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A phase 2 study of lenalidomide monotherapy in patients with deletion 5q acute myeloid leukemia: Southwest Oncology Group Study S0605
Lenalidomide, bortezomib, pegylated liposomal doxorubicin, and dexamethasone in newly diagnosed multiple myeloma: a phase 1/2 Multiple Myeloma Research Consortium trial
Paraproteins of familial MGUS/multiple myeloma target family-typical antigens: hyperphosphorylation of autoantigens is a consistent finding in familial and sporadic MGUS/MM
Dismal prognostic value of monosomal karyotype in elderly patients with acute myeloid leukemia: a GOELAMS study of 186 patients with unfavorable cytogenetic abnormalities
Predicting complete cytogenetic response and subsequent progression-free survival in 2060 patients with CML on imatinib treatment: the EUTOS score
Long-term prognostic significance of response in multiple myeloma after stem cell transplantation
Issue Archive
July 21 2011
In this Issue
Table of Contents
Inside Blood
Blood Work
Plenary Paper
PLENARY PAPER
Exome sequencing reveals germline NPAT mutation as a candidate risk factor for Hodgkin lymphoma
Silva Saarinen,Mervi Aavikko,Kristiina Aittomäki,Virpi Launonen,Rainer Lehtonen,Kaarle Franssila,Heli J. Lehtonen,Eevi Kaasinen,Peter Broderick,Jussi Tarkkanen,Barbara J. Bain,Frédéric Bauduer,Ali Ünal,Anthony J. Swerdlow,Rosie Cooke,Markus J. Mäkinen,Richard Houlston,Pia Vahteristo,Lauri A. Aaltonen
Review Article
How I Treat
Clinical Trials and Observations
A phase 2 study of lenalidomide monotherapy in patients with deletion 5q acute myeloid leukemia: Southwest Oncology Group Study S0605
Clinical Trials & Observations
Mikkael A. Sekeres,Holly Gundacker,Jeffrey Lancet,Anjali Advani,Stephen Petersdorf,Jane Liesveld,Deborah Mulford,Tom Norwood,Cheryl L. Willman,Frederick R. Appelbaum,Alan F. List
Lenalidomide, bortezomib, pegylated liposomal doxorubicin, and dexamethasone in newly diagnosed multiple myeloma: a phase 1/2 Multiple Myeloma Research Consortium trial
Clinical Trials & Observations
Andrzej J. Jakubowiak,Kent A. Griffith,Donna E. Reece,Craig C. Hofmeister,Sagar Lonial,Todd M. Zimmerman,Erica L. Campagnaro,Robert L. Schlossman,Jacob P. Laubach,Noopur S. Raje,Tara Anderson,Melissa A. Mietzel,Colleen K. Harvey,Sandra M. Wear,Jennifer C. Barrickman,Craig L. Tendler,Dixie-Lee Esseltine,Susan L. Kelley,Mark S. Kaminski,Kenneth C. Anderson,Paul G. Richardson
Hematopoiesis and Stem Cells
Loss of p19Arf in a Rag1−/− B-cell precursor population initiates acute B-lymphoblastic leukemia
Julia Hauer,Charles Mullighan,Estelle Morillon,Gary Wang,Julie Bruneau,Nicole Brousse,Marc Lelorc'h,Serge Romana,Amine Boudil,Daniela Tiedau,Sven Kracker,Frederic D. Bushmann,Arndt Borkhardt,Alain Fischer,Salima Hacein-Bey-Abina,Marina Cavazzana-Calvo
Immunobiology
Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitination
Xuan-Hung Nguyen,Philipp A. Lang,Karl S. Lang,Dieter Adam,Gulnar Fattakhova,Niko Föger,Mohammad Azhar Kamal,Patricia Prilla,Sabine Mathieu,Christina Wagner,Tak Mak,Andrew C. Chan,Kyeong-Hee Lee
Long-term restoration of the human T-cell compartment after thymectomy during infancy: a role for thymic regeneration?
Rogier van Gent,Alvin W. L. Schadenberg,Sigrid A. Otto,Rutger A. J. Nievelstein,Gertjan T. Sieswerda,Felix Haas,Frank Miedema,Kiki Tesselaar,Nicolaas J. G. Jansen,José A. M. Borghans
Paraproteins of familial MGUS/multiple myeloma target family-typical antigens: hyperphosphorylation of autoantigens is a consistent finding in familial and sporadic MGUS/MM
Brief Report
Sandra Grass,Klaus-Dieter Preuss,Stephan Thome,Dennis D. Weisenburger,Vinetta Witt,Jane Lynch,Florian Zettl,Lorenz Trümper,Natalie Fadle,Evi Regitz,Henry Lynch,Michael Pfreundschuh
Lymphoid Neoplasia
RAC2, AEP, and ICAM1 expression are associated with CNS disease in a mouse model of pre-B childhood acute lymphoblastic leukemia
Mark Holland,Fernanda V. Castro,Seema Alexander,Duncan Smith,Jizhong Liu,Michael Walker,Danny Bitton,Kate Mulryan,Garry Ashton,Morgan Blaylock,Steve Bagley,Yvonne Connolly,John Bridgeman,Crispin Miller,Shekhar Krishnan,Clare Dempsey,Ashish Masurekar,Peter Stern,Anthony Whetton,Vaskar Saha
Lack of TIR8/SIGIRR triggers progression of chronic lymphocytic leukemia in mouse models
Maria Teresa Sabrina Bertilaccio,Giorgia Simonetti,Antonis Dagklis,Martina Rocchi,Tania Veliz Rodriguez,Benedetta Apollonio,Alberto Mantovani,Maurilio Ponzoni,Paolo Ghia,Cecilia Garlanda,Federico Caligaris-Cappio,Marta Muzio
Myeloid Neoplasia
Dismal prognostic value of monosomal karyotype in elderly patients with acute myeloid leukemia: a GOELAMS study of 186 patients with unfavorable cytogenetic abnormalities
Clinical Trials & Observations
Aurore Perrot,Isabelle Luquet,Arnaud Pigneux,Francine Mugneret,Jacques Delaunay,Jean-Luc Harousseau,Carole Barin,Jean-Yves Cahn,Philippe Guardiola,Chantal Himberlin,Christian Recher,Norbert Vey,Bruno Lioure,Mario Ojeda-Uribe,Nathalie Fegueux,Christian Berthou,Edouard Randriamalala,Marie C. Béné,Norbert Ifrah,Francis Witz,for the GOELAMS (Groupe Ouest-Est des Leucémies Aiguës et Maladies du Sang)
Predicting complete cytogenetic response and subsequent progression-free survival in 2060 patients with CML on imatinib treatment: the EUTOS score
Clinical Trials & Observations
Joerg Hasford,Michele Baccarani,Verena Hoffmann,Joelle Guilhot,Susanne Saussele,Gianantonio Rosti,François Guilhot,Kimmo Porkka,Gert Ossenkoppele,Doris Lindoerfer,Bengt Simonsson,Markus Pfirrmann,Rudiger Hehlmann
Anti-CD45 pretargeted radioimmunotherapy using bismuth-213: high rates of complete remission and long-term survival in a mouse myeloid leukemia xenograft model
John M. Pagel,Aimee L. Kenoyer,Tom Bäck,Donald K. Hamlin,D. Scott Wilbur,Darrell R. Fisher,Steven I. Park,Shani Frayo,Amanda Axtman,Nural Orgun,Johnnie Orozco,Jaideep Shenoi,Yukang Lin,Ajay K. Gopal,Damian J. Green,Frederick R. Appelbaum,Oliver W. Press
Phagocytes, Granulocytes, and Myelopoiesis
Activation of hypoxia-inducible factor-1α (Hif-1α) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model
Philip M. Elks,Fredericus J. van Eeden,Giles Dixon,Xingang Wang,Constantino Carlos Reyes-Aldasoro,Philip W. Ingham,Moira K. B. Whyte,Sarah R. Walmsley,Stephen A. Renshaw
Platelets and Thrombopoiesis
Red Cells, Iron, and Erythropoiesis
Thrombosis and Hemostasis
Antithrombotic drug candidate ALX-0081 shows superior preclinical efficacy and safety compared with currently marketed antiplatelet drugs
Hans Ulrichts,Karen Silence,Anne Schoolmeester,Peter de Jaegere,Stefaan Rossenu,Jan Roodt,Sofie Priem,Marc Lauwereys,Peter Casteels,Femke Van Bockstaele,Katrien Verschueren,Patrick Stanssens,Judith Baumeister,Josefin-Beate Holz
Transplantation
Long-term prognostic significance of response in multiple myeloma after stem cell transplantation
Clinical Trials & Observations
Joaquin Martinez-Lopez,Joan Blade,María-Victoria Mateos,Carlos Grande,Adrián Alegre,José García-Laraña,Anna Sureda,Javier de la Rubia,Eulogio Conde,Rafael Martinez,Felipe de Arriba,Maria C. Viguria,Joan Besalduch,Rafael Cabrera,José D. Gonzalez-San Miguel,José Luis Guzman-Zamudio,Maria Carmen Gomez del Castillo,José Maria Moraleda,Juan C. García-Ruiz,Jesús San Miguel,Juan José Lahuerta,for the GEM (Grupo Español de MM) and PETHEMA (Programa para el Estudio de la Terapéutica en Hemopatía Maligna) Cooperative Study Groups
Vascular Biology
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Cover Image
Cover Image
The cover image shows induction of endothelial cells and mural cells from Flk1+ vascular progenitor cells. Flk1+ vascular progenitor cells derived from embryonic stem (ES) cells can reproduce early vascular organization processes, including differentiation of both endothelial and mural cells. Endothelial cells are detected with an anti-CD31 antibody and with Alexa488-conjugated anti–rat IgG antibody (green). Mural cells are detected with an anti-αSMA antibody and with Alexa546-conjugated anti–mouse IgG antibody (red). Nuclei are stained with DAPI (blue). See the article by Yamamizu et al on page 775.
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