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Volume 98, Issue 8

October 15 2001

In this Issue

INSIDE BLOOD
PLENARY PAPERS
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
GENE THERAPY
HEMATOPOIESIS
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
IMMUNOBIOLOGY
NEOPLASIA
PHAGOCYTES
RED CELLS
BRIEF REPORTS
CORRESPONDENCE

INSIDE BLOOD

An unexpected link between HCV and platelets

Harvey J. Alter

View Articletitled, An unexpected link between HCV and platelets

Leukemia stem cells and constitutive activation of NF-κB

James D. Griffin

View Articletitled, Leukemia stem cells and constitutive activation of NF-κB

C/EBPα and the G-CSF receptor gene – partners in granulopoiesis?

Alan D. Friedman

View Articletitled, C/EBPα and the G-CSF receptor gene – partners in granulopoiesis?

PLENARY PAPERS

The dynamics of hepatitis C virus binding to platelets and 2 mononuclear cell lines

Samir Hamaia,Chengyao Li,Jean-Pierre Allain

View Articletitled, The dynamics of hepatitis C virus binding to platelets and 2 mononuclear cell lines

Nuclear factor-κB is constitutively activated in primitive human acute myelogenous leukemia cells

Monica L. Guzman,Sarah J. Neering,Donna Upchurch,Barry Grimes,Dianna S. Howard,David A. Rizzieri,Selina M. Luger,Craig T. Jordan

View Articletitled, Nuclear factor-κB is constitutively activated in primitive human acute myelogenous leukemia cells

Estrogen-dependent E2a/Pbx1 myeloid cell lines exhibit conditional differentiation that can be arrested by other leukemic oncoproteins

David B. Sykes,Mark P. Kamps

View Articletitled, Estrogen-dependent E2a/Pbx1 myeloid cell lines exhibit conditional differentiation that can be arrested by other leukemic oncoproteins

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Randomized comparison of fludarabine, CAP, and ChOP in 938 previously untreated stage B and C chronic lymphocytic leukemia patients
Clinical Trials & Observations

Michel Leporrier,Sylvie Chevret,Bruno Cazin,Najda Boudjerra,Pierre Feugier,Bernard Desablens,Marie-José Rapp,Jerome Jaubert,Claudie Autrand,Marine Divine,Brigitte Dreyfus,Karim Maloum,Philippe Travade,Guillaume Dighiero,Jacques-Louis Binet,Claude Chastang,for the French Cooperative Group on Chronic Lymphocytic Leukemia

View Articletitled, Randomized comparison of fludarabine, CAP, and ChOP in 938 previously untreated stage B and C chronic lymphocytic leukemia patients

Intensive chemotherapy followed by allogeneic or autologous stem cell transplantation for patients with myelodysplastic syndromes (MDSs) and acute myeloid leukemia following MDS
Clinical Trials & Observations

Theo de Witte,Stefan Suciu,Gregor Verhoef,Boris Labar,Eric Archimbaud,Carlo Aul,Dominique Selleslag,Augustin Ferrant,Pierre Wijermans,Franco Mandelli,Sergio Amadori,Ulrich Jehn,Petra Muus,Marc Boogaerts,Robert Zittoun,Alois Gratwohl,Heintz Zwierzina,Anne Hagemeijer,Roel Willemze

View Articletitled, Intensive chemotherapy followed by allogeneic or autologous stem cell transplantation for patients with myelodysplastic syndromes (MDSs) and acute myeloid leukemia following MDS

Standardized, unrelated donor cord blood transplantation in adults with hematologic malignancies
Clinical Trials & Observations

Guillermo F. Sanz,Silvana Saavedra,Dolores Planelles,Leonor Senent,Jose Cervera,Eva Barragán,Carmen Jiménez,Luis Larrea,Guillermo Martı́n,Jesús Martı́nez,Isidro Jarque,Federico Moscardó,Gemma Plumé,Rafael Andreu,Ana I. Regadera,Inmaculada Garcı́a,Susana Mollá,Pilar Solves,Javier de la Rubia,Pascual Bolufer,Luis Benlloch,Marı́a A. Soler,Marı́a L. Marty,Miguel A. Sanz

View Articletitled, Standardized, unrelated donor cord blood transplantation in adults with hematologic malignancies

Changes in AIDS-related lymphoma since the era of highly active antiretroviral therapy
Clinical Trials & Observations

Caroline Besson,Aicha Goubar,Jean Gabarre,Willy Rozenbaum,Gilles Pialoux,François-Patrick Châtelet,Christine Katlama,Frédéric Charlotte,Bertrand Dupont,Nicole Brousse,Michel Huerre,Jacqueline Mikol,Philippe Camparo,Karima Mokhtari,Micheline Tulliez,Dominique Salmon-Céron,François Boué,Dominique Costagliola,Martine Raphaël

View Articletitled, Changes in AIDS-related lymphoma since the era of highly active antiretroviral therapy

Relationship between transferrin saturation and iron stores in the African American and US Caucasian populations: analysis of data from the third National Health and Nutrition Examination Survey
Clinical Trials & Observations

Christine E. McLaren,Kuo-Tung Li,Victor R. Gordeuk,Victor Hasselblad,Gordon D. McLaren

View Articletitled, Relationship between transferrin saturation and iron stores in the African American and US Caucasian populations: analysis of data from the third National Health and Nutrition Examination Survey

Allogeneic transplantation of CD34⁺selected cells from peripheral blood from human leukocyte antigen–identical siblings: detrimental effect of a high number of donor CD34⁺ cells?
Clinical Trials & Observations

Alvaro Urbano-Ispizua,Enric Carreras,Pedro Marı́n,Montserrat Rovira,Carmen Martı́nez,Francesc Fernández-Avilés,Blanca Xicoy,Juan-Carlos Hernández-Boluda,Emili Montserrat

View Articletitled, Allogeneic transplantation of CD34+selected cells from peripheral blood from human leukocyte antigen–identical siblings: detrimental effect of a high number of donor CD34+ cells?

Clinical, immunologic, and pathologic correlates of bone marrow involvement in 291 patients with acquired immunodeficiency syndrome–related lymphoma
Clinical Trials & Observations

Lasika Seneviratne,Byron M. Espina,Bharat N. Nathwani,Joel A. Chan,Russell K. Brynes,Alexandra M. Levine

View Articletitled, Clinical, immunologic, and pathologic correlates of bone marrow involvement in 291 patients with acquired immunodeficiency syndrome–related lymphoma

GENE THERAPY

Integrated src kinase and costimulatory activity enhances signal transduction through single-chain chimeric receptors in T lymphocytes

Terrence L. Geiger,Phuong Nguyen,David Leitenberg,Richard A. Flavell

View Articletitled, Integrated src kinase and costimulatory activity enhances signal transduction through single-chain chimeric receptors in T lymphocytes

HEMATOPOIESIS

Alterations of the phosphoinositide 3-kinase and mitogen-activated protein kinase signaling pathways in the erythropoietin-independent Spi-1/PU.1 transgenic proerythroblasts

Stéphane Barnache,Patrick Mayeux,Bernard Payrastre,Françoise Moreau-Gachelin

View Articletitled, Alterations of the phosphoinositide 3-kinase and mitogen-activated protein kinase signaling pathways in the erythropoietin-independent Spi-1/PU.1 transgenic proerythroblasts

Multipotent hematopoietic cell lines derived from C/EBPα(−/−) knockout mice display granulocyte macrophage–colony-stimulating factor, granulocyte– colony-stimulating factor, and retinoic acid–induced granulocytic differentiation

Steven J. Collins,Jon Ulmer,Louise E. Purton,Gretchen Darlington

View Articletitled, Multipotent hematopoietic cell lines derived from C/EBPα(−/−) knockout mice display granulocyte macrophage–colony-stimulating factor, granulocyte– colony-stimulating factor, and retinoic acid–induced granulocytic differentiation

Roles of tumor necrosis factor-α receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome

Ester Carballo,Perry J. Blackshear

View Articletitled, Roles of tumor necrosis factor-α receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome

Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow

Cesare Campagnoli,Irene A. G. Roberts,Sailesh Kumar,Phillip R. Bennett,Ilaria Bellantuono,Nicholas M. Fisk

View Articletitled, Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow

Molecular pathways in bone marrow homing: dominant role of α₄β₁ over β₂-integrins and selectins

Thalia Papayannopoulou,Gregory V. Priestley,Betty Nakamoto,Vivian Zafiropoulos,Linda M. Scott

View Articletitled, Molecular pathways in bone marrow homing: dominant role of α4β1 over β2-integrins and selectins

Identification of a candidate human neurohematopoietic stem-cell population

Chu-Chih Shih,Yehua Weng,Adam Mamelak,Thomas LeBon,Mickey C.-T. Hu,Stephen J. Forman

View Articletitled, Identification of a candidate human neurohematopoietic stem-cell population

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

Blood coagulation at the site of microvascular injury: effects of low-dose aspirin

Anetta Undas,Kathleen Brummel,Jacek Musial,Kenneth G. Mann,Andrew Szczeklik

View Articletitled, Blood coagulation at the site of microvascular injury: effects of low-dose aspirin

A point mutation in the cysteine-rich domain of glycoprotein (GP) IIIa results in the expression of a GPIIb-IIIa (αIIbβ3) integrin receptor locked in a high-affinity state and a Glanzmann thrombasthenia–like phenotype

Catherine Ruiz,Chao-Yan Liu,Qi-Hong Sun,Marianne Sigaud-Fiks,Edith Fressinaud,Jean-Yves Muller,Paquita Nurden,Alan T. Nurden,Peter J. Newman,Nathalie Valentin

View Articletitled, A point mutation in the cysteine-rich domain of glycoprotein (GP) IIIa results in the expression of a GPIIb-IIIa (αIIbβ3) integrin receptor locked in a high-affinity state and a Glanzmann thrombasthenia–like phenotype

Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through FcγRIIA

Michael P. Reilly,Scott M. Taylor,Nealie K. Hartman,Gowthami M. Arepally,Bruce S. Sachais,Douglas B. Cines,Mortimer Poncz,Steven E. McKenzie

View Articletitled, Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through FcγRIIA

The alternatively spliced α_EC domain of human fibrinogen-420 is a novel ligand for leukocyte integrins α_Mβ₂ and α_Xβ₂

Valeryi K. Lishko,Valentin P. Yakubenko,Kathe M. Hertzberg,Gerd Grieninger,Tatiana P. Ugarova

View Articletitled, The alternatively spliced αEC domain of human fibrinogen-420 is a novel ligand for leukocyte integrins αMβ2 and αXβ2

IMMUNOBIOLOGY

Basic helix-loop-helix proteins E2A and HEB induce immature T-cell receptor rearrangements in nonlymphoid cells

Anton W. Langerak,Ingrid L. M. Wolvers-Tettero,Ellen J. van Gastel-Mol,Monique E. C. M. Oud,Jacques J. M. van Dongen

View Articletitled, Basic helix-loop-helix proteins E2A and HEB induce immature T-cell receptor rearrangements in nonlymphoid cells

Immunophenotypic profiles in families with autoimmune lymphoproliferative syndrome
Clinical Trials & Observations

Jack J. H. Bleesing,Margaret R. Brown,Stephen E. Straus,Janet K. Dale,Richard M. Siegel,Michele Johnson,Michael J. Lenardo,Jennifer M. Puck,Thomas A. Fleisher

View Articletitled, Immunophenotypic profiles in families with autoimmune lymphoproliferative syndrome

Human herpesvirus 7 induces the functional up-regulation of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) coupled to TRAIL-R1 down-modulation in CD4⁺ T cells

Paola Secchiero,Prisco Mirandola,Davide Zella,Claudio Celeghini,Arianna Gonelli,Marco Vitale,Silvano Capitani,Giorgio Zauli

View Articletitled, Human herpesvirus 7 induces the functional up-regulation of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) coupled to TRAIL-R1 down-modulation in CD4+ T cells

HIV gp120 receptors on human dendritic cells

Stuart G. Turville,Jim Arthos,Kelli Mac Donald,Garry Lynch,Hassan Naif,Georgina Clark,Derek Hart,Anthony L. Cunningham

View Articletitled, HIV gp120 receptors on human dendritic cells

Calcium signaling inhibits interleukin-12 production and activates CD83⁺ dendritic cells that induce Th2 cell development

Mark B. Faries,Isabelle Bedrosian,Shuwen Xu,Gary Koski,James G. Roros,Mirielle A. Moise,Hung Q. Nguyen,Friederike H. C. Engels,Peter A. Cohen,Brian J. Czerniecki

View Articletitled, Calcium signaling inhibits interleukin-12 production and activates CD83+ dendritic cells that induce Th2 cell development

NEOPLASIA

Immunophenotypic analysis of hematogones (B-lymphocyte precursors) in 662 consecutive bone marrow specimens by 4-color flow cytometry

Robert W. McKenna,LaBaron T. Washington,Deborah B. Aquino,Louis J. Picker,Steven H. Kroft

View Articletitled, Immunophenotypic analysis of hematogones (B-lymphocyte precursors) in 662 consecutive bone marrow specimens by 4-color flow cytometry

Transformation of interleukin-3–dependent cells without participation of Stat5/bcl-xL: cooperation of akt with raf/erk leads to p65 nuclear factor κB–mediated antiapoptosis involving c-IAP2

Vasily M. Gelfanov,Gem S. Burgess,Sara Litz-Jackson,Alastair J. King,Mark S. Marshall,Harikrishna Nakshatri,H. Scott Boswell

View Articletitled, Transformation of interleukin-3–dependent cells without participation of Stat5/bcl-xL: cooperation of akt with raf/erk leads to p65 nuclear factor κB–mediated antiapoptosis involving c-IAP2

Rabaptin-5 is a novel fusion partner to platelet-derived growth factor β receptor in chronic myelomonocytic leukemia

Magnus K. Magnusson,Kristin E. Meade,Kevin E. Brown,Diane C. Arthur,Lisa A. Krueger,A. John Barrett,Cynthia E. Dunbar

View Articletitled, Rabaptin-5 is a novel fusion partner to platelet-derived growth factor β receptor in chronic myelomonocytic leukemia

Induction of a long-lasting antitumor immunity by a trifunctional bispecific antibody

Peter Ruf,Horst Lindhofer

View Articletitled, Induction of a long-lasting antitumor immunity by a trifunctional bispecific antibody

A comparative evaluation of conventional and pretargeted radioimmunotherapy of CD20-expressing lymphoma xenografts

Oliver W. Press,Melissa Corcoran,Krishnan Subbiah,Don K. Hamlin,D. Scott Wilbur,Timothy Johnson,Louis Theodore,Eric Yau,Robert Mallett,Damon L. Meyer,Don Axworthy

View Articletitled, A comparative evaluation of conventional and pretargeted radioimmunotherapy of CD20-expressing lymphoma xenografts

PHAGOCYTES

Bifurcation of osteoclasts and dendritic cells from common progenitors

Takeshi Miyamoto,Osamu Ohneda,Fumio Arai,Katsuya Iwamoto,Seiji Okada,Katsumasa Takagi,Dirk M. Anderson,Toshio Suda

View Articletitled, Bifurcation of osteoclasts and dendritic cells from common progenitors

RED CELLS

An IRP-like protein from Plasmodium falciparum binds to a mammalian iron-responsive element

Mark Loyevsky,Timothy LaVaute,Charles R. Allerson,Robert Stearman,Olakunle O. Kassim,Sharon Cooperman,Victor R. Gordeuk,Tracey A. Rouault

View Articletitled, An IRP-like protein from Plasmodium falciparum binds to a mammalian iron-responsive element

BRIEF REPORTS

Lineage restriction of the RARα gene expression in myeloid differentiation
Brief Report

Jun Zhu,Clare M. Heyworth,Annegret Glasow,Qiu-Hua Huang,Kevin Petrie,Michel Lanotte,Gérard Benoit,Robert Gallagher,Samuel Waxman,Tariq Enver,Arthur Zelent

View Articletitled, Lineage restriction of the RARα gene expression in myeloid differentiation

Molecular regulation of CC-chemokine receptor 3 expression in human T helper 2 cells
Brief Report

Emmanuel Scotet,Susanne Schroeder,Antonio Lanzavecchia

View Articletitled, Molecular regulation of CC-chemokine receptor 3 expression in human T helper 2 cells

TT virus contaminates first-generation recombinant factor VIII concentrates
Clinical Trials & Observations Brief Report

Alberta Azzi,Riccardo De Santis,Massimo Morfini,Krystyna Zakrzewska,Roberto Musso,Elena Santagostino,Giancarlo Castaman

View Articletitled, TT virus contaminates first-generation recombinant factor VIII concentrates

Loss of blood CD11c⁺ myeloid and CD11c⁻plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load
Brief Report

Heather Donaghy,Anton Pozniak,Brian Gazzard,Nad Qazi,Jill Gilmour,Frances Gotch,Steven Patterson

View Articletitled, Loss of blood CD11c+ myeloid and CD11c−plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load

Effect of a large deletion of the basic domain of mitranscription factor on differentiation of mast cells
Brief Report

Eiichi Morii,Hideki Ogihara,Keisuke Oboki,Tatsuki R. Kataoka,Kazutaka Maeyama,David E. Fisher,M. Lynn Lamoreux,Yukihiko Kitamura

View Articletitled, Effect of a large deletion of the basic domain of mitranscription factor on differentiation of mast cells

Detection of tryptase in cytoplasmic granules of basophils in patients with chronic myeloid leukemia and other myeloid neoplasms
Brief Report

Puchit Samorapoompichit,Hans P. Kiener,Gerit-Holger Schernthaner,John-Hendrik Jordan,Hermine Agis,Friedrich Wimazal,Mehrdad Baghestanian,Abdolreza Rezaie-Majd,Wolfgang R. Sperr,Klaus Lechner,Peter Valent

View Articletitled, Detection of tryptase in cytoplasmic granules of basophils in patients with chronic myeloid leukemia and other myeloid neoplasms

Genetic polymorphism in exon 4 of cytochrome P450 CYP2C9 may be associated with warfarin sensitivity in Chinese patients
Brief Report

Anskar Y. H. Leung,Howard C. H. Chow,Y. L. Kwong,Albert K. W. Lie,Alvin T. K. Fung,W. H. Chow,Alex S. B. Yip,Raymond Liang

View Articletitled, Genetic polymorphism in exon 4 of cytochrome P450 CYP2C9 may be associated with warfarin sensitivity in Chinese patients

CORRESPONDENCE

Longitudinal dynamics of antigen-specific CD8⁺cytotoxic T lymphocytes following primary Epstein-Barr virus infection

Mandvi Bharadwaj,Scott R. Burrows,Jacqueline M. Burrows,Denis J. Moss,Michelle Catalina,Rajiv Khanna

View Articletitled, Longitudinal dynamics of antigen-specific CD8+cytotoxic T lymphocytes following primary Epstein-Barr virus infection

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Issue Archive

Table of Contents

INSIDE BLOOD

PLENARY PAPERS

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Randomized comparison of fludarabine, CAP, and ChOP in 938 previously untreated stage B and C chronic lymphocytic leukemia patients Clinical Trials & Observations

Intensive chemotherapy followed by allogeneic or autologous stem cell transplantation for patients with myelodysplastic syndromes (MDSs) and acute myeloid leukemia following MDS Clinical Trials & Observations

Standardized, unrelated donor cord blood transplantation in adults with hematologic malignancies Clinical Trials & Observations

Changes in AIDS-related lymphoma since the era of highly active antiretroviral therapy Clinical Trials & Observations

Relationship between transferrin saturation and iron stores in the African American and US Caucasian populations: analysis of data from the third National Health and Nutrition Examination Survey Clinical Trials & Observations

Allogeneic transplantation of CD34+selected cells from peripheral blood from human leukocyte antigen–identical siblings: detrimental effect of a high number of donor CD34+ cells? Clinical Trials & Observations

Clinical, immunologic, and pathologic correlates of bone marrow involvement in 291 patients with acquired immunodeficiency syndrome–related lymphoma Clinical Trials & Observations

GENE THERAPY

HEMATOPOIESIS

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY

IMMUNOBIOLOGY

Immunophenotypic profiles in families with autoimmune lymphoproliferative syndrome Clinical Trials & Observations

NEOPLASIA

PHAGOCYTES

RED CELLS

BRIEF REPORTS

Lineage restriction of the RARα gene expression in myeloid differentiation Brief Report

Molecular regulation of CC-chemokine receptor 3 expression in human T helper 2 cells Brief Report

TT virus contaminates first-generation recombinant factor VIII concentrates Clinical Trials & Observations Brief Report

Loss of blood CD11c+ myeloid and CD11c−plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load Brief Report

Effect of a large deletion of the basic domain of mitranscription factor on differentiation of mast cells Brief Report

Detection of tryptase in cytoplasmic granules of basophils in patients with chronic myeloid leukemia and other myeloid neoplasms Brief Report

Genetic polymorphism in exon 4 of cytochrome P450 CYP2C9 may be associated with warfarin sensitivity in Chinese patients Brief Report