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Journal Articles

Mouse multipotent progenitor 5 cells are located at the interphase between hematopoietic stem and progenitor cells

Free
Brief Report
Pia Sommerkamp, Mari Carmen Romero-Mulero, Andreas Narr, Luisa Ladel, Lucie Hustin, Katharina Schönberger, Simon Renders, Sandro Altamura, Petra Zeisberger, Karin Jäcklein, Daniel Klimmeck, Alejo Rodriguez-Fraticelli, Fernando D. Camargo, Leïla Perié, Andreas Trumpp, Nina Cabezas-Wallscheid
Journal: Blood
Blood (2021) 137 (23): 3218–3224.
https://doi.org/10.1182/blood.2020007876
Published: 2021
Includes: Supplemental data
Journal Articles

Clonal evolution of acute myeloid leukemia with FLT3 -ITD mutation under treatment with midostaurin

Free
Laura K. Schmalbrock, Anna Dolnik, Sibylle Cocciardi, Eric Sträng, Frauke Theis, Nikolaus Jahn, Ekaterina Panina, Tamara J. Blätte, Julia Herzig, Sabrina Skambraks, Frank G. Rücker, Verena I. Gaidzik, Peter Paschka, Walter Fiedler, Helmut R. Salih, Gerald Wulf, Thomas Schroeder, Michael Lübbert, Richard F. Schlenk, Felicitas Thol, Michael Heuser, Richard A. Larson, Arnold Ganser, Hendrik G. Stunnenberg, Saverio Minucci, Richard M. Stone, Clara D. Bloomfield, Hartmut Döhner, Konstanze Döhner, Lars Bullinger
Journal: Blood
Blood (2021) 137 (22): 3093–3104.
https://doi.org/10.1182/blood.2020007626
Published: 2021
Includes: Supplemental data
Journal Articles

CLEC12A and CD33 coexpression as a preferential target for pediatric AML combinatorial immunotherapy

Free
Semjon Willier, Paula Rothämel, Maximilian Hastreiter, Jonas Wilhelm, Dana Stenger, Franziska Blaeschke, Meino Rohlfs, Theresa Kaeuferle, Irene Schmid, Michael H. Albert, Vera Binder, Marion Subklewe, Christoph Klein, Tobias Feuchtinger
Journal: Blood
Blood (2021) 137 (8): 1037–1049.
https://doi.org/10.1182/blood.2020006921
Published: 2021
Includes: Supplemental data
Journal Articles

How I diagnose and treat NPM1 -mutated AML

Free
Brunangelo Falini, Lorenzo Brunetti, Maria Paola Martelli
Journal: Blood
Blood (2021) 137 (5): 589–599.
https://doi.org/10.1182/blood.2020008211
Published: 2021
Journal Articles

Acute myeloid leukemia with NPM1 and FLT3 ITD mimicking acute promyelocytic leukemia

Free
Michael Pepper, Brent Tan
Journal: Blood
Blood (2020) 136 (12): 1467.
https://doi.org/10.1182/blood.2020007198
Published: 2020
Journal Articles

Glucocorticoids enhance the antileukemic activity of FLT3 inhibitors in FLT3-mutant acute myeloid leukemia

Free
Melat T. Gebru, Jennifer M. Atkinson, Megan M. Young, Lijun Zhang, Zhenyuan Tang, Zhenqiu Liu, Pinyi Lu, Christopher M. Dower, Longgui Chen, Charyguly Annageldiyev, Arati Sharma, Yuka Imamura Kawasawa, Zhongming Zhao, Barbara A. Miller, David F. Claxton, Hong-Gang Wang
Journal: Blood
Blood (2020) 136 (9): 1067–1079.
https://doi.org/10.1182/blood.2019003124
Published: 2020
Includes: Supplemental data
Journal Articles

How I treat relapsed or refractory AML

Free
Susan DeWolf, Martin S. Tallman
Journal: Blood
Blood (2020) 136 (9): 1023–1032.
https://doi.org/10.1182/blood.2019001982
Published: 2020
Journal Articles

Deletions in BCP-ALL result in a TAD more FLT3

Free
David H. Spencer
Journal: Blood
Blood (2020) 136 (8): 919–920.
https://doi.org/10.1182/blood.2020006607
Published: 2020
Journal Articles

13q12.2 deletions in acute lymphoblastic leukemia lead to upregulation of FLT3 through enhancer hijacking

Free
Minjun Yang, Setareh Safavi, Eleanor L. Woodward, Nicolas Duployez, Linda Olsson-Arvidsson, Jonas Ungerbäck, Mikael Sigvardsson, Marketa Zaliova, Jan Zuna, Thoas Fioretos, Bertil Johansson, Karolin H. Nord, Kajsa Paulsson
Journal: Blood
Blood (2020) 136 (8): 946–956.
https://doi.org/10.1182/blood.2019004684
Published: 2020
Includes: Supplemental data
Journal Articles

FLT3 inhibition upregulates HDAC8 via FOXO to inactivate p53 and promote maintenance of FLT3-ITD + acute myeloid leukemia

Free
Jun Long, Ming-Yuan Jia, Wei-Yue Fang, Xin-Jie Chen, Li-Li Mu, Zhong-Yu Wang, Yan Shen, Ru-Fang Xiang, Li-Ning Wang, Ling Wang, Chuan-He Jiang, Jie-Ling Jiang, Wen-Jun Zhang, Yi-Dan Sun, Li Chang, Wen-Hui Gao, Ying Wang, Jun-Min Li, Deng-Li Hong, Ai-Bin Liang, Jiong Hu
Journal: Blood
Blood (2020) 135 (17): 1472–1483.
https://doi.org/10.1182/blood.2019003538
Published: 2020
Includes: Supplemental data
Journal Articles

Molecular MRD status and outcome after transplantation in NPM1 -mutated AML

Free
Clinical Trials & Observations
Richard Dillon, Robert Hills, Sylvie Freeman, Nicola Potter, Jelena Jovanovic, Adam Ivey, Anju Shankar Kanda, Manohursingh Runglall, Nicola Foot, Mikel Valganon, Asim Khwaja, Jamie Cavenagh, Matthew Smith, Hans Beier Ommen, Ulrik Malthe Overgaard, Mike Dennis, Steven Knapper, Harpreet Kaur, David Taussig, Priyanka Mehta, Kavita Raj, Igor Novitzky-Basso, Emmanouil Nikolousis, Robert Danby, Pramila Krishnamurthy, Kate Hill, Damian Finnegan, Samah Alimam, Erin Hurst, Peter Johnson, Anjum Khan, Rahuman Salim, Charles Craddock, Ruth Spearing, Amanda Gilkes, Rosemary Gale, Alan Burnett, Nigel H. Russell, David Grimwade
Journal: Blood
Blood (2020) 135 (9): 680–688.
https://doi.org/10.1182/blood.2019002959
Published: 2020
Includes: Supplemental data
Journal Articles

Impact of NPM1 / FLT3 -ITD genotypes defined by the 2017 European LeukemiaNet in patients with acute myeloid leukemia

Free
Clinical Trials & Observations
Konstanze Döhner, Christian Thiede, Nikolaus Jahn, Ekaterina Panina, Agnes Gambietz, Richard A. Larson, Thomas W. Prior, Guido Marcucci, Dan Jones, Jürgen Krauter, Michael Heuser, Maria Teresa Voso, Tiziana Ottone, Josep F. Nomdedeu, Sumithra J. Mandrekar, Rebecca B. Klisovic, Andrew H. Wei, Jorge Sierra, Miguel A. Sanz, Joseph M. Brandwein, Theo de Witte, Joop H. Jansen, Dietger Niederwieser, Frederick R. Appelbaum, Bruno C. Medeiros, Martin S. Tallman, Richard F. Schlenk, Arnold Ganser, Hubert Serve, Gerhard Ehninger, Sergio Amadori, Insa Gathmann, Axel Benner, Celine Pallaud, Richard M. Stone, Hartmut Döhner, Clara D. Bloomfield
Journal: Blood
Blood (2020) 135 (5): 371–380.
https://doi.org/10.1182/blood.2019002697
Published: 2020
Includes: Supplemental data
Journal Articles

How I treat acute myeloid leukemia in the era of new drugs

Free
Courtney D. DiNardo, Andrew H. Wei
Journal: Blood
Blood (2020) 135 (2): 85–96.
https://doi.org/10.1182/blood.2019001239
Published: 2020
Includes: Supplemental data
Journal Articles

Terminal deoxynucleotidyl transferase promotes acute myeloid leukemia by priming FLT3 -ITD replication slippage

Free
Julian Borrow, Sara A. Dyer, Susanna Akiki, Michael J. Griffiths
Journal: Blood
Blood (2019) 134 (25): 2281–2290.
https://doi.org/10.1182/blood.2019001238
Published: 2019
Includes: Supplemental data
Journal Articles

Molecular roulette: nucleophosmin mutations in AML are orchestrated through N-nucleotide addition by TdT

Free
Julian Borrow, Sara A. Dyer, Susanna Akiki, Michael J. Griffiths
Journal: Blood
Blood (2019) 134 (25): 2291–2303.
https://doi.org/10.1182/blood.2019001240
Published: 2019
Includes: Supplemental data
Journal Articles

Towards Understanding & Uncovering New Key Players in T-Cell Development upon Aging

Free
Hanane Boukarabila, PhD, Kalpana Nattamai, Medhanie Assmelash Mulaw, PhD, Hartmut Geiger, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2482.
https://doi.org/10.1182/blood-2019-127294
Published: 2019
Journal Articles

Prognostic Impact of Clonal Diversity in Acute Myeloid Leukemia (AML) Treated with Intensive Chemotherapy (IC)

Free
Marco Cerrano, MD, Marie Passet, PharmD, Loic Vasseur, MD, Pierre Hirsch, MD PhD, Xavier Thomas, MD PhD, Samuel Quentin, Justine Pasanisi, Florence Rabian, MD, Ramy Rahmé, MD, Etienne Lengline, MD, Emmanuel Raffoux, MD, Nathalie Dhedin, MD, Marie Sebert, MD, Odile Maarek, Anna Raimbault, PhD, Karine Celli-Lebras, CRA, Lionel Ades, MD PhD, Pierre Fenaux, MD PhD, Nicolas Boissel, MD PhD, Francois Delhommeau, MD PhD, Jean Soulier, MD PhD, Herve Dombret, MD PhD, Emmanuelle Clappier, PhD PharmD, Pierre Sujobert, MD PhD, Raphael Itzykson, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2700.
https://doi.org/10.1182/blood-2019-127475
Published: 2019
Journal Articles

Distinct Gene Expression Profiles and Mutations Associate with Outcome in Younger Adults with De Novo Cytogenetically Normal Acute Myeloid Leukemia (CN-AML) (Alliance)

Free
Christopher J. Walker, PhD, Ann-Kathrin Eisfeld, MD, Hatice G Ozer, PhD, Jessica Kohlschmidt, PhD, Deedra Nicolet, Krzysztof Mrózek, MD PhD, Dimitrios Papaioannou, MD, Luke K Genutis, BS, Bayard L Powell, MD, Geoffrey L. Uy, MD, Jonathan E. Kolitz, MD, Andrew J. Carroll, PhD, Richard Stone, MD, Ramiro Garzon, MD, John C. Byrd, MD, Albert de la Chapelle, MD PhD, Clara D. Bloomfield, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1247.
https://doi.org/10.1182/blood-2019-127478
Published: 2019
Journal Articles

Phase II Randomized Trial of Gilteritinib Vs Midostaurin in Newly Diagnosed FLT3 Mutated Acute Myeloid Leukemia (AML)

Free
Selina M. Luger, MD FRCPC, Zhuoxin Sun, PhD, Sanam Loghavi, MD, Hillard M Lazarus, MD, Jacob M. Rowe, MB, BS, Martin S. Tallman, MD, Keith W. Pratz, MD, Mark Litzow, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1309.
https://doi.org/10.1182/blood-2019-128377
Published: 2019
Journal Articles

Identifying the Leukemia Stem Cell Niche Mediating Drug Resistance in Flt3-ITD Acute Myeloid Leukemia

Free
Nick R Anderson, BS, Hui Li, BS, Mason W Harris, Shaowei Qiu, MD, Andrew J Paterson, PhD, Ravi Bhatia, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 909.
https://doi.org/10.1182/blood-2019-124379
Published: 2019