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Journal Articles

Efficacy and Safety of Venetoclax Plus Azacitidine for Patients With Treatment-Naive High-Risk Myelodysplastic Syndromes

Clinical Trials & Observations
Jacqueline S. Garcia, Uwe Platzbecker, Olatoyosi Odenike, Shaun A Fleming, Chun Yew Fong, Uma Borate, Meagan A Jacoby, Daniel Nowak, Maria R Baer, Pierre Peterlin, Brenda Chyla, Huipei Wang, Grace Ku, David Hoffman, Jalaja Potluri, Guillermo Garcia-Manero
Journal: Blood
Blood blood.2024025464.
https://doi.org/10.1182/blood.2024025464
Published: 2024
Includes: Supplemental data
Journal Articles

Leukemia Evolution and Resistance to Graft-Versus-Leukemia Responses Revealed By Mitochondrial DNA Mutations

Livius Penter, Nicoletta Cieri, Katie Maurer, Marwan Kwok, Haoxiang Lyu, Wesley S Lu, Giacomo Oliveira, Satyen H Gohil, Ignaty Leshchiner, Caleb Lareau, Leif S Ludwig, Donna S. Neuberg, Haesook T. Kim, Shuqiang Li, Lars Bullinger, Jerome Ritz, Gad Getz, Jacqueline S. Garcia, Robert J. Soiffer, Kenneth J. Livak, Catherine J. Wu
Journal: Blood
Blood (2024) 144 (Supplement 1): 926.
https://doi.org/10.1182/blood-2024-199009
Published: 2024
Journal Articles

A Multicenter, Open-Label, Phase 1 Clinical Trial of AJ1-11095 Administered As Oral Monotherapy in Patients with Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), or Post-Essential Thrombocythemia Myelofibrosis (PET-MF) Who Have Been Failed By a Type I JAK2 Inhibitor (JAK2i)

John O. Mascarenhas, Uma Borate, Prithviraj Bose, John C. Byrd, Jacqueline S. Garcia, Michael R. Grunwald, Gabriela S. Hobbs, Ronald Hoffman, Andrew T. Kuykendall, Ruben A. Mesa, Stephen Oh, Raajit Rampal, Abdulraheem Yacoub, David P. Steensma
Journal: Blood
Blood (2024) 144 (Supplement 1): 3147.1.
https://doi.org/10.1182/blood-2024-193905
Published: 2024
Journal Articles

Outcomes of Patients with IDH1/2 Mutated Accelerated/Blast-Phase Myeloproliferative Neoplasms in the Era of IDH Inhibitors

Leah A Goldberg, James J. Yoon, Hannah Johnston, Marta Beata Davidson, Alexa Siddon, Rory M. Shallis, Evan C. Chen, Madelyn Burkart, Timothy S. Oh, Sunil G. Iyer, Ellen Madarang, Chandrasekar Muthiah, Joshua Kassner, Raajit Rampal, Guru Subramanian Guru Murthy, Terrence Bradley, Yasmin Abaza, Jacqueline S. Garcia, Vikas Gupta, Kristen M. Pettit, Olatoyosi Odenike, John F. Cursio, Anand Ashwin Patel
Journal: Blood
Blood (2024) 144 (Supplement 1): 1787.
https://doi.org/10.1182/blood-2024-197898
Published: 2024
Journal Articles

Feasibility, Safety and Efficacy of Oral Maintenance Therapy with Venetoclax Plus Decitabine/Cedazuridine after Venetoclax Plus FluBu2 for High Risk MDS/AML Undergoing RIC Allo-HCT

Jacqueline S. Garcia, Haesook T. Kim, Jennifer Brock, H. Moses Murdock, Mahasweta Gooptu, Vincent T. Ho, Roman M. Shapiro, Christopher J. Gibson, Amar H. Kelkar, Corey S. Cutler, Denbaa Bat-Erdene, Jeremy Ryan, Anna Bosch-Vilaseca, Anthony G. Letai, Jerome Ritz, Coleman Lindsley, Robert J. Soiffer, Joseph Antin
Journal: Blood
Blood (2024) 144 (Supplement 1): 1045.
https://doi.org/10.1182/blood-2024-194170
Published: 2024
Journal Articles

Clinical Activity and Safety of the Oral ATR Inhibitor Ceralasertib (AZD6738) in Patients with MDS or CMML after Prior HMA Therapy

Andrew M. Brunner, Yiwen Liu, Jacqueline S. Garcia, Lourdes Mendez, Catherine Gutierrez, Philip C. Amrein, Rupa Narayan, Rahul Vedula, Donna S. Neuberg, Marcio Andrade-Campos, Simon Smith, Richard M Stone, Amir T. Fathi, Matthew J. Walter, Timothy Aaron Graubert, Meagan Jacoby
Journal: Blood
Blood (2024) 144 (Supplement 1): 1833.
https://doi.org/10.1182/blood-2024-195793
Published: 2024
Journal Articles

A Phase Ib/II Study of Ivosidenib with Venetoclax ± Azacitidine in IDH1-Mutated Hematologic Malignancies: A 2024 Update

Jennifer Marvin-Peek, Jacqueline S. Garcia, Gautam Borthakur, Guillermo Garcia-Manero, Nicholas J. Short, Tapan M. Kadia, Sanam Loghavi, Lucia Masarova, Naval Daver, Abhishek Maiti, Koichi Takahashi, Koji Sasaki, Danielle Hammond, George Donovan Tippett, Dylan Wilson, Kelly S. Chien, Prithviraj Bose, Patrick K. Reville, Curtis A Lachowiez, Akriti G. Jain, Ghayas C. Issa, Nitin Jain, Guillermo Montalban-Bravo, Marlise R. Luskin, Hetty E. Carraway, Farhad Ravandi, Hagop M. Kantarjian, Courtney D. DiNardo
Journal: Blood
Blood (2024) 144 (Supplement 1): 219.
https://doi.org/10.1182/blood-2024-200393
Published: 2024
Journal Articles

Dual Bclxl and BCL2 Inhibition with Navitoclax (NAV), Venetoclax (VEN), and Decitabine (DEC) for Advanced Myeloid Neoplasms (MN): Safety and Biological Activity in a Phase 1 Study

Evan C. Chen, Yiwen Liu, Hayden L. Bell, Ilene A. Galinsky, Marlise R. Luskin, Eric S. Winer, Maximilian Stahl, Rahul Vedula, Virginia O. Volpe, Daniel J. DeAngelo, Karen Quillen, Jeremy Ryan, Emma-Jayne Minihane, Matthew Hersch, Rebecca Leonard, Donna S. Neuberg, Richard M. Stone, Anthony G. Letai, Andrew A. Lane, Jacqueline S. Garcia
Journal: Blood
Blood (2024) 144 (Supplement 1): 4580.
https://doi.org/10.1182/blood-2024-198284
Published: 2024
Journal Articles

Outcomes with HMA Plus Venetoclax Vs Intensive Chemotherapy in AML Patients with Chromosome 5 and 7 Abnormalities

Leora Boussi, Jan Philipp Bewersdorf, Yiwen Liu, Rory M. Shallis, Luis E. Aguirre, Andrius Zucenka, Sylvain Garciaz, Rebecca P. Bystrom, Daniel J. DeAngelo, Richard M Stone, Marlise R. Luskin, Jacqueline S. Garcia, Eric S. Winer, Evan Chen, Martha Wadleigh, Kelly Ling, Amer M. Zeidan, Aaron D. Goldberg, Eytan M. Stein, Shai O. Shimony, Maximilian Stahl
Journal: Blood
Blood (2024) 144 (Supplement 1): 4281.
https://doi.org/10.1182/blood-2024-204467
Published: 2024
Journal Articles

A Multi-Site Break through Cancer Trial: Phase II Study Investigating Dual Inhibition of BCL2 and Menin in AML MRD Using the Combination of Venetoclax and Revumenib (Trial In Progress)

Ghayas C. Issa, Alexander J. Ambinder, Wenbin Xiao, Scott Manalis, Alex K Shalek, Lukasz P. Gondek, Alex Kentsis, Nicholas J. Short, Naval Daver, Jing Ning, Lianchun Xiao, Michael Hemann, Ken Chen, Keyur P. Patel, Pavan Bachireddy, Andrew A. Lane, Marina Konopleva, Omar Abdel-Wahab, Jeffrey J. Molldrem, Ross L Levine, Mark J. Levis, Richard M Stone, Michael Andreeff, Farhad Ravandi, Aaron D. Goldberg, Jacqueline S. Garcia
Journal: Blood
Blood (2024) 144 (Supplement 1): 4265.2.
https://doi.org/10.1182/blood-2024-201582
Published: 2024
Journal Articles

The Prognostic and Predictive Value of RUNX1 Mutations in Newly Diagnosed Acute Myeloid Leukemia - an International Multicenter Cohort Study

Rebecca P. Bystrom, Jan Philipp Bewersdorf, Yiwen Liu, Eva Johanna Schaefer, Rory M. Shallis, Leora Boussi, Andrius Zucenka, Sylvain Garciaz, Luis E. Aguirre, Daniel J. DeAngelo, Richard M. Stone, Marlise R. Luskin, Jacqueline S. Garcia, Eric S. Winer, Evan C. Chen, Martha Wadleigh, Kelly Ling, Eytan M. Stein, Aaron D. Goldberg, Amer M. Zeidan, Shai O. Shimony, Maximilian Stahl
Journal: Blood
Blood (2024) 144 (Supplement 1): 2947.
https://doi.org/10.1182/blood-2024-205581
Published: 2024
Journal Articles

Comparative Analysis of Outcomes with HMA Plus Venetoclax Vs Intensive Chemotherapy in AML Patients Harboring Very-High Risk Cytogenetics

Luis E. Aguirre, Jan Philipp Bewersdorf, Yiwen Liu, Rory M. Shallis, Leora Boussi, Andrius Zucenka, Sylvain Garciaz, Rebecca P. Bystrom, Daniel J. DeAngelo, Richard M. Stone, Marlise R. Luskin, Jacqueline S. Garcia, Eric S. Winer, Kelly Ling, Evan C. Chen, Martha Wadleigh, Eytan M. Stein, Aaron D. Goldberg, Amer M. Zeidan, Shai O. Shimony, Maximilian Stahl
Journal: Blood
Blood (2024) 144 (Supplement 1): 4267.
https://doi.org/10.1182/blood-2024-202744
Published: 2024
Journal Articles

Venetoclax-Based Therapy Versus Intensive Chemotherapy Followed By Allogeneic-Stem Cell Transplantation for High-Risk Elderly Acute Myeloid Leukemia

Alexandre Iat, Jan Philipp Bewersdorf, Julia Gilhodes, Yiwen Liu, Rory M. Shallis, Leora Boussi, Andrius Zucenka, Rebecca P. Bystrom, Daniel J. DeAngelo, Guillaume Berton, Amel Soua, Kelly Ling, Luis E. Aguirre, Richard M Stone, Marlise R. Luskin, Jacqueline S. Garcia, Eric S. Winer, Evan C. Chen, Martha Wadleigh, Aaron D. Goldberg, Amer M. Zeidan, Thomas Cluzeau, Shai O. Shimony, Maximilian Stahl, Sylvain Garciaz
Journal: Blood
Blood (2024) 144 (Supplement 1): 1508.
https://doi.org/10.1182/blood-2024-207045
Published: 2024
Journal Articles

Final Analysis of a Phase I Study of Escalating Doses of the BCL-2 Inhibitor Venetoclax in Combination with Daunorubcin/Cytarabine Induction and High Dose Cytarabine Consolidation in Previously Untreated Adults with Acute Myeloid Leukemia

Richard M Stone, Daniel J. DeAngelo, Anthony G. Letai, Ilene A. Galinsky, Howard Weiner, Austen Halpin, Lexi Noyes, Hunter Smith, Carter Lombardi, Rebecca Leonard, Geoffrey Fell, Yael Flammand, Jeremy Ryan, Marina Konopleva, Martha Wadleigh, Maximilian Stahl, Evan Chen, Virginia O. Volpe, Eric S. Winer, Jacqueline S. Garcia, Marlise R. Luskin, Anand Ashwin Patel
Journal: Blood
Blood (2024) 144 (Supplement 1): 4261.
https://doi.org/10.1182/blood-2024-203683
Published: 2024
Journal Articles

Randomized Phase II Trial of Dendritic Cell/AML Fusion Cell Vaccination Compared to Standard of Care Therapy in AML CR1

Prateek Pophali, Giulia Cheloni, Richard M. Stone, Kai W Wucherpfennig, Aric C. Hall, Amir T. Fathi, Lina Bisharat, Emma K Logan, Yiwen Liu, Donna S. Neuberg, Malgorzata McMasters, Jessica Liegel, Jacqueline S. Garcia, Daniel J. DeAngelo, Michele Narcis, Dina Stroopinsky, Pavania Elavalakanar, Ioannis S Vlachos, Ilene A. Galinsky, Jason Pyrdol, Georges Chedid, Dimitra Karagkouni, Shivani Nanda, Kathrine S Rallis, Isabella Saldarriaga, Hazal Toros, Haitham Abdelhakim, Amelia Langston, Joseph P. McGuirk, Donald Kufe, David Avigan, Jacalyn Rosenblatt
Journal: Blood
Blood (2024) 144 (Supplement 1): 4256.
https://doi.org/10.1182/blood-2024-200876
Published: 2024
Journal Articles

Redefining Clinical Response Criteria in Myelodysplastic Syndromes to Better Forecast Post-Transplant Outcomes

Luis E. Aguirre, Haesook T. Kim, Hany Elmariah, Stacey M. Frumm, Amar H. Kelkar, Vincent T. Ho, Mahasweta Gooptu, John Koreth, Roman M. Shapiro, Rizwan Romee, Sarah Nikiforow, Joseph H. Antin, Robert J. Soiffer, Benjamin Rolles, Shai O. Shimony, Marlise R. Luskin, Jacqueline S. Garcia, Kelly Ling, Evan C. Chen, Martha Wadleigh, Eric S. Winer, Richard M. Stone, Daniel J. DeAngelo, Najla H. Al Ali, Corey S. Cutler, Rami S. Komrokji, Maximilian Stahl
Journal: Blood
Blood (2024) 144 (Supplement 1): 4938.
https://doi.org/10.1182/blood-2024-209087
Published: 2024
Journal Articles

Proposals for revised International Working Group–European LeukemiaNet criteria for anemia response in myelofibrosis

Brief Report
Ayalew Tefferi, Giovanni Barosi, Francesco Passamonti, Juan-Carlos Hernandez-Boluda, Prithviraj Bose, Konstanze Döhner, Martin Ellis, Naseema Gangat, Jacqueline S. Garcia, Heinz Gisslinger, Jason Gotlib, Paola Guglielmelli, Vikas Gupta, Claire Harrison, Elizabeth O. Hexner, Gabriela S. Hobbs, Jean-Jacques Kiladjian, Steffen Koschmieder, Nicolaus Kroger, Andrew T. Kuykendall, Giuseppe G. Loscocco, John Mascarenhas, Lucia Masarova, Ruben Mesa, Barbara Mora, Olatoyosi Odenike, Stephen T. Oh, Animesh Pardanani, Anand Patel, Naveen Pemmaraju, Alessandro Rambaldi, Raajit Rampal, Shireen Sirhan, Natasha Szuber, Moshe Talpaz, Pankit J. Vachhani, Alessandro M. Vannucchi, Tiziano Barbui
Journal: Blood
Blood (2024) 144 (17): 1813–1820.
https://doi.org/10.1182/blood.2024025802
Published: 2024
Journal Articles

Asciminib plus dasatinib and prednisone for Philadelphia chromosome-positive acute leukemia

Clinical Trials & Observations
Marlise R. Luskin, Mark Alan Murakami, Julia H. Keating, Yael Flamand, Eric S Winer, Jacqueline S. Garcia, Maximilian Stahl, Richard M. Stone, Martha Wadleigh, Stella Louise Jaeckle, Ella Hagopian, David M. Weinstock, Jessica Liegel, Malgorzata McMasters, Eunice S Wang, Wendy Stock, Daniel J DeAngelo
Journal: Blood
Blood blood.2024025800.
https://doi.org/10.1182/blood.2024025800
Published: 2024
Includes: Supplemental data
Journal Articles

CRISPR-based rapid molecular diagnostic tests for fusion-driven leukemias

Rahul S. Vedula, Hannah Q. Karp, Jeremy Koob, Felicia Lim, Jacqueline S. Garcia, Eric S. Winer, Marlise R. Luskin, Gabriel Ghiaur, Annette S. Kim, Lan W. Beppu, Olga Sala-Torra, Jerald Radich, Jonathan Gootenberg, Omar Abudayyeh, Feng Zhang, R. Coleman Lindsley
Journal: Blood
Blood (2024) 144 (12): 1290–1299.
https://doi.org/10.1182/blood.2023022908
Published: 2024
Includes: Supplemental data
Journal Articles

Subunit-Specific Analysis of Cohesin-Mutant Myeloid Malignancies Reveals Distinct Ontogeny and Outcomes

Johann-Christoph Jann, Christopher B. Hergott, Marisa Winkler, Yiwen Liu, Benjamin Braun, Anne Charles, Kevin Copson, Shougat Barua, Manja Meggendorfer, Niroshan Nadarajah, Shai Shimony, Eric S. Winer, Martha Wadleigh, Richard M Stone, Daniel J. DeAngelo, Jacqueline S. Garcia, Torsten Haferlach, Coleman Lindsley, Marlise R. Luskin, Maximilian Stahl, Zuzana Tothova
Journal: Blood
Blood (2023) 142 (Supplement 1): 999.
https://doi.org/10.1182/blood-2023-187519
Published: 2023