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High success rate of hematopoietic cell transplantation regardless of donor source in children with very high-risk leukemia
Escalating intravenous methotrexate improves event-free survival in children with standard-risk acute lymphoblastic leukemia: a report from the Children's Oncology Group
Human X-linked variable immunodeficiency caused by a hypomorphic mutation in XIAP in association with a rare polymorphism in CD40LG
Differential effects of HIV viral load and CD4 count on proliferation of naive and memory CD4 and CD8 T lymphocytes
Long-term follow-up of symptomatic patients with lymphoplasmacytic lymphoma/Waldenström macroglobulinemia treated with the anti-CD52 monoclonal antibody alemtuzumab
The Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF): International Prospective Validation and Reliability Trial in 402 patients
Circulating microRNAs let-7a and miR-16 predict progression-free survival and overall survival in patients with myelodysplastic syndrome
Alternative donor transplantation after reduced intensity conditioning: results of parallel phase 2 trials using partially HLA-mismatched related bone marrow or unrelated double umbilical cord blood grafts
Influence of immunosuppressive treatment on risk of recurrent malignancy after allogeneic hematopoietic cell transplantation
Issue Archive
July 14 2011
In this Issue
Table of Contents
Inside Blood
Plenary Paper
PLENARY PAPER
High success rate of hematopoietic cell transplantation regardless of donor source in children with very high-risk leukemia
Clinical Trials & Observations
Wing Leung,Dario Campana,Jie Yang,Deqing Pei,Elaine Coustan-Smith,Kwan Gan,Jeffrey E. Rubnitz,John T. Sandlund,Raul C. Ribeiro,Ashok Srinivasan,Christine Hartford,Brandon M. Triplett,Mari Dallas,Asha Pillai,Rupert Handgretinger,Joseph H. Laver,Ching-Hon Pui
Review Article
Blood Consult
Clinical Trials and Observations
Escalating intravenous methotrexate improves event-free survival in children with standard-risk acute lymphoblastic leukemia: a report from the Children's Oncology Group
Clinical Trials & Observations
Yousif Matloub,Bruce C. Bostrom,Stephen P. Hunger,Linda C. Stork,Anne Angiolillo,Harland Sather,Mei La,Julie M. Gastier-Foster,Nyla A. Heerema,Scott Sailer,Patrick J. Buckley,Blythe Thomson,Catherine Cole,James B. Nachman,Gregory Reaman,Naomi Winick,William L. Carroll,Meenakshi Devidas,Paul S. Gaynon
Hematopoiesis and Stem Cells
Immunobiology
Human X-linked variable immunodeficiency caused by a hypomorphic mutation in XIAP in association with a rare polymorphism in CD40LG
Clinical Trials & Observations
Stéphanie Rigaud,Eduardo Lopez-Granados,Sophie Sibéril,Geoffrey Gloire,Nathalie Lambert,Christelle Lenoir,Cindy Synaeve,Maria Stacey,Lars Fugger,Jean-Louis Stephan,Alain Fischer,Capucine Picard,Anne Durandy,Helen Chapel,Sylvain Latour
Differential effects of HIV viral load and CD4 count on proliferation of naive and memory CD4 and CD8 T lymphocytes
Clinical Trials & Observations
Sharat Srinivasula,Richard A. Lempicki,Joseph W. Adelsberger,Chiung-Yu Huang,Joshua Roark,Philip I. Lee,Adam Rupert,Randy Stevens,Irini Sereti,H. Clifford Lane,Michele Di Mascio,Joseph A. Kovacs
HIV infection of dendritic cells subverts the IFN induction pathway via IRF-1 and inhibits type 1 IFN production
Andrew N. Harman,Joey Lai,Stuart Turville,Shamith Samarajiwa,Lachlan Gray,Valerie Marsden,Sarah K. Mercier,Kate Jones,Najla Nasr,Arjun Rustagi,Helen Cumming,Heather Donaghy,Johnson Mak,Michael Gale, Jr,Melissa Churchill,Paul Hertzog,Anthony L. Cunningham
T and B lymphocyte abnormalities in bone marrow biopsies of common variable immunodeficiency
Manuella L. Gomes Ochtrop,Sigune Goldacker,Annette M. May,Marta Rizzi,Ruth Draeger,Dieter Hauschke,Claudia Stehfest,Klaus Warnatz,Heike Goebel,Katja Technau-Ihling,Martin Werner,Ulrich Salzer,Hermann Eibel,Michael Schlesier,Hans Hartmut Peter
Lymphoid Neoplasia
Long-term follow-up of symptomatic patients with lymphoplasmacytic lymphoma/Waldenström macroglobulinemia treated with the anti-CD52 monoclonal antibody alemtuzumab
Clinical Trials & Observations
Steven P. Treon,Jacob D. Soumerai,Zachary R. Hunter,Christopher J. Patterson,Leukothea Ioakimidis,Brad Kahl,Michael Boxer
Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies
Gerhard Niederfellner,Alfred Lammens,Olaf Mundigl,Guy J. Georges,Wolfgang Schaefer,Manfred Schwaiger,Andreas Franke,Kornelius Wiechmann,Stefan Jenewein,Jerry W. Slootstra,Peter Timmerman,Annika Brännström,Frida Lindstrom,Ekkehard Mössner,Pablo Umana,Karl-Peter Hopfner,Christian Klein
Notch-3 and Notch-4 signaling rescue from apoptosis human B-ALL cells in contact with human bone marrow–derived mesenchymal stromal cells
Armel Hervé Nwabo Kamdje,Federico Mosna,Francesco Bifari,Veronica Lisi,Giulio Bassi,Giorgio Malpeli,Mario Ricciardi,Omar Perbellini,Maria Teresa Scupoli,Giovanni Pizzolo,Mauro Krampera
Myeloid Neoplasia
The Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF): International Prospective Validation and Reliability Trial in 402 patients
Clinical Trials & Observations
Robyn Scherber,Amylou C. Dueck,Peter Johansson,Tiziano Barbui,Giovanni Barosi,Alessandro M. Vannucchi,Francesco Passamonti,Bjorn Andreasson,Maria L. Ferarri,Alessandro Rambaldi,Jan Samuelsson,Gunnar Birgegard,Ayalew Tefferi,Claire N. Harrison,Deepti Radia,Ruben A. Mesa
Circulating microRNAs let-7a and miR-16 predict progression-free survival and overall survival in patients with myelodysplastic syndrome
Brief Report
Zhuang Zuo,George A. Calin,Henrique M. de Paula,L. Jeffrey Medeiros,Michael H. Fernandez,Masayoshi Shimizu,Guillermo Garcia-Manero,Carlos E. Bueso-Ramos
Platelets and Thrombopoiesis
Protein kinase C mediates platelet secretion and thrombus formation through protein kinase D2
Olga Konopatskaya,Sharon A. Matthews,Matthew T. Harper,Karen Gilio,Judith M. E. M. Cosemans,Christopher M. Williams,Maria N. Navarro,Deborah A. Carter,Johan W. M. Heemskerk,Michael Leitges,Doreen Cantrell,Alastair W. Poole
Red Cells, Iron, and Erythropoiesis
The dominant negative β isoform of the glucocorticoid receptor is uniquely expressed in erythroid cells expanded from polycythemia vera patients
Lilian Varricchio,Elena Masselli,Elena Alfani,Angela Battistini,Giovanni Migliaccio,Alessandro Maria Vannucchi,Wenyong Zhang,Damiano Rondelli,James Godbold,Barbara Ghinassi,Carolyn Whitsett,Ronald Hoffman,Anna Rita Migliaccio
Thrombosis and Hemostasis
Transplantation
Alternative donor transplantation after reduced intensity conditioning: results of parallel phase 2 trials using partially HLA-mismatched related bone marrow or unrelated double umbilical cord blood grafts
Clinical Trials & Observations
Claudio G. Brunstein,Ephraim J. Fuchs,Shelly L. Carter,Chatchada Karanes,Luciano J. Costa,Juan Wu,Steven M. Devine,John R. Wingard,Omar S. Aljitawi,Corey S. Cutler,Madan H. Jagasia,Karen K. Ballen,Mary Eapen,Paul V. O'Donnell,on behalf of the Blood and Marrow Transplant Clinical Trials Network
Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL
Alan M. Hanash,Lucy W. Kappel,Nury L. Yim,Rebecca A. Nejat,Gabrielle L. Goldberg,Odette M. Smith,Uttam K. Rao,Lindsay Dykstra,Il-Kang Na,Amanda M. Holland,Jarrod A. Dudakov,Chen Liu,George F. Murphy,Warren J. Leonard,Glenn Heller,Marcel R. M. van den Brink
Influence of immunosuppressive treatment on risk of recurrent malignancy after allogeneic hematopoietic cell transplantation
Clinical Trials & Observations
Yoshihiro Inamoto,Mary E. D. Flowers,Stephanie J. Lee,Paul A. Carpenter,Edus H. Warren,H. Joachim Deeg,Rainer F. Storb,Frederick R. Appelbaum,Barry E. Storer,Paul J. Martin
Vascular Biology
Correspondence
Successful mobilization and engraftment of PBSCs derived from donor cord blood cells after a previous allogeneic RIC single unrelated cord blood transplantation
Fabrice Larosa,Eric Deconinck,Philippe Helias,Jean Fontan,Marian Heczko,Annie Brion,Katell Ledu,Philippe Delaby,Jacqueline Vuiller,Christophe Ferrand,Philippe Saas,Fabienne Pouthier,Anne Dormoy,Jacqueline Chabod,Caroline Malugani,Pierre S. Rohrlich,Faezeh Legrand
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Cover Image
Cover Image
![issue cover]()
Overlay of a model of the type I CD20 antibody rituximab (red) and the type II CD20 antibody GA101 (blue) bound to a model of the CD20 membrane protein (white) based on the crystal structure of GA101 Fab in complex with a cyclic CD20 peptide (cyan) and on the crystal structure of rituximab-Fab in complex with the same cyclic CD20 peptide (yellow; Du J, Wang H, Zhong C, et al. Structural basis for recognition of CD20 by therapeutic antibody rituximab. J Biol Chem. 2007;282(20):15073-15080). The comparison of the two crystal structures shows that rituximab and GA101 recognize an overlapping epitope (green) on the large loop of CD20 but bind to this epitope in a completely different orientation. Note that rituximab and GA101 cannot bind to CD20 simultaneously. This composite model was prepared by Wolfgang Schaefer and Guy Georges using the Insight/Discover software package from Accelrys Inc, San Diego. See the article by Niederfellner et al on page 358.
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