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Journal Articles

Selinexor Enhances Natural Killer Cell Function Against Multiple Myeloma Cells

Jack G Fisher, Amber DP Doyle, Lara V Graham, Francesco Forconi, Mark S Cragg, Christopher J Walker, Salim I Khakoo, Matthew D Blunt
Journal: Blood
Blood (2023) 142 (Supplement 1): 6599.
https://doi.org/10.1182/blood-2023-179744
Published: 2023
Journal Articles

A Single Bout of Exercise Enhances the Efficacy of Rituximab Against Autologous Chronic Lymphocytic Leukaemia B Cells Ex Vivo By Transiently Increasing Natural Killer Cell Frequency in Blood, and Simultaneously Mobilises CD5 + CD19 + CD20 + B Cells into Blood

Harrison D Collier-Bain, Annabelle Emery, Adam J Causer, Frankie F Brown, Rebecca Oliver, David Dutton, Josephine Crowe, Daniel Augustine, John Graby, Shoji Leach, Rachel Eddy, Daniela Rothschild Rodriguez, Juliet C Gray, Mark S Cragg, Kirstie L Cleary, Sally Moore, James Murray, James E Turner, John P Campbell
Journal: Blood
Blood (2023) 142 (Supplement 1): 1179.
https://doi.org/10.1182/blood-2023-190009
Published: 2023
Journal Articles

(SUMO)-wrestling with rituximab

Mark S. Cragg
Journal: Blood
Blood (2022) 139 (18): 2728–2730.
https://doi.org/10.1182/blood.2022015912
Published: 2022
Journal Articles

Selinexor Enhances NK Cell Activation Against Lymphoma Cells Via Downregulation of HLA-E

Jack Fisher, Christopher J. Walker, Peter Johnson, Mark S Cragg, Francesco Forconi, Yosef Landesman, Salim I Khakoo, Matthew D Blunt
Journal: Blood
Blood (2021) 138 (Supplement 1): 2411.
https://doi.org/10.1182/blood-2021-144836
Published: 2021
Journal Articles

Multiplatform Profiling Characterizes Functional Networks in Genomically Stable and Instable Chronic Lymphocytic Leukemia

Johannes Bloehdorn, MD, Andrejs Braun, PhD, Billy Michael Chelliah Jebaraj, PhD, Amaro Taylor-Weiner, PhD, Sandra Robrecht, PhD, Julia Krzykalla, PhD, Karlheinz Holzmann, PhD, Harvey Johnston, PhD, Tetyana Klymenko, PhD, Barbara Eichhorst, MD, Ru-Fang Yeh, PhD, Martin Weisser, MD, Jennifer Edelmann, MDPhD, Kirsten Fischer, MD, John G. Gribben, MD DSc, FRCP, FRCPath, FMedSci, Dan A. Landau, MD PhD, Donna S. Neuberg, ScD, Mark S Cragg, PhD, Axel Benner, Michael Hallek, MD, Catherine J. Wu, MD, Hartmut Döhner, Stephan Stilgenbauer, MD, Daniel Mertens, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 12–13.
https://doi.org/10.1182/blood-2020-141552
Published: 2020
Journal Articles

Establishment of an In Vivo Mouse Model to Study and Overcome Infusion Related Reactions Associated with Fcgriib Antibody Administration

Ingrid Karlsson, PhD, Linda Mårtensson, PhD, Marie Borggren, PhD, Mathilda Kovacek, Carl Roos, Therese Blidberg, Robert Oldham, PhD, Mats Jerkeman, MD PhD, Martin J.S. Dyer, MD PhD, Andrew Davies, MD PhD, Raul Córdoba, MD PhD, Pau Abrisqueta, MD PhD, Stephen Beers, PhD, Ingrid Teige, PhD, Andres McAllister, MD PhD, Sean H Lim, MD PhD, Mark S Cragg, PhD, Björn Frendéus, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 4–5.
https://doi.org/10.1182/blood-2020-138658
Published: 2020
Journal Articles

Rituximab and Obinutuzumab Induce Direct B-Cell Death Via B-Cell Receptor (BCR) Signaling, but Rituximab Elicits Stronger BCR-Derived Pro-Survival Signals Diminishing Apoptosis

Jennifer Edelmann, MD PhD, Arran Dokal, MSc, PhD, Karlheinz Holzmann, Dr. rer. nat., David James Britton, BSc, PhD, Emma Vilventhraraja, MSc, PhD, Ryan Jack Smith, PhD, Mark S Cragg, Prof, Andrejs Braun, PhD, Hartmut Döhner, MD, Pedro Cutillas, PhD, John G. Gribben, MD DSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 1579.
https://doi.org/10.1182/blood-2019-128704
Published: 2019
Journal Articles

Recurrent Patterns of Clonal Evolution in Relapsed-Refractory DLBCL Following Treatment with R-CHOP

Christopher Rushton, BSc, Sarah E Arthur, BSc, Miguel Alcaide, PhD, Matthew Cheung, BSc, Nicole Thomas, BSc, Laura K Hilton, PhD, Neil R Michaud, Scott Daigle, Jordan Davidson, BSc, Kevin R Bushell, BSc, MSc, Stephen Yu, MSc, Michael D. Jain, MD PhD, Lois E. Shepherd, Michael Crump, MD FRCPC, Koren Kathleen Mann, PhD, John Kuruvilla, MD, Sarit Assouline, MD, Kirstie Cleary, PhD, Mark S Cragg, Prof, David W. Scott, MBChB, PhD, Nathalie Johnson, MD, Ryan D. Morin, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 921.
https://doi.org/10.1182/blood-2019-127399
Published: 2019
Journal Articles

Anti-CD27 Enhances Lymphoma Immunotherapy through Profound Myeloid Cell Recruitment

Anna H Turaj, MSc, Vikki L Field, Claude H.T. Chan, PhD, Christine A. Penfold, BSc, Jinny H. Kim, PhD, Sonya James, PhD, Kerry L Cox, Tibor Keler, PhD, Peter M Johnson, MA, MD, Aymen Al-Shamkhani, PhD, Stephen A Beers, PhD, Martin J. Glennie, PhD, Mark S Cragg, PhD, Sean H Lim, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3024.
https://doi.org/10.1182/blood.V128.22.3024.3024
Published: 2016
Journal Articles

PI3Kδ Inhibition Elicits Anti-Leukemic Effects through Bim-Dependent Apoptosis

Matthew J Carter, PhD, Kerry L Cox, Stuart J Blakemore, Anna H Turaj, MSc, Robert J Oldham, Lekh N. Dahal, PhD, Stacey Tannheimer, Francesco Forconi, MD DM, PhD FRCPath, Graham Packham, PhD, Mark S Cragg, PhD
Journal: Blood
Blood (2016) 128 (22): 3241.
https://doi.org/10.1182/blood.V128.22.3241.3241
Published: 2016
Journal Articles

Chemical Activation of the SHIP1 Inositol Lipid Phosphatase: A Novel Therapeutic Strategy to Suppress B-Cell Receptor Signaling and CXCR4 Expression in Malignant Human B Cells

Graham Packham, PhD, Beatriz Valle-Argos, Elizabeth Lemm, Lindsay D Smith, PhD, Nicola J Weston-Bell, PhD, Yohannes Gebreselassie, Andrew J Steele, PhD, Freda K Stevenson, Mark S Cragg, PhD, Francesco Forconi, MD DM, PhD FRCPath, Jennifer Cross, Curtis Harwig, Lloyd Mackenzie
Journal: Blood
Blood (2016) 128 (22): 2037.
https://doi.org/10.1182/blood.V128.22.2037.2037
Published: 2016
Journal Articles

In Chronic Lymphocytic Leukemia ΔCT7544-7545 Mutant NOTCH1 Maintains Transcription Factor Activity with Longer Lasting Effects Due to Slower Degradation

Jennifer Edelmann, MD, Tetyana Klymenko, PhD, Chen Lu, PhD, Emma Vilventhraraja, Sven Estenfelder, Eugen Tausch, Stephen A Beers, PhD, Stephan Stilgenbauer, Mark S Cragg, PhD, Andrejs Ivanov, PhD, John Gribben
Journal: Blood
Blood (2016) 128 (22): 971.
https://doi.org/10.1182/blood.V128.22.971.971
Published: 2016
Journal Articles

CD20 Antibodies of Human IgA Isotype Mediate CDC, and ADCC By Myeloid Effector Cells

Anna Kretschmer, Stefan Lohse, PhD, Thies Rösner, PhD, Marco J.H. Jansen, Christian Kellner, PhD, Matthias Peipp, PhD, Mark S Cragg, PhD, Ameera Alsadeq, PhD, Denis M Schewe, MD, Jeanette H.W. Leusen, PhD, Thomas Valerius, MD
Journal: Blood
Blood (2016) 128 (22): 1835.
https://doi.org/10.1182/blood.V128.22.1835.1835
Published: 2016
Journal Articles

IL-4 enhances expression and function of surface IgM in CLL cells

Maria M. Aguilar-Hernandez, Matthew D. Blunt, Rachel Dobson, Alison Yeomans, Stephen Thirdborough, Marta Larrayoz, Lindsay D. Smith, Adam Linley, Jonathan C. Strefford, Andrew Davies, Peter M. W. Johnson, Natalia Savelyeva, Mark S. Cragg, Francesco Forconi, Graham Packham, Freda K. Stevenson, Andrew J. Steele
Journal: Blood
Blood (2016) 127 (24): 3015–3025.
https://doi.org/10.1182/blood-2015-11-682906
Published: 2016
Includes: Supplemental data
Journal Articles

Anti-mouse FcγRIV antibody 9E9 also blocks FcγRIII in vivo

Thomas R. W. Tipton, C. Ian Mockridge, Ruth R. French, Alison L. Tutt, Mark S. Cragg, Stephen A. Beers
Journal: Blood
Blood (2015) 126 (24): 2643–2645.
https://doi.org/10.1182/blood-2015-09-671339
Published: 2015
Includes: Supplemental data
Journal Articles

Genomic Disruption of the Histone Methyltransferase SETD2 in Chronic Lymphocytic Leukemia

Matthew John Jerome Rose-Zerilli, PhD, Helen Parker, Marta Larrayoz, PhD, Ruth Clifford, Stuart Blakemore, Jennifer Edelmann, MD, Jane Gibson, Jun Wang, Viktor Ljungstrom, Tracy Chaplin, Ali Roghanian, Zadie Davis, Anton Parker, BSc, Eugen Tausch, MD, Stavroula Ntoufa, Sara Ramos, Pauline Robbe, MSc, Andrew J Steele, PhD, Graham Packham, PhD, Ana E. Rodriguez, Lee Brown, Feargal McNicholl, Francesco Forconi, MD DM, PhD FRCPath, Andrew R Pettitt, MRCP PhD, Peter Hillmen, Martin J.S. Dyer, Prof., Mark S Cragg, PhD, Bryan D Young, BSc, PhD, Claude Chelala, Richard Rosenquist, Kostas Stamatopoulos, MD, Stephan Stilgenbauer, Samantha Knight, Anna Schuh, MD PhD, David Oscier, Jonathan C Strefford, PhD
Journal: Blood
Blood (2015) 126 (23): 365.
https://doi.org/10.1182/blood.V126.23.365.365
Published: 2015
Journal Articles

Biological Significance of B Cell Receptor Mediated Regulation of Autophagy in Chronic Lymphocytic Leukemia

Lindsay Smith, PhD, Elizabeth Hogg, BSc(Hons), Angus Haynes, Jonathan C Strefford, PhD, Francesco Forconi, MD DM, PhD FRCPath, Freda K Stevenson, DPhil, Graham Packham, PhD, Mark S Cragg, PhD, David Tumbarello, Matthew D Blunt, PhD, Andrew J Steele, PhD
Journal: Blood
Blood (2015) 126 (23): 4130.
https://doi.org/10.1182/blood.V126.23.4130.4130
Published: 2015
Journal Articles

Defining Immune Response Signatures in DLBCL As Potential Predictive Biomarkers for Outcome to Immunotherapy

Matthew A Care, PhD, Stephen M Thirdborough, PhD, Andrew J Davies, MRCP PhD, Peter W.M. Johnson, FRCP, Andrew Jack, PhD MB, Sharon Barrans, PhD, David R Westhead, PhD, Mark S Cragg, PhD, Reuben M Tooze, PhD FRCP, Stephen A Beers, PhD
Journal: Blood
Blood (2015) 126 (23): 2663.
https://doi.org/10.1182/blood.V126.23.2663.2663
Published: 2015
Journal Articles

The Syk\Jak Inhibitor Cerdulatinib (PRT062070) Shows Promising Preclinical Activity in Chronic Lymphocytic Leukemia By Antagonising B Cell Receptor and Microenvironmental Signalling

Matthew D Blunt, PhD, Jack Parnell, BSc(hons), Marta Larrayoz, PhD, Lindsay Smith, PhD, Rachel Dobson, BSc(Hons), Jonathan C Strefford, PhD, Freda K Stevenson, DPhil, Francesco Forconi, MD DM, PhD FRCPath, Andrew J Davies, MRCP, Peter W Johnson, MD, Graham Packham, PhD, Greg P. Coffey, PhD, Mark S Cragg, PhD, Andrew J Steele, PhD
Journal: Blood
Blood (2015) 126 (23): 1716.
https://doi.org/10.1182/blood.V126.23.1716.1716
Published: 2015
Journal Articles

The PI3K/mTOR inhibitor PF-04691502 induces apoptosis and inhibits microenvironmental signaling in CLL and the Eµ-TCL1 mouse model

Matthew D. Blunt, Matthew J. Carter, Marta Larrayoz, Lindsay D. Smith, Maria Aguilar-Hernandez, Kerry L. Cox, Thomas Tipton, Mark Reynolds, Sarah Murphy, Elizabeth Lemm, Samantha Dias, Andrew Duncombe, Jonathan C. Strefford, Peter W. M. Johnson, Francesco Forconi, Freda K. Stevenson, Graham Packham, Mark S. Cragg, Andrew J. Steele
Journal: Blood
Blood (2015) 125 (26): 4032–4041.
https://doi.org/10.1182/blood-2014-11-610329
Published: 2015
Includes: Supplemental data