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Journal Articles

Mouse multipotent progenitor 5 cells are located at the interphase between hematopoietic stem and progenitor cells

Brief Report
Pia Sommerkamp, Mari Carmen Romero-Mulero, Andreas Narr, Luisa Ladel, Lucie Hustin, Katharina Schönberger, Simon Renders, Sandro Altamura, Petra Zeisberger, Karin Jäcklein, Daniel Klimmeck, Alejo Rodriguez-Fraticelli, Fernando D. Camargo, Leïla Perié, Andreas Trumpp, Nina Cabezas-Wallscheid
Journal: Blood
Blood (2021) 137 (23): 3218–3224.
https://doi.org/10.1182/blood.2020007876
Published: 2021
Includes: Supplemental data
Journal Articles

Clonal evolution of acute myeloid leukemia with FLT3 -ITD mutation under treatment with midostaurin

Laura K. Schmalbrock, Anna Dolnik, Sibylle Cocciardi, Eric Sträng, Frauke Theis, Nikolaus Jahn, Ekaterina Panina, Tamara J. Blätte, Julia Herzig, Sabrina Skambraks, Frank G. Rücker, Verena I. Gaidzik, Peter Paschka, Walter Fiedler, Helmut R. Salih, Gerald Wulf, Thomas Schroeder, Michael Lübbert, Richard F. Schlenk, Felicitas Thol, Michael Heuser, Richard A. Larson, Arnold Ganser, Hendrik G. Stunnenberg, Saverio Minucci, Richard M. Stone, Clara D. Bloomfield, Hartmut Döhner, Konstanze Döhner, Lars Bullinger
Journal: Blood
Blood (2021) 137 (22): 3093–3104.
https://doi.org/10.1182/blood.2020007626
Published: 2021
Includes: Supplemental data
Journal Articles

CLEC12A and CD33 coexpression as a preferential target for pediatric AML combinatorial immunotherapy

Semjon Willier, Paula Rothämel, Maximilian Hastreiter, Jonas Wilhelm, Dana Stenger, Franziska Blaeschke, Meino Rohlfs, Theresa Kaeuferle, Irene Schmid, Michael H. Albert, Vera Binder, Marion Subklewe, Christoph Klein, Tobias Feuchtinger
Journal: Blood
Blood (2021) 137 (8): 1037–1049.
https://doi.org/10.1182/blood.2020006921
Published: 2021
Includes: Supplemental data
Journal Articles

How I diagnose and treat NPM1 -mutated AML

Brunangelo Falini, Lorenzo Brunetti, Maria Paola Martelli
Journal: Blood
Blood (2021) 137 (5): 589–599.
https://doi.org/10.1182/blood.2020008211
Published: 2021
Journal Articles

Acute myeloid leukemia with NPM1 and FLT3 ITD mimicking acute promyelocytic leukemia

Michael Pepper, Brent Tan
Journal: Blood
Blood (2020) 136 (12): 1467.
https://doi.org/10.1182/blood.2020007198
Published: 2020
Journal Articles

Glucocorticoids enhance the antileukemic activity of FLT3 inhibitors in FLT3-mutant acute myeloid leukemia

Melat T. Gebru, Jennifer M. Atkinson, Megan M. Young, Lijun Zhang, Zhenyuan Tang, Zhenqiu Liu, Pinyi Lu, Christopher M. Dower, Longgui Chen, Charyguly Annageldiyev, Arati Sharma, Yuka Imamura Kawasawa, Zhongming Zhao, Barbara A. Miller, David F. Claxton, Hong-Gang Wang
Journal: Blood
Blood (2020) 136 (9): 1067–1079.
https://doi.org/10.1182/blood.2019003124
Published: 2020
Includes: Supplemental data
Journal Articles

How I treat relapsed or refractory AML

Susan DeWolf, Martin S. Tallman
Journal: Blood
Blood (2020) 136 (9): 1023–1032.
https://doi.org/10.1182/blood.2019001982
Published: 2020
Journal Articles

13q12.2 deletions in acute lymphoblastic leukemia lead to upregulation of FLT3 through enhancer hijacking

Minjun Yang, Setareh Safavi, Eleanor L. Woodward, Nicolas Duployez, Linda Olsson-Arvidsson, Jonas Ungerbäck, Mikael Sigvardsson, Marketa Zaliova, Jan Zuna, Thoas Fioretos, Bertil Johansson, Karolin H. Nord, Kajsa Paulsson
Journal: Blood
Blood (2020) 136 (8): 946–956.
https://doi.org/10.1182/blood.2019004684
Published: 2020
Includes: Supplemental data
Journal Articles

Deletions in BCP-ALL result in a TAD more FLT3

David H. Spencer
Journal: Blood
Blood (2020) 136 (8): 919–920.
https://doi.org/10.1182/blood.2020006607
Published: 2020
Journal Articles

FLT3 inhibition upregulates HDAC8 via FOXO to inactivate p53 and promote maintenance of FLT3-ITD + acute myeloid leukemia

Jun Long, Ming-Yuan Jia, Wei-Yue Fang, Xin-Jie Chen, Li-Li Mu, Zhong-Yu Wang, Yan Shen, Ru-Fang Xiang, Li-Ning Wang, Ling Wang, Chuan-He Jiang, Jie-Ling Jiang, Wen-Jun Zhang, Yi-Dan Sun, Li Chang, Wen-Hui Gao, Ying Wang, Jun-Min Li, Deng-Li Hong, Ai-Bin Liang, Jiong Hu
Journal: Blood
Blood (2020) 135 (17): 1472–1483.
https://doi.org/10.1182/blood.2019003538
Published: 2020
Includes: Supplemental data
Journal Articles

Molecular MRD status and outcome after transplantation in NPM1 -mutated AML

Clinical Trials & Observations
Richard Dillon, Robert Hills, Sylvie Freeman, Nicola Potter, Jelena Jovanovic, Adam Ivey, Anju Shankar Kanda, Manohursingh Runglall, Nicola Foot, Mikel Valganon, Asim Khwaja, Jamie Cavenagh, Matthew Smith, Hans Beier Ommen, Ulrik Malthe Overgaard, Mike Dennis, Steven Knapper, Harpreet Kaur, David Taussig, Priyanka Mehta, Kavita Raj, Igor Novitzky-Basso, Emmanouil Nikolousis, Robert Danby, Pramila Krishnamurthy, Kate Hill, Damian Finnegan, Samah Alimam, Erin Hurst, Peter Johnson, Anjum Khan, Rahuman Salim, Charles Craddock, Ruth Spearing, Amanda Gilkes, Rosemary Gale, Alan Burnett, Nigel H. Russell, David Grimwade
Journal: Blood
Blood (2020) 135 (9): 680–688.
https://doi.org/10.1182/blood.2019002959
Published: 2020
Includes: Supplemental data
Journal Articles

Impact of NPM1 / FLT3 -ITD genotypes defined by the 2017 European LeukemiaNet in patients with acute myeloid leukemia

Clinical Trials & Observations
Konstanze Döhner, Christian Thiede, Nikolaus Jahn, Ekaterina Panina, Agnes Gambietz, Richard A. Larson, Thomas W. Prior, Guido Marcucci, Dan Jones, Jürgen Krauter, Michael Heuser, Maria Teresa Voso, Tiziana Ottone, Josep F. Nomdedeu, Sumithra J. Mandrekar, Rebecca B. Klisovic, Andrew H. Wei, Jorge Sierra, Miguel A. Sanz, Joseph M. Brandwein, Theo de Witte, Joop H. Jansen, Dietger Niederwieser, Frederick R. Appelbaum, Bruno C. Medeiros, Martin S. Tallman, Richard F. Schlenk, Arnold Ganser, Hubert Serve, Gerhard Ehninger, Sergio Amadori, Insa Gathmann, Axel Benner, Celine Pallaud, Richard M. Stone, Hartmut Döhner, Clara D. Bloomfield
Journal: Blood
Blood (2020) 135 (5): 371–380.
https://doi.org/10.1182/blood.2019002697
Published: 2020
Includes: Supplemental data
Journal Articles

How I treat acute myeloid leukemia in the era of new drugs

Courtney D. DiNardo, Andrew H. Wei
Journal: Blood
Blood (2020) 135 (2): 85–96.
https://doi.org/10.1182/blood.2019001239
Published: 2020
Includes: Supplemental data
Journal Articles

Terminal deoxynucleotidyl transferase promotes acute myeloid leukemia by priming FLT3 -ITD replication slippage

Julian Borrow, Sara A. Dyer, Susanna Akiki, Michael J. Griffiths
Journal: Blood
Blood (2019) 134 (25): 2281–2290.
https://doi.org/10.1182/blood.2019001238
Published: 2019
Includes: Supplemental data
Journal Articles

Molecular roulette: nucleophosmin mutations in AML are orchestrated through N-nucleotide addition by TdT

Julian Borrow, Sara A. Dyer, Susanna Akiki, Michael J. Griffiths
Journal: Blood
Blood (2019) 134 (25): 2291–2303.
https://doi.org/10.1182/blood.2019001240
Published: 2019
Includes: Supplemental data
Journal Articles

Fludarabine, High Dose Cytarabine and Idarubicin-Based Induction Is Highly Effective in Young AML Patients with Concomitant NPM1 and FLT3-ITD Mutation Irrespectively of FLT3-ITD Allelic Burden

Paola Minetto, MD, Anna Candoni, MD, Fabio Guolo, MD, Marino Clavio, MD, Maria Elena Zannier, MD, Maurizio Miglino, PhD, Maria Vittoria Dubbini, MD, Enrico Carminati, Anna Sicuranza, PhD, Sara Ciofini, Elisabetta Tedone, Nicoletta Colombo, PhD, Girolamo Pugliese, Riccardo Marcolin, MD, Filippo Ballerini, MD, Michele Cea, Marco Gobbi, MD, Monica Bocchia, Renato Fanin, MD, Roberto Massimo Lemoli, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3828.
https://doi.org/10.1182/blood-2019-131303
Published: 2019
Journal Articles

Loss of Gpr68 Enhances Hematopoietic Stem Cell Function during Aging

Xiaofei He, B.S., Caleb Hawkins, B.S., Lauren Lawley, B.S., Yan Xu, PhD, Xiang-ming Zha, PhD, Jing Fang, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3719.
https://doi.org/10.1182/blood-2019-125168
Published: 2019
Journal Articles

Interim Results of a First in Man Study with the Fc-Optimized FLT3 Antibody Flysyn for Treatment of Acute Myeloid Leukemia with Minimal Residual Disease

Sabine Kayser, MD, Jonas S. Heitmann, MD, Daniela Dörfel, MD, Felicitas Thol, MD, Michael Heuser, MD, Melanie Märklin, PhD, Carsten Müller-Tidow, MD, Martin Steiner, Ludger Grosse-Hovest, Gundram Jung, MD, Richard F. Schlenk, MD, Helmut R. Salih, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3928.
https://doi.org/10.1182/blood-2019-125327
Published: 2019
Journal Articles

Safety and Efficacy of Midostaurin in Combination with High-Dose Daunorubicin in 7+3 Induction for Acute Myeloid Leukemia with FLT3 Mutation

Yehuda E. Deutsch, MD, Robert Wilkinson, PharmD, Amanda Brahim, PharmD, Stephanie Boisclair, MD, Jose Sandoval-Sus, MD, Annie Kuehnel, APRN, Terrence J Bradley, MD, Chetasi Talati, MD, Ellen Madarang, PharmD, Jillian Lykon, PharmD, Justin M. Watts, MD, David A Sallman, MD, Kendra L. Sweet, MD, Jeffrey E. Lancet, MD, Hugo F. Fernandez, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3896.
https://doi.org/10.1182/blood-2019-129331
Published: 2019
Journal Articles

Tolerability and Efficacy of Crenolanib and Cytarabine/Anthracycline Chemotherapy in Older Patients (Aged 61 to 75) with Newly Diagnosed FLT3-Mutated Acute Myeloid Leukemia (AML)

Eunice S. Wang, MD, Elizabeth A. Griffiths, MD, Roland B. Walter, MD PhD MS, Martin S. Tallman, MD, Aaron D Goldberg, MD PhD, Boo Messahel, MD, Richard M. Stone, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3829.
https://doi.org/10.1182/blood-2019-130536
Published: 2019