Elise Olsen,for the ISCL/EORTC,Eric Vonderheid,for the ISCL/EORTC,Nicola Pimpinelli,for the ISCL/EORTC,Rein Willemze,for the ISCL/EORTC,Youn Kim,for the ISCL/EORTC,Robert Knobler,for the ISCL/EORTC,Herschel Zackheim,for the ISCL/EORTC,Madeleine Duvic,for the ISCL/EORTC,Teresa Estrach,for the ISCL/EORTC,Stanford Lamberg,for the ISCL/EORTC,Gary Wood,for the ISCL/EORTC,Reinhard Dummer,for the ISCL/EORTC,Annamari Ranki,for the ISCL/EORTC,Gunter Burg,for the ISCL/EORTC,Peter Heald,for the ISCL/EORTC,Mark Pittelkow,for the ISCL/EORTC,Maria-Grazia Bernengo,for the ISCL/EORTC,Wolfram Sterry,for the ISCL/EORTC,Liliane Laroche,for the ISCL/EORTC,Franz Trautinger,for the ISCL/EORTC,Sean Whittaker,for the ISCL/EORTC

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Supplemental data

REVIEW IN TRANSLATIONAL HEMATOLOGY

Trousseau's syndrome: multiple definitions and multiple mechanisms

Ajit Varki

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CHEMOKINES, CYTOKINES, AND INTERLEUKINS

p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells

Laura Patrussi,Cristina Ulivieri,Orso Maria Lucherini,Silvia Rossi Paccani,Alessandra Gamberucci,Luisa Lanfrancone,Pier Giuseppe Pelicci,Cosima T. Baldari

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Supplemental data

Lipid rafts are required for Kit survival and proliferation signals

Thomas Jahn,Erica Leifheit,Stacie Gooch,Simran Sindhu,Kenneth Weinberg

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Supplemental data

Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils

Athena Chalaris,Björn Rabe,Krzysztof Paliga,Hans Lange,Tamas Laskay,Ceri A. Fielding,Simon A. Jones,Stefan Rose-John,Jürgen Scheller

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Supplemental data

CLINICAL TRIALS AND OBSERVATIONS

Treatment of severe aplastic anemia with antithymocyte globulin and cyclosporin A with or without G-CSF in adults: a multicenter randomized study in Japan
Clinical Trials & Observations

Masanao Teramura,Akiro Kimura,Satsuki Iwase,Yuji Yonemura,Shinji Nakao,Akio Urabe,Mitsuhiro Omine,Hideaki Mizoguchi

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Supplemental data

A phase 1 clinical-laboratory study of clofarabine followed by cyclophosphamide for adults with refractory acute leukemias
Clinical Trials & Observations

Judith E. Karp,Rebecca M. Ricklis,Kumudha Balakrishnan,Janet Briel,Jacqueline Greer,Steven D. Gore,B. Douglas Smith,Michael A. McDevitt,Hetty Carraway,Mark J. Levis,Varsha Gandhi

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GENE THERAPY

Hot spots of retroviral integration in human CD34⁺ hematopoietic cells

Claudia Cattoglio,Giulia Facchini,Daniela Sartori,Antonella Antonelli,Annarita Miccio,Barbara Cassani,Manfred Schmidt,Christof von Kalle,Steve Howe,Adrian J. Thrasher,Alessandro Aiuti,Giuliana Ferrari,Alessandra Recchia,Fulvio Mavilio

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Supplemental data

Stable differentiation and clonality of murine long-term hematopoiesis after extended reduced-intensity selection for MGMT P140K transgene expression

Claudia R. Ball,Ingo H. Pilz,Manfred Schmidt,Sylvia Fessler,David A. Williams,Christof von Kalle,Hanno Glimm

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Supplemental data

The immune response to lentiviral-delivered transgene is modulated in vivo by transgene-expressing antigen-presenting cells but not by CD4⁺CD25⁺ regulatory T cells

Andrea Annoni,Manuela Battaglia,Antonia Follenzi,Angelo Lombardo,Lucia Sergi-Sergi,Luigi Naldini,Maria-Grazia Roncarolo

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Supplemental data

Chemokine-idiotype fusion DNA vaccines are potentiated by bivalency and xenogeneic sequences

Agnete Brunsvik Fredriksen,Bjarne Bogen

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Supplemental data

HEMATOPOIESIS

Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia

Robert A. J. Signer,Encarnacion Montecino-Rodriguez,Owen N. Witte,Jami McLaughlin,Kenneth Dorshkind

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Direct interaction between Kit and the interleukin-7 receptor

Thomas Jahn,Simran Sindhu,Stacie Gooch,Petra Seipel,Philip Lavori,Erica Leifheit,Kenneth Weinberg

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Supplemental data

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration

Abigail Woodfin,Christoph Andreas Reichel,Andrej Khandoga,Monica Corada,Mathieu-Benoit Voisin,Christoph Scheiermann,Dorian O. Haskard,Elisabetta Dejana,Fritz Krombach,Sussan Nourshargh

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High T-cell response to human cytomegalovirus induces chemokine-mediated endothelial cell damage

Cynthia A. Bolovan-Fritts,Rodney N. Trout,Stephen A. Spector

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Supplemental data

The oxidase activity of vascular adhesion protein-1 (VAP-1) induces endothelial E- and P-selectins and leukocyte binding

Sirpa Jalkanen,Marika Karikoski,Nathalie Mercier,Kaisa Koskinen,Tiina Henttinen,Kati Elima,Katriina Salmivirta,Marko Salmi

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The low-molecular-weight phosphotyrosine phosphatase is a negative regulator of FcγRIIA-mediated cell activation

Francesca Mancini,Stefania Rigacci,Andrea Berti,Cesare Balduini,Mauro Torti

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Conversion of platelets from a proaggregatory to a proinflammatory adhesive phenotype: role of PAF in spatially regulating neutrophil adhesion and spreading

Suhasini Kulkarni,Kevin J. Woollard,Stephen Thomas,David Oxley,Shaun P. Jackson

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Supplemental data

The cooperative activity between the carboxyl-terminal TSP1 repeats and the CUB domains of ADAMTS13 is crucial for recognition of von Willebrand factor under flow

Ping Zhang,Weilan Pan,Ann H. Rux,Bruce S. Sachais,X. Long Zheng

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A critical role for TNFα in the selective attachment of mononuclear leukocytes to angiotensin-II-stimulated arterioles

Teresa Mateo,Yafa Naim Abu Nabah,Mercedes Losada,Rossana Estellés,Chantal Company,Begoña Bedrina,Jose Miguel Cerdá-Nicolás,Stephen Poole,Peter J. Jose,Julio Cortijo,Esteban J. Morcillo,Maria-Jesus Sanz

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Endogenous platelet factor 4 stimulates activated protein C generation in vivo and improves survival after thrombin or lipopolysaccharide challenge
Brief Report

M. Anna Kowalska,Shawn A. Mahmud,Michele P. Lambert,Mortimer Poncz,Arne Slungaard

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IMMUNOBIOLOGY

Defective cytotoxic lymphocyte degranulation in syntaxin-11–deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients

Yenan T. Bryceson,Eva Rudd,Chengyun Zheng,Josefine Edner,Daoxin Ma,Stephanie M. Wood,Anne Grete Bechensteen,Jaap J. Boelens,Tiraje Celkan,Roula A. Farah,Kjell Hultenby,Jacek Winiarski,Paul A. Roche,Magnus Nordenskjöld,Jan-Inge Henter,Eric O. Long,Hans-Gustaf Ljunggren

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Adenoviral vectors persist in vivo and maintain activated CD8⁺ T cells: implications for their use as vaccines

Nia Tatsis,Julie C. Fitzgerald,Arturo Reyes-Sandoval,Kimberly C. Harris-McCoy,Scott E. Hensley,Dongming Zhou,Shih-Wen Lin,Ang Bian,Zhi Quan Xiang,Amaya Iparraguirre,Cesar Lopez-Camacho,E. John Wherry,Hildegund C. J. Ertl

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Graft-versus-leukemia effects associated with detectable Wilms tumor-1–specific T lymphocytes after allogeneic stem-cell transplantation for acute lymphoblastic leukemia

Katayoun Rezvani,Agnes S. M. Yong,Bipin N. Savani,Stephan Mielke,Keyvan Keyvanfar,Emma Gostick,David A. Price,Daniel C. Douek,A. John Barrett

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Gata1 regulates dendritic-cell development and survival

Laura Gutiérrez,Tatjana Nikolic,Thamar B. van Dijk,Hamida Hammad,Nanda Vos,Monique Willart,Frank Grosveld,Sjaak Philipsen,Bart N. Lambrecht

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Supplemental data

Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells

Christopher J. Ong,Andrew Ming-Lum,Matt Nodwell,Ali Ghanipour,Lu Yang,David E. Williams,Joseph Kim,Loutfig Demirjian,Pooran Qasimi,Jens Ruschmann,Li-Ping Cao,Kewei Ma,Stephen W. Chung,Vincent Duronio,Raymond J. Andersen,Gerald Krystal,Alice L.-F. Mui

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Supplemental data

Lymphotoxin a-dependent and -independent signals regulate stromal organizer cell homeostasis during lymph node organogenesis

Andrea White,Damian Carragher,Sonia Parnell,Aichi Msaki,Neil Perkins,Peter Lane,Eric Jenkinson,Graham Anderson,Jorge H. Caamaño

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Supplemental data

Bone marrow CD8 cells down-modulate membrane IL-7Rα expression and exhibit increased STAT-5 and p38 MAPK phosphorylation in the organ environment.

Giuliana Cassese,Elisabetta Parretta,Laura Pisapia,Angela Santoni,John Guardiola,Francesca Di Rosa

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Supplemental data

A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA

Stanimir Ivanov,Ana-Maria Dragoi,Xin Wang,Corrado Dallacosta,Jennifer Louten,Giovanna Musco,Giovanni Sitia,George S. Yap,Yinsheng Wan,Christine A. Biron,Marco E. Bianchi,Haichao Wang,Wen-Ming Chu

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Supplemental data

Farnesyltransferase inhibitors inhibit T-cell cytokine production at the posttranscriptional level

Reinhard E. Marks,Allen W. Ho,Christian Robbel,Todd Kuna,Seth Berk,Thomas F. Gajewski

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Platelet particle formation by anti–GPIIIa49-66 Ab, Ca²⁺ ionophore A23187, and phorbol myristate acetate is induced by reactive oxygen species and inhibited by dexamethasone blockade of platelet phospholipase A₂, 12-lipoxygenase, and NADPH oxidase

Michael A. Nardi,Yelena Gor,Steven J. Feinmark,Fang Xu,Simon Karpatkin

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Cytotoxic T lymphocytes carrying a pattern recognition protein Tag7 can detect evasive, HLA-negative but Hsp70-exposing tumor cells, thereby ensuring FasL/Fas-mediated contact killing

Lidia P. Sashchenko,Elena A. Dukhanina,Yury V. Shatalov,Denis V. Yashin,Tamara I. Lukyanova,Olga D. Kabanova,Elena A. Romanova,Sergei V. Khaidukov,Alexander V. Galkin,Nikolai V. Gnuchev,Georgii P. Georgiev

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Supplemental data

CD34 facilitates the development of allergic asthma

Marie-Renée Blanchet,Steven Maltby,D. James Haddon,Helen Merkens,Lori Zbytnuik,Kelly M. McNagny

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An NKT-mediated autologous vaccine generates CD4 T-cell–dependent potent antilymphoma immunity

Yeonseok Chung,Hong Qin,Chang-Yuil Kang,Sanghee Kim,Larry W. Kwak,Chen Dong

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Supplemental data

2B4 inhibits NK-cell fratricide
Brief Report

Ruth T. Taniguchi,Dustin Guzior,Vinay Kumar

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Supplemental data

Rapid generation of a functional NK-cell compartment
Brief Report

Martin Prlic,Daisuke Kamimura,Michael J. Bevan

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Supplemental data

NEOPLASIA

Novel RUNX1 isoforms determine the fate of acute myeloid leukemia cells by controlling CD56 expression

Stefan Gattenloehner,Sergei Chuvpilo,Claudia Langebrake,Dirk Reinhardt,Hans-Konrad Müller-Hermelink,Edgar Serfling,Angela Vincent,Alexander Marx

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Supplemental data

AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo

Jing Yang,Takayuki Ikezoe,Chie Nishioka,Taizo Tasaka,Ayuko Taniguchi,Yoshio Kuwayama,Naoki Komatsu,Kentaro Bandobashi,Kazuto Togitani,H. Phillip Koeffler,Hirokuni Taguchi,Akihito Yokoyama

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The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy

Yang Yang,Veronica MacLeod,Yuemeng Dai,Yekaterina Khotskaya-Sample,Zachary Shriver,Ganesh Venkataraman,Ram Sasisekharan,Annamaria Naggi,Giangiacomo Torri,Benito Casu,Israel Vlodavsky,Larry J. Suva,Joshua Epstein,Shmuel Yaccoby,John D. Shaughnessy, Jr,Bart Barlogie,Ralph D. Sanderson

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Targeted cancer therapy with a novel low-dose rate α-emitting radioimmunoconjugate

Jostein Dahle,Jørgen Borrebæk,Thora J. Jonasdottir,Anne Kristine Hjelmerud,Katrine B. Melhus,Øyvind S. Bruland,Oliver W. Press,Roy H. Larsen

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Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo

Min H. Kang,Yun Hee Kang,Barbara Szymanska,Urszula Wilczynska-Kalak,Michael A. Sheard,Theresa M. Harned,Richard B. Lock,C. Patrick Reynolds

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BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms

Samir Parekh,Jose M. Polo,Rita Shaknovich,Przemyslaw Juszczynski,Paola Lev,Stella M. Ranuncolo,Yingnan Yin,Ulf Klein,Giorgio Cattoretti,Riccardo Dalla Favera,Margaret A. Shipp,Ari Melnick

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Supplemental data

Pharmacologic inhibition of CDK4/6: mechanistic evidence for selective activity or acquired resistance in acute myeloid leukemia

Lisheng Wang,Jie Wang,Bradley W. Blaser,Anne-Marie Duchemin,Donna F. Kusewitt,Tom Liu,Michael A. Caligiuri,Roger Briesewitz

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Supplemental data

Low-dose arsenic trioxide sensitizes glucocorticoid-resistant acute lymphoblastic leukemia cells to dexamethasone via an Akt-dependent pathway

Beat C. Bornhauser,Laura Bonapace,Dan Lindholm,Rodrigo Martinez,Gunnar Cario,Martin Schrappe,Felix K. Niggli,Beat W. Schäfer,Jean-Pierre Bourquin

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Supplemental data

MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism

Xin-Yan Pei,Yun Dai,Sarah Tenorio,Jianghua Lu,Hisashi Harada,Paul Dent,Steven Grant

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Farnesyl transferase inhibitor resistance probed by target mutagenesis

Tal Raz,Valentina Nardi,Mohammad Azam,Jorge Cortes,George Q. Daley

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Supplemental data

Negative regulation of the SH₂-homology–containing protein-tyrosine phosphatase-1 (SHP-1) P2 promoter by the HTLV-1 Tax oncoprotein

Jihua Cheng,Andre R. Kydd,Koichi Nakase,Kristin M. Noonan,Akikazu Murakami,Hong Tao,Markryan Dwyer,Chen Xu,Quan Zhu,Wayne A. Marasco

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Nuclear CD40 interacts with c-Rel and enhances proliferation in aggressive B-cell lymphoma

Hai-Jun Zhou,Lan V. Pham,Archito T. Tamayo,Yen-Chiu Lin-Lee,Lingchen Fu,Linda C. Yoshimura,Richard J. Ford

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Incidence and clinical implications of GATA1 mutations in newborns with Down syndrome
Brief Report

Sharon R. Pine,Qianxu Guo,Changhong Yin,Somasundaram Jayabose,Charlotte M. Druschel,Claudio Sandoval

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RED CELLS

Cytoplasmic remodeling of erythrocyte raft lipids during infection by the human malaria parasite Plasmodium falciparum

Sean C. Murphy,Sebastian Fernandez-Pol,Paul H. Chung,S. N. Prasanna Murthy,Stephen B. Milne,Marcela Salomao,H. Alex Brown,Jon W. Lomasney,Narla Mohandas,Kasturi Haldar

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Supplemental data

HIF–prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques

Matthew M. Hsieh,N. Seth Linde,Aisha Wynter,Mark Metzger,Carol Wong,Ingrid Langsetmo,Al Lin,Reginald Smith,Griffin P. Rodgers,Robert E. Donahue,Stephen J. Klaus,John F. Tisdale

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Mosaicism due to myeloid lineage–restricted loss of heterozygosity as cause of spontaneous Rh phenotype splitting

Günther F. Körmöczi,Eva-Maria Dauber,Oskar A. Haas,Tobias J. Legler,Frederik B. Clausen,Gerhard Fritsch,Markus Raderer,Christoph Buchta,Andreas L. Petzer,Diether Schönitzer,Wolfgang R. Mayr,Christoph Gassner

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Point mutations involved in red cell stomatocytosis convert the electroneutral anion exchanger 1 to a nonselective cation conductance

Hélène Guizouarn,Sonia Martial,Nicole Gabillat,Franck Borgese

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Supplemental data

Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin

José Villagra,Sruti Shiva,Lori A. Hunter,Roberto F. Machado,Mark T. Gladwin,Gregory J. Kato

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Supplemental data

Hypoxic stress underlies defects in erythroblast islands in the Rb-null mouse

Benjamin T. Spike,Benjamin C. Dibling,Kay F. Macleod

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Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4

Lan Lin,Erika V. Valore,Elizabeta Nemeth,Julia B. Goodnough,Victoria Gabayan,Tomas Ganz

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Factor H–mediated cell surface protection from complement is critical for the survival of PNH erythrocytes
Brief Report

Viviana P. Ferreira,Michael K. Pangburn

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A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove
Brief Report

Melanie J. Percy,Paul W. Furlow,Philip A. Beer,Terence R. J. Lappin,Mary Frances McMullin,Frank S. Lee

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STEM CELLS IN HEMATOLOGY

Human multipotent mesenchymal stromal cells inhibit proliferation of PBMCs independently of IFNγR1 signaling and IDO expression
Brief Report

Friederike Gieseke,Burkhardt Schütt,Susanne Viebahn,Ewa Koscielniak,Wilhelm Friedrich,Rupert Handgretinger,Ingo Müller

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TRANSFUSION MEDICINE

Nonhemolytic antigen loss from red blood cells requires cooperative binding of multiple antibodies recognizing different epitopes

James C. Zimring,Chantel M. Cadwell,Traci E. Chadwick,Steven L. Spitalnik,David A. Schirmer,Tao Wu,Charles A. Parkos,Christopher D. Hillyer

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TRANSPLANTATION

Successful treatment of lymphoproliferative disease complicating primary immunodeficiency/immunodysregulatory disorders with reduced-intensity allogeneic stem-cell transplantation

Jonathan M. Cohen,Neil J. Sebire,Julia Harvey,H. Bobby Gaspar,Cale Cathy,Alison Jones,Kanchan Rao,David Cubitt,Persis J. Amrolia,E. Graham Davies,Paul Veys

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CORRESPONDENCE

IFN-γ and STAT1 are required for efficient induction of CXC chemokine receptor 3 (CXCR3) on CD4⁺ but not CD8⁺ T cells

Joseph Barbi,Steve Oghumu,Claudio M. Lezama-Davila,Abhay R. Satoskar

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Epigallocathechin-3-gallate in AL amyloidosis: a new therapeutic option?

Werner Hunstein

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STK10 regulates platelet function in arterial thrombosis and thromboinflammation

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Circulating tumor cells predict myeloma outcomes in patients treated with daratumumab, bortezomib, lenalidomide, and dexamethasone

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Issue Archive

Table of Contents

INSIDE BLOOD

Iron can boost hepcidin both ways Free

RIS defines risk Free

FHL4: NK cells pack less punch Free

Lock 'n' roll with VAP-1 Free

Division of labor for oncogene BCL6 Free

Watch out, MF! Free

A pill for some anemias? Free

CD40 promotes lymphoma from nuclear hideaway Free

Attractive shedding Free

PERSPECTIVE

Revisions to the staging and classification of mycosis fungoides and Sézary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC) Free

REVIEW IN TRANSLATIONAL HEMATOLOGY

Trousseau's syndrome: multiple definitions and multiple mechanisms Free

CHEMOKINES, CYTOKINES, AND INTERLEUKINS

p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells Free

Lipid rafts are required for Kit survival and proliferation signals Free

Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils Free

CLINICAL TRIALS AND OBSERVATIONS

Treatment of severe aplastic anemia with antithymocyte globulin and cyclosporin A with or without G-CSF in adults: a multicenter randomized study in Japan Free Clinical Trials & Observations

A phase 1 clinical-laboratory study of clofarabine followed by cyclophosphamide for adults with refractory acute leukemias Free Clinical Trials & Observations

GENE THERAPY

Hot spots of retroviral integration in human CD34+ hematopoietic cells Free

Stable differentiation and clonality of murine long-term hematopoiesis after extended reduced-intensity selection for MGMT P140K transgene expression Free

The immune response to lentiviral-delivered transgene is modulated in vivo by transgene-expressing antigen-presenting cells but not by CD4+CD25+ regulatory T cells Free

Chemokine-idiotype fusion DNA vaccines are potentiated by bivalency and xenogeneic sequences Free

HEMATOPOIESIS

Hematopoietic stem-cell behavior in nonhuman primates Free

The Hedgehog receptor Patched controls lymphoid lineage commitment Free

The role of jak2a in zebrafish hematopoiesis Free

Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia Free

Direct interaction between Kit and the interleukin-7 receptor Free

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration Free

High T-cell response to human cytomegalovirus induces chemokine-mediated endothelial cell damage Free

The oxidase activity of vascular adhesion protein-1 (VAP-1) induces endothelial E- and P-selectins and leukocyte binding Free

The low-molecular-weight phosphotyrosine phosphatase is a negative regulator of FcγRIIA-mediated cell activation Free

Conversion of platelets from a proaggregatory to a proinflammatory adhesive phenotype: role of PAF in spatially regulating neutrophil adhesion and spreading Free

The cooperative activity between the carboxyl-terminal TSP1 repeats and the CUB domains of ADAMTS13 is crucial for recognition of von Willebrand factor under flow Free

A critical role for TNFα in the selective attachment of mononuclear leukocytes to angiotensin-II-stimulated arterioles Free

Endogenous platelet factor 4 stimulates activated protein C generation in vivo and improves survival after thrombin or lipopolysaccharide challenge Free Brief Report

IMMUNOBIOLOGY

Defective cytotoxic lymphocyte degranulation in syntaxin-11–deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients Free

Adenoviral vectors persist in vivo and maintain activated CD8+ T cells: implications for their use as vaccines Free

Graft-versus-leukemia effects associated with detectable Wilms tumor-1–specific T lymphocytes after allogeneic stem-cell transplantation for acute lymphoblastic leukemia Free

Gata1 regulates dendritic-cell development and survival Free

Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells Free

Lymphotoxin a-dependent and -independent signals regulate stromal organizer cell homeostasis during lymph node organogenesis Free

Bone marrow CD8 cells down-modulate membrane IL-7Rα expression and exhibit increased STAT-5 and p38 MAPK phosphorylation in the organ environment. Free

A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA Free

Farnesyltransferase inhibitors inhibit T-cell cytokine production at the posttranscriptional level Free

Platelet particle formation by anti–GPIIIa49-66 Ab, Ca2+ ionophore A23187, and phorbol myristate acetate is induced by reactive oxygen species and inhibited by dexamethasone blockade of platelet phospholipase A2, 12-lipoxygenase, and NADPH oxidase Free

Cytotoxic T lymphocytes carrying a pattern recognition protein Tag7 can detect evasive, HLA-negative but Hsp70-exposing tumor cells, thereby ensuring FasL/Fas-mediated contact killing Free

CD34 facilitates the development of allergic asthma Free

An NKT-mediated autologous vaccine generates CD4 T-cell–dependent potent antilymphoma immunity Free

2B4 inhibits NK-cell fratricide Free Brief Report

Rapid generation of a functional NK-cell compartment Free Brief Report

NEOPLASIA

Novel RUNX1 isoforms determine the fate of acute myeloid leukemia cells by controlling CD56 expression Free

AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo Free

The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy Free

Targeted cancer therapy with a novel low-dose rate α-emitting radioimmunoconjugate Free

Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo Free

BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms Free

Pharmacologic inhibition of CDK4/6: mechanistic evidence for selective activity or acquired resistance in acute myeloid leukemia Free

Low-dose arsenic trioxide sensitizes glucocorticoid-resistant acute lymphoblastic leukemia cells to dexamethasone via an Akt-dependent pathway Free

MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism Free

Farnesyl transferase inhibitor resistance probed by target mutagenesis Free

Negative regulation of the SH2-homology–containing protein-tyrosine phosphatase-1 (SHP-1) P2 promoter by the HTLV-1 Tax oncoprotein Free

Nuclear CD40 interacts with c-Rel and enhances proliferation in aggressive B-cell lymphoma Free

Incidence and clinical implications of GATA1 mutations in newborns with Down syndrome Free Brief Report

RED CELLS

Cytoplasmic remodeling of erythrocyte raft lipids during infection by the human malaria parasite Plasmodium falciparum Free

HIF–prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques Free

Mosaicism due to myeloid lineage–restricted loss of heterozygosity as cause of spontaneous Rh phenotype splitting Free

Point mutations involved in red cell stomatocytosis convert the electroneutral anion exchanger 1 to a nonselective cation conductance Free

Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin Free

Hypoxic stress underlies defects in erythroblast islands in the Rb-null mouse Free

Iron can boost hepcidin both ways

RIS defines risk

FHL4: NK cells pack less punch

Lock 'n' roll with VAP-1

Division of labor for oncogene BCL6

Watch out, MF!

A pill for some anemias?

CD40 promotes lymphoma from nuclear hideaway

Attractive shedding

Revisions to the staging and classification of mycosis fungoides and Sézary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC)

Trousseau's syndrome: multiple definitions and multiple mechanisms

p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells

Lipid rafts are required for Kit survival and proliferation signals

Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils

Treatment of severe aplastic anemia with antithymocyte globulin and cyclosporin A with or without G-CSF in adults: a multicenter randomized study in Japan
Clinical Trials & Observations

A phase 1 clinical-laboratory study of clofarabine followed by cyclophosphamide for adults with refractory acute leukemias
Clinical Trials & Observations

Hot spots of retroviral integration in human CD34⁺ hematopoietic cells

Stable differentiation and clonality of murine long-term hematopoiesis after extended reduced-intensity selection for MGMT P140K transgene expression

The immune response to lentiviral-delivered transgene is modulated in vivo by transgene-expressing antigen-presenting cells but not by CD4⁺CD25⁺ regulatory T cells

Chemokine-idiotype fusion DNA vaccines are potentiated by bivalency and xenogeneic sequences

Hematopoietic stem-cell behavior in nonhuman primates

The Hedgehog receptor Patched controls lymphoid lineage commitment

The role of jak2a in zebrafish hematopoiesis

Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia

Direct interaction between Kit and the interleukin-7 receptor

JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration

High T-cell response to human cytomegalovirus induces chemokine-mediated endothelial cell damage

The oxidase activity of vascular adhesion protein-1 (VAP-1) induces endothelial E- and P-selectins and leukocyte binding

The low-molecular-weight phosphotyrosine phosphatase is a negative regulator of FcγRIIA-mediated cell activation

Conversion of platelets from a proaggregatory to a proinflammatory adhesive phenotype: role of PAF in spatially regulating neutrophil adhesion and spreading

The cooperative activity between the carboxyl-terminal TSP1 repeats and the CUB domains of ADAMTS13 is crucial for recognition of von Willebrand factor under flow

A critical role for TNFα in the selective attachment of mononuclear leukocytes to angiotensin-II-stimulated arterioles

Endogenous platelet factor 4 stimulates activated protein C generation in vivo and improves survival after thrombin or lipopolysaccharide challenge
Brief Report

Defective cytotoxic lymphocyte degranulation in syntaxin-11–deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients

Adenoviral vectors persist in vivo and maintain activated CD8⁺ T cells: implications for their use as vaccines

Graft-versus-leukemia effects associated with detectable Wilms tumor-1–specific T lymphocytes after allogeneic stem-cell transplantation for acute lymphoblastic leukemia

Gata1 regulates dendritic-cell development and survival

Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells

Lymphotoxin a-dependent and -independent signals regulate stromal organizer cell homeostasis during lymph node organogenesis

Bone marrow CD8 cells down-modulate membrane IL-7Rα expression and exhibit increased STAT-5 and p38 MAPK phosphorylation in the organ environment.

A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA

Farnesyltransferase inhibitors inhibit T-cell cytokine production at the posttranscriptional level

Platelet particle formation by anti–GPIIIa49-66 Ab, Ca²⁺ ionophore A23187, and phorbol myristate acetate is induced by reactive oxygen species and inhibited by dexamethasone blockade of platelet phospholipase A₂, 12-lipoxygenase, and NADPH oxidase

Cytotoxic T lymphocytes carrying a pattern recognition protein Tag7 can detect evasive, HLA-negative but Hsp70-exposing tumor cells, thereby ensuring FasL/Fas-mediated contact killing

CD34 facilitates the development of allergic asthma

An NKT-mediated autologous vaccine generates CD4 T-cell–dependent potent antilymphoma immunity

2B4 inhibits NK-cell fratricide
Brief Report

Rapid generation of a functional NK-cell compartment
Brief Report

Novel RUNX1 isoforms determine the fate of acute myeloid leukemia cells by controlling CD56 expression

AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo

The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy

Targeted cancer therapy with a novel low-dose rate α-emitting radioimmunoconjugate

Activity of vincristine, L-ASP, and dexamethasone against acute lymphoblastic leukemia is enhanced by the BH3-mimetic ABT-737 in vitro and in vivo

BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms

Pharmacologic inhibition of CDK4/6: mechanistic evidence for selective activity or acquired resistance in acute myeloid leukemia

Low-dose arsenic trioxide sensitizes glucocorticoid-resistant acute lymphoblastic leukemia cells to dexamethasone via an Akt-dependent pathway

MEK1/2 inhibitors potentiate UCN-01 lethality in human multiple myeloma cells through a Bim-dependent mechanism

Farnesyl transferase inhibitor resistance probed by target mutagenesis

Negative regulation of the SH₂-homology–containing protein-tyrosine phosphatase-1 (SHP-1) P2 promoter by the HTLV-1 Tax oncoprotein

Nuclear CD40 interacts with c-Rel and enhances proliferation in aggressive B-cell lymphoma

Incidence and clinical implications of GATA1 mutations in newborns with Down syndrome
Brief Report

Cytoplasmic remodeling of erythrocyte raft lipids during infection by the human malaria parasite Plasmodium falciparum

HIF–prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques

Mosaicism due to myeloid lineage–restricted loss of heterozygosity as cause of spontaneous Rh phenotype splitting

Point mutations involved in red cell stomatocytosis convert the electroneutral anion exchanger 1 to a nonselective cation conductance

Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin

Hypoxic stress underlies defects in erythroblast islands in the Rb-null mouse

Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4

Factor H–mediated cell surface protection from complement is critical for the survival of PNH erythrocytes
Brief Report

A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove
Brief Report

Human multipotent mesenchymal stromal cells inhibit proliferation of PBMCs independently of IFNγR1 signaling and IDO expression
Brief Report

Nonhemolytic antigen loss from red blood cells requires cooperative binding of multiple antibodies recognizing different epitopes

Successful treatment of lymphoproliferative disease complicating primary immunodeficiency/immunodysregulatory disorders with reduced-intensity allogeneic stem-cell transplantation

IFN-γ and STAT1 are required for efficient induction of CXC chemokine receptor 3 (CXCR3) on CD4⁺ but not CD8⁺ T cells

Epigallocathechin-3-gallate in AL amyloidosis: a new therapeutic option?