099
Published: 2011
Journal Articles

β 2 -Glycoprotein I can exist in 2 conformations: implications for our understanding of the antiphospholipid syndrome

Çetin Ağar, Gwendolyn M. A. van Os, Matthias Mörgelin, Richard R. Sprenger, J. Arnoud Marquart, Rolf T. Urbanus, Ronald H. W. M. Derksen, Joost C. M. Meijers, Philip G. de Groot
Journal: Blood
Blood (2010) 116 (8): 1336–1343.
https://doi.org/10.1182/blood-2009-12-260976
Published: 2010
Journal Articles

Association between beta2-glycoprotein I plasma levels and the risk of myocardial infarction in older men

Bas de Laat, Philip G. de Groot, Ronald H. W. M. Derksen, Rolf T. Urbanus, Koen Mertens, Frits R. Rosendaal, Carine J. M. Doggen
Journal: Blood
Blood (2009) 114 (17): 3656–3661.
https://doi.org/10.1182/blood-2009-03-212910
Published: 2009
Journal Articles

Apolipoprotein E Receptor 2′ Mediates Pathogenic Effects of Dimeric β 2 glycoprotein I and of Anti- β 2 glycoprotein I Antibodies in Vivo

Zurina Romay-Penabad, Ph.D., Rolf T Urbanus, MD, Elizabeth Pappalardo, B.S., Yong Hwang, M.D., Ronald H.W.M. Derksen, MD., Tuya Shilagard, Ph.D., Gracie Vargas, Ph.D., Maarten TT Pennings, Ph.D., Philip G De Groot, PhD, Silvia S Pierangeli, Ph.D.
Journal: Blood
Blood (2008) 112 (11): 408.
https://doi.org/10.1182/blood.V112.11.408.408
Published: 2008
Journal Articles

Identification of a Role for Apolipoprotein E Receptor 2 as a Platelet Receptor for Factor XI

Tara C White, Michelle A Berny, Erik I Tucker, Jiaqing Pang, David Gailani, MD, Rolf T Urbanus, MD, Philip G de Groot, PhD, András Gruber, MD, Owen JT McCarty, PhD
Journal: Blood
Blood (2008) 112 (11): 3914.
https://doi.org/10.1182/blood.V112.11.3914.3914
Published: 2008
Journal Articles

Activation of the PI3K-Akt Pathway by Activated Protein C Occurs Via a Novel Receptor, Apolipoprotein E Receptor 2 (ApoER2)

Xia V. Yang, PhD, Yajnavalka Banerjee, PhD, Jose A. Fernandez, MD, PhD, Hiroshi Deguchi, MD, PhD, Xiao Xu, Laurent O. Mosnier, PhD, Rolf T Urbanus, MD, Phillip G deGroot, PhD, Tara C White, Owen J.T. McCarty, PhD, John H. Griffin, PhD
Journal: Blood
Blood (2008) 112 (11): 695.
https://doi.org/10.1182/blood.V112.11.695.695
Published: 2008
Journal Articles

Decreased beta2-Glycoprotein I Plasma Levels as a Risk Factor for Myocardial Infarction in Men.

Bas De Laat, PhD, Philip G. de Groot, PhD, Ronald H.W.M. Derksen, MD., Rolf T. Urbanus, Koen Mertens, PhD, Frits Rosendaal, MD, PhD, Carine J.M. Doggen, PhD
Journal: Blood
Blood (2008) 112 (11): 1813.
https://doi.org/10.1182/blood.V112.11.1813.1813
Published: 2008
Journal Articles

IgG antibodies that recognize epitope Gly40-Arg43 in domain I of β 2 –glycoprotein I cause LAC, and their presence correlates strongly with thrombosis

Clinical Trials & Observations
Bas de Laat, Ronald H. W. M. Derksen, Rolf T. Urbanus, Philip G. de Groot
Journal: Blood
Blood (2005) 105 (4): 1540–1545.
https://doi.org/10.1182/blood-2004-09-3387
Published: 2005
Journal Articles

β 2 -glycoprotein I–dependent lupus anticoagulant highly correlates with thrombosis in the antiphospholipid syndrome

Clinical Trials & Observations
H. Bas de Laat, Ronald H.W.M. Derksen, Rolf T. Urbanus, Mark Roest, Philip G. de Groot
Journal: Blood
Blood (2004) 104 (12): 3598–3602.
https://doi.org/10.1182/blood-2004-03-1107
Published: 2004